Rocio Zamorano

发表

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.

Anna L. Blobaum, S. Jadhav, C. Lindsley, 2011, Journal of medicinal chemistry.

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

Kari A. Johnson, K. Gregory, P. Conn, 2014, The Journal of Neuroscience.

Discovery, Synthesis, SAR Development of a Series of N -4-(2,5-dioxopyrrolidin-1-yl)-phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an anti-Parkinsonian Animal Model

Colleen, Y. Smith, C. Lindsley, 2011 .

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Bruce J. Melancon, K. Gregory, Z. Xiang, 2014, ACS chemical neuroscience.

Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability.

Alison R. Gregro, Julie L. Engers, Anna L. Blobaum, 2018, Bioorganic & medicinal chemistry letters.

Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.

Anna L. Blobaum, C. Lindsley, C. Hopkins, 2011, ACS combinatorial science.

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkins

Anna L. Blobaum, Y. Smith, S. Jadhav, 2011, Journal of medicinal chemistry.

Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).

P Jeffrey Conn, Craig W Lindsley, Colleen M Niswender, 2009, Journal of medicinal chemistry.

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Anna L. Blobaum, Z. Xiang, C. Lindsley, 2017, Science Translational Medicine.

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

C. Lindsley, P. Conn, S. Stauffer, 2016, Human molecular genetics.

3'-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression.

Rocio Zamorano, S. Suchindran, J. Gainer, 2006, American journal of physiology. Renal physiology.

Regulator of Gene Expression

Rocio Zamorano, S. Suchindran, J. Gainer, 2005 .

Functional selectivity induced by mGlu4 receptor positive allosteric modulation and concomitant activation of Gq coupled receptors

P. Conn, C. Niswender, Rocio Zamorano, 2013, Neuropharmacology.

Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.

C. Lindsley, C. Hopkins, C. Niswender, 2011, Bioorganic & medicinal chemistry letters.