K. Lim

发表

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

Bin Tean Teh, Niranjan Nagarajan, Denis Bertrand, 2012, Nature Genetics.

Development and validation of automated assessment of liver fibrosis using second harmonic generation microscopy in patients with non-alcoholic fatty liver disease

G. Goh, Chee‐Kiat Tan, K. Lim, 2017 .

Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy.

Chia Huey Ooi, Sze Huey Tan, Jae Ho Cheong, 2011, Gastroenterology.

Label-free isolation of circulating tumor cells in microfluidic devices: Current research and perspectives.

Ciprian Iliescu, Igor Cima, C. Iliescu, 2013, Biomicrofluidics.

Tissue Microbiome Profiling Identifies an Enrichment of Specific Enteric Bacteria in Opisthorchis viverrini Associated Cholangiocarcinoma

Bin Tean Teh, Niranjan Nagarajan, Denis Bertrand, 2016, EBioMedicine.

Liver Transplantation in an Adult with Citrullinaemia Type 2

P. Cheow, Chee‐Kiat Tan, K. Lim, 2011, Journal of transplantation.

Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer

I. Tan, P. Tan, John Carson Allen, 2018, JNCI cancer spectrum.

475 Incidental finding of colorectal cancer in a COVID-19 patient, followed by deep profiling of SARS-CoV-2-associated immune landscape and tumour microenvironment

J. Low, J. Yeong, S. Kalimuddin, 2020 .

Macrophages in human colorectal cancer are pro‐inflammatory and prime T cells towards an anti‐tumour type‐1 inflammatory response

O. Beretta, S. Wong, Henry Yang, 2012, European journal of immunology.

Clinical and therapeutic relevance of PIM1 kinase in gastric cancer

Kol Jia Yong, M. Salto‐Tellez, R. Soong, 2012, Gastric Cancer.

Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

Swe Swe Myint, Dachuan Huang, C. Ong, 2013, Nature Genetics.

iTRAQ analysis of colorectal cancer cell lines suggests Drebrin (DBN1) is overexpressed during liver metastasis

Hwee Tong Tan, M. Chung, T. Lim, 2014, Proteomics.

S. Choo, I. Tan, R. Soo, 2021, Asia-Pacific journal of clinical oncology.

Mismatch Repair Deficiency Screening via Immunohistochemical Staining in Young Asians with Colorectal Cancers

C. Tang, M. Chew, K. Lim, 2013, World Journal of Surgery.

Title HER 2 amplification and clinicopathological characteristicsin a large Asian cohort of rare mucinous ovarian cancer

S. Lim-Tan, I. Busmanis, W. Ong, 2017 .

HER2 Amplification and Clinicopathological Characteristics in a Large Asian Cohort of Rare Mucinous Ovarian Cancer

S. Lim-Tan, I. Busmanis, W. Ong, 2013, PloS one.

Close distal margins do not increase rectal cancer recurrence after sphincter-saving surgery without neoadjuvant therapy

C. Tang, M. Chew, K. Lim, 2012, International Journal of Colorectal Disease.

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

X. Wang, Arnoud Boot, C. Ong, 2019, Cancer cell.

Detection of IDH mutations in cerebrospinal fluid: A discussion of liquid biopsy in neuropathology

K. Lim, G. S. Tan, C. Tham, 2020, Archives of Pathology and Clinical Research.

Malignant Adenomyoepithelial Tumor of the Breast: Multi-immunolabeling Technique and Detailed Immunophenotypic Study

E. Tan, M. Nga, K. Lim, 2007, Applied immunohistochemistry & molecular morphology : AIMM.

Association of Clinicopathologic and Molecular Tumor Features With Recurrence in Resected Early-Stage Epidermal Growth Factor Receptor–Positive Non–Small Cell Lung Cancer

A. Takano, E. Tan, Q. Ng, 2021, JAMA network open.

Critical analysis of mucin and signet ring cell as prognostic factors in an Asian population of 2,764 sporadic colorectal cancers

M. Chew, K. Ng, K. Eu, 2010, International Journal of Colorectal Disease.

Lack of Targetable FGFR2 Fusions in Endemic Fluke-Associated Cholangiocarcinoma

B. Teh, S. Dima, I. Popescu, 2020, JCO global oncology.

Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer

A. Ullrich, A. Takano, E. Tan, 2014, Molecular Cancer.

Diagnosis of Adenoid Cystic Carcinoma of the Lung by Bronchial Brushing

W. Yap, K. Chuah, K. Lim, 2007, Acta Cytologica.

Hepatic progenitor cells in liver cancers from Asian children

Y. N. Park, S. Thung, Ja-june Jang, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity.

B. Singh, Sujoy Ghosh, P. Yen, 2016, Biochemical and biophysical research communications.

An Improved qFibrosis Algorithm for Precise Screening and Enrollment into Non-Alcoholic Steatohepatitis (NASH) Clinical Trials

P. Bedossa, A. Wee, G. Goh, 2020, Diagnostics.

qFIBS: An Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis

F. Liu, A. Wee, M. Romero-Gómez, 2020, Hepatology.

Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease

G. Goh, Chee‐Kiat Tan, K. Lim, 2018, PloS one.

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

S. Prabhakar, P. Wirapati, W. Park, 2022, Nature Genetics.

Paracrine factors of human fetal MSCs inhibit liver cancer growth through reduced activation of IGF-1R/PI3K/Akt signaling.

