J. Holthuis

发表

The organizing potential of sphingolipids in intracellular membrane transport.

G. van Meer, G. Meer, T. Pomorski, 2001, Physiological reviews.

Identification of a family of animal sphingomyelin synthases

J. Brouwers, J. Holthuis, Klazien Huitema, 2004, The EMBO journal.

The Multigenic Sphingomyelin Synthase Family*

F. Tafesse, P. Ternes, J. Holthuis, 2006, Journal of Biological Chemistry.

Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells*

Martin Hermansson, Pentti Somerharju, M. Hermansson, 2007, Journal of Biological Chemistry.

Lipid landscapes and pipelines in membrane homeostasis

Anant K. Menon, A. Menon, J. Holthuis, 2014, Nature.

Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry

Ali Rashidfarrokhi, H. Leier, F. Tafesse, 2019, mBio.

Two syntaxin homologues in the TGN/endosomal system of yeast

H. Pelham, B. Nichols, J. Holthuis, 1998, The EMBO journal.

Cellular microcompartments constitute general suborganellar functional units in cells

C. Ungermann, J. Holthuis, 2013, Biological chemistry.

Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

C. Burd, M. Hensel, M. Imlau, 2022, Nature communications.

Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

C. Burd, M. Hensel, M. Imlau, 2021, Nature Communications.

Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins.

V. Schoonderwoert, S. Tooze, J. Holthuis, 2000, European journal of biochemistry.

Membrane contact sites, ancient and central hubs of cellular lipid logistics.

J. Holthuis, Amrita Jain, 2017, Biochimica et biophysica acta. Molecular cell research.

Protein Sorting in the Late Golgi of Saccharomyces cerevisiae Does Not Require Mannosylated Sphingolipids*

T. Pomorski, J. Holthuis, Quirine Lisman, 2004, Journal of Biological Chemistry.

Sphingolipid transport in eukaryotic cells.

G. van Meer, G. Meer, J. Holthuis, 2000, Biochimica et biophysica acta.

Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary.

J. Holthuis, G. Martens, M. V. van Riel, 1995, The Biochemical journal.

Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles.

T. Pomorski, Nele Alder-Baerens, J. Holthuis, 2006, Molecular biology of the cell.

Ceramide Phosphoethanolamine Biosynthesis in Drosophila Is Mediated by a Unique Ethanolamine Phosphotransferase in the Golgi Lumen♦

P. Ternes, J. Holthuis, Joep B van den Dikkenberg, 2013, The Journal of Biological Chemistry.

Secretogranin III Is a Sulfated Protein Undergoing Proteolytic Processing in the Regulated Secretory Pathway*

E. Jansen, J. Holthuis, G. Martens, 1996, The Journal of Biological Chemistry.

The Sec1p homologue Vps45p binds to the syntaxin Tlg2p.

H. Pelham, B. Nichols, J. Holthuis, 1998, European journal of cell biology.

Folding defects in P‐type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4‐phenylbutyrate

E. Krieger, R. Houwen, J. Stapelbroek, 2010, Hepatology.

Production of insulin-like growth factors, platelet-derived growth factor, and transforming growth factors and their role in the density-dependent growth regulation of a differentiated embryonal carcinoma cell line.

C. Mummery, E. J. V. van Zoelen, I. Koornneef, 1989, Endocrinology.

Deposited in DRO : 01 August 2018 Version of attached le : Published Version Peer-review status of attached

P. Somerharju, F. Tafesse, J. G. Mina, 2020 .

A switchable ceramide transfer protein for dissecting the mechanism of ceramide‐induced mitochondrial apoptosis

J. Holthuis, Amrita Jain, Shashank Dadsena, 2020, FEBS letters.

The Neuroendocrine Proteins Secretogranin II and III Are Regionally Conserved and Coordinately Expressed with Proopiomelanocortin in Xenopus Intermediate Pituitary

G. Martens, J. Holthuis, G. Martens, 1996, Journal of neurochemistry.

Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death

F. Tafesse, J. Holthuis, Birol Cabukusta, 2017, Bioscience reports.

The syntaxin Tlg1p mediates trafficking of chitin synthase III to polarized growth sites in yeast.

H. Pelham, B. Nichols, J. Holthuis, 1998, Molecular biology of the cell.

Tales and mysteries of the enigmatic sphingomyelin synthase family.

