D. Mendel

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Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity

D. Mendel, D. B. Barkhimer, M. S. Chen, 1995, Antimicrobial agents and chemotherapy.

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

Juthamas Sukbuntherng, Robert A Blake, Guangmin Li, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.

B. Graves, M. Williams, X. Chen, 1999, Bioorganic & medicinal chemistry letters.

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Norbert Bischofberger, Matt Williams, C. Sweet, 1998, Antimicrobial Agents and Chemotherapy.

Synthesis and activity of C2-substituted analogs of influenza neuraminidase inhibitor GS 4071

Matthew A. Williams, D. Mendel, Lijun Zhang, 1997 .

Novel Robust Hepatitis C Virus Mouse Efficacy Model

M. Patawaran, A. Weiner, P. Hollenbach, 2006, Antimicrobial Agents and Chemotherapy.

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site: Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Antiinfluenza Activity.

R. Stevens, W. G. Laver, S. Swaminathan, 1997 .

CHIR-265, a novel inhibitor that targets B-Raf and VEGFR, shows efficacy in a broad range of preclinical models

Fernando Salangsang, E. Venetsanakos, D. Stuart, 2006 .

CCR 20th Anniversary Commentary: Determining a Pharmacokinetic/Pharmacodynamic Relationship for Sunitinib—A Look Back

J. Cherrington, D. Mendel, A. Laird, 2015, Clinical Cancer Research.

Isoform composition and stoichiometry of the approximately 90-kDa heat shock protein associated with glucocorticoid receptors.

D. Mendel, E. Ortí, 1988, The Journal of biological chemistry.

C3-Thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R,4R,5S)-4-acetamido-5-amino-3-propoxyl-1-cyclohexene-1-carboxylic acid

Matthew A. Williams, D. Mendel, W. Lew, 1997 .

HNF-1, a member of a novel class of dimerizing homeodomain proteins.

G. Crabtree, D. Mendel, Gerald R. Crabtree, 1991, The Journal of biological chemistry.

Glucocorticoid receptors and actions.

A. Munck, D. Mendel, E. Ortí, 1990, The American review of respiratory disease.

HNF- 1 and HNF- 1 (vHNF- 1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro

G. Crabtree, P. Conley, D. Mendel, 2007 .

Evidence for a glucocorticoid receptor cycle and nuclear dephosphorylation of the steroid-binding protein.

A. Munck, D. Mendel, J. Bodwell, 1990, Progress in clinical and biological research.

Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells.

A. Munck, D. Mendel, E. Ortí, 1989, The Journal of biological chemistry.

GS 4071 is a potent and selective inhibitor of the growth and neuraminidase activity of influenza A and B viruses in vitro

R. Sidwell, J. Huffman, Matthew A. Williams, 1997 .

SU 11248 Maintenance Therapy Prevents Tumor Regrowth after Fractionated Irradiation of Murine Tumor Models 1

D. Hallahan, G. Mcmahon, D. Mendel, 2003 .

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Z. H. Li, K. Kent, D. Mendel, 1994, Antimicrobial Agents and Chemotherapy.

Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.

G. Crabtree, P. Khavari, A. Admon, 1991, Science.

Structure and Function of Cytosolic Glucocorticoid Receptors in WEHI-7 Mouse Thymoma Cells: Receptor Composition and Phosphorylation

A. Munck, D. Mendel, J. Bodwell, 1987 .

Independent regulation of HNF‐1 alpha and HNF‐1 beta by retinoic acid in F9 teratocarcinoma cells.

G. Crabtree, C. Kuo, D. Mendel, 1991, The EMBO journal.

Phosphorylated sites within the functional domains of the approximately 100-kDa steroid-binding subunit of glucocorticoid receptors.

A. Munck, D. Mendel, J. Bodwell, 1989, Biochemistry.

Comparison of AMG 416 and cinacalcet in rodent models of uremia

D. Maclean, D. Mendel, Randolph M. Johnson, 2014, BMC Nephrology.

Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase

T. Cihlar, D. Mendel, M. S. Chen, 1997, Antimicrobial agents and chemotherapy.

In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).

J. Cherrington, D. Mendel, M. S. Chen, 1997, Antiviral research.

Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation.