H. Huynh, A. Chung, N. Iyer, 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

Rapamycin and thalidomide treatment of a patient with refractory metastatic gastroesophageal adenocarcinoma: a case report.

S. Choo, M. Teo, H. Toh, 2010, The oncologist.

HER2 positive rates are enriched amongst colorectal cancer brain metastases: a study amongst 1920 consecutive patients.

M. Ng, K. Lim, T. Lim, 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan.

C. Chan, S. Lee, K. Lim, 2013, World journal of gastroenterology.

Eosinophilic gastroenteritis: Clinical profiles and treatment outcomes, a retrospective study of 18 adult patients in a Singapore Tertiary Hospital.

K. Lim, W. Wan, G. Wong, 2015, The Medical journal of Malaysia.

Pulmonary intimal sarcoma presenting as an ascending colonic polyp and mimicking a gastrointestinal stromal tumour.

K. Lim, S. Ng, V. Lee, 2008, Pathology.

Preliminary Results of Mismatch Repair Deficiency Screening via Immunohistochemical Staining in Young Asian Colorectal Cancers

C. Tang, M. Chew, K. Eu, 2010 .

Mesenchymal Stromal Cell (MSC)-Derived Combination of CXCL5 and Anti-CCL24 Is Synergistic and Superior to MSC and Cyclosporine for the Treatment of Graft-versus-Host Disease.

Shang Li, Z. Poon, S. Bari, 2018, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19

C. Chan, P. Cheow, S. Kalimuddin, 2021, Gut.

Clinical and Genomic Features of HER2 Exon 20 Insertion Mutations and Characterization of HER2 Expression by Immunohistochemistry in East Asian Non-Small-Cell Lung Cancer.

A. Takano, Q. Ng, R. Kanesvaran, 2022, JCO precision oncology.

A Randomized Phase 2 Trial of Nivolumab Versus Nivolumab-Ipilimumab Combination in EGFR-Mutant NSCLC

Jacob Josiah Santiago Alvarez, W. Tam, A. Takano, 2022, JTO clinical and research reports.

Focal nodular hyperplasia-like lesion in a cirrhotic liver mimicking a cholangiocarcinoma

K. Lim, W. Wan, J. Wong, 2013, Journal of Clinical Pathology.

Residual cervical lymphadenopathy after definitive treatment of nasopharyngeal carcinoma: fine needle aspiration cytology, computed tomography and histopathological findings

H. Yuen, S. Toh, K. Lim, 2010, The Journal of Laryngology & Otology.

Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus

O. Kon, K. Lim, H. Loh, 2012, Journal of Molecular Medicine.

Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer

Bauke Ylstra, Alex Boussioutas, Jacinta Murray, 2012, Gut.

Characterization of the human gastric fluid proteome reveals distinct pH-dependent protein profiles: implications for biomarker studies.

Oi Lian Kon, Thomas Hennessy, Mengfatt Ho, 2011, Journal of proteome research.

Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

P. Chow, C. Chan, S. Lee, 2017, Proceedings of the National Academy of Sciences.

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

Khay Guan Yeoh, Alex Boussioutas, Sandra Bell, 2012, Gut.

First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum

Bin Tean Teh, Khee Chee Soo, Choon Kiat Ong, 2011, Genome Biology.

Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

Jacob Josiah Santiago Alvarez, W. Tam, D. Anantham, 2021, Clinical Cancer Research.

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Bin Tean Teh, Hiromi Nakamura, Chern Han Yong, 2017, Cancer discovery.

Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma

M. Garnelo, P. Chow, I. Ng, 2015, Gut.

High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer

N. Nagarajan, B. Teh, C. Chan, 2015, Genome Biology.

GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition.

