R. Cardin

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Kinetics of Murine Gammaherpesvirus 68 Gene Expression following Infection of Murine Cells in Culture and in Mice

A. Clavo, R. Rochford, M. Lutzke, 2001, Journal of Virology.

Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials

D. Bernstein, K. Kousoulas, R. Cardin, 2019, PloS one.

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

D. Bernstein, T. Foster, D. Knipe, 2014, Science Translational Medicine.

Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection.

N. Shastri, M. Blackman, D. Woodland, 1999, Journal of Immunology.

Gammaherpesvirus Infection T Cells In Vivo During Latent Murine + CD 8 Apparent MHC-Independent Stimulation of Woodland and

N. Shastri, M. Blackman, D. Woodland, 1999 .

Infectious Diseases Division Photo

D. Bernstein, R. Ward, R. Frenck, 2009 .

An Adjuvanted Herpes Simplex Virus 2 Subunit Vaccine Elicits a T Cell Response in Mice and Is an Effective Therapeutic Vaccine in Guinea Pigs

D. Long, D. Bernstein, R. Cardin, 2013, Journal of Virology.

Analysis of the Virus-Specific and Nonspecific B Cell Response to a Persistent B-Lymphotropic Gammaherpesvirus1

P. Doherty, M. Sangster, R. Cardin, 2000, The Journal of Immunology.

The Coxsackievirus and Adenovirus Receptor, a Required Host Factor for Recovirus Infection, Is a Putative Enteric Calicivirus Receptor

J. Le Pendu, J. Baines, R. Cardin, 2019, Journal of Virology.

CMV Infection Attenuates the Disease Course in a Murine Model of Multiple Sclerosis

Aaron J. Johnson, R. Dunn, R. Zivadinov, 2012, PloS one.

Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

H. Rothan, A. Gribenko, K. White, 2022, bioRxiv.

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

K. Gajiwala, A. Kalgutkar, P. Verhoest, 2021, Science.

Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation1

A. Waisman, F. Finkelman, M. Khodoun, 2009, The Journal of Immunology.

Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection.

F. Guirakhoo, T. Monath, D. Bernstein, 2016, Vaccine.

Gamma interferon is not essential for recovery from acute infection with murine gammaherpesvirus 68

X. Mo, P. Doherty, R. Cardin, 1997, Journal of virology.

Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study

C. Steppan, D. Rai, A. Anderson, 2022, Antiviral Research.

Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus

N. Davis-Poynter, P. Stevenson, R. Cardin, 2016, PLoS pathogens.

Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus

G. Abenes, C. Stoddart, E. Mocarski, 1994, Journal of virology.

Peripheral BloodMononuclear Phagocytes Mediate Dissemination ofMurineCytomegalovirus

G. Abenes, C. Stoddart, R. Cardin, 1994 .

Topical SMIP-7.7, a Toll–Like Receptor 7 Agonist, Protects against Genital Herpes Simplex Virus Type-2 Disease in the Guinea Pig Model of Genital Herpes

Jennifer R. Clark, M. Cooke, D. Bernstein, 2014, Antiviral chemistry & chemotherapy.

Pathogenesis of murine gammaherpesvirus-68 infection in interleukin-6-deficient mice.

P. Doherty, R. Cardin, S. Sarawar, 1998, Virology.

Luciferase-tagged wild-type and tropism-deficient mouse cytomegaloviruses reveal early dynamics of host colonization following peripheral challenge.

N. Davis-Poynter, P. Stevenson, M. Mach, 2016, The Journal of general virology.

CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.

P. Doherty, J. Christensen, R. Cardin, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine (cid:103) -Herpesvirus: Role for a Viral Superantigen?

F. Behm, P. Doherty, R. Tripp, 1997 .

Don’t Go Breaking My Heart: MCMV as a Model for HCMV-Associated Cardiovascular Diseases

R. Cardin, Cassandra M. Bonavita, Cassandra M Bonavita, 2021, Pathogens.

Cytokine production in the immune response to murine gammaherpesvirus 68

P. Doherty, M. Mehrpooya, R. Tripp, 1996, Journal of virology.

Characterization of Murine Cytomegalovirus Infection and Induction of Calcification in Murine Aortic Vascular Smooth Muscle Cells (MOVAS).

