D. Dobritzsch

发表

High Resolution Crystal Structure of Pyruvate Decarboxylase from Zymomonas mobilis

Gunter Schneider, G. Schneider, S. König, 1998, The Journal of Biological Chemistry.

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Bradley C Doak, Jan Kihlberg, J. Kihlberg, 2016, Journal of medicinal chemistry.

Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity.

A. V. van Kuilenburg, L. Zoetekouw, D. Dobritzsch, 2017, Molecular genetics and metabolism.

Amidohydrolases of the reductive pyrimidine catabolic pathway purification, characterization, structure, reaction mechanisms and enzyme deficiency.

D. Dobritzsch, K. Schnackerz, 2008, Biochimica et biophysica acta.

The Crystal Structures of Dihydropyrimidinases Reaffirm the Close Relationship between Cyclic Amidohydrolases and Explain Their Substrate Specificity*

J. Piškur, B. Lohkamp, B. Andersen, 2006, Journal of Biological Chemistry.

Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum.

J. Piškur, B. Lohkamp, B. Andersen, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri.

J. Piškur, B. Andersen, D. Dobritzsch, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

β-Ureidopropionase deficiency due to novel and rare UPB1 mutations affecting pre-mRNA splicing and protein structural integrity and catalytic activity.

A. V. van Kuilenburg, J. Bierau, A. Kaindl, 2022, Molecular genetics and metabolism.

Yeast β-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases*

J. Piškur, D. Dobritzsch, Z. Gojkovic, 2003, Journal of Biological Chemistry.

Crystal structure of the glycosyltransferase SnogD from the biosynthetic pathway of nogalamycin in Streptomyces nogalater

G. Schneider, M. Metsä-Ketelä, V. Siitonen, 2012, The FEBS journal.

Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis

C. Ge, R. Holmdahl, D. Dobritzsch, 2022, Arthritis & rheumatology.

Multiplexed experimental strategies for fragment library screening using SPR biosensors

Hanna F. Klein, I. D. de Esch, B. Davis, 2020, bioRxiv.

Large-scale identification of phospho-modulated motif-based protein-protein interactions

Norman E. Davey, N. Davey, J. Nilsson, 2022, bioRxiv.

The crystal structure of beta-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly.

J. Piškur, B. Lohkamp, B. Andersen, 2008, Journal of molecular biology.

Crystal Structures of Yeast β-Alanine Synthase Complexes Reveal the Mode of Substrate Binding and Large Scale Domain Closure Movements*

J. Piškur, B. Andersen, D. Dobritzsch, 2007, Journal of Biological Chemistry.

Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.

J. Piškur, B. Andersen, D. Dobritzsch, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray analysis of beta-alanine synthase from the yeast Saccharomyces kluyveri.

J. Piškur, B. Andersen, D. Dobritzsch, 2003, Acta Crystallographica Section D: Biological Crystallography.

Crystallization and preliminary X-ray study of pig liver dihydropyrimidine dehydrogenase.

G. Schneider, Y. Lindqvist, D. Dobritzsch, 2001, Acta crystallographica. Section D, Biological crystallography.

Positional Identification of RT1-B (HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

R. Holmdahl, E. C. Peters, D. Mason, 2015, The Journal of Immunology.

Arthritis as Susceptibility Locus for Autoimmune ) HLA-DQ ( RT 1-B Positional Identification of Bäcklund

R. Holmdahl, Johan, E. C. Peters, 2015 .

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS

Phillip A. Richmond, S. Scherer, R. Yuen, 2019, The New England journal of medicine.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

Norman E. Davey, N. Davey, E. Petsalaki, 2022, bioRxiv.

Saccharomyces kluyveri as a model organism to study pyrimidine degradation.

J. Piškur, D. Dobritzsch, Halfdan Beck, 2008, FEMS yeast research.

Relaxation of nonproductive binding and increased rate of coenzyme release in an alcohol dehydrogenase increases turnover with a nonpreferred alcohol enantiomer

M. Widersten, D. Dobritzsch, Thilak Reddy Enugala, 2017, The FEBS journal.

Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme.

G. Schneider, Shukun Yu, D. Dobritzsch, 2014, The Biochemical journal.

Structural and Mutagenesis Studies of the Thiamine‐Dependent, Ketone‐Accepting YerE from Pseudomonas protegens

G. Schneider, M. Richter, Michael Müller, 2018, Chembiochem : a European journal of chemical biology.

A gene duplication led to specialized γ‐aminobutyrate and β‐alanine aminotransferase in yeast

J. Piškur, B. Andersen, D. Dobritzsch, 2007, The FEBS journal.

Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti‐cancer drug 5‐fluorouracil

G. Schneider, Y. Lindqvist, D. Dobritzsch, 2001, The EMBO journal.

Severe fluoropyrimidine toxicity due to novel and rare DPYD missense mutations, deletion and genomic amplification affecting DPD activity and mRNA splicing.

A. V. van Kuilenburg, L. Zoetekouw, R. Hennekam, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Novel approach to radionuclide therapy of cancer: affibody-based bio-orthogonal chemistry mediated pretargeting

V. Tolmachev, D. Dobritzsch, 2015 .

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

A. V. van Kuilenburg, J. Maring, E. Gross, 2010, Human Genetics.

Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.

Gunter Schneider, G. Schneider, P. Kallio, 2007, Journal of molecular biology.

Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination.

Y. Lindqvist, B. Lohkamp, D. Dobritzsch, 2010, Biochimica et biophysica acta.

Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.