P. Chow, C. Chan, P. Cheow, 2017, The Journal of clinical investigation.

Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development

H. Ng, K. Soo, Dachuan Huang, 2014, Gut.

Novel Therapies for Metastatic Non-Small Cell Lung Cancer with MET Exon 14 Alterations: A Spotlight on Capmatinib

D. Tan, K. Lim, G. S. Tan, 2021, Lung Cancer.

Germline Bone Morphogenesis Protein Receptor 1A Mutation Causes Colorectal Tumorigenesis in Hereditary Mixed Polyposis Syndrome

P. Cheah, K. Eu, K. Lim, 2009, The American Journal of Gastroenterology.

Multiregion ultra‐deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer

Sarah Ng, C. Chua, I. Tan, 2016, Molecular oncology.

Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients

N. Copeland, N. Jenkins, I. Ng, 2012, Journal of the National Cancer Institute.

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

Jean Paul Thiery, Wen Shan Yew, J. Thiery, 2018, Nature Biomedical Engineering.

Preclinical Evaluation of Transcriptional Targeting Strategy for Human Hepatocellular Carcinoma in an Orthotopic Xenograft Mouse Model

H. Huynh, A. Chung, K. Hui, 2013, Molecular Cancer Therapeutics.

Exome sequencing of liver fluke–associated cholangiocarcinoma

Bin Tean Teh, Sopit Wongkham, Choon Kiat Ong, 2012, Nature Genetics.

SETD2 histone modifier loss in aggressive GI stromal tumours

Swe Swe Myint, K. Soo, H. Ong, 2015, Gut.

Tumor‐adjacent tissue co‐expression profile analysis reveals pro‐oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma

H. Lee, P. Chow, S. P. Yenamandra, 2017, Molecular oncology.

Inflammatory pseudotumour of the liver mimicking cholangiocarcinoma.

C. Thng, L. Ooi, K. Lim, 2013, Annals of the Academy of Medicine, Singapore.

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma

I. Ng, M. Heikenwalder, Jinmiao Chen, 2011, Gut.

Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

H. Koong, A. Takano, E. Tan, 2015, PloS one.

Germline Mutations in Cancer Predisposition Genes are Frequent in Sporadic Sarcomas

K. Soo, B. Teh, P. Tan, 2017, Scientific Reports.

Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion

G. Pugalenthi, T. Tan, Henry Yang, 2016, Oncotarget.

Intravenous extension of sarcomatoid carcinoma of the lung to the left atrium.

W. Yap, K. Chuah, K. Lim, 2006, Pathology.

Toxic Haemorrhagic Colitis: A Rare Presentation of Eosinophilic Colitis

C. Tang, Y. Lim, K. Lim, 2012, Case reports in gastrointestinal medicine.

Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo.

Derek Y. Chiang, V. Mazzaferro, S. Friedman, 2009, Journal of hepatology.

Clinical Validation of an Ultra High-Throughput Spiral Microfluidics for the Detection and Enrichment of Viable Circulating Tumor Cells

Ali Asgar S. Bhagat, Jongyoon Han, Chwee Teck Lim, 2014, PloS one.

An integrative approach identified genes associated with drug response in gastric cancer.

I. Tan, P. Tan, B. Singh, 2015, Carcinogenesis.

Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH.

I. Tan, P. Tan, N. Deng, 2014, Cancer letters.

Multidimensional identification of tissue biomarkers of gastric cancer.

S. Sze, O. Kon, W. Ong, 2012, Journal of proteome research.

t(11;18)(q21;q21)‐positive transformed MALT lymphoma

M. Du, H. Ye, A. Wotherspoon, 2008, Histopathology.

Detection of Usual and Unusual IDH Mutations in Cerebrospinal Fluid: A Case Illustration and Discussion around the Potential of Liquid Biopsy in the Practice of Surgical Neuropathology

K. Lim, C. Tham, Ming Lee, 2020 .

Novel proteomic biomarker panel for prediction of aggressive metastatic hepatocellular carcinoma relapse in surgically resectable patients.

Sze Huey Tan, Hwee Tong Tan, H. Toh, 2014, Journal of proteome research.

Chronic Hepatitis E Infection Resulting in Graft Failure in a Liver Transplant Tourist

J. Chang, Chee‐Kiat Tan, L. Oon, 2011, Case reports in transplantation.

Y. Leung, D. Tan, K. Lim, 2018, Clinical and experimental rheumatology.

Intertumor heterogeneity of non‐small‐cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics

N. Iyer, A. Takano, E. Tan, 2014, International journal of cancer.

A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer

Zitong Zhao, K. Taghipour, K. Lim, 2022, Scientific Reports.

Follicular dendritic cell sarcoma of the liver with metachronous small bowel and splenic metastases: a case report and literature review.

S. Lee, K. Lim, Y. Chung, 2017, Hepatobiliary surgery and nutrition.

Combined hepatocellular and cholangiocarcinoma with sarcomatoid transformation: radiologic–pathologic correlation of a case

U. Pua, K. Lim, Yu-meng Tan, 2009, Hepatology international.

Molecular profiling for druggable genetic abnormalities in carcinoma of unknown primary.

