N. Wideburg

发表

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

A. Molla, S. Vasavanonda, D. Norbeck, 1998, Journal of medicinal chemistry.

Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores.

D. Kempf, G. Krafft, N. Wideburg, 1995, Journal of medicinal chemistry.

Synthetic Chemical Diversity: Solid Phase Synthesis of Libraries of C2 Symmetric Inhibitors of HIV Protease Containing Diamino Diol and Diamino Alcohol Cores.

D. Kempf, Gary T. Wang, G. Krafft, 1995 .

Evaluation of substituted benzamides as P2 ligands for symmetry-based inhibitors of HIV protease

S. Vasavanonda, D. Norbeck, D. Kempf, 1995 .

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.

D. Norbeck, D. Kempf, J. Erickson, 1990, Science.

Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-Based Diol Inhibitors of HIV-1 Protease

Dale J. Kempf, John W. Erickson, Eric T. Baldwin, 1994 .

Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors

S. Vasavanonda, D. Norbeck, D. Kempf, 1996 .

Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282

N. Wideburg, W. Kohlbrenner, D. Weigl, 1992, Antimicrobial Agents and Chemotherapy.

Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.

S. Vasavanonda, D. Kempf, H. Sham, 1993, Journal of medicinal chemistry.

Synthesis of some C-8-modified 3-deoxy-beta-D-manno-2-octulosonic acid analogs as inhibitors of CMP-Kdo synthetase.

N. Wideburg, D. Whittern, C. M. Lee, 1990, Carbohydrate research.

Induction ofCalfThymusTopoisomerase II-Mediated DNA Breakage bytheAntibacterial Isothiazoloquinolones A-65281 andA-65282

N. Wideburg, D. Weigl, A. Saldivar, 1992 .

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Dale J. Kempf, John M. Leonard, Jacob J. Plattner, 1998, Antimicrobial Agents and Chemotherapy.

β-Carboxy-β-hydroxyisocaprioc acid formation by microorganisms

W. H. Coleman, W. Martin, N. Wideburg, 1962 .

A new aminoglycoside antibiotic complex--the seldomycins. IV. The structure of seldomycin factor 5.

S. Sato, L. Mitscher, J. McAlpine, 1977, The Journal of antibiotics.

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease

A. D. Rodrigues, S. Muchmore, A. Molla, 1997 .

Facile synthesis of potent HIV-1 protease inhibitors containing a novel pseudo-symmetric dipeptide isostere

D. Norbeck, D. Kempf, H. Sham, 1993 .

2-deoxy-2-(substituted-methyl)analogs of β-Kdop

N. Wideburg, D. Whittern, W. Rosenbrook, 1990 .

Structure-based, C2 symmetric inhibitors of HIV protease.

S. Vasavanonda, D. Norbeck, D. Kempf, 1990, Journal of medicinal chemistry.

Design of orally bioavailable, symmetry-based inhibitors of HIV protease.

S. Vasavanonda, D. Kempf, H. Sham, 1994, Bioorganic & medicinal chemistry.

Potent HIV-1 protease inhibitors with antiviral activities in vitro.

S. Vasavanonda, D. Norbeck, D. Kempf, 1991, Biochemical and biophysical research communications.

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

D Norbeck, D. Ho, D. Norbeck, 1994, Journal of virology.

Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.

S. Vasavanonda, H. Sham, T. Robins, 1995, Biochemical and biophysical research communications.

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

S. Vasavanonda, D. Norbeck, D. Kempf, 2003, Bioorganic & medicinal chemistry letters.

Peptide anti-bacterien

N. Wideburg, A. Thomas, D. Chu, 1979 .

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

A. Molla, S. Vasavanonda, N. Lyons, 1996, Journal of medicinal chemistry.

Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane: the core unit of a potent HIV proteinase inhibitor

D. Norbeck, D. Kempf, J. Erickson, 1991 .

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

S. Vasavanonda, D. Norbeck, D. Kempf, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.

A. Molla, S. Vasavanonda, D. Norbeck, 1996, Biochemical and Biophysical Research Communications - BBRC.

Pseudo‐symmetrical difluoroketones

S. Vasavanonda, D. Norbeck, D. Kempf, 1993, FEBS letters.