B. Valsasina

发表

Characterization of a saporin isoform with lower ribosome-inhibiting activity.

U. Cavallaro, M. Fabbrini, D. Carpani, 1997, The Biochemical journal.

Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors.

S. Knapp, C. Cristiani, S. Thieffine, 2003, Journal of molecular biology.

Cancer Therapy : Preclinical NMS-E 973 , a Novel Synthetic Inhibitor of Hsp 90 with Activity against Multiple Models of Drug Resistance to Targeted Agents , Including Intracranial Metastases

A. Isacchi, E. Casale, E. Felder, 2013 .

NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases

A. Isacchi, E. Casale, E. Felder, 2013, Clinical Cancer Research.

Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach.

A. Isacchi, J. Moll, B. Valsasina, 2005, Journal of proteome research.

EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors

S. Iacobelli, V. de Laurenzi, C. Rossi, 2021, Pharmaceutics.

Abstract 822: Thienoindoles, a novel class of DNA minor groove alkylating agents highly suited for the generation of novel antibody drug conjugates (ADCs)

A. Isacchi, E. Felder, M. Ciomei, 2014 .

Abstract 734: Thienoindoles: New highly promising agents for antibody-drug conjugates generation

A. Isacchi, E. Felder, M. Ciomei, 2018, Experimental and Molecular Therapeutics.

Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases*

A. Montagnoli, D. Brotherton, C. Santocanale, 2006, Journal of Biological Chemistry.

Detection of traces of a trisulphide derivative in the preparation of a recombinant truncated interleukin-6 mutein.

B. Valsasina, U. Breme, J. Breton, 1995, Journal of chromatography. A.

4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors.

F. Fiorentini, M. Brasca, F. Roletto, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

L. Belvisi, F. Gasparri, F. Sola, 2015, Chemistry.

Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.

R. Bosotti, A. Isacchi, O. Acuto, 1999, European journal of biochemistry.

Discovery of 2-(cyclohexylmethylamino)pyrimidines as a new class of reversible valosine containing protein inhibitors.

A. Isacchi, E. Felder, R. D'Alessio, 2014, Journal of medicinal chemistry.

Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

P. Cappella, F. Sola, R. Alzani, 2010, Anticancer research.

NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.

F. Fiorentini, M. Brasca, E. Pesenti, 2011, Bioorganic & Medicinal Chemistry Letters.

Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

R. Versteeg, P. Picci, C. Hattinger, 2014, Investigational New Drugs.

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

A. Rosato, P. Carloni, E. Baloglu, 2017, Nature Communications.

434 POSTER Antitumoral activity of pyrazoloquinazoline derivatives as potent oral Plk-1 specific inhibitors

M. Brasca, E. Pesenti, M. Rocchetti, 2008 .

Recombinant human IL-2 is cytotoxic to oligodendrocytes after in vitro self aggregation.

B. Valsasina, L. Curatolo, C. Caccia, 1997, Cytokine.

Basic fibroblast growth factor stimulates hepatocyte growth factor/scatter factor secretion by human mesenchymal cells

A. Galvani, F. Roletto, C. Cristiani, 1996, Journal of cellular physiology.

The C‐terminal domain of yeast Ero1p mediates membrane localization and is essential for function

R. Sitia, S. Pilati, M. Pagani, 2001, FEBS letters.

Investigation on minor degraded derivatives of the recombinant hirudin variant HM2 from Hirudinaria manillensis isolated by isoelectric focusing in multicompartment electrolyzers

P. Righetti, A. Bossi, C. Visco, 1996, Electrophoresis.

Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1.

P. Dell’Era, M. Rusnati, M. Presta, 1994, Biochemical and biophysical research communications.

Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.

R. Bosotti, A. Isacchi, A. Montagnoli, 2008, Journal of medicinal chemistry.

First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery.

A. Isacchi, A. Montagnoli, J. Berthelsen, 2009, Journal of medicinal chemistry.

Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.

