J. Leaney

发表

Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID‐19

B. Corrigan, B. Damle, M. Vourvahis, 2020, Clinical pharmacology and therapeutics.

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Michael J Sutcliffe, Claire Wood, Phillip J Stansfeld, 2006, Molecular Pharmacology.

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

J. Hancox, H. Witchel, C. Dempsey, 2006, Biochemical and biophysical research communications.

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

J. Hancox, H. Witchel, D. Leishman, 2006, Biochemical and biophysical research communications.

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2010, Journal of pharmacological and toxicological methods.

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin

Jules C Hancox, Derek J Leishman, Harry J Witchel, 2006, British journal of pharmacology.

PKC-δ sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells

Alison M. Thomas, L. Dekker, A. Tinker, 2005 .

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.

A. Mcharg, R. Wallis, D. Leishman, 2008, Journal of pharmacological and toxicological methods.

A swelling‐activated chloride current in rat sympathetic neurones

D. A. Brown, J. Leaney, S. Marsh, 1997, The Journal of physiology.

The Dynamics of Formation and Action of the Ternary Complex Revealed in Living Cells Using a G-protein-gated K+ Channel as a Biosensor*

G. Milligan, A. Tinker, J. Leaney, 2003, The Journal of Biological Chemistry.

Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels

A. Tinker, J. Leaney, A. Benians, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Drug binding interactions in the inner cavity of hERG: Molecular insights from structure-activity relationships of clofilium and ibutilide analogues

M. Sutcliffe, P. Stansfeld, J. Mitcheson, 2005 .

The G Protein α Subunit Has a Key Role in Determining the Specificity of Coupling to, but Not the Activation of, G Protein-gated Inwardly Rectifying K+ Channels*

G. Milligan, A. Tinker, J. Leaney, 2000, The Journal of Biological Chemistry.

The Molecular Assembly of ATP-sensitive Potassium Channels

A. Tinker, J. Leaney, J. Giblin, 1999, The Journal of Biological Chemistry.

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin

J. Hancox, H. Witchel, D. Leishman, 2007, Biochemical pharmacology.

A Novel Strategy to Engineer Functional Fluorescent Inhibitory G-protein α Subunits*

A. Tinker, J. Leaney, A. Benians, 2002, The Journal of Biological Chemistry.

A novel strategy to engineer functional fluorescent inhibitory G-protein alpha subunits.

A. Tinker, J. Leaney, A. Benians, 2002, The Journal of biological chemistry.

Regulation of a G protein‐gated inwardly rectifying K+ channel by a Ca2+‐independent protein kinase C

L. Dekker, A. Tinker, J. Leaney, 2001, The Journal of physiology.

The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel.

A. Tinker, J. Leaney, Andrew Tinker, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

B. Fermini, J. Hancox, A. Alexandrou, 2014, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein‐gated inwardly rectifying potassium currents in cultured hippocampal neurons

J. Leaney, 2003, The European journal of neuroscience.

Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle.

A. Tinker, J. Leaney, D. Kelly, 2004, American journal of physiology. Cell physiology.

Differential Phosphoinositide Binding to Components of the G Protein-Gated K+ Channel

Alison M. Thomas, A. Tinker, J. Leaney, 2006, The Journal of Membrane Biology.

Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

D. Leishman, J. Leaney, A. Davis, 2007, Journal of pharmacological and toxicological methods.