Hui Xu

发表

Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells.

V. Bunik, C. Thompson, G. Gibson, 2005, Biochemistry.

Mild metabolic perturbations alter succinylation of mitochondrial proteins

G. Gibson, V. Belousov, D. Bilan, 2017, Journal of neuroscience research.

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.

M. Beal, G. Gibson, N. Calingasan, 2009, Free radical biology & medicine.

Benfotiamine and Cognitive Decline in Alzheimer's Disease: Results of a Randomized Placebo-Controlled Phase IIa Clinical Trial.

Y. Stern, L. Bettendorff, N. Schupf, 2020, Journal of Alzheimer's disease : JAD.

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins

M. Beal, Lichuan Yang, G. Gibson, 2009, Neurobiology of Disease.

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

D. Pauli, G. Gibson, S. Noggle, 2020, bioRxiv.

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

G. Gibson, Zuoshang Xu, T. Denton, 2012, Neurobiology of Aging.

Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism

G. Gibson, S. Karuppagounder, L. Degiorgio, 2008, Neurochemical Research.

Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.

J. Blass, Soo-Youl Kim, R. Ratan, 2005, Biochemistry.

Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy

M. Beal, D. S. Albers, J. Lindsay, 2001 .

Reduction in the E2k Subunit of the α-Ketoglutarate Dehydrogenase Complex Has Effects Independent of Complex Activity*

G. Gibson, Hui Xu, Huanlian Chen, 2005, Journal of Biological Chemistry.

Inhibition of the α‐ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono‐N‐chloramine

G. Gibson, T. Jeitner, Hui Xu, 2005, Journal of neurochemistry.

Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.

G. Gibson, Arthur J. L. Cooper, B. Krasnikov, 2006, Biochemistry.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism

G. Gibson, S. Karuppagounder, Hui Xu, 2007, Neurobiology of Disease.

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Elizabeth T. Anderson, Shenmin Zhang, V. Haroutunian, 2022, Nature communications.

Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease

Hsueh‐Meei Huang, C. Fowler, Hui Zhang, 2005, Neurobiology of Aging.

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme.

Hui Zhang, G. Gibson, T. Jeitner, 2002, Biochimica et biophysica acta.

Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines

S. Zhang, G. Gibson, T. Denton, 2015, Journal of neurochemistry.

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human‐induced pluripotent stem cells, neural stem cells, and neurons

G. Gibson, S. Noggle, L. Kruger, 2020, Journal of neurochemistry.

Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.

G. Gibson, Hui Xu, W. Kleinman, 2008, Biochimica et biophysica acta.

Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease.

Hsueh‐Meei Huang, G. Gibson, Hui Xu, 2005, Free radical biology & medicine.

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

Hsueh‐Meei Huang, C. Fowler, G. Gibson, 2003, Journal of neuroscience research.

Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation.

Hsueh‐Meei Huang, Hui Zhang, G. Gibson, 2003, Biochimica et biophysica acta.

Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease

G. Gibson, Hui Xu, Kalpita Banerjee, 2016, Neurochemistry International.

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

M. Beal, S. Gandy, G. Gibson, 2009, Neurobiology of Aging.

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

M. Beal, G. Gibson, S. Karuppagounder, 2009, Neurochemistry International.

Succinylation Links Metabolic Reductions to Amyloid and Tau Pathology

Elizabeth T. Anderson, V. Haroutunian, M. Beal, 2019 .

Activation of autophagy attenuates motor deficits and extends lifespan in a C. elegans model of ALS.

H. Cai, W. Le, Hui Xu, 2022, Free radical biology & medicine.

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease

Elizabeth T. Anderson, Shenmin Zhang, G. Gibson, 2021, Journal of neurochemistry.

Abnormalities in the Tricarboxylic Acid Cycle in Huntington Disease and in a Huntington Disease Mouse Model

J. Vonsattel, E. Cortes, G. Gibson, 2015, Journal of neuropathology and experimental neurology.

Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators

Youshuo Liu, Hui Xu, Yi-yang Liu, 2023, Aging and disease.

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

M. Beal, L. Bettendorff, N. Starkova, 2018, Human molecular genetics.

Phosphonate Analogues of α-Ketoglutarate Inhibit the Activity of the α-Ketoglutarate Dehydrogenase Complex Isolated from Brain and in Cultured Cells†

V. Bunik, C. Thompson, G. Gibson, 2005 .

Reductions in the mitochondrial enzyme α‐ketoglutarate dehydrogenase complex in neurodegenerative disease – beneficial or detrimental?

M. Beal, G. Gibson, N. Calingasan, 2016, Journal of neurochemistry.

Chitinase-3 like-protein-1, matrix metalloproteinase -9 and positive intracranial arterial remodelling

Ming Tang, Hui Xu, Hui Xu, 2023, Frontiers in Aging Neuroscience.

Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington’s Disease Patients

Zhengming Chen, G. Gibson, L. Park, 2016, PloS one.

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex*

G. Gibson, Y. Ye, Hui Xu, 2011, The Journal of Biological Chemistry.

Mitochondrial enzymes in schizophrenia

K. Davis, V. Haroutunian, J. Blass, 2007, Journal of Molecular Neuroscience.

Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability

G. Gibson, S. Karuppagounder, Hui Xu, 2007, Neurochemistry International.

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex*

G. Gibson, Y. Ye, Hui Xu, 2011, The Journal of Biological Chemistry.