C. Alexander

发表

Reviewing and identifying amino acids of human, murine, canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid A, or antagonistic effects by Eritoran, in contrast to species-dependent modulation by lipid IVa

U. Zaehringer, T. Scior, C. Alexander, 2013, Computational and structural biotechnology journal.

Three-dimensional mapping of differential amino acids of human, murine, canine and equine TLR4/MD-2 receptor complexes conferring endotoxic activation by lipid A, antagonism by Eritoran and species-dependent activities of Lipid IVA in the mammalian LPS sensor system

U. Zähringer, T. Scior, C. Alexander, 2013, Computational and structural biotechnology journal.

Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis

A. Ulmer, E. Rietschel, D. Heumann, 2018, International immunopharmacology.

An altered REDOX environment, assisted by over‐expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression

A. Ulmer, E. Rietschel, U. Zähringer, 2017, International immunopharmacology.

Mediates Innate Immune Responses Triacylated and Diacylated Lipopeptides and Lipopolysaccharide Binding Protein Binds to

U. Göbel, H. Heine, R. Schumann, 2013 .

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses

U. Göbel, H. Heine, C. Alexander, 2004 .

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses 1

U. Göbel, H. Heine, R. Schumann, 2004 .

Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595

S. Gronow, H. Heine, B. Lindner, 2002, Journal of endotoxin research.

Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins

A. Ulmer, E. Rietschel, K. Brandenburg, 2015, Innate immunity.

Characterization of an interaction between fetal hemoglobin and lipid A of LPS resulting in augmented induction of cytokine production in vivo and in vitro.

W. Bessler, E. Rietschel, O. Westphal, 2004, International immunopharmacology.

IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity

S. Wirtz, D. Christensen, C. Schubart, 2021, bioRxiv.

A fetal sheep liver extract containing immunostimulatory substances including LPS acts as leukocyte activator in cells of LPS responder and non responder mice.

W. Bessler, E. Rietschel, U. Zähringer, 2005, International immunopharmacology.

Cutting Edge: TNF Is Essential for Mycobacteria-Induced MINCLE Expression, Macrophage Activation, and Th17 Adjuvanticity

K. Pfeffer, P. Murray, D. Christensen, 2020, The Journal of Immunology.

Acute-Phase Concentrations of Lipopolysaccharide (LPS)-Binding Protein Inhibit Innate Immune Cell Activation by Different LPS Chemotypes via Different Mechanisms

R. Schumann, U. Zähringer, C. Stamme, 2005, Infection and Immunity.

Role of MIF and glutathione, in association with fetal ovine globin chain (Hbgamma) and LPS, in induction of TNFalpha from cells of young and aged mice, and PBL from healthy human populations.

W. Bessler, E. Terzioğlu, A. Ulmer, 2006, Immunology letters.

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses1

U. Göbel, H. Heine, R. Schumann, 2004, The Journal of Immunology.

Invited review: Bacterial lipopolysaccharides and innate immunity

E. Rietschel, C. Alexander, 2001 .

An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins.

A. Blume, K. Brandenburg, P. Garidel, 2009, Medicinal chemistry (Shariqah (United Arab Emirates)).

Bacterial lipopolysaccharides and innate immunity.

E. Rietschel, C. Alexander, 2001, Journal of endotoxin research.

Bacterial Lipopolysaccharides: Chemical Constitution, Endotoxic Activity, and Biological Neutralization

E. Rietschel, U. Mamat, W. Brabetz, 1999 .

Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides

T. Goldmann, H. Heine, K. Wiesmüller, 2015, Scientific Reports.

TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.

H. Heine, B. Lindner, U. Zähringer, 2008, Immunobiology.

Analysis of interaction of cloned human and/or sheep fetal hemoglobin gamma-chain and LPS in augmenting induction of inflammatory cytokine production in vivo and in vitro.

W. Bessler, E. Rietschel, O. Westphal, 2005, Immunology letters.

Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved*

U. Göbel, T. Hartung, S. Morath, 2003, The Journal of Biological Chemistry.

Exploring electrostatic patterns of human, murine, equine and canine TLR4/MD-2 receptors

T. Scior, C. Alexander, Jorge Lozano-Aponte, 2019, Innate immunity.

Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A

A. Ulmer, E. Rietschel, K. Brandenburg, 2016, Innate immunity.

An alteration in the levels of populations of CD4+ Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract.

W. Bessler, A. Ulmer, E. Rietschel, 2007, Immunology letters.

Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle.

A. Ulmer, E. Rietschel, H. Brade, 2008, Medicinal chemistry (Shariqah (United Arab Emirates)).

Biophysical investigations into the interactions of endotoxins with bile acids

K. Brandenburg, T. Gutsmann, W. Richter, 2012, Innate immunity.

Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins

M. Roessle, A. Ulmer, E. Rietschel, 2008, Innate immunity.

Biophysical characterization of the interaction of endotoxins with hemoglobins.

A. Ulmer, E. Rietschel, U. Zähringer, 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein.

E. Tuomanen, R. Schumann, J. Weber, 2003, Immunity.

Chemical Structure of Lipid A-The Primary Immunomodulatory Center of Bacterial Lipopolysaccharides

U. Zähringer, C. Alexander, 泰生隅田, 2002 .

Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain.

E. Terzioğlu, A. Ulmer, E. Rietschel, 2009, Immunology letters.

A role for altered TLR gene expression in association with increased expression of CD200R in the induction of mucosal tissue CD4+ Treg in aged mice following gavage with a liver extract along with intramuscular monophosphoryl lipid A (MPLA) injection

A. Ulmer, E. Rietschel, K. Brandenburg, 2008, Experimental Gerontology.

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

A. Terskikh, A. Ulmer, E. Rietschel, 2018, The Pharmacogenomics Journal.

B-cell subsets responsive to fluorescein-conjugated antigens. II. "Cross-priming" and its elimination by bromodeoxyuridine and light.

D. Scott, C. Alexander, 1980, Cellular immunology.

QSAR Applied to 4-Chloro-3-Formylcoumarin Derivatives Targeting Human Thymidine Phosphorylase

H. Abdallah, T. Scior, C. Alexander, 2022, Clinical Complementary Medicine and Pharmacology.

Analysis of cytokine immune response profile in response to inflammatory stimuli in mice with genetic defects in fetal and adult hemoglobin chain expression

A. Terskikh, A. Ulmer, E. Rietschel, 2018, The Pharmacogenomics Journal.

Structural and biological characterization of highly purified hepta-acyl lipid A present in the lipopolysaccharide of the Salmonella enterica sv. Minnesota Re deep rough mutant strain R595

S. Gronow, H. Heine, B. Lindner, 2002, Journal of endotoxin research.