J. Holthuis, C. Luberto, 2010, Advances in experimental medicine and biology.

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

J. Brouwers, C. Rabouille, V. Kondylis, 2009, The Journal of cell biology.

Biofunctional nanodot arrays in living cells uncover synergistic co-condensation of Wnt signalodroplets

A. Plückthun, M. Steinhart, J. Piehler, 2022, bioRxiv.

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

J. Dittman, A. Menon, J. Holthuis, 2023, bioRxiv.

A vertebrate homolog of the actin-bundling protein fascin.

V. Schoonderwoert, J. Holthuis, G. Martens, 1994, Biochimica et biophysica acta.

Sensing membrane curvature.

Koert N. J. Burger, J. Holthuis, 2003, Developmental Cell.

The activation of human blood coagulation factor X on the surface of endothelial cells: a comparison with various vascular cells, platelets and monocytes

K. Mertens, J. Holthuis, J. A. Mourik, 1994, British journal of haematology.

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

P. Schwille, D. Trauner, J. Holthuis, 2019, eLife.

On the origin of lipid asymmetry: the flip side of ion transport.

P. Williamson, G. Lenoir, J. Holthuis, 2007, Current opinion in chemical biology.

Tracking down lipid flippases and their biological functions

A. Herrmann, G. van Meer, T. Pomorski, 2004, Journal of Cell Science.

Lipid Traffic: The ABC of Transbilayer Movement

G. van Meer, T. Pomorski, J. Holthuis, 2000, Traffic.

10 – Molecular Mechanisms That Mediate a Functional Relationship between Proliferation and Differentiation

G. Stein, J. Lian, R. Bortell, 1992 .

Cell Structure and the Regulation of Genes Controlling Proliferation and Differentiation: The Nuclear Matrix and Cytoskeleton

G. Stein, J. Lian, J. Stein, 1991 .

Coordination of protein‐DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development

G. Stein, J. Lian, A. V. van Wijnen, 1991, Journal of cellular physiology.

Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D.

J. Lian, M. Kennedy, K. Wright, 1990, Science.

Fat & fabulous: bifunctional lipids in the spotlight.

P. Haberkant, J. Holthuis, 2014, Biochimica et biophysica acta.

Nerve Growth Factor-induced Changes in the Intracellular Localization of the Protein Kinase C Substrate B-50 in Pheochromocytoma PC 12 Cells

J. Holthuis, A. Oestreicher, C. V. Hooff, 2002 .

Nerve growth factor-induced changes in the intracellular localization of the protein kinase C substrate B-50 in pheochromocytoma PC12 cells

J. Boonstra, W. Gispen, P. de Graan, 1989, The Journal of cell biology.

Regulating membrane curvature

J. Holthuis, 2004 .

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7[S]

A. Heck, R. Raijmakers, J. G. Mina, 2018, Journal of Lipid Research.

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

S. Marrink, F. Tafesse, J. G. Mina, 2019, Nature Communications.

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.

A. Gavin, A. Heck, R. Raijmakers, 2013, Angewandte Chemie.

The CLN9 Protein, a Regulator of Dihydroceramide Synthase*

A. Bielawska, G. Dbaibo, S. Jazwinski, 2006, Journal of Biological Chemistry.

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice[S]

J. Degen, K. Willecke, D. Vance, 2015, Journal of Lipid Research.

HOR7, a Multicopy Suppressor of the Ca2+-induced Growth Defect in Sphingolipid Mannosyltransferase-deficient Yeast*

J. Holthuis, Quirine Lisman, Dorothy Urli-Stam, 2004, Journal of Biological Chemistry.

Membrane damage and repair: a thin line between life and death

Caroline Barisch, J. Holthuis, Katia Cosentino, 2023, Biological chemistry.

Molecular probing of the secretory pathway in peptide hormone-producing cells.

E. Jansen, J. Holthuis, G. Martens, 1995, Journal of cell science.

Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary.

V. Schoonderwoert, J. Burbach, E. Jansen, 1999, European journal of biochemistry.

Intracellular trafficking of the vacuolar H+-ATPase accessory subunit Ac45.

J. Burbach, E. Jansen, J. Holthuis, 1998, Journal of cell science.

Mechanism and significance of P4 ATPase-catalyzed lipid transport: lessons from a Na+/K+-pump.

J. Holthuis, C. F. Puts, 2009, Biochimica et biophysica acta.

Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation.

G. Stein, J. Lian, A. V. van Wijnen, 1990, Proceedings of the National Academy of Sciences of the United States of America.

