C. Freeman

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Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

John Vu, Eric Mayer, J. Paul Robinson, 2015, eLife.

Rural Residence and Chronic Obstructive Pulmonary Disease Exacerbations. Analysis of the SPIROMICS Cohort

Meilan K. Han, J. Curtis, R. Bowler, 2018, Annals of the American Thoracic Society.

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

Jeffrey L. Curtis, Christine M. Freeman, James M. Beck, 2015, mBio.

Presence of Tropheryma whipplei in Different Body Sites in a Cohort of Healthy Subjects.

J. Curtis, S. Qin, A. Morris, 2016, American journal of respiratory and critical care medicine.

Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL‐15R&agr;

J. Curtis, D. Finch, T. Blackwell, 2018, American journal of respiratory and critical care medicine.

Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function

J. Curtis, Sophina H. Taitano, C. Freeman, 2015, The Journal of Immunology.

Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.

J. Curtis, Steven K. Huang, B. Moore, 2015, American journal of physiology. Lung cellular and molecular physiology.

Transforming growth factor-induces microRNA-29 b to promote murine alveolar macrophage dysfunction after bone marrow transplantation

J. Curtis, Steven K. Huang, B. Moore, 2014 .

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report

J. Curtis, R. Brinkman, W. Janssen, 2019, American journal of respiratory cell and molecular biology.

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

Meilan K. Han, J. Curtis, F. Martinez, 2015, Respiratory Research.

The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.

J. Murabito, J. Curtis, R. Bowler, 2020, American journal of respiratory and critical care medicine.

Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation.

S. Kunkel, S. Chensue, P. Lincoln, 2003, American journal of respiratory cell and molecular biology.

Why do we need a nonhuman primate model of smoking-induced COPD?

J. Curtis, C. Freeman, 2015, The American journal of pathology.

Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score‐Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study

Meilan K. Han, J. Curtis, R. Bowler, 2019, Chest.

The innate pulmonary granuloma: characterization and demonstration of dendritic cell recruitment and function.

S. Chensue, C. Freeman, E. Komuniecki, 2004, The American journal of pathology.

Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure.

J. Curtis, M. Olszewski, S. Chensue, 2014, The American journal of pathology.

AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation.

S. Chensue, S. Fricker, G. Bridger, 2006, The American journal of pathology.

PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

J. Curtis, M. Peters-Golden, L. Penke, 2020, Life Science Alliance.

Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD

Meilan K. Han, E. Hoffman, E. Bleecker, 2020, Chest.

Analysis of inducible costimulatory molecule participation during the induction and elicitation of granulomatous responses to mycobacterial and schistosomal antigens.

S. Chensue, C. Freeman, E. Komuniecki, 2005, Cellular immunology.

Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function.

J. Curtis, M. Peters-Golden, M. Myers, 2018, American journal of physiology. Lung cellular and molecular physiology.

CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice1

S. Lira, S. Kunkel, S. Chensue, 2005, The Journal of Immunology.

Impaired lung dendritic cell activation in CCR2 knockout mice.

S. Lira, S. Chensue, I. Charo, 2004, The American journal of pathology.

Cytokine-Chemokine Networks in Experimental Mycobacterial and Schistosomal Lung Granuloma Formation

S. Kunkel, S. Chensue, P. Lincoln, 2002 .

Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression

Theresa M. Ames, J. Curtis, F. Martinez, 2013, Respiratory Research.

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

Meilan K. Han, E. Bleecker, D. Couper, 2019, NPJ biofilms and microbiomes.

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

Meilan K. Han, J. Curtis, E. Hoffman, 2018, The Journal of allergy and clinical immunology.

CCR 8 Is Expressed by Antigen-Elicited , IL-10-Producing CD 4 CD 25 T Cells , Which Regulate Th 2-Mediated Granuloma Formation in Mice 1

S. Lira, S. Kunkel, S. Chensue, 2005 .

Glucocorticoids Relieve Collectin-Driven Suppression of Apoptotic Cell Uptake in Murine Alveolar Macrophages through Downregulation of SIRPα

Theresa M. Ames, J. Curtis, C. Freeman, 2012, The Journal of Immunology.

Murine Alveolar Macrophages through Suppression of Apoptotic Cell Uptake in Glucocorticoids Relieve Collectin-Driven

Theresa M. Ames, J. Curtis, C. Freeman, 2012 .

