R. Needleman

发表

Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes.

A. Tzagoloff, A. Akai, R. Needleman, 1975, The Journal of biological chemistry.

Interaction of proton and chloride transfer pathways in recombinant bacteriorhodopsin with chloride transport activity: implications for the chloride translocation mechanism.

J. Lanyi, L. Brown, R. Needleman, 1996, Biochemistry.

Existence of a proton transfer chain in bacteriorhodopsin: participation of Glu-194 in the release of protons to the extracellular surface.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 1998, Biochemistry.

Connectivity of the retinal Schiff base to Asp85 and Asp96 during the bacteriorhodopsin photocycle: the local-access model.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 1998, Biophysical journal.

Coupling photoisomerization of retinal to directional transport in bacteriorhodopsin.

B. Schobert, J. Lanyi, A. Rosengarth, 2000, Journal of molecular biology.

Assembly of the mitochondrial membrane system: isolation of nuclear and cytoplasmic mutants of Saccharomyces cerevisiae with specific defects in mitochondrial functions

A. Tzagoloff, A. Akai, R. Needleman, 1975, Journal of bacteriology.

Assembly of the mitochondrial membrane system. Cytoplasmic mutants of Saccharomyces cerevisiae with lesions in enzymes of the respiratory chain and in the mitochondrial ATPase.

A. Tzagoloff, A. Akai, R. Needleman, 1975, The Journal of biological chemistry.

Water-mediated hydrogen-bonded network on the cytoplasmic side of the Schiff base of the L photointermediate of bacteriorhodopsin.

R. Gennis, J. Herzfeld, T. Ebrey, 2003, Biochemistry.

Reversal of the surface charge asymmetry in purple membrane due to single amino acid substitutions.

G. Rayfield, R. Needleman, K. Hsu, 1996, Biophysical journal.

Intramembrane signaling mediated by hydrogen-bonding of water and carboxyl groups in bacteriorhodopsin and rhodopsin.

J. Lanyi, H. Kandori, R. Needleman, 1997, Journal of biochemistry.

Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 2. Chloride release and uptake, protein conformation change, and thermodynamics.

J. Lanyi, G. Varo, R. Needleman, 1995, Biochemistry.

The dispersed, repeated family of MAL loci in Saccharomyces spp

C. Michels, R. Needleman, 1984, Journal of bacteriology.

Identification of a second trans-acting gene controlling maltose fermentation in Saccharomyces carlsbergensis

R. Dubin, C. Michels, E. Perkins, 1986, Molecular and cellular biology.

Location of a cation-binding site in the loop between helices F and G of bacteriorhodopsin as studied by 13C NMR.

J. Lanyi, A. Naito, H. Saitǒ, 1999, Biophysical journal.

Purification and characterization of an alpha-glucosidase from Saccharomyces carlsbergensis.

J. Marmur, R. Needleman, H. Federoff, 1978, Biochemistry.

MAL64c is a global regulator of α-glucoside fermentation: identification of a new gene involved in melezitose fermentation

E. Perkins, R. Needleman, 1988, Current Genetics.

Removal of Mig1p binding site converts a MAL63 constitutive mutant derived by interchromosomal gene conversion to glucose insensitivity.

R. Needleman, J. Wang, 1996, Genetics.

Amino acids as biomarkers in the SOD1(G93A) mouse model of ALS.

R. Needleman, R. Grier, W. Brusilow, 2014, Biochimica et biophysica acta.

Identification of the structural gene encoding maltase within the MAL6 locus of Saccharomyces carlsbergensis

R. Dubin, C. Michels, R. Needleman, 1985, Journal of bacteriology.

Selection of yeast mutants constitutive for maltase synthesis

R. Needleman, N. Eaton, 2004, Molecular and General Genetics MGG.

Structural change of threonine 89 upon photoisomerization in bacteriorhodopsin as revealed by polarized FTIR spectroscopy.

J. Lanyi, J. Herzfeld, H. Kandori, 1999, Biochemistry.

Cysteine S−H as a Hydrogen-Bonding Probe in Proteins

J. Lanyi, H. Kandori, Y. Shichida, 1998 .

Hydration of the counterion of the Schiff base in the chloride-transporting mutant of bacteriorhodopsin: FTIR and FT-raman studies of the effects of anion binding when Asp85 is replaced with a neutral residue.

