H. Shuman

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Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

Tal Pupko, Ofir Cohen, Jack A Gilbert, 2016, Nature Genetics.

Legionella pneumophila Utilizes the Same Genes To Multiply within Acanthamoeba castellanii and Human Macrophages

H. Shuman, G. Segal, Gil Segal, 1999, Infection and Immunity.

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal

Tal Pupko, D. Burstein, T. Pupko, 2013, Proceedings of the National Academy of Sciences.

Maltose/Maltodextrin System of Escherichia coli: Transport, Metabolism, and Regulation

Winfried Boos, W. Boos, H. Shuman, 1998, Microbiology and Molecular Biology Reviews.

A dual-targeting approach to inhibit Brucella abortus replication in human cells

S. Crosson, H. Shuman, N. Jain-Gupta, 2016, Scientific Reports.

Use of gene fusions to study outer membrane protein localization in Escherichia coli.

J. Beckwith, T. Silhavy, H. Shuman, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Dominant constitutive mutations in malT, the positive regulator gene of the maltose regulon in Escherichia coli.

M. Débarbouillé, T. Silhavy, H. Shuman, 1978, Journal of molecular biology.

Overproduction of MalK protein prevents expression of the Escherichia coli mal regulon

H. Shuman, M. Reyes, Moraima Reyes, 1988, Journal of bacteriology.

Genetic analysis of periplasmic binding protein dependent transport in Escherichia coli. Each lobe of maltose-binding protein interacts with a different subunit of the MalFGK2 membrane transport complex.

L. Hor, H. Shuman, Howard A. Shuman, 1993, Journal of molecular biology.

The iron superoxide dismutase of Legionella pneumophila is essential for viability

H. Shuman, J. Wilson, A. B. Sadosky, 1994, Journal of bacteriology.

Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.

S. Emr, J. Efe, H. Shuman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The perplexing functions and surprising origins of Legionella pneumophila type IV secretion effectors

X. Charpentier, H. Shuman, I. S. Franco, 2009, Cellular microbiology.

Early Events in Phagosome Establishment Are Required for Intracellular Survival of Legionella pneumophila

F. Maxfield, K. Dunn, H. Shuman, 1998, Infection and Immunity.

Legionella pneumophila Transcriptional Response following Exposure to CuO Nanoparticles

N. Ashbolt, S. Faucher, H. Buse, 2013, Applied and Environmental Microbiology.

Icm/Dot‐dependent upregulation of phagocytosis by Legionella pneumophila

H. Hilbi, H. Shuman, G. Segal, 2001, Molecular microbiology.

ArgR-Regulated Genes Are Derepressed in the Legionella-Containing Vacuole

S. Faucher, X. Charpentier, H. Shuman, 2010, Journal of bacteriology.

Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010

H. Shuman, G. Segal, 1998, Molecular microbiology.

Small Regulatory RNA and Legionella pneumophila

S. Faucher, H. Shuman, 2011, Front. Microbio..

A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy

L. Schlesinger, A. Amer, H. Shuman, 2013, European journal of immunology.

Acinetobacter baumannii NCIMB8209: a Rare Environmental Strain Displaying Extensive Insertion Sequence-Mediated Genome Remodeling Resulting in the Loss of Exposed Cell Structures and Defensive Mechanisms

A. Viale, H. Shuman, G. Repizo, 2020, mSphere.

Obesity and Insulin Resistance Promote Atherosclerosis through an IFNγ-Regulated Macrophage Protein Network

A. Hoofnagle, T. Vaisar, C. Reardon, 2018, Cell reports.

Virulence Conversion of Legionella pneumophila by Conjugal Transfer of Chromosomal DNA

S. Yoshida, H. Taniguchi, H. Shuman, 2003, Journal of bacteriology.

Structure of the malB region in Escherichia coli K12

L. Guarente, J. Beckwith, T. Silhavy, 1979, Molecular and General Genetics MGG.

GigC, a LysR Family Transcription Regulator, Is Required for Cysteine Metabolism and Virulence in Acinetobacter baumannii

D. Zurawski, Shweta Singh, H. Shuman, 2020, Infection and Immunity.

Identification of Legionella pneumophila genes required for growth within and killing of human macrophages

H. Shuman, L. Wiater, A. Sadosky, 1993, Infection and immunity.

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila

U. Jenal, M. Folcher, H. Shuman, 2011, mBio.

Active transport of maltose in Escherichia coli K12. Role of the periplasmic maltose-binding protein and evidence for a substrate recognition site in the cytoplasmic membrane.

