S. Freeman

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Analytical chemistry of synthetic routes to psychoactive tryptamines. Part II. Characterisation of the Speeter and Anthony synthetic route to N,N-dialkylated tryptamines using GC-EI-ITMS, ESI-TQ-MS-MS and NMR.

J. F. Alder, J. Alder, S. Brandt, 2005, The Analyst.

Analytical chemistry of synthetic routes to psychoactive tryptamines. Part I. Characterisation of the Speeter and Anthony synthetic route to 5-methoxy-N,N-diisopropyltryptamine using ESI-MS-MS and ESI-TOF-MS.

J. F. Alder, J. Alder, S. Brandt, 2004, The Analyst.

Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon–phosphorus bond

J. Knowles, H. Seto, S. Freeman, 1988, Nature.

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

M Jaffar, I. Stratford, M. Jaffar, 2003, Bioorganic & medicinal chemistry letters.

In vitro evaluation of dendrimer prodrugs for oral drug delivery.

A. D'emanuele, D. Attwood, S. Freeman, 2007, International journal of pharmaceutics.

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses

D. Brough, S. Allan, E. Karran, 2018, Scientific Reports.

Synthesis, Bioactivation and Anti-HIV Activity of 4-Acyloxybenzyl bis(Nucleosid-5′-yl) Phosphates

Ian Walker, A. Hay, A. Routledge, 1995 .

Inositol polyphosphate‐mediated iron transport in Pseudomonas aeruginosa

A. M. Riley, B. Potter, D. Poyner, 1999, Journal of applied microbiology.

The naphyrone story: The alpha or beta-naphthyl isomer?

R. Wootton, G. De Paoli, S. Brandt, 2010, Drug testing and analysis.

Synthesis, bioactivation and anti-HIV activity of the bis(4-acyloxybenzyl) and mono(4-acyloxybenzyl) esters of the 5′-monophosphate of AZT

W. J. Irwin, A. Hay, D. Nicholls, 1993 .

Is metabolism an important arbiter of anticancer activity of ether lipids? metabolism of SRI 62-834 and hexadecylphosphocholine by [31P]-NMR spectroscopy and comparison of their cytotoxicities with those of their metabolites

C. Dive, A. Gescher, S. Freeman, 2004, Cancer Chemotherapy and Pharmacology.

Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (+/-)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates.

Y. Chang, J. Gardiner, D. Poyner, 1996, Carbohydrate research.

Pentapeptides for the treatment of small cell lung cancer: Optimisation by Nind-alkyl modification of the tryptophan side chain

H. Aojula, S. Freeman, Osama Haitham Abusara, 2017, European journal of medicinal chemistry.

N-tert-Prenylation of the indole ring improves the cytotoxicity of a short antagonist G analogue against small cell lung cancer

B. Telfer, K. Williams, H. Aojula, 2017, MedChemComm.

Profiling psychoactive tryptamine- drug synthesis by focusing on detection using mass spectrometry

J. F. Alder, T. Passie, S. Brandt, 2010 .

The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.

M. Jaffar, C. Cole, S. Freeman, 1999, Anti-cancer drug design.

3 Prodrug Design for Phosphates and Phosphonates

K. C. Ross, S. Freeman, 1997 .

Acyclic nucleosides as antiviral compounds

J. Gardiner, S. Freeman, J. M. Gardiner, 1996, Molecular biotechnology.

Structural studies on bio-active molecules. Part 17. Crystal structure of 9-(2′-phosphonomethoxyethyl)adenine (PMEA)

S. Freeman, C. Schwalbe, W. Thomson, 1991 .

In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates

A. D'emanuele, D. Attwood, S. Freeman, 2017, Molecules.

Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones.

