S. McGaraughty

发表

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

J. Segreti, S. Baker, Robert G. Schmidt, 2011, PAIN.

Mapping brain activity following administration of a nicotinic acetylcholine receptor agonist, ABT-594, using functional magnetic resonance imaging in awake rats

S. McGaraughty, G. Fox, Chih-Liang Chin, 2006, Neuroscience.

Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy

D. Donnelly-roberts, S. McGaraughty, T. Esbenshade, 2016, American Journal of Nephrology.

Pharmacological and functional magnetic resonance imaging techniques in CNS drug discovery

G. Fox, S. McGaraughty, Yanping Luo, 2006, Expert opinion on drug discovery.

Endogenous opioid mechanisms partially mediate P2X3/P2X2/3‐related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain

P. Honore, H. McDonald, M. Jarvis, 2005, British journal of pharmacology.

IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases

S. Gauld, R. Duggan, P. Honore, 2017, Scientific Reports.

Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats.

D. Donnelly-roberts, M. Gopalakrishnan, S. McGaraughty, 2018, Journal of pharmacological and toxicological methods.

Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats

M. Jarvis, S. McGaraughty, K. Chu, 2013, PAIN®.

Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain

Jill-Desiree Brederson, M. Jarvis, R. Edelmayer, 2018, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

Matthew S. Johnson, J. Sullivan, C. Shieh, 2007, Proceedings of the National Academy of Sciences.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.

A. Gomtsyan, R. Snyder, Chih-Hung Lee, 2005, Bioorganic & medicinal chemistry.

Losartan improves renal function and pathology in obese ZSF-1 rats

D. Donnelly-roberts, M. Gopalakrishnan, S. McGaraughty, 2018, Journal of basic and clinical physiology and pharmacology.

JPET # 105890 PIP 1 Painful Purinergic Receptors

D. Donnelly-roberts, C. Shieh, P. Honore, 2007 .

Distinct neurochemical mechanisms are activated following administration of different P2X receptor agonists into the hindpaw of a rat

M. Jarvis, C. Faltynek, S. McGaraughty, 2003, Brain Research.

A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats

M. Jarvis, J. Mikusa, S. McGaraughty, 2001, Brain Research.

TRPA1 in Drug Discovery

P. Kym, Jun Chen, S. McGaraughty, 2012 .

Characterization of psoriasiform dermatitis induced by systemic injection of interleukin‐23 minicircles in mice

D. Donnelly-roberts, P. Honore, R. Edelmayer, 2019, The Journal of dermatology.

Pharmacological MRI in awake rats predicts selective binding of α4β2 nicotinic receptors

G. Fox, Chih-Liang Chin, J. R. Pauly, 2008 .

Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach.

M. Gopalakrishnan, S. McGaraughty, Todd B. Cole, 2017, Journal of the American Society of Nephrology : JASN.

Characterization of Fasudil in preclinical models of pain.

A. Vasudevan, P. Honore, G. Simler, 2010, The journal of pain : official journal of the American Pain Society.

A mixed Ca channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain

A. Swensen, Lance Lee, M. Jarvis, 2013 .

Mechanistic and pharmacological assessment of murine IL-23 mediated psoriasiform dermatitis; implications for drug discovery.

S. Gauld, P. Honore, R. Edelmayer, 2018, Journal of dermatological science.

Pharmacological MRI in awake rats predicts selective binding of alpha4beta2 nicotinic receptors.

G. Fox, Chih-Liang Chin, J. R. Pauly, 2008, Synapse.

A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors

S. McGaraughty, K. Chu, M. Dart, 2009, Neuroscience.

Antinociceptive properties of a non-nucleotide P2X3/P2X2/3 receptor antagonist.

M. Jarvis, S. McGaraughty, 2005, Drug news & perspectives.

A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

T. Brennan, J. Sullivan, M. Williams, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Simultaneous multi- and single-unit recordings in the rostral ventromedial medulla of ketamine-anaesthetized rats, and the cross-correlogram analysis of their interactions

S. Reinis, S. McGaraughty, 2004, Experimental Brain Research.

Uninjured Rats Dynamic Range Neurons in CFA-Treated and Selective TRPV1 Receptor Antagonist, on Wide Systemic and Site-Specific Effects of A-425619, a

J. Brioni, A. Swensen, Lance Lee, 2015 .

Coexpression and activation of TRPV1 suppress the activity of the KCNQ2/3 channel

T. Neelands, C. Surowy, P. Honore, 2011, The Journal of general physiology.

Systemic and site-specific effects of A-425619, a selective TRPV1 receptor antagonist, on wide dynamic range neurons in CFA-treated and uninjured rats.

M. Jarvis, C. Faltynek, S. McGaraughty, 2006, Journal of neurophysiology.

4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.

