S. Despa

发表

Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes.

D. Bers, M. Shattock, R. G. Berry, 2007, Cardiovascular research.

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes

Donald M Bers, D. Bers, S. Pogwizd, 2002, The Journal of physiology.

Intracellular Na+ regulation in cardiac myocytes.

Donald M Bers, D. Bers, W. Barry, 2003, Cardiovascular research.

Na/K pump current and [Na](i) in rabbit ventricular myocytes: local [Na](i) depletion and Na buffering.

Donald M Bers, D. Bers, Sanda Despa, 2003, Biophysical journal.

Junctional Cleft [Ca]i Measurements using Novel Cleft-Targeted Ca Sensors

D. Bers, M. Kotlikoff, Bo Shui, 2012 .

Differential distribution and regulation of mouse cardiac Na+/K+-ATPase α1 and α2 subunits in T-tubule and surface sarcolemmal membranes

D. Bers, M. Shattock, R. G. Berry, 2007 .

Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+–Glucose Cotransport

K. Margulies, F. Despa, S. Despa, 2015, Journal of the American Heart Association.

Hyperamylinemia Increases IL-1β Synthesis in the Heart via Peroxidative Sarcolemmal Injury

M. Netea, L. Hersh, J. Chen, 2016, Diabetes.

Cardioprotection by Controlling Hyperamylinemia in a “Humanized” Diabetic Rat Model

K. Margulies, H. Taegtmeyer, B. Hammock, 2014, Journal of the American Heart Association.

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes: A Study in Humans and Rats

D. Bers, K. Margulies, H. Taegtmeyer, 2012, Circulation Research.

Measurement of cytosolic and mitochondrial pH in living cells during reversible metabolic inhibition.

M. Ameloot, M. Vandeven, I. Smets, 2008, Kidney international.

Na 1 / K 1-ATPase a 2-isoform preferentially modulates Ca 2 1 transients and sarcoplasmic reticulum Ca 2 1 release in cardiac myocytes

D. Bers, J. Lingrel, S. Despa, 2012 .

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.

D. Bers, J. Lingrel, S. Despa, 2012, Cardiovascular research.

Lower sarcoplasmic reticulum Ca2+ threshold for triggering afterdepolarizations in diabetic rat hearts.

F. Despa, S. Despa, Jeffrey R. Erickson, 2019, Heart rhythm.

Junctional Cleft [Ca2+]i Measurements Using Novel Cleft-Targeted Ca2+ Sensors

D. Bers, M. Kotlikoff, S. Despa, 2014, Circulation Research.

Deranged sodium to sudden death

B. Fermini, J. Weiss, Z. Qu, 2015, The Journal of physiology.

Disruption of sodium homeostasis in cardiac disease In the session on ‘ Disruption of Na + homeostasis

B. Fermini, J. Weiss, Z. Qu, 2015 .

Phospholemman-Phosphorylation Mediates the β-Adrenergic Effects on Na/K Pump Function in Cardiac Myocytes

A. Tucker, D. Bers, S. Despa, 2005, Circulation research.

Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium.

D. Bers, F. Despa, S. Despa, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Amylin-mediated regulation of LRP1 by miR-103/107 induces cerebral microvascular dysfunction and impairs β-amyloid efflux

L. Goldstein, P. Nelson, Savita Sharma, 2020 .

Isoform Specificity of the Na/K-ATPase Association and Regulation by Phospholemman*

D. Bers, J. Lingrel, S. Despa, 2009, The Journal of Biological Chemistry.

Membrane potential changes associated with calcium signals in human lymphocytes and rat mast cells.

M. Vieytes, L. Botana, A. Cabado, 1999, Life sciences.

Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes.

D. Bers, S. Despa, 2007, American journal of physiology. Cell physiology.

Membrane potential changes in activated cells: connection with cytosolic calcium oscillator.

S. Despa, 1996, Bio Systems.

University of Birmingham Nitric oxide regulates cardiac intracellular Na and Ca² by modulating Na/K ATPase via PKC and phospholemman-dependent mechanism

D. Bers, M. Shattock, S. Despa, 2013 .

Role of mitochondrial Na+ concentration, measured by CoroNa red, in the protection of metabolically inhibited MDCK cells.

