S. Joshi

发表

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

J. Segreti, S. Baker, Robert G. Schmidt, 2011, PAIN.

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.

M. Jarvis, Qingwei Zhang, S. Joshi, 2015, ACS medicinal chemistry letters.

PARP inhibitors attenuate chemotherapy‐induced painful neuropathy

K. Browman, X. Liu, V. Giranda, 2012, Journal of the peripheral nervous system : JPNS.

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.

Matthew S. Johnson, C. Shieh, James B. Thomas, 2010, Bioorganic & medicinal chemistry.

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.

Matthew S. Johnson, Dong Liu, C. Shieh, 2008, Bioorganic & medicinal chemistry.

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.

A. Gomtsyan, Chih-Hung Lee, E. Bayburt, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.

A. Gomtsyan, Chih-Hung Lee, Robert G. Schmidt, 2010, Bioorganic & medicinal chemistry.

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

Matthew S. Johnson, J. Sullivan, C. Shieh, 2007, Proceedings of the National Academy of Sciences.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states

J. Sullivan, C. Shieh, S. Baker, 2006, Pain.

Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects.

G. Gebhart, S. Joshi, X. Su, 2002, Journal of neurophysiology.

Nonopioid Actions of U50,488 Enantiomers Contribute to Their Peripheral Cutaneous Antinociceptive Effects

G. Gebhart, S. Joshi, 2003, Journal of Pharmacology and Experimental Therapeutics.

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.

Matthew S. Johnson, Dong Liu, C. Shieh, 2010, Bioorganic & medicinal chemistry letters.

A-887826 is a structurally novel, potent and voltage-dependent Nav1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

C. Shieh, R. Atkinson, P. Honore, 2010, Neuropharmacology.

Morphine and ABT-594 (a nicotinic acetylcholine agonist) exert centrally mediated antinociception in the rat cyclophosphamide cystitis model of visceral pain.

P. Honore, S. Joshi, J. Mikusa, 2008, The journal of pain : official journal of the American Pain Society.

Animal models of pain for drug discovery

P. Honore, S. Joshi, 2006, Expert opinion on drug discovery.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

S. Baker, T. Neelands, P. Honore, 2010, PAIN.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.

Matthew S. Johnson, C. Shieh, James B. Thomas, 2008, Journal of medicinal chemistry.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.

P. Honore, M. Jarvis, C. Faltynek, 2008, Journal of neurophysiology.

Arylacetamide κ-Opioid Receptor Agonists Produce a Tonic- and Use-Dependent Block of Tetrodotoxin-Sensitive and -Resistant Sodium Currents in Colon Sensory Neurons

K. Bielefeldt, G. Gebhart, S. Joshi, 2003, Journal of Pharmacology and Experimental Therapeutics.

Peripheral Opioid Modulation of Visceral Pain a

G. Gebhart, N. Ozaki, S. Joshi, 2000, Annals of the New York Academy of Sciences.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

P. Chandran, M. Jarvis, P. Kym, 2011, Brain Research.

κ-Opioid Receptor Agonists Modulate Visceral Nociception at a Novel, Peripheral Site of Action

G. Gebhart, F. Porreca, S. Joshi, 2000, The Journal of Neuroscience.

Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation.

Michael Decker, David Leblond, M. Decker, 2012, The journal of pain : official journal of the American Pain Society.

Development and validation of mechanical allodynia as a pain readout in a preclinical model of osteoarthritis

P. Honore, S. Joshi, G. Simler, 2012 .

Pharmacological modulation of brain activity in a preclinical model of osteoarthritis

Michael J. Wald, Mark Day, John Beaver, 2013, NeuroImage.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of medicinal chemistry.

Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models.

A. Gomtsyan, Robert G. Schmidt, P. Honore, 2009, The journal of pain : official journal of the American Pain Society.