H. Shuman, 1982, The Journal of biological chemistry.

Legionella pneumophila 6S RNA optimizes intracellular multiplication

G. Friedlander, H. Margalit, J. Livny, 2010, Proceedings of the National Academy of Sciences.

The amoebae plate test implicates a paralogue of lpxB in the interaction of Legionella pneumophila with Acanthamoeba castellanii.

H. Hilbi, H. Shuman, U. Albers, 2005, Microbiology.

Direct targeting of membrane fusion by SNARE mimicry: Convergent evolution of Legionella effectors

R. Jahn, Xingqi Shi, H. Shuman, 2016, Proceedings of the National Academy of Sciences.

Intracellular Bacteria Encode Inhibitory SNARE-Like Proteins

J. Rothman, Cédric Delevoye, A. Subtil, 2009, PloS one.

[12] Use of 1ac gene fusions to study transport proteins

H. Shuman, 1986 .

Sites within gene lacZ of Escherichia coli for formation of active hybrid beta-galactosidase molecules

J. Beckwith, T. Silhavy, H. Shuman, 1979, Journal of bacteriology.

Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes

L. Guarente, J. Beckwith, T. Silhavy, 1980 .

Genetic Manipulation of Acinetobacter baumannii

S. Yildirim, D. Zurawski, M. Thompson, 2014, Current protocols in microbiology.

GigA and GigB are Master Regulators of Antibiotic Resistance, Stress Responses, and Virulence in Acinetobacter baumannii

H. Shuman, Michael J. Gebhardt, 2017, Journal of bacteriology.

Correction: Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

O. Anderson, C. Pericone, X. Charpentier, 2010, PLoS Pathogens.

Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages.

M. Horwitz, H. Shuman, Alberto Marra, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Intergration of the receptor for bacteriophage lambda in the outer membrane of Escherichia coli: coupling with cell division

A. Ryter, H. Shuman, M. Schwartz, 1975, Journal of bacteriology.

Legionella pneumophila Contains a Type II General Secretion Pathway Required for Growth in Amoebae as Well as for Secretion of the Msp Protease

H. Shuman, L. Hales, 1999, Infection and Immunity.

How is the intracellular fate of the Legionella pneumophila phagosome determined?

H. Shuman, G. Segal, 1998, Trends in microbiology.

An immunoprotective molecule, the major secretory protein of Legionella pneumophila, is not a virulence factor in a guinea pig model of Legionnaires' disease.

M. Horwitz, H. Shuman, S. Blander, 1990, The Journal of clinical investigation.

The Legionella pneumophila major secretory protein, a protease, is not required for intracellular growth or cell killing

H. Shuman, L. Szeto, 1990, Infection and immunity.

Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages.

N. Cianciotto, N. Engleberg, B. Eisenstein, 1989, Molecular biology & medicine.

Isolation and characterization of auxotrophic mutants of Legionella pneumophila that fail to multiply in human monocytes

H. Shuman, C. S. Mintz, J. X. Chen, 1988, Infection and immunity.

Labeling of proteins with beta-galactosidase by gene fusion. Identification of a cytoplasmic membrane component of the Escherichia coli maltose transport system.

J. Beckwith, T. Silhavy, H. Shuman, 1980, The Journal of biological chemistry.

Genetics of Legionella pneumophila virulence.

H. Shuman, Alberto Marra, 1992, Annual review of genetics.

Amphipols: polymeric surfactants for membrane biology research

D. Engelman, E. Berry, Y. Gohon, 2003, Cellular and Molecular Life Sciences CMLS.

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections

C. Goss, S. Salipante, D. Hornick, 2018, Science Translational Medicine.

Genetic Analysis of Legionella pneumophila Intracellular Multiplication in Human and Protozoan Hosts

H. Shuman, G. Segal, 2002 .

Antibiotics and UV Radiation Induce Competence for Natural Transformation in Legionella pneumophila

D. Schneider, X. Charpentier, H. Shuman, 2010, Journal of bacteriology.

In vitro derivation of macrophage from guinea pig bone marrow with human M-CSF.

S. Porcelli, H. Shuman, Karl O. A. Yu, 2013, Journal of immunological methods.

The Legionella pneumophila Effector VipA Is an Actin Nucleator That Alters Host Cell Organelle Trafficking

H. Shuman, N. Shohdy, I. S. Franco, 2012, PLoS pathogens.

Function of Legionella Effectors

M. Clarke, C. Pericone, H. Shuman, 2006 .

Phagocytosis of Wild-Type Legionella pneumophila Occurs through a Wortmannin-Insensitive Pathway

F. Maxfield, H. Shuman, N. Khelef, 2001, Infection and Immunity.

Intracellular multiplication of Legionella pneumophila: human pathogen or accidental tourist?