M. Ameloot, I. Smets, I. Lambrichts, 2005, Journal of the American Society of Nephrology : JASN.

Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase.

D. Bers, Jody L. Martin, S. Despa, 2010, American journal of physiology. Cell physiology.

Overexpression of the Na+/K+ ATPase &agr;2 But Not &agr;1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling

D. Bers, J. Molkentin, S. Despa, 2014, Circulation Research.

Ca2+ uptake in mitochondria occurs via the reverse action of the Na+/Ca2+ exchanger in metabolically inhibited MDCK cells.

M. Ameloot, M. Vandeven, I. Smets, 2004, American journal of physiology. Renal physiology.

Na⁺ transport in the normal and failing heart - remember the balance.

D. Bers, S. Despa, 2013, Journal of molecular and cellular cardiology.

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart

J. Balligand, H. Koepsell, L. Bertrand, 2017, Scientific Reports.

Myocyte [Na⁺]_i Dysregulation in Heart Failure and Diabetic Cardiomyopathy

C. Zuurbier, S. Despa, 2019 .

Myocyte [Na+]i Dysregulation in Heart Failure and Diabetic Cardiomyopathy

S. Despa, 2018, Front. Physiol..

Intracellular Na+ Concentration Is Elevated in Heart Failure But Na/K Pump Function Is Unchanged

Donald M Bers, Christopher R. Weber, D. Bers, 2002, Circulation.

Phospholemman Phosphorylation Mediates the Protein Kinase C–Dependent Effects on Na+/K+ Pump Function in Cardiac Myocytes

A. Tucker, D. Bers, S. Despa, 2006, Circulation research.

Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy.

D. Bers, L. Blatter, S. Despa, 2004, Biophysical journal.

Phospholemman Phosphorylation Alters Its Fluorescence Resonance Energy Transfer with the Na/K-ATPase Pump*

D. Bers, Jody L. Martin, S. Despa, 2006, Journal of Biological Chemistry.

Phospholemman-Mediated Activation of Na/K-ATPase Limits [Na]i and Inotropic State During &bgr;-Adrenergic Stimulation in Mouse Ventricular Myocytes

A. Tucker, D. Bers, S. Despa, 2008, Circulation.

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas

Manuel F. Navedo, G. Jicha, C. Troakes, 2023, Communications Biology.

Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries.

K. Campbell, L. Goldstein, D. Bers, 2019, Kidney international.

The influence of membrane permeability for ions on cell behaviour in an electric alternating field.

S. Despa, 1995, Physics in medicine and biology.

The association of circulating amylin with β‐amyloid in familial Alzheimer's disease

J. Hardy, G. Jicha, R. Guerreiro, 2021, Alzheimer's & dementia.

Na/Ca exchange and Na/K-ATPase function are equally concentrated in transverse tubules of rat ventricular myocytes.

D M Bers, D. Bers, C. Orchard, 2003, Biophysical journal.

Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.

D. Bers, S. Despa, 2006, Journal of pharmacological sciences.

Diffusion model for growth factors--cell receptors interaction.

F. Despa, S. Despa, 1997, Bio Systems.

Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts.

P. Mohler, S. Despa, Iuliana Popescu, 2016, Cardiovascular research.

From Single Myocyte to Whole Heart: The Intricate Dance of Electrophysiology and Modeling.

E. Vigmond, S. Despa, 2016, Circulation research.

Gestational diabetes triggers postpartum cardiac hypertrophy via activation of calcineurin/NFAT signaling

F. Despa, S. Despa, Nirmal Verma, 2021, Scientific Reports.

Y Ears of Study Have Made It Clear That Na Molecular Medicine Rationale: the Na Atpase (nka) Directly Regulates Intracellular Na

D. Bers, J. Molkentin, S. Despa, 2022 .

Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.

B. Hammock, F. Despa, N. Chiamvimonvat, 2012, American journal of physiology. Heart and circulatory physiology.

Regulation of Ca2+ and Na+ in Normal and Failing Cardiac Myocytes

D. Bers, S. Despa, DONALD M. BERS, 2006, Annals of the New York Academy of Sciences.

Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes.

D. Bers, C. Orchard, F. Brette, 2005, Journal of molecular and cellular cardiology.

Fluorescence lifetime microscopy of the sodium indicator sodium-binding benzofuran isophthalate in HeLa cells.