H. Sumnall, J. Cole, F. Measham, 2011, Drug testing and analysis.

LRRC8A regulates hypotonicity-induced NLRP3 inflammasome activation

D. Brough, N. Humphreys, R. Bryce, 2020, bioRxiv.

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome

D. Brough, S. Freeman, A. Baldwin, 2018, Chemmedchem.

Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl− channel modulation

D. Brough, Stephane De Cesco, C. Lawrence, 2020, Chemical science.

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

S. Barry, S. Ashton, I. Stratford, 2005, Journal of medicinal chemistry.

Resveratrol-mediated cleavage of amyloid β1–42 peptide: potential relevance to Alzheimer's disease

H. Aojula, I. Alsalahat, J. Penny, 2020, Neurobiology of Aging.

Preparation and properties of the endotoxins of Aspergillus fumigatus and Aspergillus flavus

S. Freeman, E. Hatton, V. L. Koenig, 1961, Mycopathologia et mycologia applicata.

Drug delivery via active transport at the blood-brain barrier: II. Investigation of monocarboxylic acid transport in vitro

W. J. Irwin, Ian Walker, D. Nicholls, 1994 .

Drug delivery via active transport at the blood-brain barrier : affinity of a prodrug of phosphonoformate for the large amino acid transporter

W. J. Irwin, Ian Walker, D. Nicholls, 1994 .

Thymidine phosphorylase from Escherichia coli: Tight-binding inhibitors as enzyme active-site titrants

M. Jaffar, K. Douglas, S. Freeman, 2006, Journal of enzyme inhibition and medicinal chemistry.

Structure of (+/-)-1,2;4,5-di-O-cyclohexylidene myo-inositol and synthesis of myo-inositol 3-phosphate via its phosphorylation with (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

A. J. Blake, A. Blake, S. Freeman, 1997 .

The first synthesis and iron binding studies of the natural product, myo-inositol 1,2,3-trisphosphate

D. Poyner, S. Freeman, I. Spiers, 1995 .

Conformational Evaluation of Indol-3-yl-N-alkyl-glyoxalylamides and Indol-3-yl-N,N-dialkyl-glyoxalylamides

J. F. Alder, D. Mansell, S. Brandt, 2009 .

Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2).

I. Stratford, R. Bryce, G. Halbert, 2019, European journal of medicinal chemistry.

Arylethylamine psychotropic recreational drugs: a chemical perspective.

J. F. Alder, S. Freeman, 2002, European journal of medicinal chemistry.

Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group

N. Rattray, Ramkumar Rajendran, C. Demonacos, 2011 .

Prodrugs of phosphonoformate: products, kinetics and mechanisms of hydrolysis of dibenzyl (methoxycarbonyl)phosphonate

W. J. Irwin, Ian Walker, D. Nicholls, 1991 .

Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.

I. Stratford, Soraya Alnabulsi, K. Nolan, 2016, European journal of medicinal chemistry.

Synthesis and hydrolysis studies of phosphonopyruvate

W. J. Irwin, S. Freeman, C. Schwalbe, 1991 .

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

I. Stratford, M. Jaffar, K. Douglas, 2003, Journal of medicinal chemistry.

An analytical perspective on favoured synthetic routes to the psychoactive tryptamines.

J. F. Alder, S. Brandt, S. Freeman, 2004, Journal of pharmaceutical and biomedical analysis.

Solid state conformations of six 1,3,2-oxazaphospholidines derived from (–)-ephedrine: X-ray crystal structures of the 2-phenoxy-2-oxo, 2-phenyl-2-oxo and 2-phenyl-2-thio analogues

J. V. Carey, John M. Brown, S. Freeman, 1991 .

Stereohemistry of reaction of a phosphonamidic chloride with t-butylamine

S. Freeman, M. J. Harger, 1985 .

Prodrugs of phosphonoformate: the effect of para-substituents on the products, kinetics and mechanism of hydrolysis of dibenzyl methoxycarbonylphosphonate

W. J. Irwin, D. Nicholls, S. Freeman, 1992 .

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid

D. Brough, J. Bevan, R. Ledder, 2017, Medicinal Chemistry Research.

A stereochemical study of the dissociative substitution reactions of N-(S)-α-phenylethyl-P-t-butylphosphonamidic chloride with t-butylamine and isopropylamine

S. Freeman, M. J. Harger, 1988 .

Influence of ortho methyl and isopropyl substituents on the reactivity of N-t-butyl P-arylphosphonamidic chlorides with isopropylamine and t-butylamine: steric acceleration of metaphosphonimidate formation by an elimination addition mechanism; contrasting behaviour of N,N-dimethyl P-arylphosphonamid

S. Freeman, M. J. Harger, 1987 .

S-Acylthioethyl prodrugs of phosphonoformate

M. Camplo, S. Freeman, J. Lundström, 1997 .

Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.