H. Shuman, G. Segal, L. Hales, 1998, Current topics in microbiology and immunology.

Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome.

H. Shuman, G. Segal, M. Purcell, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

O. Anderson, R. Isberg, C. Pericone, 2008, PLoS pathogens.

Chemical synthesis enables biochemical and antibacterial evaluation of streptolydigin antibiotics.

K. Severinov, S. Kozmin, H. Shuman, 2011, Journal of the American Chemical Society.

Identification of the malK gene product. A peripheral membrane component of the Escherichia coli maltose transport system.

T. Silhavy, H. Shuman, 1981, The Journal of biological chemistry.

Isolation of a Legionella pneumophila restriction mutant with increased ability to act as a recipient in heterospecific matings

H. Shuman, Alberto Marra, 1989, Journal of bacteriology.

Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages

A. Casadevall, H. Shuman, J. Steenbergen, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A pathogen’s journey in the host cell

H. Shuman, I. S. Franco, 2012, Bioarchitecture.

The malZ gene of Escherichia coli, a member of the maltose regulon, encodes a maltodextrin glucosidase.

W. Boos, H. Shuman, S. Tapio, 1991, The Journal of biological chemistry.

The inhibition of maltose transport by the unliganded form of the maltose-binding protein of Escherichia coli: experimental findings and mathematical treatment.

E. Bohl, W. Boos, H. Shuman, 1995, Journal of theoretical biology.

Mechanism of maltose transport in Escherichia coli: transmembrane signaling by periplasmic binding proteins.

H. Nikaido, A. Davidson, H. Shuman, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The effect of nalidixic acid on the expression of some genes in Escherichia coli K-12.

H. Shuman, M. Schwartz, 1975, Biochemical and biophysical research communications.

The Genomic Sequence of the Accidental Pathogen Legionella pneumophila

I. Chou, P. D. de Jong, A. Rzhetsky, 2004, Science.

The HL-60 model for the interaction of human macrophages with the Legionnaires' disease bacterium.

M. Horwitz, H. Shuman, Alberto Marra, 1990, Journal of immunology.

Metabolic regulation of gene expression by histone lactylation

B. Ren, Z. Ye, R. Roeder, 2019, Nature.

Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii

L. Peterson, D. Zurawski, L. Gallagher, 2015, mBio.

Selection of Legionella Virulence-Related Traits by Environmental Protozoa.

F. Amaro, H. Shuman, 2019, Methods in molecular biology.

Characterization of a new region required for macrophage killing by Legionella pneumophila

H. Shuman, G. Segal, 1997, Infection and immunity.

Microbial genetics: The art and design of genetic screens: Escherichia coli

T. Silhavy, H. Shuman, 2003, Nature Reviews Genetics.

The Detergent-Soluble Maltose Transporter Is Activated by Maltose Binding Protein and Verapamil

C. Panagiotidis, H. Shuman, R. Reich-Slotky, 2000, Journal of bacteriology.

Host cell‐dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila

M. Clarke, John W. Chen, H. Shuman, 2007, Cellular microbiology.

Host-Directed Antimicrobial Drugs with Broad-Spectrum Efficacy against Intracellular Bacterial Pathogens

Sean P. Riley, S. Crosson, T. Steck, 2014, mBio.

Mutations that alter the transmembrane signalling pathway in an ATP binding cassette (ABC) transporter.

C. Panagiotidis, L. Hor, H. Shuman, 1994, The EMBO journal.

Chemical Genetics Reveals Bacterial and Host Cell Functions Critical for Type IV Effector Translocation by Legionella pneumophila

A. Weiss, X. Charpentier, H. Shuman, 2009, PLoS pathogens.

Tinkering with transporters: Periplasmic binding protein-dependent maltose transport inE. coli

C. Panagiotidis, H. Shuman, 1993, Journal of bioenergetics and biomembranes.

The Legionella pneumophila Sequencing Project

P. Dejong, A. Rzhetsky, J. Russo, 2002 .

Crystal structures and solution conformations of a dominant-negative mutant of Escherichia coli maltose-binding protein.

S. Mowbray, B. Shilton, H. Shuman, 1996, Journal of molecular biology.

Seeing red; the development of pON.mCherry, a broad-host range constitutive expression plasmid for Gram-negative bacteria

H. Shuman, R. Jacobson, Michael J. Gebhardt, 2017, PloS one.

The maltose-maltodextrin transport system of Escherichia coli.