Y. Lindqvist, P. Cook, D. Dobritzsch, 2004, Biochimica et biophysica acta.

Crystal Structure of the Productive Ternary Complex of Dihydropyrimidine Dehydrogenase with NADPH and 5-Iodouracil

G. Schneider, Y. Lindqvist, D. Dobritzsch, 2002, The Journal of Biological Chemistry.

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G>A and a large intragenic inversion in DPYD spanning intron 8 to intron 12

C. Ross, W. Wasserman, A. V. van Kuilenburg, 2018, Human mutation.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes.

Ida E. Andersson, C. Lindgren, A. Linusson, 2015, Organic & biomolecular chemistry.

Structural Basis of Cross‐Reactivity of Anti–Citrullinated Protein Antibodies

Peter Nilsson, Thomas Skogh, Theo Rispens, 2019, Arthritis & rheumatology.

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

P. Nilsson, C. Ge, R. Holmdahl, 2017, JCI insight.

Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene

A. V. van Kuilenburg, D. Dobritzsch, Tetsuya Ito, 2016, International journal of molecular sciences.

Phenotypic and clinical implications of variants in the dihydropyrimidine dehydrogenase gene.

L. Zoetekouw, R. Hennekam, C. Largiadèr, 2016, Biochimica et biophysica acta.

A mixture of fortunes: the curious determination of the structure of Escherichia coli BL21 Gab protein.

B. Lohkamp, D. Dobritzsch, 2008, Acta crystallographica. Section D, Biological crystallography.

Clinical, biochemical and molecular analysis of 13 Japanese patients with β-ureidopropionase deficiency demonstrates high prevalence of the c.977G > A (p.R326Q) mutation

A. V. van Kuilenburg, L. Zoetekouw, Y. Takeshima, 2014, Journal of Inherited Metabolic Disease.

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Vasanthanathan Poongavanam, Jie Yang, B. Simon, 2020, ACS omega.

Degradation of Pyrimidines in Saccharomyces Kluyveri: Transamination of β-Alanine

J. Piškur, D. Dobritzsch, K. Schnackerz, 2008, Nucleosides, nucleotides & nucleic acids.

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.

Hans R Waterham, Y. Lindqvist, H. Waterham, 2002, The Biochemical journal.

Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases

Shina Caroline Lynn Kamerlin, M. Widersten, D. Petrović, 2018, ACS Catalysis.

Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients.

M. Durán, A. V. van Kuilenburg, L. Zoetekouw, 2010, Biochimica et Biophysica Acta.

Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.

M. Durán, A. V. van Kuilenburg, L. Zoetekouw, 2007, Molecular genetics and metabolism.

Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism.

B. Lohkamp, M. Widersten, D. Dobritzsch, 2018, The Biochemical journal.

A recruited protease is involved in catabolism of pyrimidines.

J. Piškur, B. Andersen, D. Dobritzsch, 2008, Journal of molecular biology.

ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients.

A. V. van Kuilenburg, L. Zoetekouw, R. Hennekam, 2012, Biochimica et biophysica acta.

Atypical presentation of Arts syndrome due to a novel hemizygous loss-of-function variant in the PRPS1 gene

A. V. van Kuilenburg, W. Stenzel, S. Pajusalu, 2020, Molecular genetics and metabolism reports.

The structural basis of substrate activation in yeast pyruvate decarboxylase. A crystallographic and kinetic study.

G. Schneider, S. Baumann, S. König, 2000, European journal of biochemistry.

Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms

Kutty Selva Nandakumar, G. Schneider, Diana Ekman, 2014 .

Crystal structure of an arthritogenic anticollagen immune complex.

Kutty Selva Nandakumar, G. Schneider, R. Holmdahl, 2011, Arthritis and rheumatism.

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

C. Ge, R. Holmdahl, H. Lanig, 2022, Annals of the Rheumatic Diseases.

Novel PRPS1 gain‐of‐function mutation in a patient with congenital hyperuricemia and facial anomalies

E. Schröck, A. Rump, A. V. van Kuilenburg, 2017, American journal of medical genetics. Part A.

Co-therapy with S-adenosylmethionine and nicotinamide riboside improves t-cell survival and function in Arts Syndrome (PRPS1 deficiency)

A. V. van Kuilenburg, J. Christodoulou, M. Huemer, 2021, Molecular genetics and metabolism reports.

Large‐scale phosphomimetic screening identifies phospho‐modulated motif‐based protein interactions

Norman E. Davey, N. Davey, J. Nilsson, 2023, Molecular systems biology.

Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin.

M. Widersten, D. Dobritzsch, D. Maurer, 2018, Biochemistry.

Laboratory‐Evolved Enzymes Provide Snapshots of the Development of Enantioconvergence in Enzyme‐Catalyzed Epoxide Hydrolysis

S. C. Kamerlin, M. Widersten, M. Nilsson, 2016, Chembiochem : a European journal of chemical biology.

PYRUVATE DECARBOXYLASE FROM ZYMOMONAS MOBILIS

G. Schneider, D. Dobritzsch, G. Lu, 1999 .

Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms

D. Dobritzsch, Bingze Xu, K. Nandakumar, 2014, The Journal of experimental medicine.

Brief Definitive Report

E. Ciccone, L. Moretta, A. Moretta, 2022 .

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

I. D. de Esch, D. Dobritzsch, Margaret T Butko, 2021, RSC advances.