U. Le

发表

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

Anna L. Blobaum, S. Jadhav, C. Lindsley, 2011, Journal of medicinal chemistry.

Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype.

C. Lindsley, P. Conn, Stacey Lindsley, 2009, Bioorganic & medicinal chemistry letters.

A Thermo-Sensitive Polymeric Gel Containing a Gadolinium (Gd) Compound Encapsulated into Liposomes Significantly Extended the Retention of the Gd in Tumors

U. Le, Brian R. Sloat, Z. Cui, 2008 .

Advancement in Gemcitabine Delivery for Cancer Treatment

U. Le, 2015 .

Immunization by application of DNA vaccine onto a skin area wherein the hair follicles have been induced into anagen-onset stage.

C. Löhr, U. Le, Brian R. Sloat, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Biodistribution and tumor-accumulation of gadolinium (Gd) encapsulated in long-circulating liposomes in tumor-bearing mice for potential neutron capture therapy.

U. Le, Z. Cui, 2006, International journal of pharmaceutics.

Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

Andrew S. Felts, C. Lindsley, P. Conn, 2009, Bioorganic & medicinal chemistry letters.

Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

D. Sheffler, C. Lindsley, C. Hopkins, 2013, Bioorganic & medicinal chemistry letters.

Localized irradiation of tumors prior to synthetic dsRNA therapy enhanced the resultant anti-tumor activity.

U. Le, D. Kaurin, Brian R. Sloat, 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Tumor chemo-immunotherapy using gemcitabine and a synthetic dsRNA

C. Lohr, U. Le, Z. Cui, 2008, Cancer biology & therapy.

Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.

Bruce J. Melancon, Anna L. Blobaum, D. Sheffler, 2013, Bioorganic & medicinal chemistry letters.

Nasal immunization with the mixture of PA63, LF, and a PGA conjugate induced strong antibody responses against all three antigens.

U. Le, Brian R. Sloat, Z. Cui, 2008, FEMS immunology and medical microbiology.

Long-circulating gadolinium-encapsulated liposomes for potential application in tumor neutron capture therapy.

U. Le, Z. Cui, 2006, International journal of pharmaceutics.

Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.

O. McManus, C. Lindsley, Haibo Yu, 2012, Bioorganic & medicinal chemistry letters.

Extended Probe Characterization: Development of an M4 PAM with Improved Activity and Brain Exposure, while Avoiding Species Bias

Julie L. Engers, Bruce J. Melancon, D. Sheffler, 2013 .

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.

C. Lindsley, P. Conn, C. Niswender, 2009, Bioorganic & medicinal chemistry letters.

A thermo-sensitive polymeric gel containing a gadolinium (Gd) compound encapsulated into liposomes significantly extended the retention of the Gd in tumors.

U. Le, Brian R. Sloat, Z. Cui, 2008, Drug development and industrial pharmacy.

Learning from Viruses: The Necrotic Bodies of Tumor Cells with Intracellular Synthetic dsRNA Induced Strong Anti-tumor Immune Responses

Fu Qiu, U. Le, Z. Cui, 2007, Pharmaceutical Research.

Enhanced selective cellular uptake and cytotoxicity of epidermal growth factor-conjugated liposomes containing curcumin on EGFR-overexpressed pancreatic cancer cells

U. Le, G. Pillai, Amanda Hartman, 2017, Journal of drug targeting.

Methods for Polymeric Nanoparticle Conjugation to Monoclonal Antibodies

H. T. Tran, Y. Pathak, U. Le, 2012 .

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor.

Anna L. Blobaum, D. Sheffler, C. Lindsley, 2012, Bioorganic & medicinal chemistry letters.

Gabapentin in Elastic Liposomes: Preparation, Characterization, Drug Release, and Penetration Through Porcine Skin.

U. Le, Sarah Baltzley, Abeer AlGhananeem, 2018, International journal of pharmaceutical compounding.