P. Vinson

发表

Challenges in the Discovery and Optimization of mGlu2/4 Heterodimer Positive Allosteric Modulators

Anna L. Blobaum, C. Lindsley, C. Niswender, 2019, Letters in drug design & discovery.

Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships

Andrew S. Felts, Brian A. Chauder, K. Gregory, 2012, Molecular Pharmacology.

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

F. Dudek, K. Gregory, Z. Xiang, 2013, Biological Psychiatry.

Structure based virtual screening identifies small molecule effectors for the sialoglycan binding protein Hsa.

Jeremy C. Smith, J. Baudry, T. Iverson, 2020, The Biochemical journal.

Structure based virtual screening identifies novel competitive inhibitors for the sialoglycan binding protein Hsa

Jeremy C. Smith, J. Baudry, T. Iverson, 2020, bioRxiv.

Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Amanda M. Duran, Anna L. Blobaum, J. Meiler, 2018, Molecular Pharmacology.

A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling

K. Gregory, C. Lindsley, P. Conn, 2013, Molecular Pharmacology.

Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators.

J. Bartolomé-Nebreda, Carlos M Martínez-Viturro, G. Macdonald, 2015, Bioorganic & medicinal chemistry letters.

Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia.

A. Megens, X. Langlois, J. Bartolomé-Nebreda, 2015, ACS medicinal chemistry letters.

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism

Z. Xiang, C. Lindsley, P. Conn, 2013, Drug Metabolism and Disposition.

Functional impact of allosteric agonist activity of selective positive allosteric modulators of mGlu 5 in regulating CNS function

H. Lavreysen, Z. Xiang, C. Lindsley, 2011 .

Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

Bruce J. Melancon, Anna L. Blobaum, D. Sheffler, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a potent M5 antagonist with improved clearance profile. Part 1: piperidine amide-based antagonists.

Andrew S. Felts, Anna L. Blobaum, C. Lindsley, 2022, Bioorganic & medicinal chemistry letters.

Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.

Matthew T. Dickerson, Emily L. Days, C. Weaver, 2017, ACS chemical neuroscience.

Large-Scale Identification of Multiple Classes of Host Defense Peptide-Inducing Compounds for Antimicrobial Therapy

P. Vinson, Guolong Zhang, Yingping Xiao, 2022, International journal of molecular sciences.

Development and characterization of a highly selective M5 PAM probe molecule with improved potency

Julie L. Engers, C. Lindsley, P. Conn, 2013 .

Extended Probe Characterization: Development of an M4 PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias

Julie L. Engers, Bruce J. Melancon, D. Sheffler, 2013 .

A BRET Ca2+ sensor enables high-throughput screening in the presence of background fluorescence

Tetsuya Mori, C. Johnson, Jie Yang, 2022, Science Signaling.

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu5)

S. Jadhav, J. Bartolomé-Nebreda, M. Martín-Martín, 2014, Journal of medicinal chemistry.

A Novel Approach To Identify Inhibitors of Iron Acquisition Systems of Pseudomonas aeruginosa

N. M. Nebane, P. Vinson, Avishek Mitra, 2022, Microbiology spectrum.

Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.

Andrew S. Felts, Anna L. Blobaum, N. Schnetz-Boutaud, 2022, Journal of medicinal chemistry.

Delayed treatment with PTBA analogs reduces post injury renal fibrosis after kidney injury 1 2 3

D. Huryn, N. Hukriede, L. Vernetti, 2015 .

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.

G. Macdonald, H. Lavreysen, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).

K. Gregory, J. Meiler, Z. Xiang, 2013, Journal of medicinal chemistry.

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2010, Molecular Pharmacology.

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Kari A. Johnson, K. Gregory, J. Bartolomé-Nebreda, 2015, Neuron.

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

H. Lavreysen, Z. Xiang, C. Lindsley, 2012, Molecular Pharmacology.

Discovery of ML326: The first sub-micromolar, selective M5 PAM.

Julie L. Engers, C. Lindsley, P. Conn, 2013, Bioorganic & medicinal chemistry letters.

Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury.

D. Huryn, N. Hukriede, M. D. de Caestecker, 2016, American journal of physiology. Renal physiology.

Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery.

Elaine L. Shelton, Q. Sheng, B. Paria, 2019, Pharmacological research.

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.

Cody J. Wenthur, Anna L. Blobaum, D. Sheffler, 2012, Bioorganic & medicinal chemistry letters.

Metabotropic glutamate receptors as therapeutic targets for schizophrenia

P. Conn, P. Vinson, P. Jeffrey Conn, 2012, Neuropharmacology.

Screening for AMPA receptor auxiliary subunit specific modulators

S. Stauffer, T. Nakagawa, Emily L. Days, 2017, PloS one.

Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.

C. Niswender, P. Vinson, M. T. Klein, 2013, Progress in molecular biology and translational science.

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.

Anna L. Blobaum, D. Sheffler, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Effect of neostigmine on concentration and extraction fraction of acetylcholine using quantitative microdialysis

J. B. Justice, P. Vinson, 1997, Journal of Neuroscience Methods.

De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome c in cells

W. McDonald, N. Castellana, R. Jemmerson, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency.

J. Bartolomé-Nebreda, H. Tong, G. Macdonald, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.

C. Lindsley, P. Conn, S. Stauffer, 2011, Bioorganic & medicinal chemistry letters.

Allosteric Modulators of Metabotropic Glutamate Receptor 5 for Treatment of Schizophrenia

S. Jadhav, C. Lindsley, P. Conn, 2011 .

Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats

E. Luijtelaar, C. Lindsley, F. Biagioni, 2013, Neuropharmacology.

A Robust and Scalable High-Throughput Compatible Assay for Screening Amyloid-β-Binding Compounds.

R. Redha, P. Vinson, W. Pham, 2019, Journal of Alzheimer's disease : JAD.

Epileptiform Discharges in Hippocampal Slices Role of Synaptic Metabotropic Glutamate Receptors in

R. Wong, Z. Xiang, P. Conn, 2015 .

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D

Geetika Aggarwal, C. Weaver, P. Vinson, 2020, The Journal of Biological Chemistry.

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D

Geetika Aggarwal, C. Weaver, P. Vinson, 2020, The Journal of Biological Chemistry.

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.

S. Jadhav, K. Gregory, G. Macdonald, 2012, Bioorganic & medicinal chemistry letters.

Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility

S. Jadhav, C. Lindsley, P. Conn, 2010 .

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

S. Jadhav, J. Bartolomé-Nebreda, F. Delgado, 2013, Journal of medicinal chemistry.

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.

C. Lindsley, C. Hopkins, C. Niswender, 2011, Bioorganic & medicinal chemistry letters.

Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.

S. Jadhav, C. Lindsley, P. Conn, 2010, ACS medicinal chemistry letters.

Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function

H. Lavreysen, C. Lindsley, Hyekyung P. Cho, 2012, Molecular Pharmacology.

C. Lindsley, P. Conn, C. Niswender, 2013 .