B. Ross

发表

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

William A. Lee, Sina Bavari, Robert Jordan, 2017, Journal of medicinal chemistry.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Mike Flint, Donald K. Nichols, 2016, Nature.

Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

M. Otto, C. Espiritu, A. Lam, 2011, ACS medicinal chemistry letters.

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

M. Otto, D. Smee, C. Espiritu, 2010, Antimicrobial Agents and Chemotherapy.

A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups

M. Manoharan, M. Egli, B. Ross, 2022, Organic letters.

PSI-7851, a Pronucleotide of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) -Fluoro-2 (cid:2) - C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication (cid:1)

M. Otto, D. Smee, C. Espiritu, 2010 .

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

W. Stec, M. Sofia, B. Ross, 2009, The Journal of organic chemistry.

Synthesis of diastereomerically pure nucleotide phosphoramidates.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

M. Otto, C. Espiritu, A. Lam, 2010, Bioorganic & Medicinal Chemistry Letters.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

M. Otto, C. Espiritu, A. Lam, 2011, Antiviral research.

A liquid chromatography-tandem mass spectrometry method for the quantitative determination of diastereomers of a phosphoramidate nucleotide prodrug (PSI-7851) in human plasma.

M. Sofia, B. Ross, Donghui Bao, 2012, Biomedical chromatography : BMC.

Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides.

M. Manoharan, B. Monia, A. M. Kawasaki, 2008, Journal of medicinal chemistry.

Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.

P. D. Cook, M. Manoharan, M. Maier, 2001, Journal of Organic Chemistry.

Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents

M. Otto, Véronique Zennou, M. Sofia, 2012, Antiviral chemistry & chemotherapy.

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.

Wonsuk Chang, M. Sofia, R. Mosley, 2012, Journal of medicinal chemistry.

Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.

M. Sofia, B. Ross, P. G. Reddy, 2012, Rapid communications in mass spectrometry : RCM.

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.

E. Lesnik, M. Manoharan, M. Teplova, 2005, Biochemistry.

KILO-SCALE SYNTHESIS PROCESS FOR 2′-O-(2-METHOXYETHYL)-PYRIMIDINE DERIVATIVES

B. Ross, Q. Song, Mingming Han, 2005, Nucleosides, nucleotides & nucleic acids.

A NOVEL AND ECONOMICAL SYNTHESIS OF 2'-O-ALKYL-URIDINES

B. Ross, Zeb Tortorici, R. Springer, 1997 .

Synthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides

R. Griffey, E. Lesnik, B. Ross, 1997 .

General preparative synthesis of 2'-O-methylpyrimidine ribonucleosides

P. D. Cook, R. S. Andrews, B. Ross, 1994 .

Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

C. Espiritu, M. Sofia, B. Ross, 2011, Nucleosides, nucleotides & nucleic acids.

A New, Efficient Exocyclic Amine Protection Scheme for 2-Aminoadenosine and Derivatives for Incorporation into Oligonucleotides

M. Manoharan, B. Ross, R. Springer, 1999 .

Process Research on the Preparation of DMT Protected 2′-O-Methoxyethylguanosine for Oligonucleotide Synthesis in Therapeutic Applications

B. Ross, Y. Sanghvi, V. Ravikumar, 2008, Nucleosides, nucleotides & nucleic acids.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

M. Otto, C. Espiritu, A. Lam, 2010, Journal of medicinal chemistry.

An easy access of 2′,3′-dideoxy-3′-α-C-formyl-adenosine and -guanosine analogs via stereoselective CC bond forming radical reaction

J. Vasseur, B. Ross, Y. Sanghvi, 1994 .

Discovery of a β-D-2 0-Deoxy-2 0-r-fluoro-2 0-β-C-methyluridine Nucleotide Prodrug ( PSI-7977 ) for the Treatment of Hepatitis C Virus

M. Otto, C. Espiritu, A. Lam, 2010 .

Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.

M. Otto, M. Sofia, B. Ross, 2010, Bioorganic & medicinal chemistry letters.

An Easy Access to 2′,3′‐Dideoxy‐3′‐α‐C‐formyl‐adenosine and ‐ guanosine Analogues via Stereoselective C‐C Bond Forming Radical Reaction.

J. Vasseur, B. Ross, Y. Sanghvi, 1994 .

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

M. Otto, C. Espiritu, A. Lam, 2012, Bioorganic & medicinal chemistry letters.

Efficient Large-Scale Synthesis of 5′-O-Dimethoxytrityl-N 4-Benzoyl-5-Methyl-2′-Deoxycytidine

B. Ross, V. Ravikumar, Mingming Han, 2006, Nucleosides, nucleotides & nucleic acids.

2′- and 3′- Cholesterol-Conjugated Adenosine and Cytosine Nucleoside Building Blocks: Synthesis of Lipidic Nucleic Acids

P. D. Cook, M. Manoharan, B. Ross, 1997 .

Commercial-Scale Synthesis of Protected 2′-Deoxycytidine and Cytidine Nucleosides

B. Ross, Y. Sanghvi, Y. Mulla, 2003, Nucleosides, nucleotides & nucleic acids.

Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles.

B. Ross, D. Cioli, S. Archer, 1987, Journal of medicinal chemistry.

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

William A. Lee, Jeffrey R. Kugelman, G. Palacios, 2016, Nature.

A 2'-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry.

P. D. Cook, M. Manoharan, B. Ross, 1994, Gene.

Synthesis of diastereomerically pure nucleotide phosphoramidates.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

W. Stec, M. Sofia, B. Ross, 2009, The Journal of organic chemistry.