Hong Liu

发表

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Wei Zhu, Hong Liu, Yu Zhou, 2016, Chemical reviews.

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

Cheng Luo, Bairong Shen, Zhongjie Liang, 2015, Scientific Reports.

Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.

Cheng Luo, Ying Wang, Zhongjie Liang, 2013, Bioorganic & medicinal chemistry.

Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases?

Weiliang Zhu, Jian Li, Honglin Li, 2011, Journal of medicinal chemistry.

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Li Zhang, Yu Qin, Jingkang Shen, 2006, Bioorganic & Medicinal Chemistry.

Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant

Cheng Luo, Mingyue Zheng, Zhongjie Liang, 2011, PloS one.

Inhibitor discovery targeting the intermediate structure of beta-amyloid peptide on the conformational transition pathway: implications in the aggregation mechanism of beta-amyloid peptide.

Jianpeng Ma, Xu Shen, Kaixian Chen, 2006, Biochemistry.

Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking

Weiliang Zhu, Weihua Li, Yun Tang, 2008, Proteins.

Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.

Bing Xiong, Kaixian Chen, Jianhua Shen, 2002, Journal of medicinal chemistry.

Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

George F. Gao, Feng Gao, Jun Liu, 2011, PLoS pathogens.

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Weiliang Zhu, Jian Li, Ky-Youb Nam, 2012, European journal of medicinal chemistry.

Possible Pathway(s) of Metyrapone Egress from the Active Site of Cytochrome P450 3A4: A Molecular Dynamics Simulation

Weiliang Zhu, Weihua Li, Yun Tang, 2007, Drug Metabolism and Disposition.

Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)?

Cheng Luo, Jianpeng Ma, Weiliang Zhu, 2009, Cell Research.

Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.

Honglin Li, Kunqian Yu, Mingyue Zheng, 2009, Journal of medicinal chemistry.

Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.

Weiliang Zhu, Jian Li, Mingyue Zheng, 2006, Bioorganic & medicinal chemistry letters.

[Application of methyl in drug design].

Hong Liu, Haifeng Sun, Hong Liu, 2013, Yao xue xue bao = Acta pharmaceutica Sinica.

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix.

Hong Liu, J. Halpert, E. Scott, 2004, Archives of biochemistry and biophysics.

Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing.

Yang Li, Jianmin Yue, Suxin Zheng, 2003, Chemistry & biology.

Structural optimization and biological evaluation of substituted bisphenol A derivatives as beta-amyloid peptide aggregation inhibitors.

Cheng Luo, Zhongjie Liang, Xin Xie, 2010, Journal of medicinal chemistry.

Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.

Cheng Luo, Weiliang Zhu, Mingyue Zheng, 2012, Organic & biomolecular chemistry.

Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay.

Weiliang Zhu, Yang Li, Suxin Zheng, 2007, Journal of medicinal chemistry.

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs

Fei Zhao, Mingyue Zheng, Rolf Hilgenfeld, 2012, ChemMedChem.

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

Weiliang Zhu, Jian Li, Mingyue Zheng, 2013, Journal of medicinal chemistry.

Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Cheng Luo, Fei Ye, Haiyan Li, 2012, Journal of the American Chemical Society.

Reduced Catalytic Activity of P450 2A6 Mutants with Coumarin: A Computational Investigation.

Weihua Li, Yun Tang, Hualiang Jiang, 2009, Journal of chemical theory and computation.

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A

Cheng Luo, Jingkang Shen, Suxin Zheng, 2004, Biochemical and Biophysical Research Communications - BBRC.

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

Zhuxi Chen, Ping Li, Hao Li, 2013, Cell Research.

Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).

Hong Liu, Jiang Wang, C. del Pozo, 2014, Chemical reviews.

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

Jianhua He, Di Liu, Christopher J Vavricka, 2010, Nature Structural &Molecular Biology.

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

Zihe Rao, Luke W. Guddat, Bing Zhang, 2020, medRxiv.

POSSIBLE PATHWAY(S) OF TESTOSTERONE EGRESS FROM THE ACTIVE SITE OF CYTOCHROME P450 2B1: A STEERED MOLECULAR DYNAMICS SIMULATION

Weihua Li, Frauke Gräter, Hualiang Jiang, 2005, Drug Metabolism and Disposition.

Gold-catalyzed Michael addition/intramolecular annulation cascade: an effective pathway for the chemoselective- and regioselective synthesis of tetracyclic indole derivatives in water

Hualiang Jiang, Jinyi Xu, Hualiang Jiang, 2013 .