A. Gomtsyan, S. Muchmore, Chih-Hung Lee, 2007, Bioorganic & medicinal chemistry.

Analgesic and anti-inflammatory effects of A-286501, a novel orally active adenosine kinase inhibitor

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002, Pain.

Pyridopyrimidine analogues as novel adenosine kinase inhibitors.

A. Gomtsyan, S. Muchmore, M. Jarvis, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla.

M. Heinricher, S. McGaraughty, V. Tortorici, 2001, Journal of neurophysiology.

Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla.

D. Grandy, M. Heinricher, S. McGaraughty, 1997, Journal of neurophysiology.

The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine

M. Heinricher, S. McGaraughty, D. A. Farr, 1999, Pain.

Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats.

P. Honore, M. Jarvis, C. Faltynek, 2008, Journal of neurophysiology.

A selective α2B adrenoceptor agonist (A‐1262543) and duloxetine modulate nociceptive neurones in the medial prefrontal cortex, but not in the spinal cord of neuropathic rats

L. Li, J. Xu, M. Jarvis, 2015, European journal of pain.

Purinergic control of neuropathic pain

M. Jarvis, S. McGaraughty, Michael F. Jarvis, 2006 .

Anticonvulsant and antinociceptive actions of novel adenosine kinase inhibitors.

M. Jarvis, R. Berman, S. McGaraughty, 2005, Current topics in medicinal chemistry.

Recent developments in the discovery of novel adenosine kinase inhibitors: mechanism of action and therapeutic potential.

M. Jarvis, S. McGaraughty, M F Jarvis, 2006, CNS drug reviews.

Adenosine kinase inhibitors: polar 7-substitutent of pyridopyrimidine derivatives improving their locomotor selectivity.

Chih-Hung Lee, Changcheng Zhu, M. Jarvis, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.

S. Bhagwat, E. Bayburt, M. Jarvis, 2001, Bioorganic & medicinal chemistry letters.

Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats

P. Honore, M. Jarvis, J. Mikusa, 2002, Pharmacology Biochemistry and Behavior.

PII: S0304-3959(01)00435-3

Chih-Hung Lee, M. Jarvis, J. Mikusa, 2002 .

Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.

M. Jarvis, J. Mikusa, S. McGaraughty, 2001, The Journal of pharmacology and experimental therapeutics.

Painful Purinergic Receptors

D. Donnelly-roberts, C. Shieh, P. Honore, 2008, Journal of Pharmacology and Experimental Therapeutics.

D. Donnelly-roberts, C. Shieh, P. Honore, 2007, Neuroscience.

Pain-Modulating Neurons and Behavioral State

M. Heinricher, S. McGaraughty, 1998, Handbook of Behavioral State Control.

Characterization of the triazine, T4, a representative from a novel series of CaV2 inhibitors with strong state-dependence, poor use-dependence, and distinctively fast kinetics.

A. Swensen, Chih-Hung Lee, M. Jarvis, 2014, European journal of pharmacology.

Heat-excited and heat-inhibited neurones in the ventroposterior nucleus of thalamus of anaesthetized rats.

S. Reinis, S. McGaraughty, J. Tsoukatos, 1997, Physiological research.

Characterization and pharmacological modulation of noci-responsive deep dorsal horn neurons across diverse rat models of pathological pain.

S. McGaraughty, K. Chu, Jun Xu, 2018, Journal of neurophysiology.

TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.

A. Gomtsyan, Jill-Desiree Brederson, Robert G. Schmidt, 2017, Journal of neurophysiology.

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain.

A. Swensen, Lance Lee, M. Jarvis, 2014, Journal of neurophysiology.

A mixed Ca 2 channel blocker , A-1264087 , utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain

A. Swensen, Lance Lee, M. Jarvis, 2013 .

Antagonism of Supraspinal Histamine H3 Receptors Modulates Spinal Neuronal Activity in Neuropathic Rats

J. Brioni, S. McGaraughty, K. Chu, 2012, Journal of Pharmacology and Experimental Therapeutics.

Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats

Jill-Desiree Brederson, M. Jarvis, S. McGaraughty, 2012, Journal of neuroscience research.

Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial

M. Rowbotham, P. Svensson, C. Faltynek, 2011, PAIN.

P. Chandran, M. Jarvis, P. Kym, 2011, Brain Research.

TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

P. Kym, M. Kort, S. Didomenico, 2010, Molecular pain.

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

A. Gomtsyan, J. Sullivan, Chih-Hung Lee, 2008, Journal of Pharmacology and Experimental Therapeutics.

A Selective Nav1.8 Sodium Channel Blocker, A-803467 [5-(4-Chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], Attenuates Spinal Neuronal Activity in Neuropathic Rats

M. Jarvis, C. Faltynek, M. Kort, 2008, Journal of Pharmacology and Experimental Therapeutics.

Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A‐841720, a novel non‐competitive mGluR1 receptor antagonist

G. Fox, S. Baker, M. Mezler, 2006, British journal of pharmacology.

Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity

M. Jarvis, C. Faltynek, S. McGaraughty, 2004, Neuroscience Letters.

Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM.