H. Shuman, 1982, Annales de microbiologie.

Interferons Direct an Effective Innate Response to Legionella pneumophila Infection*

Courtney R. Plumlee, C. Schindler, T. Decker, 2009, The Journal of Biological Chemistry.

Conversion of beta-galactosidase to a membrane-bound state by gene fusion.

J. Beckwith, T. Silhavy, M. Casadaban, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

G. Kaplan, J. Blanchard, S. Silverstein, 2009, Journal of bacteriology.

Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila

J. Russo, H. Shuman, G. Segal, 1999, Molecular microbiology.

A New Heterolobosean Amoeba Solumitrus palustris n. g., n. sp. Isolated from Freshwater Marsh Soil

S. Faucher, O. Anderson, Wen Wang, 2011, The Journal of eukaryotic microbiology.

Evidence for Acquisition of Legionella Type IV Secretion Substrates via Interdomain Horizontal Gene Transfer

C. Pericone, H. Shuman, S. Kalachikov, 2005, Journal of bacteriology.

Diverse protist grazers select for virulence-related traits in Legionella

J. Gilbert, O. Anderson, Wen Wang, 2015, The ISME Journal.

Loss of RNase R Induces Competence Development in Legionella pneumophila

S. Faucher, X. Charpentier, H. Shuman, 2008, Journal of bacteriology.

The Legionella pneumophila rpoS Gene Is Required for Growth within Acanthamoeba castellanii

H. Shuman, L. Hales, 1999, Journal of bacteriology.

The Legionella pneumophila icmGCDJBFGenes Are Required for Killing of Human Macrophages

H. Shuman, M. Purcell, 1998, Infection and Immunity.

The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages

H. Shuman, B. Brand, A. Sadosky, 1994, Molecular microbiology.

Legionella pneumophila invasion of mononuclear phagocytes.

M. Horwitz, H. Shuman, 1996, Current topics in microbiology and immunology.

Mutagenesis of Legionella pneumophila using Jn903 dllIacZ: identification of a growth‐phase‐regulated pigmentation gene

H. Shuman, A. Sadosky, Lawrence A. Wlater, 1994, Molecular microbiology.

Disulfide Cross-linking Reveals a Site of Stable Interaction between C-terminal Regulatory Domains of the Two MalK Subunits in the Maltose Transport Complex*

Tulin Ayvaz, Jue Chen, A. Davidson, 2003, Journal of Biological Chemistry.

σS Controls Multiple Pathways Associated with Intracellular Multiplication of Legionella pneumophila

J. Russo, P. Morozov, S. Faucher, 2009, Journal of bacteriology.

The use of gene fusions to study bacterial transport proteins

H. Shuman, 2005, The Journal of Membrane Biology.

The activities of the Escherichia coli MalK protein in maltose transport, regulation, and inducer exclusion can be separated by mutations

W. Boos, H. Shuman, M. Reyes, 1991, Journal of bacteriology.

Formation and Excretion of Acetylmaltose After Accumulation of Maltose in Escherichia coli

W. Boos, T. Ferenci, H. Shuman, 1981, Journal of bacteriology.

Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactoside transport system

J. Beckwith, H. Shuman, 1979, Journal of bacteriology.

The overlapping host responses to bacterial cyclic dinucleotides.

H. Erdjument-Bromage, C. Schindler, S. Beaucage, 2012, Microbes and infection.

Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis

G. Kaplan, J. Blanchard, S. Silverstein, 2009 .

The gigA/gigB Genes Regulate the Growth, Stress Response, and Virulence of Acinetobacter baumannii ATCC 17978 Strain

H. Shuman, Hua Zhou, Yake Yao, 2021, Frontiers in Microbiology.

Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum

R. Kessin, H. Hilbi, O. Anderson, 2003, Molecular microbiology.

Legionella Effectors That Promote Nonlytic Release from Protozoa

O. Anderson, M. Clarke, John W. Chen, 2004, Science.

Conjugal Transfer of Chromosomal DNA in Legionella pneumophila

S. Yoshida, H. Taniguchi, H. Shuman, 2002 .

Unliganded maltose-binding protein triggers lactose transport in an Escherichia coli mutant with an alteration in the maltose transport system

H. Shuman, G. Merino, 1997, Journal of bacteriology.

The ATP‐binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon

W. Boos, C. Panagiotidis, H. Shuman, 1998, Molecular microbiology.

Truncation of MalF Results in Lactose Transport via the Maltose Transport System of Escherichia coli *

H. Shuman, G. Merino, 1998, The Journal of Biological Chemistry.

Interaction between maltose‐binding protein and the membrane‐associated maltose transporter complex in Escherichia coli

H. Nikaido, L. Hor, D. Dean, 1992, Molecular microbiology.

Allele-specific malE mutations that restore interactions between maltose-binding protein and the inner-membrane components of the maltose transport system.