H. Riezman, G. van Meer, P. Devaux, 2003, Molecular biology of the cell.

Membrane Contact Sites between Apicoplast and ER in Toxoplasma gondii Revealed by Electron Tomography

B. Humbel, A. Verkleij, W. Geerts, 2009, Traffic.

Mapping Functional Interactions in a Heterodimeric Phospholipid Pump*

P. Williamson, J. Holthuis, C. F. Puts, 2012, The Journal of Biological Chemistry.

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

O. Mäkitie, J. Carey, P. Bayrak-Toydemir, 2019, JCI insight.

Cell biology: A brake on lipid synthesis

F. Tafesse, J. Holthuis, 2010, Nature.

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis

M. Hermansson, P. Somerharju, F. Tafesse, 2014, Journal of Cell Science.

Flip or Flop: Mechanism and (Patho)Physiology of P4‐ATPase‐Catalyzed Lipid Transport

T. Pomorski, J. Holthuis, P. M. Verhulst, 2011 .

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

J. Acharya, U. Acharya, K. Nagashima, 2018, Proceedings of the National Academy of Sciences.

Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

C. Burd, O. Mäkitie, J. Piehler, 2022, bioRxiv.

Inner workings and biological impact of phospholipid flippases

J. Holthuis, Radhakrishnan Panatala, H. Hennrich, 2015, Journal of Cell Science.

Lipid traffic: floppy drives and a superhighway

J. Holthuis, T. Levine, 2005, Nature Reviews Molecular Cell Biology.

Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate*

C. Jaxel, M. le Maire, P. Champeil, 2012, The Journal of Biological Chemistry.

Pumping lipids with P4-ATPases

T. Pomorski, J. Holthuis, R. López-Marqués, 2011, Biological chemistry.

A P4-ATPase protein interaction network reveals a link between aminophospholipid transport and phosphoinositide metabolism.

P. Williamson, J. Krijgsveld, G. Lenoir, 2010, Journal of proteome research.

Lipid microdomains, lipid translocation and the organization of intracellular membrane transport (Review)

G. van Meer, J. Holthuis, Klazien Huitema, 2003, Molecular membrane biology.

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery*

P. Devaux, G. Lenoir, J. Holthuis, 2010, The Journal of Biological Chemistry.

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase[S]

J. Brouwers, P. Ternes, J. Holthuis, 2009, Journal of Lipid Research.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

P. Somerharju, F. Tafesse, J. G. Mina, 2016, Journal of Lipid Research.

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

Oliver Beutel, J. Holthuis, Amrita Jain, 2017, Journal of Cell Science.

Toxoplasma ceramide synthases: a curious case of gene duplication, divergence and key functionality

E. Pohl, J. G. Mina, P. Denny, 2022, bioRxiv.

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p*♦

P. Williamson, G. Lenoir, J. Holthuis, 2009, The Journal of Biological Chemistry.

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

J. G. Mina, J. Holthuis, S. Korneev, 2017, Scientific Reports.

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases

P. Somerharju, F. Tafesse, J. G. Mina, 2016, Journal of Lipid Research.

Sphingomyelin is critical in organizing phosphoinositide dynamics during phagocytic uptake of Mycobacterium tuberculosis

H. Leier, F. Tafesse, Gaelen Guzman, 2019, bioRxiv.

Ca2+‐activated Sphingomyelin Scrambling and Turnover Mediate ESCRT‐independent Lysosomal Repair

J. Holthuis, Patrick Niekamp, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching*

C. You, C. Richter, J. Holthuis, 2016, The Journal of Biological Chemistry.

The elusive flippases

G. Lenoir, J. Holthuis, 2004, Current Biology.

Systematic analysis of the sphingomyelin synthase family in C. elegans

L. Bramer, J. Kyle, F. Tafesse, 2023, bioRxiv.

Complex Sphingolipid Profiling and Identification of an Inositol Phosphorylceramide Synthase in Dictyostelium discoideum

F. Fröhlich, Caroline Barisch, J. Holthuis, 2023, bioRxiv.

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

J. Brouwers, C. Rabouille, V. Kondylis, 2022 .

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

J. Dittman, A. Menon, J. Holthuis, 2023, bioRxiv.

Mechanism and significance of P4 ATPase-catalyzed lipid transport: lessons from a Na+/K+-pump.

J. Holthuis, C. F. Puts, 2009, Biochimica et biophysica acta.

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness

P. Denny, J. Holthuis, M. Kol, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Prevention of side effects by hemoglobin solutions; the selection of optimal test models, especially concerning thrombogenicity.

W. Bleeker, K. Mertens, J. Holthuis, 1994, Artificial cells, blood substitutes, and immobilization biotechnology.

Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry

H. Leier, F. Tafesse, Gaelen Guzman, 2021, mBio.