R. Cardin, Brent A. Stanfield, T. White, 2021, Journal of virological methods.

Mononucleosis-Like Syndrome Cells , and B Cells in an Infectious T + Requirement for CD 40 Ligand , CD 4

C. L. Hardy, R. Cardin, J. Brooks, 1999 .

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

H. van Bakel, A. García-Sastre, V. Simon, 2022, bioRxiv.

Factors controlling levels of CD8+ T-cell lymphocytosis associated with murine gamma-herpesvirus infection.

I. Kim, M. Blackman, D. Woodland, 2001, Viral immunology.

Apparent MHC-independent stimulation of CD8+ T cells in vivo during latent murine gammaherpesvirus infection.

N. Shastri, M. Blackman, D. Woodland, 1999, Journal of immunology.

Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig.

Jennifer R. Clark, D. Bernstein, R. Eisenberg, 2011, Vaccine.

Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

D. Bernstein, J. Cummins, L. Flamand, 2009, Virology Journal.

Vivo Replication and Latency Differential Tissue-Specific Role during In Murine Cytomegalovirus Exhibits a The M33 Chemokine Receptor Homolog of

N. Davis-Poynter, R. Cardin, H. Farrell, 2014 .

The M33 Chemokine Receptor Homolog of Murine Cytomegalovirus Exhibits a Differential Tissue-Specific Role during In Vivo Replication and Latency

N. Davis-Poynter, R. Cardin, H. Farrell, 2009, Journal of Virology.

Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy.

D. Bernstein, R. Cardin, N. Sawtell, 2010, Antiviral research.

Potent Adjuvant Activity of Cationic Liposome-DNA Complexes for Genital Herpes Vaccines

D. Bernstein, C. Chalk, R. Cardin, 2009, Clinical and Vaccine Immunology.

Efficacy of N-methanocarbathymidine against genital herpes simplex virus type 2 shedding and infection in guinea pigs

D. Bernstein, R. Glazer, Aquilur Rahman, 2015, Antiviral chemistry & chemotherapy.

Pathogenesis of an Infectious Mononucleosis-like Disease Induced by a Murine γ-Herpesvirus: Role for a Viral Superantigen?

F. Behm, P. Doherty, R. Tripp, 1997, The Journal of experimental medicine.

Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection

D. Bernstein, K. Hostetler, R. Cardin, 2010, Antimicrobial Agents and Chemotherapy.

Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection.

D. Bernstein, R. Cardin, F. Bravo, 2006, The Journal of infectious diseases.

N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs.

D. Bernstein, R. Glazer, Aquilur Rahman, 2011, Antiviral research.

NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin

D. Bernstein, J. Domagala, W. Wold, 2022, Molecular pharmaceutics.

Amphipathic DNA Polymers Exhibit Antiherpetic Activity In Vitro and In Vivo

D. Bernstein, G. Boivin, N. Goyette, 2008, Antimicrobial Agents and Chemotherapy.

Amphipathic DNA Polymers Exhibit Anti-herpetic Activity 1 In vitro and In vivo 2 3 Running Title: Herpetic activity of amphipathic DNA polymers 4 5

D. Bernstein, G. Boivin, N. Goyette, 2008 .

Canadian workshop on the Colpidium campylum ciliate protozoan growth inhibition test

C. Blaise, D. Dive, R. Cardin, 1990 .

Tuning into immunological dissonance: an experimental model for infectious mononucleosis.

P. Doherty, R. Tripp, M. Blackman, 1997, Current opinion in immunology.

Intranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes.

D. Bernstein, G. Cohen, A. Fattom, 2019, Vaccine.

Requirement for CD40 Ligand, CD4+ T Cells, and B Cells in an Infectious Mononucleosis-Like Syndrome

P. Doherty, J. Christensen, R. Cardin, 1999, Journal of Virology.

Tissue-specific control of latent CMV reactivation by regulatory T cells

Maha Almanan, C. Chougnet, David A Hildeman, 2017, PLoS pathogens.