Animal Models of COPD—Current Status of an Evolving Field

P. Christensen, C. Freeman, W. Fields, 2008 .

CCR4 Participation in Th Type 1 (Mycobacterial) and Th Type 2 (Schistosomal) Anamnestic Pulmonary Granulomatous Responses1

S. Kunkel, S. Chensue, N. Lukacs, 2006, The Journal of Immunology.

Outer Membrane Protein-Specific Monoclonal Antibodies Protect SCID Mice from Fatal Infection by the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis

G. Reddy, C. Freeman, M. Reilly, 2001 .

Immunopathology and Infectious Disease Impaired Lung Dendritic Cell Activation in CCR 2 Knockout Mice

S. Lira, S. Chensue, I. Charo, 2004 .

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

J. Curtis, D. Couper, S. Rennard, 2015, Journal of Translational Medicine.

Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in Chronic Obstructive Pulmonary Disease.

J. Curtis, C. Freeman, A. Tretyakova, 2021, American journal of physiology. Lung cellular and molecular physiology.

Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS

N. Hansel, R. Barr, N. Alexis, 2022, Respiratory Research.

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

J. Curtis, F. Martinez, B. Sundaram, 2011, PloS one.

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

A. Reiner, J. Curtis, R. Bowler, 2020, Proteomics.

Changes in the Lung Microbiome following Lung Transplantation Include the Emergence of Two Distinct Pseudomonas Species with Distinct Clinical Associations

Jeffrey L. Curtis, Christine M. Freeman, James M. Beck, 2014, PloS one.

CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity.

J. Curtis, S. Chensue, C. Freeman, 2007, The American journal of pathology.

Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography.

J. Curtis, J. Erb-Downward, G. Huffnagle, 2015, Annals of the American Thoracic Society.

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1

J. Curtis, W. Janssen, C. Freeman, 2016, The Journal of Immunology.

GDF-15 in Pulmonary and Critical Care Medicine.

J. Curtis, K. Bracke, G. Brusselle, 2019, American journal of respiratory cell and molecular biology.

Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.

J. Curtis, J. Osterholzer, C. Freeman, 2009, Frontiers in bioscience.

Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.

Theresa M. Ames, J. Curtis, F. Martinez, 2009, American journal of respiratory and critical care medicine.

The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research.

J. Curtis, J. Hogg, C. Freeman, 2007, Proceedings of the American Thoracic Society.

Bacterial Topography of the Healthy Human Lower Respiratory Tract

Jeffrey L. Curtis, Christine M. Freeman, J. Curtis, 2017, mBio.

Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

J. Curtis, J. Swanson, M. Peters-Golden, 2015, The Journal of experimental medicine.

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease

J. Wedzicha, J. Curtis, E. Hoffman, 2018, American journal of respiratory and critical care medicine.

Human CD56+ Cytotoxic Lung Lymphocytes Kill Autologous Lung Cells in Chronic Obstructive Pulmonary Disease

J. Curtis, F. Martinez, D. Arenberg, 2014, PloS one.

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

J. Curtis, G. Washko, F. Martinez, 2013, Respiratory Research.

Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15

Theresa M. Ames, J. Curtis, F. Martinez, 2010, The Journal of Immunology.

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

E. Regan, J. Curtis, R. Casaburi, 2016, PLoS genetics.

Clinical Significance of Radiologic Characterizations in COPD

J. Curtis, F. Martinez, E. Kazerooni, 2009, COPD.

Lung dendritic cells : shaping immune responses throughout COPD progression

J. Curtis, C. Freeman, 2016 .

chaffeensis Ehrlichia Intracellular Bacterial Pathogen from Fatal Infection by the Obligate Monoclonal Antibodies Protect SCID Mice Outer Membrane Protein-Specific

G. Reddy, C. Freeman, M. Reilly, 2001 .

Mononuclear phagocyte-derived interleukin-10 suppresses the innate pulmonary granuloma cytokine response in aged mice.

S. Chensue, C. Freeman, Bo-chin Chiu, 2007, The American journal of pathology.

GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

E. Regan, J. Curtis, J. Hokanson, 2017, Respiratory Research.

Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

J. Curtis, S. Adar, K. Shedden, 2020, mBio.

Murine Inducible Nitric Oxide Synthase Expression Is Essential for Antifungal Defenses in Kidneys during Disseminated Cryptococcus deneoformans Infection

Jintao Xu, M. Olszewski, C. Freeman, 2021, The Journal of Immunology.

Murine iNOS expression is essential for antifungal defenses in kidneys during disseminated Cryptococcus deneoformans infection

Jintao Xu, M. Olszewski, C. Freeman, 2021 .

