Suresh V Ambudkar

发表

Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies.

S. Ambudkar, Eduardo E Chufan, Hong-May Sim, 2015, Advances in cancer research.

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

Jean-Pierre Gillet, Sudhir Varma, Anil K Sood, 2011, Proceedings of the National Academy of Sciences.

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Zuben E Sauna, Z. Sauna, S. Ambudkar, 2006, Biochemistry.

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

Suneet Shukla, S. Ambudkar, S. Shukla, 2006, Molecular Cancer Therapeutics.

Structure of a multidrug transporter

Michael M Gottesman, M. Gottesman, S. Ambudkar, 2009, Nature Biotechnology.

New inhibitors of ABCG2 identified by high-throughput screening

Michael Dean, Suneet Shukla, Curtis J Henrich, 2007, Molecular Cancer Therapeutics.

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2007, Cancer research.

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

In-Wha Kim, Zuben E Sauna, Z. Sauna, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen

Suneet Shukla, S. Bates, S. Holbeck, 2009, Molecular Pharmacology.

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.

Suneet Shukla, Zuben E Sauna, Rajendra Prasad, 2004, Biochemical and biophysical research communications.

Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy.

S. Ambudkar, S. Ohnuma, Suresh V Ambudkar, 2011, Current pharmaceutical biotechnology.

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

Ruth Nussinov, Chung-Jung Tsai, Chava Kimchi-Sarfaty, 2008, Journal of molecular biology.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Suneet Shukla, Michael M Gottesman, M. Gottesman, 2011, Molecular pharmaceutics.

Silent (synonymous) SNPs: should we care about them?

Ryan Hunt, Chava Kimchi-Sarfaty, Zuben E Sauna, 2009, Methods in molecular biology.

Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor

A. Calcagno, S. Ambudkar, S. Emanuel, 2006, Molecular Cancer Therapeutics.

Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins

A. Calcagno, S. Ambudkar, Suresh V Ambudkar, 2006, BMC Molecular Biology.

Multidrug Resistance–Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma

Jean-Pierre Gillet, Sudhir Varma, Anil K Sood, 2012, Clinical Cancer Research.

P-glycoprotein: from genomics to mechanism

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2003, Oncogene.

Botryllamides: natural product inhibitors of ABCG2.

Suneet Shukla, Kentaro Takada, Curtis J Henrich, 2009, ACS chemical biology.

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

Suneet Shukla, S. Bates, R. Robey, 2006, Biochemistry.

Mutational analysis of ABCG2: role of the GXXXG motif.

Michael Dean, Zuben E Sauna, S. Bates, 2004, Biochemistry.

Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2

Suneet Shukla, S. Bates, R. Robey, 2009, Drug Metabolism and Disposition.

Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Stephan Kopp, In-Wha Kim, Peter Chiba, 2007, Biochemistry.

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Suneet Shukla, Michael M Gottesman, Matthew D Hall, 2007, Molecular Cancer Therapeutics.

The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?

Leopold May, S. Ambudkar, Suresh V Ambudkar, 2007, Biochemical and biophysical research communications.

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Xin Hu, Suneet Shukla, Damien Y. Duveau, 2013, Bioorganic & medicinal chemistry letters.