R. Williams

发表

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Kari A. Johnson, Z. Xiang, C. Lindsley, 2008, Molecular Pharmacology.

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Kari A. Johnson, C. Lindsley, C. Hopkins, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS.

C. Lindsley, P. Conn, C. Weaver, 2009, Bioorganic & medicinal chemistry letters.

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.

C. Lindsley, P. Conn, Stacey Lindsley, 2009, Bioorganic & medicinal chemistry letters.

Design of potent GlyT1 inhibitors: in vitro and in vivo profiles.

C. Lindsley, R. Williams, T. Bridges, 2008, Current opinion in molecular therapeutics.

Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7

Kari A. Johnson, P. Conn, C. Niswender, 2010, Molecular Pharmacology.

Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

C. Lindsley, H. Brown, Joy E. Marlo, 2009, Molecular Pharmacology.

Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago‐potentiator ADX‐47273

C. Lindsley, P. Conn, D. Engers, 2009, ChemMedChem.

Running title : Context-dependent pharmacology of mGluR 7 antagonists

Kari A. Johnson, P. Conn, C. Niswender, 2009 .

Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS).

C. Lindsley, C. Hopkins, P. Conn, 2010, Bioorganic & medicinal chemistry letters.

Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.

G. Macdonald, H. Lavreysen, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.

C. Lindsley, P. Conn, C. Niswender, 2009, Bioorganic & medicinal chemistry letters.

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2010, Molecular Pharmacology.

Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4.

C. Lindsley, C. Hopkins, P. Conn, 2010, ACS chemical neuroscience.

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.

D. Sheffler, J. P. Kennedy, C. Lindsley, 2008, Bioorganic & medicinal chemistry letters.

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

S. Jadhav, D. Sheffler, Z. Xiang, 2009, Molecular Pharmacology.

[125I]-Omega conotoxin binding to human frontal cortex from normal, Alzheimer's and non-Alzheimer's dementia patients

R. Williams, G. Miner, R. Colvin, 1990, Neurobiology of Aging.

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.

Andrew S. Felts, D. Sheffler, C. Lindsley, 2014, Bioorganic & medicinal chemistry letters.

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.

J. Macor, C. Albright, R. Olson, 2010, ACS medicinal chemistry letters.

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.

Kari A. Johnson, J. Wess, Z. Xiang, 2008, Nature chemical biology.

mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

M. Foster Olive, P. Jeffrey Conn, Craig W. Lindsley, 2009, Neuropsychopharmacology.

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold.

C. Lindsley, P. Conn, S. Stauffer, 2011, Bioorganic & medicinal chemistry letters.

Allosteric Modulators of Metabotropic Glutamate Receptor 5 for Treatment of Schizophrenia

S. Jadhav, C. Lindsley, P. Conn, 2011 .

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres.

D. Sheffler, C. Lindsley, P. Conn, 2014, Bioorganic & medicinal chemistry letters.

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover.

S. Jadhav, K. Gregory, G. Macdonald, 2012, Bioorganic & medicinal chemistry letters.

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

S. Jadhav, D. Sheffler, C. Lindsley, 2009, Molecular Pharmacology.