J. Lanyi, L. Brown, H. Kandori, 1996, Biochemistry.

Water-Mediated Proton Transfer in Proteins: An FTIR Study of Bacteriorhodopsin

J. Lanyi, H. Kandori, R. Needleman, 1995 .

MAL63 codes for a positive regulator of maltose fermentation in Saccharomyces cerevisiae

R. Dubin, C. Michels, E. Perkins, 1988, Current Genetics.

A genetic and physical analysis of the MAL1 and MAL3 standard strains of Saccharomyces cerevisiae

C. Michels, R. Needleman, 1983, Molecular and General Genetics MGG.

Saccharomyces spp. The dispersed, repeated family of MAL loci in

C. Michels, R. Needleman, 2013 .

Repeated Family of Genes Controlling Maltose Fermentation in Saccharomyces carlsbergensis

C. Michels, R. Needleman, 1983, Molecular and cellular biology.

Isolation of a maltase structural gene from Saccharomyces carlsbergensis

J. Cohen, J. Marmur, R. Needleman, 1982, Journal of bacteriology.

Photocycle of halorhodopsin from Halobacterium salinarium.

L. Sun, X. Fan, J. Lanyi, 1995, Biophysical journal.

Regulation of maltose fermentation in Saccharomyces carlsbergensis

R. Needleman, G. Zoutewelle, A. Berge, 2004, Molecular and General Genetics MGG.

A linkage of the pKa's of asp-85 and glu-204 forms part of the reprotonation switch of bacteriorhodopsin.

J. Lanyi, L. Brown, R. Needleman, 1996, Biochemistry.

Structure of the N intermediate of bacteriorhodopsin revealed by x-ray diffraction.

J. Lanyi, H. Kamikubo, M. Kataoka, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Protein structural change at the cytoplasmic surface as the cause of cooperativity in the bacteriorhodopsin photocycle.

J. Lanyi, G. Varo, R. Needleman, 1996, Biophysical journal.

Identification and characterization of the maltose permease in genetically defined Saccharomyces strain

R. Dubin, C. Michels, E. Perkins, 1989, Journal of bacteriology.

Constitutive expression of the maltose fermentative enzymes in Saccharomyces carlsbergensis is dependent upon the mutational activation of a nonessential homolog of MAL63

M. J. Charron, R. Dubin, C. Michels, 1988, Molecular and cellular biology.

Genomic Footprinting of Mig1p in the MAL62 Promoter

R. Needleman, Jianfan Wang, O. Sirenko, 1997, The Journal of Biological Chemistry.

Local-access model for proton transfer in bacteriorhodopsin.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 1998, Biochemistry.

Glutamic Acid 204 is the Terminal Proton Release Group at the Extracellular Surface of Bacteriorhodopsin (*)

J. Lanyi, L. Brown, H. Kandori, 1995, The Journal of Biological Chemistry.

A temperature-sensitive yeast mitochondrial mutant with altered cytochrome c oxidase subunit

J. Marmur, R. Needleman, E. Storm, 1978, Nature.

Breakage of yeast: a method for processing multiple samples.

A. Tzagoloff, R. Needleman, 1975, Analytical biochemistry.

Energy coupling in an ion pump. The reprotonation switch of bacteriorhodopsin.

J. Lanyi, L. Brown, M. Sheves, 1994, Journal of molecular biology.

Photoreaction of the N intermediate of bacteriorhodopsin, and its relationship to the decay kinetics of the M intermediate.

J. Lanyi, L. Brown, L. Zimányi, 1993, Biochemistry.

The back photoreaction of the M intermediate in the photocycle of bacteriorhodopsin: mechanism and evidence for two M species

J. Lanyi, M. Sheves, N. Friedman, 1992, Photochemistry and photobiology.

Pathways of proton release in the bacteriorhodopsin photocycle.

J. Lanyi, L. Zimányi, G. Varo, 1992, Biochemistry.

Crystal structure of the D85S mutant of bacteriorhodopsin: model of an O-like photocycle intermediate.

M. Facciotti, R. Glaeser, J. Lanyi, 2001, Journal of molecular biology.

Binding of calcium ions to bacteriorhodopsin.

J. Lanyi, L. Brown, G. Varo, 1999, Biophysical journal.

Perturbed interaction between residues 85 and 204 in Tyr-185-->Phe and Asp-85-->Glu bacteriorhodopsins.

J. Lanyi, R. Needleman, H. Richter, 1996, Biophysical journal.

Local and distant protein structural changes on photoisomerization of the retinal in bacteriorhodopsin.

J. Lanyi, J. Herzfeld, H. Kandori, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Complete identification of C = O stretching vibrational bands of protonated aspartic acid residues in the difference infrared spectra of M and N intermediates versus bacteriorhodopsin.

J. Lanyi, Jun Sasaki, T. Yoshizawa, 1994, Biochemistry.

Trimeric mutant bacteriorhodopsin, D85N, shows a monophasic CD spectrum

J. Lanyi, H. Kamikubo, M. Kataoka, 1993, FEBS letters.

Proton transfer from Asp-96 to the bacteriorhodopsin Schiff base is caused by a decrease of the pKa of Asp-96 which follows a protein backbone conformational change.

D. Czajkowsky, J. Lanyi, G. Varo, 1993, Biochemistry.

Relationship of retinal configuration and internal proton transfer at the end of the bacteriorhodopsin photocycle.

