C. Dean

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Ricin B chain converts a non‐cytotoxic antibody‐ricin A chain conjugate into a potent and specific cytotoxic agent

D. C. Edwards, W. Ross, A. Cumber, 1983, FEBS Letters.

Production and characterization of monoclonal antibodies to the c-erbB-2 proto-oncogene protein using a synthetic peptide immunogen.

W. Gullick, D. Venter, C. Dean, 1988, Biochemical Society transactions.

Monoclonal antibodies : a practical approach

C. Dean, P. Shepherd, 2000 .

Differentiation or immune destruction: two pathways for therapy of squamous cell carcinomas with antibodies to the epidermal growth factor receptor.

H. Modjtahedi, S. Eccles, J. Titley, 1994, Cancer research.

Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer.

M. Gore, T. Hickish, J. Sloane, 1996, British Journal of Cancer.

Brk, a Breast Tumor-derived Non-receptor Protein-tyrosine Kinase, Sensitizes Mammary Epithelial Cells to Epidermal Growth Factor*

B. Gusterson, T. Kamalati, P. J. Mitchell, 1996, The Journal of Biological Chemistry.

Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer

S. Eccles, C. Dean, M. Valeri, 2009, Cell Biophysics.

Preparation of 67Ga-labelled human IgG and its Fab fragments using desferoxamine as chelating agent

S. Eccles, C. Dean, C. Motta-Hennessy, 2004, European Journal of Nuclear Medicine.

Monoclonal antibodies for the treatment of metastases

M. Collins, S. Eccles, C. Dean, 2009, Cell Biophysics.

c-erbB2 protein overexpression in breast cancer as a target for PET using iodine-124-labeled monoclonal antibodies.

R. Ott, S. Eccles, J. Babich, 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Preparation and characterization of monoclonal antibodies to proteins and other cellular components.

C. Dean, 1994, Methods in molecular biology.

Preparation and testing of monoclonal antibodies to recombinant proteins.

C. Dean, 1992, Methods in molecular biology.

Preparation and testing of monoclonal antibodies to recombinant proteins.

C. Dean, 1992, Methods in molecular biology.

Immunological detection of DNA damage caused by melphalan using monoclonal antibodies.

M. Tilby, C. Dean, J. Styles, 1987, Cancer research.

Pharmacokinetic studies of radiolabelled rat monoclonal antibodies recognising syngeneic sarcoma antigens

S. Eccles, S. Hobbs, C. Dean, 2005, Cancer Immunology, Immunotherapy.

Pharmacokinetic studies of radiolabelled rat monoclonal antibodies recognising syngeneic sarcoma antigens

S. Eccles, S. Hobbs, C. Dean, 2005, Cancer Immunology, Immunotherapy.

Potential of monoclonal antibodies for localisation and treatment of disseminated disease: studies in syngeneic rat tumour systems.

S. Eccles, C. Dean, H. Purvies, 1988, Advances in experimental medicine and biology.

The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468.

H. Modjtahedi, C. Dean, J. Styles, 1993, British Journal of Cancer.

The effect of circulating antigen and radiolabel stability on the biodistribution of an indium labelled antibody.

W. Waddington, B. Davidson, J. Babich, 1991, British Journal of Cancer.

A novel protein of rat neutrophils (NDP): its use in estimating the neutrophil content of solid tissues.

C. Dean, D. Darcy, 1981, British journal of experimental pathology.

Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody.

M. Tilby, J. Roberts, C. Dean, 1991, Cancer research.

Application of a sensitive immunoassay to the study of DNA adducts formed in peripheral blood mononuclear cells of patients undergoing high-dose melphalan therapy.

M. Tilby, D. Newell, P. Selby, 1993, European journal of cancer.

Detailed investigation of the diagnostic value in tumour histopathology of ICR.2, a new monoclonal antibody to epithelial membrane antigen

J. Sloane, C. Dean, S. Imrie, 1990, Histopathology.

Rat monoclonal antibodies to the external domain of the product of the C‐erbB‐2 proto‐oncogene

B. Gusterson, C. Dean, S. Harrison, 1990, International journal of cancer.

The chondroitin sulfate proteoglycan NG2 is a tumour‐specific antigen on the chemically induced rat chondrosarcoma HSN

C. Dean, C. Dean, B. Coles, 1994, International journal of cancer.

Failure to detect autologous antibodies in the remission sera of patients with AML: complications introduced by the presence of rheumatoid factor.

C. Dean, S. E. James, P. Alexander, 1980, British Journal of Cancer.

Methodology for selection of human antibodies to membrane proteins from a phage-display library.

