P. Cheng

发表

Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols.

K. Engle, Tae-Ah Kang, Nana Kim, 2021, Journal of the American Chemical Society.

Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).

Steven A. Spronk, K. Behnia, J. Barrish, 2022, Journal of medicinal chemistry.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

M. Blanar, Rongan Zhang, S. Krystek, 2016, ACS medicinal chemistry letters.

Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.

Litao Zhang, K. O'Malley, P. Cheng, 2008, Bioorganic & medicinal chemistry letters.

Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.

Darpandeep Aulakh, Amy A Sarjeant, P. Cheng, 2021, Organic letters.

Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.

Wei Wang, Jonathan Lippy, Arthur M Doweyko, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Weiqi Wang, A. Doweyko, T. Harrity, 2015, Bioorganic & medicinal chemistry letters.

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Weiqi Wang, A. Doweyko, W. Humphreys, 2005, Journal of medicinal chemistry.

PPARs as targets for metabolic and cardiovascular diseases.

P. Cheng, R. Mukherjee, 2005, Mini reviews in medicinal chemistry.

Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

Wei Wang, Wei Sun, Zhengping Ma, 2007 .

Lysophosphatidic Acid Receptor Antagonism Protects against Diabetic Nephropathy in a Type 2 Diabetic Model.

R. Harris, A. Fogo, Ming-Zhi Zhang, 2017, Journal of the American Society of Nephrology : JASN.

Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.

J. Groves, W. R. Ewing, P. Cheng, 2018, Angewandte Chemie.

Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.

Maximilian D Palkowitz, M. Poss, Simon Kolb, 2022, Journal of the American Chemical Society.

Alkene Difunctionalization Directed by Free Amines: Diamine Synthesis via Nickel-Catalyzed 1,2-Carboamination

K. Engle, Tae-Ah Kang, P. Cheng, 2021, ACS Catalysis.

Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols.

K. Engle, Tae-Ah Kang, Nana Kim, 2021, Journal of the American Chemical Society.

Determination of the absolute configuration and solution conformation of a novel disubstituted pyrrolidine acid A by vibrational circular dichroism.

Y. Shu, Xiaolin Cao, L. Nafie, 2006, Chirality.

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

C. Chu, S. Jusuf, Yanou Yang, 2021, Journal of medicinal chemistry.

Ligand-Promoted Borylation of C(sp(3))-H Bonds with Palladium(II) Catalysts.

jin-quan yu, P. Cheng, Heng Jiang, 2016, Angewandte Chemie.

Discovery, synthesis, and structure-activity studies of tetrazole based growth hormone secretagogues.

K. Dickinson, R. Seethala, G. Grover, 2007, Bioorganic & medicinal chemistry letters.

Manganese-Catalyzed Desaturation of N-Acyl Amines and Ethers

Gang Li, J. Groves, Patrick A. Kates, 2019, ACS Catalysis.

Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.

J. Barrish, M. Hermsmeier, E. Gordon, 1994, Journal of medicinal chemistry.

Ligand-accelerated non-directed C–H functionalization of arenes

M. Poss, K. Yeung, jin-quan yu, 2017, Nature.

A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

Ping Chen, S. Spergel, J. Barrish, 1997 .

Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180).

W. Humphreys, K. Dickinson, R. Seethala, 2007, Journal of medicinal chemistry.

A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen

K. Yeung, W. R. Ewing, Zhen Wang, 2021, Science.

Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.

A. Doweyko, T. Harrity, Litao Zhang, 2008, Bioorganic & medicinal chemistry letters.

Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.

Ping Chen, S. Spergel, O. Kocy, 1996, Journal of medicinal chemistry.

The Enantioselective Synthesis of anti-β-Hydroxy-α-Amino Acids via the Reaction of Lithium Enolates of Glycine Bearing an Oxazolidine Chiral Auxiliary with Aldehydes

Henry H. Gu, E. Iwanowicz, P. Cheng, 1998 .

The regioselectivity of the formation of dihydro- and tetrahydrocarbazoles by the Fischer indole synthesis

S. Mclean, P. Cheng, G. W. Reed, 1982 .

A general synthesis of dioxolenone prodrug moieties

M. Poss, P. Cheng, J. Robl, 2002 .

Modulateurs de récepteurs gpr120 à base d'acide bicyclo [2.2.2]

P. Cheng, Hao Zhang, Shiwei Tao, 2014 .

α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease

Ping Chen, S. Spergel, J. Barrish, 1995 .

Nuclear Hormone Receptor Medicinal Chemistry

P. Cheng, E. Kick, R. Mukherjee, 2010, Burger's Medicinal Chemistry and Drug Discovery.

A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARα/γ activator

R. Seethala, Rajasree Golla, Zhengping Ma, 2007 .

BMS-986327 as a novel PET imaging agent for assessment of LPA1 receptors in IPF

Joonyoung Kim, W. Hayes, P. Chow, 2019, Rare ILD/DPLD.

Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.

W. R. Ewing, P. Cheng, R. Knowles, 2019, Journal of the American Chemical Society.

Synthesis and structure-activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARalpha selective activators- PPARalpha and PPARgamma selectivity modulation.

Daniel Meyers, Jonathan Lippy, Rongan Zhang, 2010, Bioorganic & medicinal chemistry letters.

2,5-Bis-(sulfonyl)pyrazines as unprecedented building blocks and their SNAr reactions

J. Li, P. Cheng, Yong-Jin Wu, 2013 .

Selective C-H Halogenation with a Highly Fluorinated Manganese Porphyrin.

J. Groves, W. R. Ewing, P. Cheng, 2018, Angewandte Chemie.