D. Babusis

发表

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Lisa E. Gralinski, Vineet D. Menachery, R. Baric, 2017, Science Translational Medicine.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Mike Flint, Donald K. Nichols, 2016, Nature.

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2014, Bioorganic & medicinal chemistry letters.

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

J. Arnold, C. Cameron, A. Gnatt, 2012, PLoS pathogens.

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

D. Stefanidis, A. Ray, Yeojin Park, 2014, Antimicrobial Agents and Chemotherapy.

Efficacy of oral tenofovir alafenamide/emtricitabine combination or single agent tenofovir alafenamide against vaginal SHIV infection in macaques.

W. Heneine, J. Rooney, Yeojin Park, 2019, The Journal of infectious diseases.

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 and a variant of concern in ferrets

R. Plemper, Julien Sourimant, R. Mackman, 2021 .

Cancer Therapy : Preclinical Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin ' s Lymphoma

R. Jeraj, D. Thamm, M. Vanderhoek, 2009 .

Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma

R. Jeraj, D. Thamm, M. Vanderhoek, 2009, Clinical Cancer Research.

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection

Xuping Xie, P. Shi, R. Mackman, 2022, Antiviral Research.

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

R. Baric, T. Sheahan, R. Mackman, 2022, Science Translational Medicine.

Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.

R. Baric, T. Sheahan, R. Mackman, 2021, bioRxiv.

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

R. Baric, T. Sheahan, A. Pruijssers, 2020, Cell Reports.

Sofosbuvir and Ribavirin Liver Pharmacokinetics in Patients Infected with Hepatitis C Virus

A. Mathias, N. Afdhal, J. McHutchison, 2018, Antimicrobial Agents and Chemotherapy.

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

M. Fenaux, A. Ray, Joy Y. Feng, 2015, Bioorganic & Medicinal Chemistry Letters.

Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.

R. Mackman, J. Bilello, T. Cihlar, 2021, Journal of medicinal chemistry.

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

William A. Lee, A. Gigliotti, R. Mackman, 2021, Science Translational Medicine.

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

G. Stepan, T. Cihlar, Gary Lee, 2020, Antimicrobial Agents and Chemotherapy.

Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection.

W. Heneine, J. Rooney, A. Ray, 2016, The Journal of infectious diseases.

Subcutaneous remdesivir administration prevents interstitial pneumonia in rhesus macaques inoculated with SARS-CoV-2

R. Mackman, T. Cihlar, E. de Wit, 2022, Antiviral Research.

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

P. German, A. Mathias, R. Humeniuk, 2021, Clinical Pharmacokinetics.

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.

P. Schafer, K. Blease, J. Leisten, 2009, Journal of medicinal chemistry.

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

J. Copland, H. Tun, P. Huang, 2013, PloS one.

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus

Helen Yu, G. Stepan, A. Ray, 2015, Antimicrobial Agents and Chemotherapy.

Pharmacological Characterization of a Novel Antiglaucoma Agent, Bimatoprost (AGN 192024)

L. Wheeler, M. Garst, D. Welty, 2003, Journal of Pharmacology and Experimental Therapeutics.

Intracellular Nucleotide Levels during Coadministration of Tenofovir Disoproxil Fumarate and Didanosine in HIV-1-Infected Patients

A. Ray, T. Hawkins, D. Babusis, 2011, Antimicrobial Agents and Chemotherapy.

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

J. Bilello, T. Cihlar, Venice Du Pont, 2022, Molecules.

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

W. Zhong, M. Fenaux, H. Ye, 2014, Journal of medicinal chemistry.

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.

Huiling Yang, T. Appleby, M. Fenaux, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.

A. Ray, Joy Y. Feng, D. Babusis, 2012, Bioorganic & medicinal chemistry letters.

Tenofovir alafenamide (TAF) does not deplete mitochondrial DNA in human T-cell lines at intracellular concentrations exceeding clinically relevant drug exposures.

