Lin Wu

发表

A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias

Lin Wu, Lina Yao, W. Crumb, 2012, The Journal of Pharmacology and Experimental Therapeutics.

Reduction of Repolarization Reserve Unmasks the Proarrhythmic Role of Endogenous Late Na Ϩ Current in the Heart Female Rabbit Isolated Heart Model

C. January, J. Shryock, S. Rajamani, 2022 .

Antagonism by Ranolazine of the Pro-Arrhythmic Effects of Increasing Late INa in Guinea Pig Ventricular Myocytes

J. Shryock, L. Belardinelli, Lin Wu, 2004, Journal of cardiovascular pharmacology.

Late sodium current in atrial cardiomyocytes contributes to the induced and spontaneous atrial fibrillation in rabbit hearts.

Lin Wu, Pei-hua Zhang, Jihua Ma, 2020, Journal of cardiovascular pharmacology.

Electrophysiologic Properties and Antiarrhythmic Actions of a Novel Antianginal Agent

J. M. Di Diego, J. Fish, C. Antzelevitch, 2004, Journal of cardiovascular pharmacology and therapeutics.

Increased intracellular calcium concentration causes electrical turbulence in guinea pig ventricular myocytes

Lin Wu, Pei-hua Zhang, Jihua Ma, 2011, Science China Life Sciences.

Increase in CO2 levels by upregulating late sodium current is proarrhythmic in the heart.

Ying Wu, Lin Wu, Hong Li, 2019, Heart rhythm.

Wenxin Keli diminishes Ca2+ overload induced by hypoxia/reoxygenation in cardiomyocytes through inhibiting INaL and ICaL

Bu-chang Zhao, Jie Hao, Lin Wu, 2017, Pacing and clinical electrophysiology : PACE.

A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts

J. Shryock, L. Belardinelli, Lin Wu, 2001 .

Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).

Zhihe Li, P. Ibrahim, Hiba Ahmed, 2004, Bioorganic & medicinal chemistry letters.

A Novel Partial Fatty Acid Oxidation Inhibitor Decreases Myocardial Oxygen Consumption and Improves Cardiac Efficiency in Demand-induced Ischemic Heart

L. Belardinelli, Lin Wu, H. Fraser, 2008, Journal of cardiovascular pharmacology.

Chemerin Stimulates Vascular Smooth Muscle Cell Proliferation and Carotid Neointimal Hyperplasia by Activating Mitogen-Activated Protein Kinase Signaling

F. Liu, Bihong Liao, Shaohong Dong, 2016, PloS one.

Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

Lin Wu, Yanpeng Chu, L. Ren, 2017, Scientific Reports.

Role of A2A‐adenosine receptor activation for ATP‐mediated coronary vasodilation in guinea‐pig isolated heart

J. Shryock, L. Belardinelli, C. Seubert, 2000, British journal of pharmacology.

Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3

V. Yarov-Yarovoy, N. Chiamvimonvat, Lin Wu, 2020, Frontiers in Pharmacology.

Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome

C. Antzelevitch, J. Shryock, L. Belardinelli, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine.

Xiaofen Li, Tetsuya Kobayashi, S. Rajamani, 2016, Bioorganic & medicinal chemistry letters.

Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine.

W. Lammers, Xin Wang, J. Shryock, 2008, Progress in biophysics and molecular biology.

Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF).

J. Shryock, L. Belardinelli, Lin Wu, 2004, Current topics in medicinal chemistry.

A Novel Partial Agonist of the A1 -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes

J. Shryock, L. Belardinelli, Lin Wu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Modernized Classification of Cardiac Antiarrhythmic Drugs

Lin Wu, Ming Lei, Derek A. Terrar, 2018, Circulation.

Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron

Xiao-Rong Zeng, Ji-min Cao, Zhongcai Fan, 2019, Front. Cell. Neurosci..

Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.

J. Shryock, L. Belardinelli, Lin Wu, 2012, American journal of physiology. Cell physiology.

Selective Attenuation of Isoproterenol-Stimulated Arrhythmic Activity by a Partial Agonist of Adenosine A1 Receptor

J. Shryock, L. Belardinelli, Lin Wu, 2002, Circulation.

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine.

Lin Wu, Charles Antzelevitch, C. Antzelevitch, 2008, Heart rhythm.

Late sodium current associated cardiac electrophysiological and mechanical dysfunction

Lin Wu, M. Lei, Shan-dong Yu, 2018, Pflügers Archiv - European Journal of Physiology.

An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts

J. Shryock, L. Belardinelli, Lin Wu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

Lin Wu, Yanpeng Chu, L. Ren, 2017, Scientific Reports.

Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation

Lin Wu, Pengkang He, L. Ren, 2023, Philosophical Transactions of the Royal Society of London. Biological Sciences.

Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of IKr Inhibition on Ventricular Repolarization

Lin Wu, Donald M. Bers, Peihua Zhang, 2011, Circulation.

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

J. Ruskin, C. Antzelevitch, J. Shryock, 2008, Cardiovascular research.

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.

David A. Lustig, E. Elzein, K. Shenk, 2004, Bioorganic & medicinal chemistry letters.

Late sodium current associated cardiac electrophysiological and mechanical dysfunction

Lin Wu, M. Lei, Shan-dong Yu, 2017, Pflügers Archiv: European Journal of Physiology.

Statin Use and the Risk of Cataracts: A Systematic Review and Meta‐Analysis

Lin Wu, Yanpeng Chu, L. Ren, 2017, Journal of the American Heart Association.

Remodeling of myocardial energy and metabolic homeostasis in a sheep model of persistent atrial fibrillation.

Lin Wu, Fei Liu, Ji-hong Guo, 2019, Biochemical and biophysical research communications.

Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytes

Lin Wu, Pei-hua Zhang, Jihua Ma, 2012, Pflügers Archiv: European Journal of Physiology.

Abstract 20283: Calmodulin Kinase and Protein Kinase C Mediate the Effect of Increased Intracellular Calcium to Augment Late Sodium Current in Ventricular Myocytes

Lin Wu, Pei-hua Zhang, Jihua Ma, 2010 .

Ventral Neurons of the Neonatal Rat Currents by Activation of Protein Kinase C in Spinal Modulation of Transient and Persistent Inward

L. Jordan, B. Fedirchuk, J. Shryock, 2015 .

A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias

W. Crumb, J. Shryock, S. Rajamani, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome

C. Antzelevitch, J. Shryock, L. Belardinelli, 2004, Journal of Pharmacology and Experimental Therapeutics.