C. Dean, C. Sawyer, J. Embleton, 1997, Journal of immunological methods.

Radioimmunotherapy of breast cancer xenografts with monoclonal antibody ICR12 against c-erbB2 p185: comparison of iodogen and N-succinimidyl 4-methyl-3-(tri-n-butylstannyl)benzoate radioiodination methods.

S. Eccles, P. Garg, M. Zalutsky, 1995, Cancer research.

The use of [125I]C1q subcomponent for the measurement of complement binding antibodies on cell surfaces.

C. Dean, P. Shepherd, 1979, Journal of immunological methods.

Comparative study of carcinoembryonic antigen and epithelial membrane antigen expression in normal colon, adenomas and adenocarcinomas of the colon and rectum.

B. Davidson, C. Dean, P. Boulos, 1989, Gut.

A comparison of carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA) in human colorectal cancer

C. Clark, B. Davidson, C. Dean, 1988, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Isolation and characterization of a monoclonal rheumatoid factor specific for the hinge region of rat IgG2b.

C. Dean, O. Leger, 1991, Molecular immunology.

Isolation and characterization of a serologically defined tumour membrane antigen from a chemically‐induced rat sarcoma, HSN

C. Dean, B. Coles, O. Leger, 1991, International journal of cancer.

Production of IgA-secreting rat X rat hybridomas.

J. Hall, C. Dean, J. Styles, 1986, Methods in enzymology.

Production of IgA secreting hybridomas: a monoclonal rat antibody of the IgA class with specificity for RT1c.

J. Hall, S. Hobbs, C. Dean, 1982, Journal of immunological methods.

Preoperative imaging of colorectal cancers. Targeting the epithelial membrane antigen with a radiation‐labeled monoclonal antibody

W. Waddington, P. Ell, B. Davidson, 1992, Cancer.

Immunotherapy with antibodies to the EGF receptor

H. Modjtahedi, S. Eccles, S. Eccles, 1994, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Rejoining of X-ray Induced Breaks in the DNA of Leukaemia Cells

J. Lett, C. Dean, P. Alexander, 1967, Nature.

Radioimmunolocalisation in breast cancer using the gene product of c-erbB2 as the target antigen.

M. Baum, S. Eccles, C. Dean, 1993, British Journal of Cancer.

An ineffective monoclonal antibody-ricin A chain conjugate is converted to a tumouricidal agent in vivo by subsequent systemic administration of ricin B chain

S. Eccles, A. Cumber, D. Mcintosh, 2004, Cancer Immunology, Immunotherapy.

Repair of X-Ray Damage to the Deoxyribonucleic Acid in Micrococcus radiodurans

J. Lett, C. Dean, C. J. DEAN, 1966, Nature.

Sensitization of Radio-resistant Bacteria to X-rays by lodoacetamide

C. Dean, P. Alexander, 1962, Nature.

DNA Strand Breakage in Cells irradiated with X-rays

M. Ormerod, C. Dean, R. Serianni, 1969, Nature.

The receptor for EGF and its ligands - expression, prognostic value and target for therapy in cancer (review).

H. Modjtahedi, C. Dean, 1994, International journal of oncology.

Antitumor activity of combinations of antibodies directed against different epitopes on the extracellular domain of the human EGF receptor

H. Modjtahedi, S. Eccles, C. Dean, 2009, Cell Biophysics.

Preclinical models for the evaluation of targeted therapies of metastatic disease

S. Eccles, S. Eccles, C. Dean, 2007, Cell Biophysics.

The repair of X-ray damage to the deoxyribonucleic acid in Micrococcus radiodurans: a study of the excision process

J. Lett, C. Dean, P. Feldschreiber, 1967, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Use of [125I]C1q subcomponent for the measurement of complement-binding antibodies on cell surfaces.

C. Dean, P. Shepherd, 1979, Methods in enzymology.

Primary structure of the variable regions encoding antibody to NG2, a tumour-specific antigen on the rat chondrosarcoma HSN. Correlation of idiotypic specificities with amino acid sequences.

C. Dean, O. Leger, E. Jackson, 1995, Molecular immunology.

Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gp120.

J. McKeating, P. Balfe, C. Dean, 1992, Virology.

Targeting of cells expressing wild‐type EGFR and type‐III mutant EGFR (EGFRvIII) by anti‐EGFR MAb ICR62: A two‐pronged attack for tumour therapy

H. Modjtahedi, S. Eccles, C. Dean, 2003, International journal of cancer.

Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction.

H. Modjtahedi, S. Eccles, C. Dean, 1993, British Journal of Cancer.

The control of post irradiation DNA breakdown in Micrococcus radiodurans.