T. Cihlar, Kirsten M. Stray, A. Ray, 2017, Antiviral research.

Effects of Human Immunodeﬁciency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro (cid:1)

I. Hidalgo, K. Robinson, A. Ray, 2007 .

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018, Antimicrobial Agents and Chemotherapy.

Evaluation of 2'-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase.

I. Shih, R. Mackman, A. Ray, 2013, Bioorganic & medicinal chemistry letters.

Two-dose emtricitabine/tenofovir alafenamide plus bictegravir prophylaxis protects macaques against SHIV infection

M. Das, T. Cihlar, D. Barouch, 2020, The Journal of antimicrobial chemotherapy.

Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

A. Ray, Yeojin Park, D. Babusis, 2015, Antimicrobial Agents and Chemotherapy.

Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.

R. Mackman, T. Cihlar, J. Douglas, 2007, Bioorganic & medicinal chemistry letters.

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir.

A. Ray, Yeojin Park, D. Babusis, 2020, Drug Metabolism and Pharmacokinetics.

1 Non-proteinogenic Amino Acid Containing Nucleotide Prodrug to Improve Oral Delivery of a 1 Hepatitis C Virus Treatment 2

Huiling Yang, M. Fenaux, Neeraj Tirunagari, 2018 .

Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations

K. Kitrinos, A. Ray, D. Babusis, 2017, PloS one.

Metabolism and Antiretroviral Activity of Tenofovir Alafenamide in CD4+ T-Cells and Macrophages from Demographically Diverse Donors

S. Yant, T. Cihlar, D. Babusis, 2014, Antiviral therapy.

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

Xiaotao Lu, Alexandra Schäfer, Ralph S. Baric, 2020, bioRxiv.

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

R. Baric, R. Jordan, T. Sheahan, 2020, Nature Communications.

Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340.

William A. Lee, A. Ray, D. Babusis, 2013, Molecular pharmaceutics.

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

M. Otto, A. Lam, M. Sofia, 2012, Antimicrobial Agents and Chemotherapy.

Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro

I. Hidalgo, K. Robinson, A. Ray, 2007, Antimicrobial Agents and Chemotherapy.

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Xuping Xie, P. Shi, J. Bilello, 2021, Antimicrobial agents and chemotherapy.

Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.

P. Schafer, Alexander L. Ruchelman, L. Corral, 2013, Bioorganic & medicinal chemistry letters.

GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma

D. Thamm, D. Vail, A. Ray, 2014, BMC Veterinary Research.

Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

R. Plemper, Julien Sourimant, R. Mackman, 2021, Nature Communications.

Compared to Subcutaneous Tenofovir, Oral Tenofovir Disoproxyl Fumarate Administration Preferentially Concentrates the Drug into Gut-Associated Lymphoid Cells in Simian Immunodeficiency Virus-Infected Macaques

W. Heneine, K. Abel, K. V. Van Rompay, 2012, Antimicrobial Agents and Chemotherapy.

SELECTIVITY OF PHENYLHEXYL-BONDED SILICA GEL FOR LIQUID CHROMATOGRAPHY

D. Babusis, T. Hanai, F. Ahmed, 1999 .

Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates

William A. Lee, R. Jordan, R. Mackman, 2015 .

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

R. Baric, Nicholas Catanzaro, T. Sheahan, 2023, bioRxiv.

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

R. Mackman, J. Bilello, T. Cihlar, 2023, bioRxiv.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Jeffrey R. Kugelman, G. Palacios, 2016, Nature.

Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma

R. Jeraj, D. Thamm, M. Vanderhoek, 2009, Clinical Cancer Research.

Effects of Human Immunodeficiency Virus Protease Inhibitors on the Intestinal Absorption of Tenofovir Disoproxil Fumarate In Vitro

I. Hidalgo, K. Robinson, A. Ray, 2007, Antimicrobial Agents and Chemotherapy.

Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing

J. Dye, T. Cihlar, R. Bannister, 2023, Viruses.

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

R. Geleziunas, J. Bilello, T. Geisbert, 2024, Science.

Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits.

S. Whitcup, D. Welty, D. Tang-Liu, 2004, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.