A. Thompson

发表

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Kari A. Johnson, Z. Xiang, C. Lindsley, 2008, Molecular Pharmacology.

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

S. Jadhav, J. P. Kennedy, C. Lindsley, 2008, Journal of Pharmacology and Experimental Therapeutics.

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Brittney S. Bates, K. Gregory, Z. Xiang, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

C. Lindsley, S. Daniels, K. Niswender, 2014, Journal of medicinal chemistry.

Discovery, Synthesis, SAR Development of a Series of N -4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an anti-Parkinsonian Animal Model

Colleen, Y. Smith, C. Lindsley, 2011 .

Partial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects

Andrew S. Felts, C. Lindsley, P. Conn, 2016, Neuropsychopharmacology.

Sex-specific modulation of spinal nociception by α2-adrenoceptors: Differential regulation by estrogen and testosterone

A. Thompson, S. Nag, S. Mokha, 2008, Neuroscience.

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease.

Bruce J. Melancon, Z. Xiang, O. McManus, 2011, ACS chemical neuroscience.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Anna L. Blobaum, Y. Smith, S. Jadhav, 2011, Journal of medicinal chemistry.

Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents

Kari A. Johnson, K. Gregory, J. Bartolomé-Nebreda, 2015, Neuron.

Phosphodiesterase 10 A Regulates Alcohol and Saccharin Self-Administration in Rats

Robert L Barry, John C Gore, P Jeffrey Conn, 2014 .

Inhibition of ABL1 by tyrosine kinase inhibitors leads to a downregulation of MLH1 by Hsp70-mediated lysosomal protein degradation

Eva M. Goellner, A. Thompson, R. Plattner, 2022, Frontiers in Genetics.

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson's Disease

Anna L. Blobaum, M. Amalric, S. Jadhav, 2012, Journal of Pharmacology and Experimental Therapeutics.

Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia

A. Thompson, S. Nag, S. Mokha, 2010, PAIN®.

Roles of the M 1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson ’ s Disease

Z. Xiang, C. Lindsley, P. Conn, 2012 .

Roles of the M1 Muscarinic Acetylcholine Receptor Subtype in the Regulation of Basal Ganglia Function and Implications for the Treatment of Parkinson's Disease

Z. Xiang, C. Lindsley, P. Conn, 2012, Journal of Pharmacology and Experimental Therapeutics.

Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents.

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2015, Journal of medicinal chemistry.

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

C. Lindsley, C. Hopkins, P. Conn, 2015, Neuropharmacology.

The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU 0364770 Produces Efficacy Alone and in Combination with L-DOPA or an Adenosine 2 A Antagonist in Preclinical Rodent Models of Parkinson ’ s Disease

Anna L. Blobaum, M. Amalric, S. Jadhav, 2012 .

Microsoft Word-26751875-file00

Kari A. Johnson, Days, C. Lindsley, 2008 .

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Stephen M. Damon, A. Deutch, J. Wess, 2014, Neuropsychopharmacology.

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

S. Jadhav, J. P. Kennedy, C. Lindsley, 2008, Journal of Pharmacology and Experimental Therapeutics.