H. Hara

发表

Synergistic potentiation of in vivo antitumor activity of anti-human T-leukemia immunotoxins by recombinant alpha-interferon and daunorubicin.

Y. Luo, S. Yokota, H. Hara, 1990, Cancer research.

IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections

G. Núñez, E. Tolosano, Yun-Gi Kim, 2017, Science Immunology.

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation

N. Yoshida, T. Kishimoto, K. Yoshizaki, 1983, The Journal of experimental medicine.

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

I. Kawamura, M. Mitsuyama, H. Hara, 2010, The Journal of Immunology.

Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3-Kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine Macrophages

I. Kawamura, M. Mitsuyama, H. Hara, 2010, Infection and Immunity.

Nuclease-sensitive binding of an Actinobacillus actinomycetemcomitans leukotoxin to the bacterial cell surface

H. Ohta, K. Fukui, S. Kokeguchi, 1991, Infection and immunity.

Age-associated changes in proliferative and differentiative response of human B cells and production of T cell-derived factors regulating B cell functions

Toshio Tanaka, K. Yoshizaki, H. Hara, 1987, Mechanisms of Ageing and Development.

Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified tac-positive T cells

Toshio Tanaka, K. Yoshizaki, H. Hara, 1986, Mechanisms of Ageing and Development.

Synergistic Potentiation of in VivoAntitumor Activity of Anti-Human T-Leukemia Immunotoxins by Recombinant Â «-Interferonand Daunorubicin 1

Yi Luo, S. Yokota, H. Hara, 2006 .

Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.

H. Hara, B. Seon, 1987, Proceedings of the National Academy of Sciences of the United States of America.

mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line.

G. Barnett, J. Peterson, Y. Kondo, 1996, British Journal of Cancer.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

D. Vaux, K. Schroder, L. Whitehead, 2017, Proceedings of the National Academy of Sciences.

Regulation of beta-endorphin receptor expression in mouse spleen cells with Con A and rIL-2.

H. Hara, S. Negoro, L. Jia, 1992, International journal of immunopharmacology.

Chemo‐radioresistance of Small Cell Lung Cancer Cell Lines Derived from Untreated Primary Tumors Obtained by Diagnostic Bronchofiberscopy

H. Kitamura, I. Kawase, K. Kubota, 1990, Japanese journal of cancer research : Gann.

Development of selective IgM deficiency in systemic lupus erythematosus patients with disease of long duration.

Y. Saeki, H. Hara, T. Tanaka, 1987, Arthritis and rheumatism.

Synergy of Nocardia rubra Cell Wall Skeleton and Interleukin 2 in the in vivo Induction of Murine Lymphokine‐activated Killer Cell Activity

I. Kawase, Masatoshi Watanabe, T. Shirasaka, 1989, Japanese journal of cancer research : Gann.

Augmentation of Murine Lymphokine‐activated Killer Cell Induction by a Factor Produced by Nocardia rubra Cell Wall Skeleton‐stimulated T Cells

I. Kawase, Masatoshi Watanabe, T. Shirasaka, 1989, Japanese journal of cancer research : Gann.

Cellular vacuolation induced by Clostridium perfringens epsilon‐toxin

I. Nakagawa, Keiko Kobayashi, M. Nagahama, 2011, The FEBS journal.

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

E. Alnemri, T. Fernandes-Alnemri, I. Kawamura, 2011, The Journal of Immunology.

Infection Streptococcus pneumoniae Resistance to Caspase-1 Activation and Host Innate Critical Roles of ASC Inflammasomes in

E. Alnemri, T. Fernandes-Alnemri, I. Kawamura, 2011 .

Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection

I. Kawamura, M. Mitsuyama, H. Hara, 2014, Infection and Immunity.

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism

H. Tsutsui, I. Kawamura, M. Mitsuyama, 2019, Mucosal Immunology.

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2013, Nature Immunology.

Listeria monocytogenes Infected with Inflammasome Activation in Macrophages Involvement of Absent in Melanoma 2 in

I. Kawamura, M. Mitsuyama, H. Hara, 2010 .

Dependency of Caspase-1 Activation Induced in Macrophages by Listeria monocytogenes on Cytolysin, Listeriolysin O, after Evasion from Phagosome into the Cytoplasm1

I. Kawamura, M. Mitsuyama, H. Hara, 2008, The Journal of Immunology.

Cytolysin-Dependent Escape of the Bacterium from the Phagosome Is Required but Not Sufficient for Induction of the Th1 Immune Response against Listeria monocytogenes Infection: Distinct Role of Listeriolysin O Determined by Cytolysin Gene Replacement

I. Kawamura, M. Mitsuyama, H. Hara, 2007, Infection and Immunity.

Toshio Tanaka, K. Yoshizaki, N. Nishimoto, 1987, Mechanisms of Ageing and Development.