C. Dean, J. G. Little, R. Serianni, 1970, Biochemical and biophysical research communications.

DNA-membrane association and the repair of double breaks in x-irradiated Micrococcus radiodurans.

C. Dean, A D Burrell, P Feldschreiber, 1971, Biochimica et biophysica acta.

Significance of the c-erbB family of receptor tyrosine kinases in metastatic cancer and their potential as targets for immunotherapy.

H. Modjtahedi, S. Eccles, C. Dean, 1994, Invasion & metastasis.

Preclinical Studies with Human Tumour Xenografts Using Rat Monoclonal Antibodies Directed Against the Epidermal Growth Factor Receptor

H. Modjtahedi, S. Eccles, G. Box, 1997 .

The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes

M. Lyon, K. Willison, M. Marsh, 1989, Cell.

Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185.

C. Springer, S. Eccles, S. Eccles, 1994, Cancer research.

The production of hybridomas from the gut associated lymphoid tissue of tumour bearing rats. II. Peripheral intestinal lymph as a source of IgA producing cells.

J. Hall, S. Hobbs, C. Dean, 1984, Clinical and experimental immunology.

A rat monoclonal antibody that catalyses the hydrolysis of a nitrophenyl-beta-lactam.

K. Brocklehurst, M. Resmini, C. Dean, 2002, Biochemical and biophysical research communications.

EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

H. Modjtahedi, C. Stubberfield, K. Affleck, 1998, International journal of oncology.

Immunocytochemical Staining For the C‐Erbb‐2 Gene Product In Breast Aspirates: A Preliminary Report

C. Dean, I. Fernando, J. Sandle, 1993, Cytopathology : official journal of the British Society for Clinical Cytology.

Vaccination with syngeneic monoclonal anti-idiotype protects against a tumour challenge.

C. Dean, C. Johnson, P. L. Dunn, 1987, Immunology.

Rat monoclonal antibodies to nonoverlapping epitopes of human immunodeficiency virus type 1 gp120 block CD4 binding in vitro.

J. Moore, R. Weiss, J. McKeating, 1991, Virology.

Syngeneic antitumour antibodies in rats: clearance of cell-bound antibody in vivo and in vitro.

J. Hopkins, S. Hobbs, C. Dean, 1982, British Journal of Cancer.

REPAIR OF DNA AND THE MODE OF ACTION OF SENSITIZERS AND PROTECTORS IN BIOLOGICAL SYSTEMS OF DIFFERENT COMPLEXITY.

A. Lehmann, M. Ormerod, C. Dean, 1970 .

The production of hybridomas from the gut associated lymphoid tissue of tumour bearing rats. I. Mesenteric nodes as a source of IgG producing cells.

J. Hall, S. Hobbs, C. Dean, 1984, Clinical and experimental immunology.

Monoclonal antibodies to rat sarcomata. I. Immunization procedures and source of lymphoid cells for hybridoma production.

S. Hobbs, C. Dean, S. North, 1982, Immunology.

Characterization of syngeneic rat monoclonal antibodies to the HSN tumor using syngeneic monoclonal anti-idiotopic antibodies.

C. Dean, O. Leger, 1991, Journal of immunology.

Clinical radioimmunolocalization with a rat monoclonal antibody directed against c-erbB-2

S. Eccles, C. Dean, N. Sacks, 2007, Cell Biophysics.

The shedding of viable cells into the local lymph by tumours growing in the gut of rats.

J. Hall, C. Dean, K. Nagy, 1985, British Journal of Cancer.

The Binding of HB-EGF to Tumor Cells Is Blocked by mAbs Which Act as EGF and TGFα Antagonists

H. Modjtahedi, C. Dean, 1995 .

The binding of HB-EGF to tumour cells is blocked by mAbs which act as EGF and TGF alpha antagonists.

H. Modjtahedi, C. Dean, 1995, Biochemical and biophysical research communications.

Clearance of immune complexes formed in normal and leukaemic rats.

C. Dean, P. Shepherd, R. Pendry, 1980, British Journal of Cancer.

THE ROLE OF POST-IRRADIATION REPAIR PROCESSES IN CHEMICAL PROTECTION AND SENSITIZATION

J. Lett, C. Dean, P. Alexander, 1965 .

Tumour-specific antibodies of the IgA class in rats after the implantation of a syngeneic tumour in the gut.

J. Hall, C. Dean, J. Styles, 1980, British Journal of Cancer.

Reversible suppression of allo-antibody production by cyclosporin A.

C. Dean, R. Barfoot, J. Styles, 1980, International archives of allergy and applied immunology.

Chemical Study of the Radiosensitization of Micrococcus sodonensis by Iodine Compounds

M. Ormerod, C. Dean, L. Mullenger, 1967, Nature.