J. Lanyi, H. Kandori, R. Needleman, 1996, Biochemistry.

Estimated acid dissociation constants of the Schiff base, Asp-85, and Arg-82 during the bacteriorhodopsin photocycle.

J. Lanyi, L. Brown, R. Needleman, 1993, Biophysical journal.

Properties of Asp212----Asn bacteriorhodopsin suggest that Asp212 and Asp85 both participate in a counterion and proton acceptor complex near the Schiff base.

S H White, S. White, J. Lanyi, 1991, The Journal of biological chemistry.

Evidence of local conformational fluctuations and changes in bacteriorhodopsin, dependent on lipids, detergents and trimeric structure, as studied by 13C NMR.

J. Lanyi, A. Naito, M. Tanio, 1998, Biochimica et biophysica acta.

Existence of two L photointermediates of halorhodopsin from Halobacterium salinarium, differing in their protein and water FTIR bands.

J. Lanyi, H. Kandori, A Maeda, 1999, Biochemistry.

Light-driven chloride ion transport by halorhodopsin from Natronobacterium pharaonis. 1. The photochemical cycle.

J. Lanyi, L. Brown, H. Kandori, 1995, Biochemistry.

Fourier transform infrared spectra of a late intermediate of the bacteriorhodopsin photocycle suggest transient protonation of Asp-212.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 1999, Biochemistry.

Relationship of proton uptake on the cytoplasmic surface and reisomerization of the retinal in the bacteriorhodopsin photocycle: an attempt to understand the complex kinetics of the pH changes and the N and O intermediates.

J. Lanyi, L. Brown, R. Needleman, 1993, Biochemistry.

Relationship of proton release at the extracellular surface to deprotonation of the schiff base in the bacteriorhodopsin photocycle.

J. Lanyi, L. Brown, R. Needleman, 1995, Biophysical journal.

Water is required for proton transfer from aspartate-96 to the bacteriorhodopsin Schiff base.

J. Lanyi, G. Varo, J K Lanyi, 1991, Biochemistry.

The retinal Schiff base-counterion complex of bacteriorhodopsin: changed geometry during the photocycle is a cause of proton transfer to aspartate 85.

J. Lanyi, L. Brown, M. Sheves, 1994, Biochemistry.

A covalent link between the chromophore and the protein backbone of bacteriorhodopsin is not required for forming a photochemically active pigment analogous to the wild type.

J. Lanyi, M. Sheves, A. Lewis, 1994, Biochemistry.

MAL6 of Saccharomyces: a complex genetic locus containing three genes required for maltose fermentation.

D. Kaback, K. Sutherland, R. Dubin, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Time-resolved fourier transform infrared study of structural changes in the last steps of the photocycles of Glu-204 and Leu-93 mutants of bacteriorhodopsin.

J. Lanyi, L. Brown, H. Kandori, 1997, Biochemistry.

The proton transfers in the cytoplasmic domain of bacteriorhodopsin are facilitated by a cluster of interacting residues.

L. Sun, J. Lanyi, L. Brown, 1994, Journal of molecular biology.

A residue substitution near the beta-ionone ring of the retinal affects the M substates of bacteriorhodopsin.

J. Lanyi, L. Zimányi, G. Varo, 1992, Biophysical journal.

Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate

Ming Liu, R. Needleman, W. Brusilow, 2004, Current Genetics.

Immunosuppressant-like effects of phenylbutyrate on growth inhibition of Saccharomyces cerevisiae

R. Needleman, W. Brusilow, A. Grzanowski, 2002, Current Genetics.

Control of maltase synthesis in yeast

R. Needleman, 1991, Molecular microbiology.

Functional significance of a protein conformation change at the cytoplasmic end of helix F during the bacteriorhodopsin photocycle.

J. Lanyi, L. Brown, G. Varo, 1995, Biophysical journal.

A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure

P. Bernardi, V. Petronilli, E. Palma, 2011, Liver international : official journal of the International Association for the Study of the Liver.

Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase.

J. Cohen, J. Marmur, R. Needleman, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Properties of cytoplasmic mutants of Saccharomyces cerevisiae with specific lesions in cytochrome oxidase.

A. Tzagoloff, A. Akai, R. Needleman, 1975, Proceedings of the National Academy of Sciences of the United States of America.

THE TWO CONSECUTIVE M SUBSTATES IN THE PHOTOCYCLE OF BACTERIORHODOPSIN ARE AFFECTED SPECIFICALLY BY THE D85N AND D96N RESIDUE REPLACEMENTS

J. Lanyi, L. Zimányi, R. Needleman, 1992, Photochemistry and photobiology.

Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS

Richard Needleman, M. Galloway, F. Ghoddoussi, 2010, Journal of the Neurological Sciences.

