R. Reilly

发表

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

J. Segreti, S. Baker, Robert G. Schmidt, 2011, PAIN.

TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

A. Gomtsyan, J. Segreti, Robert G. Schmidt, 2015, Temperature.

Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.

A. Gomtsyan, Chih-Hung Lee, Robert G. Schmidt, 2010, Bioorganic & medicinal chemistry.

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

A. Gomtsyan, P. Mantyh, J. Sullivan, 2009, Pain.

Structural analysis of UBL5, a novel ubiquitin‐like modifier

E. Olejniczak, Zhihong Liu, R. Reilly, 2003, Protein science : a publication of the Protein Society.

Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile.

Haiyan Xu, R. Gimeno, C. Collins, 2006, Biochemical and biophysical research communications.

Pore dilation occurs in TRPA1 but not in TRPM8 channels

Donghee Kim, C. Faltynek, P. Kym, 2009, Molecular pain.

Diacylglycerol Acyltransferase 1 Inhibition Lowers Serum Triglycerides in the Zucker Fatty Rat and the Hyperlipidemic Hamster

A. Souers, J. Segreti, A. King, 2009, Journal of Pharmacology and Experimental Therapeutics.

Reduction of protein-tyrosine phosphatase-1B increases insulin signaling in FAO hepatoma cells.

C. Rondinone, J. Trevillyan, Harriet T. Smith, 2003, Biochemical and biophysical research communications.

In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.

A. Souers, J. Segreti, A. King, 2010, European journal of pharmacology.

Characterization of ghrelin rec eptor activity in a rat pituitary cell line RC4 B / C H

C. Collins, B. Dayton, W. Kaszubska, 2006 .

Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.

C. Collins, B. Dayton, W. Kaszubska, 2006, Journal of molecular endocrinology.

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

J. Waring, R. Ulrich, B. Monia, 2002, Diabetes.

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in

J. Waring, R. Ulrich, B. Monia, 2002 .

Cloning and characterization of the glucagon receptor from cynomologous monkey

T. Pederson, C. Collins, R. Reilly, 2004, Peptides.

Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.

Steven C. Cullen, P. Hajduk, A. Souers, 2012, Journal of medicinal chemistry.

Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.

A. Souers, G. Diaz, H. Sham, 2008, Journal of medicinal chemistry.

Species Comparison and Pharmacological Characterization of Human, Monkey, Rat, and Mouse TRPA1 Channels

P. Kym, Jun Chen, Xufeng Zhang, 2012, Journal of Pharmacology and Experimental Therapeutics.

Analgesic potential of TRPV3 antagonists.

P. Kym, R. Reilly, 2011, Current topics in medicinal chemistry.

Application of large-scale transient transfection to cell-based functional assays for ion channels and GPCRs.

John Locklear, Jun Chen, B. Bianchi, 2010, Methods in enzymology.

Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1).

C. Collins, L. Frost, B. Dayton, 2006, The international journal of biochemistry & cell biology.

Mapping effector functions of a monoclonal antibody to GD3 by characterization of a mouse-human chimeric antibody

A. Houghton, P. Chapman, S. Gillies, 1994, Cancer Immunology, Immunotherapy.

Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.

A. Gomtsyan, J. Segreti, A. King, 2014, Journal of medicinal chemistry.

A-995662 [(R)-8-(4-methyl-5-(4-(trifluoromethyl)phenyl)oxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol], a novel, selective TRPV1 receptor antagonist, reduces spinal release of glutamate and CGRP in a rat knee joint pain model

S. Baker, T. Neelands, P. Honore, 2010, PAIN.

Pharmacology of Modality-Specific Transient Receptor Potential Vanilloid-1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012, Journal of Pharmacology and Experimental Therapeutics.

TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds’ pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

A. A. Romanovsky, A. Gomtsyan, E. Pintér, 2018, Acta physiologica.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

Bruce Clapham, Bin Li, A. Gomtsyan, 2016, Journal of medicinal chemistry.

An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.

A. Souers, G. Diaz, H. Sham, 2007, Bioorganic & medicinal chemistry letters.

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

J. Waring, R. Ulrich, S. Crosby, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacology of Modality-Specific TRPV1 Antagonists That Do Not Alter Body Temperature

A. Gomtsyan, P. Mantyh, J. Segreti, 2012 .

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC.

D. Halbert, D. Haasch, Yung-wu Chen, 2002, Cellular immunology.

Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels

P. Hajduk, J. R. Huth, Chaohong Sun, 2008, The Journal of Neuroscience.

A single mutation in loop IV of Escherichia coli SuIII tRNA blocks processing at both 5'- and 3'-ends of the precursor tRNA.

U. RajBhandary, R. Reilly, 1986, The Journal of biological chemistry.

Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.

G. Diaz, E. Bush, H. Sham, 2006, Journal of medicinal chemistry.

Expression, purification, and enzymatic characterization of the dual specificity mitogen-activated protein kinase phosphatase, MKP-4.

T. Parsons, S. Hong, J. Trevillyan, 2005, Bioorganic chemistry.

Amino acid and nucleotide sequences of variable regions of mouse immunoglobulin light chains of the lambda 3-subtype.

R. Sauer, R. Breyer, H. Eisen, 1984, Journal of immunology.

The recognition by RNase P of precursor tRNAs.

S. Altman, U. RajBhandary, R. Reilly, 1988, Journal of Biological Chemistry.

Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.

G. Gintant, A. Souers, G. Diaz, 2007, Bioorganic & medicinal chemistry letters.

Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.

A. Souers, G. Diaz, E. Bush, 2007, Bioorganic & medicinal chemistry letters.

Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.

Haiyan Xu, Harriet T. Smith, R. Reilly, 2007, Frontiers in bioscience : a journal and virtual library.

Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.

Ju Gao, Anil Vasudevan, John K Lynch, 2006, Journal of medicinal chemistry.

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.

A. Gomtsyan, J. Segreti, R. Henry, 2016, Journal of medicinal chemistry.