M. Ameloot, S. Despa, P. Steels, 2000, Analytical biochemistry.

Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman.

A. Tucker, D. Bers, J. Lingrel, 2009, American journal of physiology. Cell physiology.

Nitric oxide regulates cardiac intracellular Na+ and Ca2 + by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism☆

D. Bers, M. Shattock, D. Pavlovic, 2013, Journal of molecular and cellular cardiology.

Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes.

Peter M Kekenes-Huskey, Caitlin E. Scott, P. Kekenes-Huskey, 2017, Cell calcium.

Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity.

D. Bers, P. Mohler, S. Despa, 2012, Journal of molecular and cellular cardiology.

Na/K-ATPase--an integral player in the adrenergic fight-or-flight response.

D. Bers, S. Despa, 2009, Trends in cardiovascular medicine.

Na+ transport in cardiac myocytes; Implications for excitation‐contraction coupling

D. Bers, S. Despa, 2009, IUBMB life.

Fluorescence lifetime microscopy of the Na+ indicator Sodium Green in HeLa cells.

M. Ameloot, P. Steels, S. Despa, 2000, Analytical biochemistry.

Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes?

D. Bers, S. Despa, D. Sato, 2012, Biophysical journal.

Junctional Cleft [Ca2+]i Measurements Using Novel Cleft-Targeted Ca2+ Sensors

D. Bers, M. Kotlikoff, S. Despa, 2014, Circulation research.

Intracellular Na Intracellular Na ++ Concentration ([Na Concentration ([Na ++ ]i) Is Elevated in Diabetic ]i) Is Elevated in Diabetic Hearts Due to Enhanced Na Hearts Due to Enhanced Na ++ –Glucose Cotransport –Glucose Cotransport

K. Margulies, F. Despa, S. Despa, 2022 .

Junctional Cleft [Ca 2+ ] i Measurements Using Novel Cleft-Targeted Ca 2+ Sensors

D. Bers, M. Kotlikoff, S. Despa, 2014 .

Junctional Cleft [Ca2+]i Measurements Using Novel Cleft-Targeted Ca2+ Sensors

D. Bers, M. Kotlikoff, S. Despa, 2014, Circulation research.

Overexpression of the Na+/K+ ATPase &agr;2 But Not &agr;1 Isoform Attenuates Pathological Cardiac Hypertrophy and Remodeling

D. Bers, J. Molkentin, S. Despa, 2014, Circulation research.

Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium.

D. Bers, F. Despa, S. Despa, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Na/K-ATPase--an integral player in the adrenergic fight-or-flight response.

D. Bers, S. Despa, 2009, Trends in cardiovascular medicine.

Elevated local [Ca2+] and CaMKII promote spontaneous Ca2+ release in ankyrin-B-deficient hearts.

P. Mohler, S. Despa, Iuliana Popescu, 2016, Cardiovascular research.

Na+/K+-ATPase E960 and phospholemman F28 are critical for their functional interaction

D. Bers, V. Yarov-Yarovoy, S. Despa, 2012, Proceedings of the National Academy of Sciences.

Distinct Effects of Mitochondrial Na+/Ca2+ Exchanger Inhibition and Ca2+ Uniporter Activation on Ca2+ Sparks and Arrhythmogenesis in Diabetic Rats.

B. O’Rourke, Ting Liu, F. Despa, 2023, Journal of the American Heart Association.

Abstract 18345: Accumulation of Islet Amyloid Polypeptide Oligomers in the Heart in Type-2 Diabetes Alters Ca Cycling in Myocytes

D. Bers, F. Despa, S. Despa, 2010 .

Abstract 1157: Cardiac Consequences of Increased Amylin Secretion in Diabetics

D. Bers, K. Margulies, F. Despa, 2009 .

Hyperamylinemia Contributes to Cardiac Dysfunction in Obesity and Diabetes: A Study in Humans and Rats

D. Bers, K. Margulies, H. Taegtmeyer, 2012, Circulation research.

Simultaneous Measurement of [Na]i, [Ca]i, and INCX in Intact Cardiac Myocytes

Christopher R. Weber, D. Bers, S. Despa, 2002, Annals of the New York Academy of Sciences.