Effector CD4+ and CD8+ T‐cell mechanisms in the control of respiratory virus infections

P. Doherty, R. Tripp, P. Stevenson, 1997, Immunological reviews.

Immunological control of murine gammaherpesvirus infection is independent of perforin.

D. Allen, P. Doherty, A. Nash, 1997, The Journal of general virology.

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells.

P. Doherty, J. Christensen, P. Stevenson, 1999, The Journal of general virology.

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

P. Doherty, R. Cardin, S. Sarawar, 1996, The Journal of experimental medicine.

Successful application of prime and pull strategy for a therapeutic HSV vaccine

A. Iwasaki, D. Bernstein, H. Friedman, 2019, npj Vaccines.

The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model

G. E. Pickard, D. Bernstein, Gregory A. Smith, 2020, npj Vaccines.

The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model

G. E. Pickard, D. Bernstein, Gregory A. Smith, 2020, NPJ vaccines.

A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2.

D. Bernstein, D. Spector, R. Cardin, 2020, Vaccine.

The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs.

D. Bernstein, R. Cardin, M. McNeal, 2010, Vaccine.

The CMV-encoded G protein-coupled receptors M33 and US28 play pleiotropic roles in immune evasion and alter host T cell responses

N. Davis-Poynter, R. Cardin, Brent A. Stanfield, 2022, Frontiers in Immunology.

The Viral G-Protein-Coupled Receptor Homologs M33 and US28 Promote Cardiac Dysfunction during Murine Cytomegalovirus Infection

J. Francis, N. Davis-Poynter, R. Cardin, 2023, Viruses.

Development of a mouse salivary gland-derived mesenchymal cell line for immunological studies of murine cytomegalovirus

R. Cardin, Brent A. Stanfield, T. White, 2022, bioRxiv.

Heart Dysfunction Following Long-Term Murine Cytomegalovirus Infection: Fibrosis, Hypertrophy, and Tachycardia

J. Francis, R. Cardin, T. White, 2020, Viral immunology.

Partial Functional Complementation between Human and Mouse Cytomegalovirus Chemokine Receptor Homologues

M. Rosenkilde, N. Davis-Poynter, A. H. Sparre-Ulrich, 2011, Journal of Virology.

HomologuesChemokine Receptor between Human and Mouse Partial Functional Complementation

M. Rosenkilde, R. Cardin, E. Farrell, 2014 .

Murine cytomegalovirus IE2, an activator of gene expression, is dispensable for growth and latency in mice.

G. Abenes, C. Stoddart, E. Mocarski, 1995, Virology.

Identification of Common Mechanisms by Which Human and Mouse Cytomegalovirus Seven-Transmembrane Receptor Homologues Contribute to In Vivo Phenotypes in a Mouse Model

M. Rosenkilde, N. Davis-Poynter, R. Cardin, 2013, Journal of Virology.

Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor Paxlovid

A. Gribenko, B. S. Perrin, P. Liberator, 2022, bioRxiv.

Consequences of viral infections for lymphocyte compartmentalization and homeostasis.

P. Doherty, J. Riberdy, D. Topham, 1997, Seminars in immunology.

Immunisation Using Novel DNA Vaccine Encoding Virus Membrane Fusion Complex and Chemokine Genes Shows High Protection from HSV-2

D. Bernstein, U. Gompels, R. Cardin, 2022, Viruses.

The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes.

D. Bernstein, K. Kousoulas, R. Cardin, 2019, Vaccine.

Murine Cytomegalovirus Spreads by Dendritic Cell Recirculation

N. Davis-Poynter, P. Stevenson, R. Cardin, 2017, mBio.

A model of human cytomegalovirus infection in severe combined immunodeficient mice.

D. Bernstein, R. Cardin, F. Bravo, 2007, Antiviral research.

Phenotypes in a Mouse Model In Vivo Homologues Contribute to Seven-Transmembrane Receptor Which Human and Mouse Cytomegalovirus Identification of Common Mechanisms by

M. Rosenkilde, N. Davis-Poynter, R. Cardin, 2014 .