J. Moon

发表

Cation binding to the integrin CD11b I domain and activation model assessment.

B. Finzel, R. Heinrikson, N. Horton, 1998, Structure.

Recent advances in de novo molecular design

Joseph B. Moon, W. Howe, J. Moon, 1993 .

Computer design of bioactive molecules: A method for receptor‐based de novo ligand design

W. Howe, J. Moon, W. Jeffrey Howe, 1991, Proteins.

Rational Use of Chemical and Sequence Databases

Mark A. Johnson, J. D. Petke, P. Willett, 1994 .

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1.

A. Tomasselli, M. Bienkowski, J. Moon, 2007, Bioorganic & medicinal chemistry letters.

Design of potent inhibitors of human beta-secretase. Part 2.

A. Tomasselli, Y. M. Fobian, G. Winterrowd, 2007, Bioorganic & medicinal chemistry letters.

Primary and secondary kinetic deuterium isotope effects and transition-state structures for benzylic chlorination and bromination of toluene

J. Moon, R. Hanzlik, A. Schaefer, 1987 .

Reversible covalent inhibition of papain by a peptide nitrile. Carbon-13 NMR evidence for a thioimidate ester adduct

R. S. Coleman, R. Coleman, J. Moon, 1986 .

Reversible covalent binding of peptide nitriles to papain.

J. Zygmunt, J. Moon, R. Hanzlik, 1990, Biochimica et biophysica acta.

Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease ( HIV‐PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy, and Cell Permeability Properties.

D. Decamp, C. Craik, W. Lowther, 1995 .

Intramolecular kinetic deuterium isotope effects on microsomal hydroxylation and chemical chlorination of toluene-.alpha.-d1 and toluene-.alpha.,.alpha.-d2

J. Moon, R. Hanzlik, K. Hogberg, 1985 .

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).

D. Rohrer, C. Carron, C. Wegner, 2010, ACS medicinal chemistry letters.

Enthalpy and entropy of hippuraldehyde hydration and binding to papain.

J. Moon, R. Hanzlik, 1987, Biochimica et biophysica acta.

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

D. J. Rogier, Y. M. Fobian, S. Curtiss, 2010, Journal of medicinal chemistry.

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.

W. Stallings, D. J. Rogier, Y. M. Fobian, 2009, Bioorganic & medicinal chemistry letters.

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.

W. Stallings, Y. M. Fobian, D. Owen, 2009, Bioorganic & medicinal chemistry letters.

Random optimizations for direct heteronuclear correlations

C. Hadden, J. Moon, Daneen T. A. Hadden, 2001 .

Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.

Wei Huang, Atli Thorarensen, James R Kiefer, 2012, Bioorganic & medicinal chemistry letters.

Predicting the Three-Dimensional Structure of Proteins by Homology-Based Model Building

Gerald M. Maggiora, James R. Blinn, C. A. Granatir, 1991 .

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.

W. Howe, A. Tomasselli, R. Heinrikson, 1991, Journal of medicinal chemistry.

Crystal structure of a complex of HIV‐1 protease with a dihydroxyethylene‐containing inhibitor: Comparisons with molecular modeling

Narmada Thanki, Alexander Wlodawer, A. Wlodawer, 1992, Protein science : a publication of the Protein Society.

Computer Modeling of Constrained Peptide Systems

K. Chou, W. Howe, J. Blinn, 1992 .

3D database searching and de novo construction methods in molecular design

Joseph B. Moon, W. Jeffrey Howe, W. Howe, 1990 .

Design and Synthesis of Hydroxyethylene-Based Peptidomimetic Inhibitors of Human β-Secretase

Joseph B. Moon, Eugene D. Thorsett, E. Thorsett, 2004 .

Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase.

Joseph B. Moon, Michel Maillard, Alfredo G. Tomasselli, 2007, Journal of medicinal chemistry.

Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties

D. Decamp, C. Craik, W. Lowther, 1993 .

Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.

E. Thorsett, N. Jewett, J. Tung, 2004, Journal of medicinal chemistry.

Design of potent inhibitors of human beta-secretase. Part 1.

A. Tomasselli, Y. M. Fobian, G. Winterrowd, 2007, Bioorganic & medicinal chemistry letters.

HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs.

T K Sawyer, W. Howe, A. Tomasselli, 2009, International journal of peptide and protein research.