R. Harrison, A. Munck, D. Mendel, 1986, The Journal of biological chemistry.

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

W G Laver, M A Williams, R C Stevens, 1997, Journal of the American Chemical Society.

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

Paul A. Khavari, Craig L. Peterson, G. Crabtree, 1993, Nature.

Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.

B. Graves, X. Chen, D. Mendel, 2000, Bioorganic & medicinal chemistry letters.

Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.

T. Cihlar, E. Ho, D. Mendel, 2000, Journal of the American Society of Nephrology : JASN.

Successful treatment of an acyclovir- and foscarnet-resistant herpes simplex virus type 1 lesion with intravenous cidofovir.

D. Mendel, J. Levine, G. Munk, 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals.

C. Elmets, H. Mukhtar, M. Athar, 1989, The Journal of biological chemistry.

Phase I dose-escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies.

N. Shenoy, G. Mcmahon, J. Cherrington, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins.

G. Crabtree, S. Milstien, S. Kaufman, 1992, Proceedings of the National Academy of Sciences of the United States of America.

'Non-specific' binding. The problem, and a solution.

D. Mendel, C. Mendel, 1985, The Biochemical journal.

The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.

T. Cihlar, D. Mendel, D. H. Sweet, 1999, Molecular pharmacology.

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

G. Crabtree, G. Courtois, C. Kuo, 1990, Genes & development.

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

W G Laver, M A Williams, R C Stevens, 1998, Journal of medicinal chemistry.

Mechanism by Which Mutations at His274 Alter Sensitivity of Influenza A Virus N1 Neuraminidase to Oseltamivir Carboxylate and Zanamivir

D. Mendel, Michael Zhuo Wang, Dirk B. Mendel, 2002, Antimicrobial Agents and Chemotherapy.

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

J. Christensen, J. Cui, J. Cherrington, 2003, Cancer research.

The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo.

J. Oxford, F. Hayden, J S Oxford, 2002, Antiviral research.

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

R. Sidwell, C. Sweet, J. Huffman, 1998, Antimicrobial Agents and Chemotherapy.

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

C. Liang, J. Cherrington, S. Vasile, 2006, Molecular Cancer Therapeutics.

Regulation of the steady state level of Fc gamma RI mRNA by IFN-gamma and dexamethasone in human monocytes, neutrophils, and U-937 cells.

D. Mendel, P. Guyre, J. Zurlo, 1990, Journal of immunology.

Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells.

J. Cherrington, D. Mendel, Guangmin Li, 2003, Molecular cancer therapeutics.

Non-ATP-competitive kinase inhibitors – enhancing selectivity through new inhibition strategies

K. Das, D. Maclean, D. Mendel, 2008, Expert opinion on drug discovery.

SU 14813 : a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

C. Liang, J. Cherrington, S. Vasile, 2006 .

Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors.

N. Shenoy, G. Mcmahon, J. Cherrington, 2002, Blood.

A dynamic model of glucocorticoid receptor phosphorylation and cycling in intact cells.

A. Munck, D. Mendel, J. Bodwell, 1989, Journal of steroid biochemistry.

SU6668 inhibits Flk‐1/KDR and PDGFRβ in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice

J. Cherrington, J. Christensen, D. Mendel, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models.

Gerald McMahon, D. Hallahan, G. Mcmahon, 2003, Cancer research.

Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent.

L. Ellis, C. Liang, J. Cherrington, 2000, Anti-cancer drug design.

The angiogenesis inhibitor SU5416 has long-lasting effects on vascular endothelial growth factor receptor phosphorylation and function.

J. Cherrington, S. Vasile, D. Mendel, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans

J. Cherrington, D. Mendel, A. Laird, 2003, Journal of Pharmacology and Experimental Therapeutics.

Translational sciences approach to RSV vaccine development

M. Esser, F. Sifakis, D. Mendel, 2013, Expert review of vaccines.

CHIR-258 Is Efficacious in A Newly Developed Fibroblast Growth Factor Receptor 3–Expressing Orthotopic Multiple Myeloma Model in Mice

Yan Tang, S. Trudel, M. Embry, 2006, Clinical Cancer Research.