E. Burgard, M. Jarvis, C. Faltynek, 2003, Journal of neurophysiology.

Effects of Noxious Hindpaw Immersion on Evoked and Spontaneous Firing of Contralateral Convergent Dorsal Horn Neurons in Both Intact and Spinalized Rats

S. McGaraughty, J. Henry, 1997, Brain Research Bulletin.

The effects of strychnine, bicuculline, and ketamine on `immersion-inhibited' dorsal horn convergent neurons in intact and spinalized rats

S. McGaraughty, J. Henry, 1998, Brain Research.

Relationship between mechano-receptive fields of dorsal horn convergent neurons and the response to noxious immersion of the ipsilateral hindpaw in rats

S. McGaraughty, J. Henry, 1997, Pain.

Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis

Chih-Liang Chin, Gerard B. Fox, Vincent P. Hradil, 2006, NeuroImage.

IL‐36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis

P. Honore, R. Edelmayer, J. Seagal, 2018, Experimental dermatology.

Rats housed on corncob bedding show less slow-wave sleep.

S. McGaraughty, R. Radek, L. Leys, 2012, Journal of the American Association for Laboratory Animal Science : JAALAS.

Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation

S. Gauld, P. Honore, R. Edelmayer, 2019, Scientific Reports.

Effects of A‐317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration

Chih-Hung Lee, P. Honore, M. Jarvis, 2003, British journal of pharmacology.

Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity

M. Heinricher, S. McGaraughty, 2002, Pain.

PII: S0304-3959(01)00440-7

M. Heinricher, S. McGaraughty, 2002 .

Small Molecule IL-36 gamma Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.

P. Richardson, Chaohong Sun, R. Henry, 2019 .

Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis

P. Richardson, Chaohong Sun, R. Henry, 2019, Scientific Reports.

Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala

M. Heinricher, S. McGaraughty, D. A. Farr, 2004, Brain Research.

Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats

J. Segreti, R. Fryer, C. Faltynek, 2009, Brain Research.

Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry

M. Heinricher, S. McGaraughty, Steve McGaraughty, 1998, Pain.

Two distinct unit activity responses to morphine in the rostral ventromedial medulla of awake rats

S. Reinis, S. McGaraughty, J. Tsoukatos, 1993, Brain Research.

Investigating the role of anaesthetics on the rostral ventromedial medulla: implications for a GABAergic link between ON and OFF cells

S. Reinis, S. McGaraughty, J. Tsoukatos, 1993, Neuroscience Letters.

A correlogram analysis of the activity in the rostral ventromedial medulla of awake rats and in rats anesthetized with ketamine or pentobarbital following the administration of morphine

S. Reinis, S. McGaraughty, J. Tsoukatos, 2004, Experimental Brain Research.

Inhibition of Interleukin-23–Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt

S. Gauld, K. Cusack, P. Honore, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

Jean M. Severin, E A Kowaluk, P. Hajduk, 2000, Journal of medicinal chemistry.

A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury.

Chih-Hung Lee, M. Gopalakrishnan, S. McGaraughty, 2016, European journal of pharmacology.

ACT1 is required for murine IL-23-induced psoriasiform inflammation potentially independent of E3 ligase activity.

A. Lipovsky, S. Gauld, P. Slivka, 2021, The Journal of investigative dermatology.

Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.

T. Neelands, C. Surowy, M. Jarvis, 2013, Assay and drug development technologies.

IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases

S. Gauld, P. Honore, M. Kort, 2019, Scientific Reports.

Perspectives in Pharmacology Painful Purinergic Receptors

C. Shieh, P. Honore, M. Jarvis, 2008 .

A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats.

M. Jarvis, Qingwei Zhang, S. Joshi, 2014, Biochemical pharmacology.

An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics.

A. Swensen, Lance Lee, T. Vortherms, 2012, Assay and drug development technologies.

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.

G. Gintant, R. Gum, T. Neelands, 2022, Bioorganic & medicinal chemistry.

A. Gomtsyan, J. Sullivan, Chih-Hung Lee, 2008, Journal of Pharmacology and Experimental Therapeutics.

Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach.

M. Gopalakrishnan, S. McGaraughty, Todd B. Cole, 2017, Journal of the American Society of Nephrology.

Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.

A. Swensen, Chih-Hung Lee, T. Neelands, 2014, The journal of pain : official journal of the American Pain Society.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of Medicinal Chemistry.

TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.

A. Gomtsyan, Robert G. Schmidt, P. Kym, 2017, Journal of neurophysiology.

Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats

M. Jarvis, S. McGaraughty, K. Chu, 2012, Journal of neuroscience research.