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

E. Alnemri, M. Chamaillard, Grace Y Chen, 2018, Cell.

Combined therapy of mice bearing a lymphokine-activated killer-resistant tumor with recombinant interleukin 2 and an antitumor monoclonal antibody capable of inducing antibody-dependent cellular cytotoxicity.

I. Kawase, T. Inoue, T. Shirasaka, 1988, Cancer research.

Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus.

H. Hara, T. Tanaka, S. Kishimoto, 1989, Arthritis and rheumatism.

The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation.

I. Kawamura, M. Mitsuyama, H. Hara, 2014, Pathogens and disease.

Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6.

Y. Luo, H. Hara, B. Seon, 1988, Cancer research.

Effect of Weakly-Virulent Bacteriocin-Producing Strain of Pseudomonas solanacearum on the Protection of Tobacco Plant from Bacterial Wilt

H. Hara, K. Ono, 1991 .

Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice.

Y. Luo, H. Hara, B. Seon, 1989, Cancer research.

Listeriolysin O-Dependent Bacterial Entry into the Cytoplasm Is Required for Calpain Activation and Interleukin-1α Secretion in Macrophages Infected with Listeria monocytogenes

I. Kawamura, M. Mitsuyama, H. Hara, 2010, Infection and Immunity.

Midline malignant B‐cell lymphoma with leukemic transformation

K. Yoneda, T. Yamamoto, T. Osaki, 1992, Cancer.

H. Hara, S. Kishimoto, S. Negoro, 1988, Mechanisms of Ageing and Development.

HTLV-1 bZIP factor impairs cell-mediated immunity by suppressing production of Th1 cytokines.

K. Ohshima, M. Matsuoka, A. Utsunomiya, 2012, Blood.

Protooncogene expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus as an indicator of the disease activity.

H. Hara, T. Kakunaga, S. Kishimoto, 1987, Clinical immunology and immunopathology.

mdm2genemediates theexpression ofmdrlgeneandP-glycoprotein ina humanglioblastoma cellline

Y. Kondo, H. Hara, T. Morimura, 1996 .

Listeria monocytogenes Strain-Specific Impairment of the TetR Regulator Underlies the Drastic Increase in Cyclic di-AMP Secretion and Beta Interferon-Inducing Ability

F. Sato, M. Matsuura, I. Kawamura, 2012, Infection and Immunity.

Effector mechanism in concomitant immunity potentiated by intratumoral injection of Nocardia rubra cell wall skeleton.

I. Kawase, S. Yokota, H. Hara, 1985, Cancer research.

Malignant lymphoma antigen expressed in nude mouse tumor cells derived from carcinogen-transformed Bloom's syndrome B-lymphoblastoid cell lines.

A. Sandberg, H. Hara, M. Kozuru, 1990, Cancer research.

Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomes.

M. Nagahama, M. Fernández-Miyakawa, H. Hara, 2006, Biochemistry.

Enhanced tumor growth and metastatic spread of an mh 134 variant lacking a part of the mm antigen: A possible role of antibody‐dependent cellular cytotoxicity in control of tumor growth and metastases

H. Hara, K. Komuta, S. Kishimoto, 1989, International journal of cancer.

Association of Actinobacillus actinomycetemcomitans leukotoxin with nucleic acids on the bacterial cell surface

H. Ohta, K. Fukui, H. Hara, 1993, Infection and immunity.

Mechanism and Regulation of NLRP3 Inflammasome Activation.

G. Núñez, H. Hara, Yuan He, 2016, Trends in biochemical sciences.

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

S. Akira, I. Kawamura, M. Mitsuyama, 2012, The Journal of Immunology.

Listeria toxin promotes phosphorylation of the inflammasome adaptor ASC through Lyn and Syk to exacerbate pathogen expansion.

G. Núñez, N. Inohara, M. Mitsuyama, 2022, Cell reports.

Listeria Toxin Promotes Phosphorylation of the Inflammasome Adaptor ASC Through Lyn and Syk to Exacerbate Pathogen Expansion

G. Núñez, N. Inohara, M. Mitsuyama, 2021 .

5-Azacytidine induced inhibition of mitogenic response by agents that activate or augment activation of human peripheral blood T lymphocytes.