R. Bryce, D. Mansell, M. Rajabi, 2011, European journal of medicinal chemistry.

Locked energy of axial to equatorial transformation monitored by exciplex and excimer fluorescence

A. D'emanuele, S. Freeman, E. Bichenkova, 2006 .

Design, synthesis and enzymatic evaluation of 6‐bridged imidazolyluracil derivatives as inhibitors of human thymidine phosphorylase

I. Stratford, M. Jaffar, K. Douglas, 2007, The Journal of pharmacy and pharmacology.

Boron-Based Inhibitors of the NLRP3 Inflammasome

N. Rothwell, D. Brough, S. Allan, 2017, Cell chemical biology.

Synthesis and bioactivation of bis(aroyloxymethyl) and mono(aroyloxymethyl) esters of benzylphosphonate and phosphonoacetate

W. J. Irwin, D. Nicholls, S. Freeman, 1993 .

Bioreversible protection for the phospho group: bioactivation of the di(4-acyloxybenzyl) and mono(4-acyloxybenzyl) phosphoesters of methylphosphonate and phosphonoacetate

W. J. Irwin, D. Nicholls, S. Freeman, 1992 .

Synthesis and Bioactivation of Bis(aroyloxymethyl) and Mono( aroyloxymethyl) Esters of Benzylphosphonate and Phosphonoacetate.

W. J. Irwin, D. Nicholls, S. Freeman, 1994 .

Bioreversible Protection for the Phospho Group: Bioactivation of the Di(4‐acyloxybenzyl) and Mono(4‐acyloxybenzyl) Phosphoesters of Methylphosphonate and Phosphonoacetate

W. J. Irwin, D. Nicholls, S. Freeman, 1993 .

Soft β-adrenergic agonists for the topical treatment of psoriasis

Sally Freeman, S. Freeman, HS Gill, 1996 .

Detection of apoptosis by PET/CT with the diethyl ester of [¹⁸F]ML-10 and fluorescence imaging with a dansyl analogue.

K. Williams, Gavin Brown, A. Smigova, 2014, Bioorganic & medicinal chemistry.

Chemical and bacterial reduction of azo-probes: monitoring a conformational change using fluorescence spectroscopy

N. Rattray, M. Jaffar, D. Mansell, 2013 .

Fluorescent probe for detection of bacteria: conformational trigger upon bacterial reduction of an azo bridge.

A. J. Blake, N. Rattray, D. Mansell, 2012, Chemical communications.

Synthesis and assessment of first-generation polyamidoamine dendrimer prodrugs to enhance the cellular permeability of P-gp substrates.

A. D'emanuele, D. Attwood, S. Freeman, 2007, Bioconjugate chemistry.

Stereochemistry of phospho group transfer catalyzed by a mutant alkaline phosphatase.

J. Knowles, E. Kaiser, S. Freeman, 1988, Biochemistry.

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.

I. Stratford, R. Bryce, S. Freeman, 2008, European journal of medicinal chemistry.

Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.

E. Chinje, I. Stratford, K. Douglas, 2004, Bioorganic & medicinal chemistry letters.

Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate

M. Camplo, S. Freeman, J. Lundström, 1996 .

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

I. Stratford, K. Williams, M. Jaffar, 2002, Bioorganic & medicinal chemistry.

Insight into the protonation and K(I)-interaction of the inositol 1,2,3-trisphosphate as provided by 31P NMR and theoretical calculations.

D. Mansell, Gabriel González, S. Domínguez, 2011 .

D. Marks, I. Stratford, M. Jaffar, 1999, Anti-cancer drug design.

SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

I. Stratford, K. Finegan, R. Bryce, 2022, Journal of medicinal chemistry.

Characterization of the synthesis of N,N-dimethyltryptamine by reductive amination using gas chromatography ion trap mass spectrometry.

A. B. Kanu, S. Brandt, S. Freeman, 2010, Drug testing and analysis.

The quest for free metaphosphate in solution: racemization at phosphorus in the transfer of the phospho group from aryl phosphate monoesters to tert-butyl alcohol in acetonitrile or in tert-butyl alcohol

J. Knowles, J. Friedman, S. Freeman, 1988 .

Synthesis and Enzymatic Evaluation of Pyridinium‐Substituted Uracil Derivatives as Novel Inhibitors of Thymidine Phosphorylase.