A. Takano, E. Tan, Q. Ng, 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

t oll- l ike r eceptor 3 e xpressing t umor P arenchyma and i nfiltrating Natural Killer c ells in Hepatocellular c arcinoma Patients

N. Copeland, N. Jenkins, I. Ng, 2012 .

Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas.

L. Tucker-Kellogg, C. Eng, Haiwei Song, 2015, Gastroenterology.

Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index

W. Yap, H. Lui, K. Lim, 2008, Alimentary pharmacology & therapeutics.

Evaluation of Long-Term Outcomes of Microsatellite Instability Status in an Asian Cohort of Sporadic Colorectal Cancers

I. Tan, S. Acharyya, W. Tan, 2018, Journal of Gastrointestinal Cancer.

Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer.

Hwee Tong Tan, M. Chung, T. Lim, 2012, Journal of proteome research.

89 The immune marker LAG-3 increases the predictive value of CD38+ immune cells for survival outcome in immunotherapy-treated hepatocellular carcinoma

S. Choo, J. Yeong, H. Toh, 2021, Journal for ImmunoTherapy of Cancer.

National Cancer Centre Singapore Consensus Guidelines for Hepatocellular Carcinoma

C. Thng, P. Chow, S. Choo, 2016, Liver Cancer.

Thyroid hormone decreases hepatic steatosis, inflammation, and fibrosis in a dietary mouse model of NASH.

B. Bay, B. Singh, P. Yen, 2022, Thyroid : official journal of the American Thyroid Association.

Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery

Sarah Ng, W. Burkholder, S. Choo, 2017, Scientific Reports.

The Singapore Liver Cancer Recurrence (SLICER) Score for Relapse Prediction in Patients with Surgically Resected Hepatocellular Carcinoma

P. Chow, S. Choo, P. Cheow, 2015, PloS one.

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women.

N. Iyer, D. Tan, W. Chay, 2018, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women

N. Iyer, D. Tan, W. Chay, 2018, International Journal of Gynecologic Cancer.

Examining the effects of metformin on survival outcome in stage II/III colorectal cancer patients with diabetes mellitus.

W. Tan, I. Tan, K. Lim, 2012 .

The classification of intestinal polyposis

C. Tang, P. Cheah, K. Lim, 2012, Nature Genetics.

Bosutinib inhibits migration and invasion via ack1 in kras mutant non-small cell lung cancer

A. Ullrich, A. Takano, E. Tan, 2014, Molecular Cancer.

CARD9 Promotes Sex-Biased Colon Tumors in the APCmin Mouse Model

J. Ruland, M. Chew, P. Reilly, 2015, Cancer Immunology Research.

Correction: The Singapore Liver Cancer Recurrence (SLICER) Score for Relapse Prediction in Patients with Surgically Resected Hepatocellular Carcinoma

P. Chow, S. Choo, P. Cheow, 2015, PloS one.

Image Guided Percutaneous Lung and Liver Biopsy: Is Performing More Needle Passes a Risk Factor for Post-Biopsy Complications?

A. Takano, E. Tan, D. Tan, 2015 .

RNA-Seq analyses of immune cell-type enrichments in 158 Asian colorectal cancers (CRCs).

Charles J. Vaske, S. Benz, C. Szeto, 2018 .

Real-World Data on Clinical Outcomes of Patients with Liver Cancer: A Prospective Validation of the National Cancer Centre Singapore Consensus Guidelines for the Management of Hepatocellular Carcinoma

C. Thng, P. Chow, S. Choo, 2021, Liver Cancer.

Clinicopathologic Characteristics and Survival of Patients with Gastroenteropancreatic Neuroendocrine Neoplasm in a Multi-Ethnic Asian Institution

S. Lee, S. Ong, B. Goh, 2018, Neuroendocrinology.

Rare Incidence of ROS1 Rearrangement in Cholangiocarcinoma

Y. N. Park, S. Lim, B. Cho, 2016, Cancer research and treatment : official journal of Korean Cancer Association.

A phase II open-label, single-centre, non-randomized trial of Y90 transarterial radioembolization in combination with nivolumab in Asian patients with intermediate stage hepatocellular carcinoma: An immunological study of radioembolization in combination with anti-PD1 therapy in HCC.

C. Thng, P. Chow, W. Zhai, 2018 .

Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein.

Hwee Tong Tan, M. Chung, I. Tan, 2013, Journal of proteome research.

Inflammatory myofibroblastic tumour of the rectum with a novel anaplastic lymphoma kinase fusion diagnosed on cytology: Not just another submucosal gastrointestinal stromal tumour!

D. Tan, K. Lim, C. Ong, 2022, Cytopathology : official journal of the British Society for Clinical Cytology.