H. Hara, S. Kishimoto, S. Negoro, 1988, Biochemical and biophysical research communications.

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.

T. Suda, H. Hara, T. Kinoshita, 2021, Cell reports.

Administration of recombinant IL-2 augments the level of serum IgM in an IL-2 deficient patient

H. Hara, S. Kishimoto, H. Yabuuchi, 1989, European Journal of Pediatrics.

Novel receptor-mediated internalization of interleukin 2 in B cells.

K. Sugamura, H. Hara, S. Kishimoto, 1988, Journal of immunology.

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.

S. Yamanaka, Kazutoshi Takahashi, S. Ogawa, 2012, Blood.

The RD1 Locus in the Mycobacterium tuberculosis Genome Contributes to Activation of Caspase-1 via Induction of Potassium Ion Efflux in Infected Macrophages

I. Kawamura, M. Mitsuyama, H. Hara, 2009, Infection and Immunity.

Inactivation of the MAPK signaling pathway by Listeria monocytogenes infection promotes trophoblast giant cell death

M. Watarai, Kenta Watanabe, Takashi Shimizu, 2015, Front. Microbiol..

The adaptor ASC exacerbates lethal Listeria monocytogenes infection by mediating IL‐18 production in an inflammasome‐dependent and ‐independent manner

X. Chen, I. Kawamura, M. Mitsuyama, 2014, European journal of immunology.

The effect of taurine on the age-related decline of the immune response in mice: the restorative effect on the T cell proliferative response to costimulation with ionomycin and phorbol myristate acetate.

H. Hara, S. Negoro, 1992, Advances in experimental medicine and biology.

The effect of taurine on age-related immune decline in mice: The effect of taurine on T cell and B cell proliferative response under costimulation with ionomycin and phorbol myristate acetate

Toshio Tanaka, J. Azuma, N. Awata, 1990, Mechanisms of Ageing and Development.

Critical Involvement of Pneumolysin in Production of Interleukin-1α and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

I. Kawamura, M. Mitsuyama, H. Hara, 2008, Infection and Immunity.

[A case of Marie-Bamberger's syndrome associated with small cell carcinoma of the lung].

I. Kawase, S. Yokota, H. Hara, 1985, Nihon Kyobu Shikkan Gakkai zasshi.

Two monoclonal antibodies against small-cell lung cancer show existence of synergism in binding

I. Kawase, Masatoshi Watanabe, H. Hara, 2005, Cancer Immunology, Immunotherapy.

Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.

I. Kawamura, M. Mitsuyama, H. Hara, 2011, Journal of medical microbiology.

Suppressive Soils to Bacterial Wilt of Tobacco in Japan and Population Dynamics of Pseudomonas solanacearum in These Soils

Hiroshi Tanaka, H. Hara, K. Koga, 1997 .

Ecological studies on the bacterial wilt of tobacco, caused by Pseudomonas solanacearum E.F. Smith. V. The movement of the pathogen in tobacco plants.

K. Ono, H. Hara, J. Akazawa, 1984 .

MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis.

G. Barnett, S. Kondo, H. Hara, 1995, Oncogene.

Toshio Tanaka, H. Hara, S. Kishimoto, 1988, Mechanisms of Ageing and Development.

model for dissecting somatic mosaicism and drug discovery Induced pluripotent stem cells from CINCA syndrome patients as a

S. Yamanaka, Kazutoshi Takahashi, S. Ogawa, 2013 .

The inflammasome and its regulation.

H. Hara, K. Tsuchiya, 2014, Critical reviews in immunology.

New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells.

H. Hara, B. Seon, H. Matsuzaki, 1986, Experimental hematology.

Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes

H. Hara, Hajime Yamauchi, Yasuyuki Matsuda, 2023, Microbiology and immunology.

Human pulmonary infection with Corynebacterium equi.

I. Kawase, H. Hara, S. Kishimoto, 1990, European Respiratory Journal.

Correction to Supporting Information for Conos et al., Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

D. Vaux, K. Schroder, L. Whitehead, 2017, Proceedings of the National Academy of Sciences.

Title Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Tybulewicz, J. Mizuguchi, I. Kawamura, 2016 .

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism

H. Tsutsui, I. Kawamura, M. Mitsuyama, 2019, Mucosal Immunology.

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2013, Nature Immunology.

Phosphorylation of ASC acts as a molecular switch controlling the formation of speck-like aggregates and inflammasome activity

V. Tybulewicz, J. Mizuguchi, I. Kawamura, 2016 .