I. Stratford, K. Williams, M. Jaffar, 2002 .

Free monomeric metaphosphate in protic solution: complete racemization at phosphorus in the tert-butanolysis of p-nitrophenyl phosphate

J. Knowles, J. Friedman, S. Freeman, 1987 .

Inhibiting the NLRP3 Inflammasome

D. Brough, S. Freeman, Lina Y. El-Sharkawy, 2020, Molecules.

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

D. Brough, P. Paszek, J. Bagnall, 2016, Nature Communications.

Inhibiting the Inflammasome: A Chemical Perspective.

Sally Freeman, David Brough, D. Brough, 2016, Journal of medicinal chemistry.

Halogenated solvent interactions with N,N-dimethyltryptamine: formation of quaternary ammonium salts and their artificially induced rearrangements during analysis.

J. F. Alder, N. Dempster, P. Riby, 2008, Forensic science international.

N,N-Dimethyltryptamine and dichloromethane: rearrangement of quaternary ammonium salt product during GC-EI and CI-MS-MS analysis.

J. F. Alder, N. Dempster, P. Riby, 2008, Journal of pharmaceutical and biomedical analysis.

Characterisation of a siderophore from Acinetobacter calcoaceticus

P. Lambert, S. Freeman, A. Smith, 1990 .

Inhibitors of inositol monophosphatase.

S. Freeman, C. Fauroux, Sally Freeman, 1999, Journal of enzyme inhibition.

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

D. Brough, N. Humphreys, R. Bryce, 2020, eLife.

Effects of 1,1-Dichloroethene and of Some of Its Metabolites on the Functional Viability of Mouse Hepatocytes

A. Gescher, J. Chipman, A. Kainz, 1993 .

Effects of 1,1-dichloroethene and of some of its metabolites on the functional viability of mouse hepatocytes.

A. Gescher, J. Chipman, A. Kainz, 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

D. Brough, C. Lawrence, S. Freeman, 2018, SLAS discovery : advancing life sciences R & D.

Selected Derivatives of Erythromycin B-In Silico and Anti-Malarial Studies

S. Freeman, J. Barber, B. Arsić, 2021, Materials.

Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

S. Freeman, M. Kadirvel, Gavin Brown, 2018, Journal of Radioanalytical and Nuclear Chemistry.

Characterisation of a proposed internet synthesis of N,N-dimethyltryptamine using liquid chromatography/electrospray ionisation tandem mass spectrometry.

J. F. Alder, S. Brandt, S. Freeman, 2009, Journal of chromatography. A.

Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

J. F. Alder, M. Awan, S. Brandt, 2008, Journal of chromatography. A.

Microwave‐accelerated synthesis of psychoactive deuterated N,N‐dialkylated‐[α,α,β,β‐d4]‐tryptamines

N. Dempster, P. Daley, S. Brandt, 2008 .

In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand.

G. Booker, C. Dive, R. Bryce, 2008, Bioorganic & medicinal chemistry letters.

Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.

J. Knowles, S. Pollack, D. Pompliano, 1992, European journal of biochemistry.

Analytical chemistry of synthetic routes to psychoactive tryptamines. Part III. Characterisation of the Speeter and Anthony route to N,N-dialkylated tryptamines using CI-IT-MS-MS.

J. F. Alder, S. Brandt, S. Freeman, 2005, The Analyst.

AMT (3-(2-aminopropyl)indole) and 5-IT (5-(2-aminopropyl)indole): an analytical challenge and implications for forensic analysis.

S. Brandt, S. Freeman, R. Archer, 2013, Drug testing and analysis.

myo-Inositol esters of indomethacin as COX-2 inhibitors.

Ramkumar Rajendran, C. Demonacos, S. Freeman, 2012, Carbohydrate research.

Conformational study of the natural iron chelator myo-inositol 1,2,3-trisphosphate using restrained/flexible analogues and computational analysis

R. Bryce, D. Mansell, S. Freeman, 2010 .

Redox and structural aspects on iron inositol 1,2,3-trisphosphate interaction: An experimental and computational approach

D. Mansell, Gabriel González, S. Domínguez, 2011 .

Conformational analysis of the natural iron chelator myo-inositol 1,2,3-trisphosphate using a pyrene-based fluorescent mimic.

A. J. Blake, N. Rattray, A. Blake, 2010, Organic & biomolecular chemistry.

Fluorescent probe: complexation of Fe3+ with the myo-inositol 1,2,3-trisphosphate motif.

