L. Kovari

发表

Crystal structure of the extracellular domain of human myelin protein zero

J. Kamholz, Zhigang Liu, Yong Wang, 2011, Proteins.

Sperm chromatin-condensing protamine enhances SMYD5 thermal stability.

L. Kovari, Nicholas Spellmon, Yingxue Zhang, 2021, Biochemical and biophysical research communications.

Reduced HIV-1 integrase flexibility as a mechanism for raltegravir resistance.

Tamaria G. Dewdney, Yong Wang, I. Kovari, 2013, Journal of structural biology.

The use of antibody fragments for crystallization and structure determinations.

M. Rossmann, L. Kovari, C. Momany, 1995, Structure.

Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance

Arun K. Ghosh, H. Mitsuya, Y. Takamatsu, 2019, Antimicrobial Agents and Chemotherapy.

Synthesis and antiviral evaluation of novel peptidomimetics as norovirus protease inhibitors.

R. Schinazi, P. Liu, L. Kovari, 2018, Bioorganic & medicinal chemistry letters.

X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release.

B. Jena, D. Taatjes, Jin‐sook Lee, 2014, Micron.

The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach.

M. U. Mirza, John F. Trant, M. Froeyen, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Crystal structure of dimeric HIV-1 capsid protein

Carol Carter, Liang Tong, Walter Keller, 1996, Nature Structural Biology.

Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.

P. Woster, L. Kovari, Deepak Gupta, 2010, Journal of medicinal chemistry.

Crystals of Rous sarcoma virus capsid protein show a helical arrangement of protein subunits.

M. Rossmann, V. Vogt, L. Kovari, 1997, Virology.

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.

Tamaria G. Dewdney, Zhigang Liu, Yong Wang, 2013, Biochemical and biophysical research communications.

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.

Tamaria G. Dewdney, Zhigang Liu, Yong Wang, 2013, Biochemical and biophysical research communications.

Genetic diversity and response to IFN of the NS3 protease gene from clinical strains of the hepatitis C virus

E. Golenberg, D. Mayers, L. Kovari, 2002, Archives of Virology.

Aquifex aeolicus Aspartate Transcarbamoylase, an Enzyme Specialized for the Efficient Utilization of Unstable Carbamoyl Phosphate at Elevated Temperature*

C. Purcarea, H. Guy, David R. Evans, 2003, Journal of Biological Chemistry.

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.

Zhigang Liu, I. Kovari, L. Kovari, 2014, Journal of molecular graphics & modelling.

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

M. Spaller, Zhigang Liu, I. Kovari, 2013, Biochemical and biophysical research communications.

Design , synthesis and evaluation of a potent substrate-analog peptide-inhibitor identified by scanning Ala / Phe chemical mutagenesis

M. Spaller, Zhigang Liu, I. Kovari, 2013 .

Crystal Structures of a Multidrug-Resistant Human Immunodeficiency Virus Type 1 Protease Reveal an Expanded Active-Site Cavity

Ladislau C. Kovari, T. Merigan, M. Winters, 2004, Journal of Virology.

Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease

Zhigang Liu, Yong Wang, J. Brunzelle, 2011, The protein journal.

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target.

T. Merigan, M. Winters, Z. Wawrzak, 2005, Structure.

Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors

T. Merigan, M. Winters, L. Kovari, 2000, Journal of Virology.

HIV-1 protease variants from 100-fold drug resistant clinical isolates: expression, purification, and crystallization.

T. Merigan, M. Winters, S. Palmer, 2003, Protein expression and purification.

The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops

Tamaria G. Dewdney, P. Chordia, R. MacArthur, 2015, Biochemistry and biophysics reports.

The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.

Tamaria G. Dewdney, Zhigang Liu, Yong Wang, 2011, Biochemical and biophysical research communications.

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance.

Tamaria G. Dewdney, Zhigang Liu, Yong Wang, 2013, Biochemical and biophysical research communications.

Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.

R. Schinazi, P. Liu, J. Brunzelle, 2019, Biochemistry.

Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease.

R. Schinazi, I. Kovari, L. Kovari, 2017, Biochemical and biophysical research communications.

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

P. Woster, Zhigang Liu, Yong Wang, 2012, Biochemical and biophysical research communications.

[12] TELAPREVIR (VX-950) IS A POTENT INHIBITOR OF HCV NS3 PROTEASES DERIVED FROM GENOTYPE NON-1 HCV-INFECTED PATIENTS

A. Kwong, D. Bartels, B. Hanzelka, 2007 .

The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics

Tamaria G. Dewdney, P. Chordia, R. MacArthur, 2014, Discoveries.

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.

G. Proteasa, Z. Wawrzak, Zhigang Liu, 2011, Acta crystallographica. Section D, Biological crystallography.