H. Shuman, N. Treptow, Howard A. Shuman, 1988, Journal of molecular biology.

Genetic evidence for substrate and periplasmic-binding-protein recognition by the MalF and MalG proteins, cytoplasmic membrane components of the Escherichia coli maltose transport system

H. Shuman, N. Treptow, 1985, Journal of bacteriology.

An Immunoprotective Molecule, theMajorSecretory Protein ofLegionella pneumophila, IsNota Virulence Factor ina GuineaPigModelofLegionnaires' Disease

H. Shuman, S. Blander, 1990 .

Possible origin of the Legionella pneumophila virulence genes and their relation to Coxiella burnetii

H. Shuman, G. Segal, 1999, Molecular microbiology.

Identification of Novel Coxiella burnetii Icm/Dot Effectors and Genetic Analysis of Their Involvement in Modulating a Mitogen-Activated Protein Kinase Pathway

D. Burstein, T. Pupko, Ziv Lifshitz, 2014, Infection and Immunity.

Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element.

Hana Trigui, S. Faucher, H. Shuman, 2013, Microbiology.

Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages

S. Faucher, H. Shuman, C. A. Mueller, 2010, Front. Microbio..

Comparative sequence analysis of the icm/dot genes in Legionella.

J. Russo, Xiaoyan Qu, H. Shuman, 2004, Plasmid.

Maltose transport in Escherichia coli: mutations that uncouple ATP hydrolysis from transport.

C. Panagiotidis, H. Shuman, 1998, Methods in enzymology.

Genome Rearrangements and Horizontal Gene Transfer in Legionella pneumophila

J. Russo, P. Morozov, H. Shuman, 2006 .

Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H

J. Gilbert, S. Owens, F. Amaro, 2012, Journal of bacteriology.

Characterization of the structural requirements for assembly and nucleotide binding of an ATP-binding cassette transporter. The maltose transport system of Escherichia coli.

W. Boos, C. Panagiotidis, H. Shuman, 1993, The Journal of biological chemistry.

Acinetobacter baumannii ATCC 17978 encodes a microcin system with antimicrobial properties for contact-independent competition

S. Pukatzki, M. Feldman, H. Shuman, 2023, Microbiology.

Identification of Legionella pneumophila genes required for growth within and killing of human macrophages

H. Shuman, L. Wiater, A. Sadosky, 1993, Infection and immunity.

The Dimer of the Escherichia coli Galactose-Binding Protein

W. Boos, I. Rasched, H. Shuman, 1976 .

New Channelrhodopsin with a Red-Shifted Spectrum and Rapid Kinetics from Mesostigma viride

J. Spudich, E. Govorunova, E. Spudich, 2011, mBio.

Analysis of Gene Expression in Legionella during Axenic Growth and Infection

J. Russo, P. Morozov, D. Hilbert, 2006 .

Gemfibrozil Inhibits Legionella pneumophila and Mycobacterium tuberculosis Enoyl Coenzyme A Reductases and Blocks Intracellular Growth of These Bacteria in Macrophages

G. Kaplan, J. Blanchard, S. Silverstein, 2009, Journal of bacteriology.

Mapping of Two ugp Genes Coding for the pho Regulon- Dependent sn-Glycerol-3-Phosphate Transport System of Escherichia coli

M., Schwartz, H. Shuman, 2003 .

Whole-Genome Sequence of the Human Pathogen Legionella pneumophila Serogroup 12 Strain 570-CO-H

J. Gilbert, S. Owens, F. Amaro, 2012, Journal of bacteriology.

A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy

L. Schlesinger, A. Amer, H. Shuman, 2013, European journal of immunology.

Transport of p-nitrophenyl-alpha-maltoside by the maltose transport system of Escherichia coli and its subsequent hydrolysis by a cytoplasmic alpha-maltosidase

H. Shuman, M. Reyes, N. Treptow, 1986, Journal of bacteriology.

Evaluation of the microbial community structure of potable water samples from occupied and unoccupied buildings using16S rRNA amplicon sequencing

Kimothy L Smith, H. Shuman, Douglas Findeisen, 2020, bioRxiv.