Inference of Cellular Immune Environments in Sputum and Peripheral Blood Associated with Acute Exacerbations of COPD

J. Curtis, F. Martinez, C. Freeman, 2019, Cellular and molecular bioengineering.

The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS

R. Bowler, T. Schlange, F. Martinez, 2019, Respiratory Research.

Lung Dendritic Cells: Shaping Immune Responses throughout Chronic Obstructive Pulmonary Disease Progression

J. Curtis, C. Freeman, 2016, American journal of respiratory cell and molecular biology.

It’s Complicated: Lung Dendritic Cells in Chronic Obstructive Pulmonary Disease

J. Curtis, C. Freeman, 2020, American journal of respiratory and critical care medicine.

Title GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease Permalink

E. Regan, J. Curtis, J. Hokanson, 2017 .

Explorer GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

E. Regan, J. Curtis, J. Hokanson, 2017 .

Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

J. Curtis, G. Washko, F. Martinez, 2014, PloS one.

Diet-induced obesity in mice impairs host defense against Klebsiella pneumonia in vivo and glucose transport and bactericidal functions in neutrophils in vitro.

D. Bridges, C. Freeman, P. Mancuso, 2021, American Journal of Physiology - Lung cellular and Molecular Physiology.

The Immunopathogenesis of Chronic Obstructive Pulmonary Disease

J. Curtis, J. Hogg, C. Freeman, 2012 .

Outer Membrane Protein-Specific Monoclonal Antibodies Protect SCID Mice from Fatal Infection by the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis1

G. Reddy, C. Freeman, M. Reilly, 2001, The Journal of Immunology.

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

J. Curtis, R. Bowler, F. Martinez, 2020, Scientific Reports.

Blood Gene Expression and Immune Cell Subtypes Associated with COPD Exacerbations.

C. Hersh, P. Castaldi, J. Morrow, 2023, American journal of respiratory and critical care medicine.

Genome-wide association study of lung function and clinical implication in heavy smokers

E. Hoffman, F. Martinez, E. Bleecker, 2018, BMC Medical Genetics.

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

Andrew D. Johnson, Benjamin D. Heavner, May E. Montasser, 2020, Genome Medicine.

Finding the Right Biological: Eosinophil Subset Differences in Asthma and Chronic Obstructive Pulmonary Disease

C. Freeman, A. Hastie, J. Curtis, 2023, American journal of respiratory and critical care medicine.

Anemia and Adverse Outcomes in a Chronic Obstructive Pulmonary Disease Population with a High Burden of Comorbidities. An Analysis from SPIROMICS

Meilan K. Han, F. Martinez, D. Couper, 2018, Annals of the American Thoracic Society.

A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD

D. Couper, G. Criner, N. Hansel, 2023, Scientific reports.

Frequency of Exacerbations in COPD: An Analysis of the SPIROMICS Cohort

Meilan K. Han, J. Wedzicha, J. Curtis, 2017, The Lancet. Respiratory medicine.

The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS.

E. Hoffman, F. Martinez, E. Bleecker, 2020, American journal of respiratory and critical care medicine.

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

F. Martinez, D. Couper, G. Criner, 2018, Respiratory Research.

Sputum or blood eosinophil association with clinical measures of COPD severity in the SPIROMICS cohort

Meilan K. Han, J. Curtis, E. Hoffman, 2017, The Lancet. Respiratory medicine.

"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease.

J. Curtis, G. Huffnagle, C. Freeman, 2015, American journal of respiratory and critical care medicine.

CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity.

J. Curtis, S. Chensue, C. Freeman, 2007, The American journal of pathology.

Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage COPD.

D. Couper, R. Barr, R. Paine, 2022, American journal of respiratory and critical care medicine.

Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15

Theresa M. Ames, J. Curtis, F. Martinez, 2010, The Journal of Immunology.

Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort

E. Bleecker, D. Couper, N. Hansel, 2021, npj Biofilms and Microbiomes.

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

E. Hoffman, F. Martinez, E. Bleecker, 2018, Respiratory Research.

A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease.

C. Freeman, D. Mengistu, Jeffrey L Curtis, 2024, Trends in immunology.

Associations between 25-hydroxy-vitamin D levels, lung function, and exacerbation outcomes in COPD: An analysis of the SPIROMICS cohort.

R. Bowler, E. Hoffman, D. Couper, 2020, Chest.

Alignment of Inhaled Chronic Obstructive Pulmonary Disease Therapies with Published Strategies. Analysis of the Global Initiative for Chronic Obstructive Lung Disease Recommendations in SPIROMICS

Meilan K. Han, J. Curtis, F. Martinez, 2019, Annals of the American Thoracic Society.

Lung Dendritic Cell Expression of Maturation Molecules Increases with Worsening COPD

Theresa M. Ames, J. Curtis, F. Martinez, 2009 .