A. Isacchi, A. Montagnoli, R. D'Alessio, 2010, Journal of medicinal chemistry.

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.

A. Isacchi, A. Montagnoli, N. Colombo, 2009, Journal of medicinal chemistry.

Identification of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as a new class of orally and selective Polo-like kinase 1 inhibitors.

D. Ballinari, V. Croci, D. Volpi, 2010, Journal of medicinal chemistry.

Novel hirudin variants from the leech Hirudinaria manillensis. Amino acid sequence, cDNA cloning and genomic organization.

E. Scacheri, G. Nitti, P. Sarmientos, 1993, European journal of biochemistry.

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

A. Isacchi, A. Montagnoli, D. Ballinari, 2008, Nature chemical biology.

NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

A. Isacchi, E. Felder, D. Ballinari, 2012, Molecular Cancer Therapeutics.

5-(2-amino-pyrimidin-4-yl)-1H-pyrrole and 2-(2-amino-pyrimidin-4-yl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one derivatives as new classes of selective and orally available Polo-like kinase 1 inhibitors.

D. Ballinari, F. Fiorentini, M. Brasca, 2012, Bioorganic & medicinal chemistry letters.

Preclinical Development NMSP 937 , an Orally Available , Speci fi c Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

A. Isacchi, E. Felder, D. Ballinari, 2012 .

Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors

A. Isacchi, G. Weiss, F. Fiorentini, 2018, Investigational New Drugs.

Structure, stability and biological properties of a N-terminally truncated form of recombinant human interleukin-6 containing a single disulfide bond.

V. De Filippis, A. Fontana, B. Valsasina, 1995, European journal of biochemistry.

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.

A. Isacchi, E. Casale, Daniel J. Anderson, 2013, Nature chemical biology.

The Polo-Like Kinase 1 (PLK1) Inhibitor NMS-P937 Is Effective in a New Model of Disseminated Primary CD56+ Acute Monoblastic Leukaemia

M. Losa, E. Pesenti, R. Alzani, 2013, PloS one.

A new approach to phosphoserine and phosphothreonine analysis in peptides and proteins: chemical modification, enrichment via solid-phase reversible binding, and analysis by mass spectrometry

J. Xie, A. Isacchi, A. Stewart, 2003, Analytical and bioanalytical chemistry.

Stabilization of recombinant human basic fibroblast growth factor by chemical modifications of cysteine residues.

F Bertolero, G. Cauet, F. Roletto, 1992, European journal of biochemistry.

Hydroxylamine-induced cleavage of the asparaginyl-glycine motif in the production of recombinant proteins: the case of insulin-like growth factor I.

R. Todeschini, E. Marengo, B. Valsasina, 1997, Protein expression and purification.

Identification of Myb-binding Protein 1A (MYBBP1A) as a Novel Substrate for Aurora B Kinase

M. Modugno, A. Isacchi, P. Cappella, 2010, The Journal of Biological Chemistry.

Kinase selectivity profiling by inhibitor affinity chromatography

A. Isacchi, B. Valsasina, H. Kalisz, 2004, Expert review of proteomics.

Bean homologs of the mammalian glucose-regulated proteins: induction by tunicamycin and interaction with newly synthesized seed storage proteins in the endoplasmic reticulum.

M. Fabbrini, G. Nitti, L. D’amico, 1992, The Plant journal : for cell and molecular biology.

Disulfide isoform intermediates in the reoxidation of recombinant human basic fibroblast growth factor.

G. Marino, G. Nitti, A. Malorni, 1993, Biochemistry.

Synthesis and biological evaluation of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

L. Belvisi, F. Gasparri, F. Sola, 2015, Chemistry.

A Saporin‐6 cDNA containing a precursor sequence coding for a carboxyl‐terminal extension

L. Benatti, M. Soria, G. Nitti, 1991, FEBS letters.