Bacillus Calmette-Guérin Packaged for Percutaneous Vaccination Can Be Safely Used for Intravesical Instillation in Patients with Urothelial Carcinoma of the Bladder

R. Uzzo, A. Srivastava, David Y. T. Chen, 2020 .

Conversion of bacteriorhodopsin into a chloride ion pump.

J. Lanyi, L. Brown, Jun Sasaki, 1995, Science.

Effect of sex on lifespan, disease progression, and the response to methionine sulfoximine in the SOD1 G93A mouse model for ALS.

R. Needleman, Patricia A Pentiak, W. Brusilow, 2012, Gender medicine.

Interaction of aspartate-85 with a water molecule and the protonated Schiff base in the L intermediate of bacteriorhodopsin: a Fourier-transform infrared spectroscopic study.

J. Lanyi, R. Needleman, A. Maeda, 1994, Biochemistry.

Conformational changes of bacteriorhodopsin along the proton-conduction chain as studied with (13)C NMR of [3-(13)C]Ala-labeled protein: arg(82) may function as an information mediator.

J. Lanyi, A. Naito, M. Tanio, 1999, Biophysical journal.

Water structural changes at the proton uptake site (the Thr46-Asp96 domain) in the L intermediate of bacteriorhodopsin.

J. Herzfeld, H. Kandori, R. Needleman, 1995, Biochemistry.

Structures of aspartic acid-96 in the L and N intermediates of bacteriorhodopsin: analysis by Fourier transform infrared spectroscopy.

J. Lanyi, T. Yoshizawa, Y. Shichida, 1992, Biochemistry.

Origins of deuterium kinetic isotope effects on the proton transfers of the bacteriorhodopsin photocycle.

J. Lanyi, L. Brown, R. Needleman, 2000, Biochemistry.

Transient channel-opening in bacteriorhodopsin: an EPR study.

T. Thorgeirsson, J. Lanyi, L. Brown, 1997, Journal of molecular biology.

Partitioning of free energy gain between the photoisomerized retinal and the protein in bacteriorhodopsin.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 1998, Biochemistry.

Proton transport by halorhodopsin.

J. Lanyi, L. Brown, G. Varo, 1996, Biochemistry.

An efficient system for the synthesis of bacteriorhodopsin in Halobacterium halobium.

J. Lanyi, A. Duschl, R. Needleman, 1990, Gene.

Stability of the C-terminal alpha-helical domain of bacteriorhodopsin that protrudes from the membrane surface, as studied by high-resolution solid-state 13C NMR.

J. Lanyi, A. Naito, M. Tanio, 1998, Journal of biochemistry.

Pathway of proton uptake in the bacteriorhodopsin photocycle.

J. Lanyi, L. Zimányi, R. Needleman, 1993, Biochemistry.

Long-distance effects of site-directed mutations on backbone conformation in bacteriorhodopsin from solid state NMR of [1-13C]Val-labeled proteins.

J. Lanyi, A. Naito, M. Tanio, 1999, Biophysical journal.

Changes in hydrogen bonding and environment of tryptophan residues on helix F of bacteriorhodopsin during the photocycle: a time-resolved ultraviolet resonance Raman study.

J. Lanyi, H. Takeuchi, R. Needleman, 2002, Biochemistry.

Glutamate as a target in Tourette syndrome and other neuropsychiatric disorders

M. Galloway, F. Ghoddoussi, R. Needleman, 2010, Journal of the Neurological Sciences.

Light-induced Rotation of a Transmembrane α-Helix in Bacteriorhodopsin

J. Lanyi, L. Brown, W. Xiao, 2000 .

Irreversible conformational change of bacterio-opsin induced by binding of retinal during its reconstitution to bacteriorhodopsin, as studied by (13)C NMR.

J. Lanyi, A. Naito, M. Tanio, 2000, Journal of biochemistry.

Coupling of the reisomerization of the retinal, proton uptake, and reprotonation of Asp-96 in the N photointermediate of bacteriorhodopsin.

Andrei K. Dioumaev, J. Lanyi, L. Brown, 2001, Biochemistry.

Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin.

J. Lanyi, L. Brown, R. Needleman, 2002, Journal of molecular biology.

Improved sensitivity in blue-membrane bacteriorhodopsin films.

J. Millerd, N. Brock, A. Rohrbacher, 1999, Optics letters.

X‐Ray Diffraction Studies of Bacteriorhodopsin. Determination of the Positions of Mercury Label at Several Engineered Cysteine Residues

J. Lanyi, H. Kamikubo, M. Kataoka, 1997, Photochemistry and photobiology.

Component analysis of the fast photoelectric signal from model bacteriorhodopsin membranes: Part III. Effect of the point mutation aspartate 212 → asparagine 212

F. Hong, R. Needleman, B. Ni, 1994 .