Sally Freeman, Richard A Bryce, A. J. Blake, 2008, Chemical communications.

“Chelatable iron pool”: inositol 1,2,3-trisphosphate fulfils the conditions required to be a safe cellular iron ligand

D. Mansell, S. Domínguez, S. Freeman, 2008, JBIC Journal of Biological Inorganic Chemistry.

Crystal structure and modelling studies of myo-inositol 1,2,3-trisphosphate

S. Freeman, I. Spiers, C. Schwalbe, 1995 .

Boron-Based Inhibitors of the NLRP 3 Inflammasome Graphical Abstract Highlights

N. Rothwell, D. Brough, S. Allan, 2022 .

Inhibition of aggregation of amyloid-β through covalent modification with benzylpenicillin; potential relevance to Alzheimer's disease

M. Taha, H. Aojula, I. Alsalahat, 2021, Biochemistry and biophysics reports.

Synthesis and bioluminescence-inducing properties of autoinducer (S)-4,5-dihydroxypentane-2,3-dione and its enantiomer.

Sally Freeman, Andrew J. McBain, John M. Gardiner, 2010, Bioorganic & medicinal chemistry letters.

Synthesis, characterization and stability of dendrimer prodrugs.

Sally Freeman, Antony D'Emanuele, Mohammad Najlah, 2006, International journal of pharmaceutics.

Synthesis of 3-arsonopyruvate and its interaction with phosphoenolpyruvate mutase.

H. Dixon, S. Freeman, E. K. Mutenda, 1995, The Biochemical journal.

Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; a novel potent inhibitor of signalling.

J. Gardiner, A. McBain, S. Freeman, 2014, Chemical communications.

SYNTHESIS OF 3,4,5,6-TETRAKISPHOSPHATES OF DL-1,2-DIDEOXY-1,2-DIFLUORO-MYO-INOSITOL AND DL-1,2-DIDEOXY-1,2-DIFLUORO-SCYLLO-INOSITOL AS ANALOGUES OF DL -MYO-INOSITOL 3,4,5,6-TETRAKISPHOSPHATE

D. Poyner, S. Freeman, K. Solomons, 1996 .

Evaluation of analogues of furan-amidines as inhibitors of NQO2.

I. Stratford, Soraya Alnabulsi, R. Bryce, 2018, Bioorganic & Medicinal Chemistry Letters.

Drug Delivery

A. D'emanuele, Y. Perrie, D. Attwood, 2007, An Introduction to Biomaterials Science and Engineering.

Difluoro analogue of UCS15A triggers activation of exogenously expressed c-Src in HCT 116 human colorectal carcinoma cells

C. Dive, R. Bryce, C. Cawthorne, 2007, Journal of enzyme inhibition and medicinal chemistry.

Phosphonate biosynthesis: the stereochemical course of phosphoenolpyruvate phosphomutase

J. Knowles, S. Freeman, H. Seidel, 1989 .

The Henry reaction: spectroscopic studies of nitrile and hydroxylamine by-products formed during synthesis of psychoactive phenylalkylamines

J. F. Alder, S. Brandt, S. Freeman, 2008 .

Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones.

H. Sumnall, J. Cole, F. Measham, 2011, Drug testing and analysis.

Conformational probe: static quenching is reduced upon acid triggered ring flip of a myo-inositol derivative

S. Freeman, B. Arsić, E. Bichenkova, 2008 .

EFFECT OF ASPERGILLUS FUMIGATUS ENDOTOXIN ON THE RESPIRATION AND PHOSPHORYLATION OF KIDNEY TISSUE.

E. L. Coe, S. Freeman, I. -. Lee, 1965, Archives of biochemistry and biophysics.

Analytical characterisation of the routes by thermolytic decarboxylation from tryptophan to tryptamine using ketone catalysts, resulting in tetrahydro-beta-carboline formation.

J. F. Alder, S. Brandt, S. Freeman, 2006, Journal of pharmaceutical and biomedical analysis.

The crystal structure of the tri(cyclohexylammonium) salt of phosphonopyruvate; theoretical calculations on the equilibrium constant for the rearrangement of phosphonopyruvate to phosphoenolpyruvate

S. Freeman, C. Schwalbe, 1990 .