Daniel J. Wilson

发表

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.

S. Sarafianos, F. Liu, E. Nagy, 2016, Journal of medicinal chemistry.

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

B. Finzel, C. Aldrich, Daniel J. Wilson, 2014, Chembiochem : a European journal of chemical biology.

Evaluating the Sensitivity of Mycobacterium tuberculosis to Biotin Deprivation Using Regulated Gene Expression

D. Schnappinger, A. Blumenthal, K. Rhee, 2011, PLoS pathogens.

Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues.

Y. Sham, G. Magni, M. Di Stefano, 2009, Bioorganic & medicinal chemistry.

Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.

D. Sherman, Hung‐wen Liu, Lishan Zhao, 1998, Chemistry & biology.

Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.

C. Aldrich, C. Barry, H. Boshoff, 2012, ACS chemical biology.

Synthesis of macrocyclic α-ketoamide as a selective and reversible immunoproteasome inhibitor

Daniel J. Wilson, Liqiang Chen, Rui Ding, 2021, Medicinal Chemistry Research.

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.

G. Minasov, W. Anderson, L. Shuvalova, 2016, ACS infectious diseases.

Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.

Swati S. More, H. Cui, Daniel J. Wilson, 2014, Journal of medicinal chemistry.

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

L. Bonnac, Daniel J. Wilson, E. Bennett, 2007, Bioorganic & medicinal chemistry letters.

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

S. Sarafianos, E. Nagy, M. Parniak, 2014, Journal of medicinal chemistry.

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

C. Aldrich, C. Barry, H. Boshoff, 2006, Journal of medicinal chemistry.

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, K. Kirby, 2017, European journal of medicinal chemistry.

A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

D. Schnappinger, S. Chakraborty, K. Rhee, 2013, Proceedings of the National Academy of Sciences.

Aryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.

C. Aldrich, J. Neres, Daniel J. Wilson, 2008, Biochemistry.

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.

C. Aldrich, C. Barry, H. Boshoff, 2006, Organic letters.

N-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)benzamides: Antiproliferative Activity and Effects on mTORC1 and Autophagy.

R. Puertollano, Do-Hyung Kim, Jiashu Xie, 2017, ACS medicinal chemistry letters.

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2017, Journal of medicinal chemistry.

4,7-Disubstituted 7H-Pyrrolo[2,3-d]pyrimidines and Their Analogs as Antiviral Agents against Zika Virus

R. Geraghty, Daniel J. Wilson, Li Qiu, 2021, Molecules.

Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae

K. Reynolds, D. Sherman, Daniel J. Wilson, 2001 .

Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.

C. Salomon, Daniel J. Wilson, Zhengqiang Wang, 2007, Journal of medicinal chemistry.

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

Courtney C Aldrich, C. Xing, C. Aldrich, 2008, Journal of medicinal chemistry.

A continuous fluorescence displacement assay for BioA: an enzyme involved in biotin biosynthesis.

Joseph M. Muretta, Y. Sham, David D. Thomas, 2011, Analytical biochemistry.

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

C. Aldrich, C. Barry, H. Boshoff, 2008, Journal of medicinal chemistry.

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis.

C. Aldrich, H. Boshoff, Daniel J. Wilson, 2020, European journal of medicinal chemistry.

Bisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.

D. Schnappinger, Christopher L. Seiler, C. Aldrich, 2013, ACS medicinal chemistry letters.

Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli.

J. Blanchard, C. Aldrich, Daniel J. Wilson, 2010, Biochemistry.

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii.

C. Aldrich, C. Barry, H. Boshoff, 2013, Journal of medicinal chemistry.

Triazole-linked inhibitors of inosine monophosphate dehydrogenase from human and Mycobacterium tuberculosis.

Y. Sham, C. Aldrich, Daniel J. Wilson, 2010, Journal of medicinal chemistry.

β‐Diketonate versus β‐Ketoiminate: The Importance of a Ferrocenyl Moiety in Improving the Anticancer Potency

Daniel J. Wilson, C. Pask, P. McGowan, 2020, Chembiochem : a European journal of chemical biology.

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2019, European journal of medicinal chemistry.

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2018, European journal of medicinal chemistry.

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2018, European journal of medicinal chemistry.

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.

Andrew D. Huber, S. Sarafianos, Jing Tang, 2017, European journal of medicinal chemistry.

3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2016, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.

S. Sarafianos, F. Liu, E. Nagy, 2016, Journal of medicinal chemistry.

Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains.

C. Aldrich, Daniel J. Wilson, C. Shi, 2012, Chemistry & biology.

A mechanism-based aryl carrier protein/thiolation domain affinity probe.

Courtney C Aldrich, C. Aldrich, Chunhua Qiao, 2007, Journal of the American Chemical Society.

Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.

Leonardo K. Martinelli, V. Mizrahi, C. Aldrich, 2014, Bioorganic & medicinal chemistry.

Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase

Jiashu Xie, R. Geraghty, Daniel J. Wilson, 2022, ACS medicinal chemistry letters.

Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway ofStreptomyces venezuelae

K. Reynolds, D. Sherman, Daniel J. Wilson, 2001, Journal of bacteriology.

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Joshua A. Bittker, S. Schreiber, B. Finzel, 2015, Chemistry & biology.

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

B. Finzel, D. Schnappinger, Orishadipe Abayomi, 2011, Journal of the American Chemical Society.

Novel inhibitors of inosine monophosphate dehydrogenase in patent literature of the last decade.

Riccardo Petrelli, R. Petrelli, L. Cappellacci, 2013, Recent patents on anti-cancer drug discovery.

Mycophenolic acid analogs with a modified metabolic profile.

Daniel J. Wilson, Liqiang Chen, K. Pankiewicz, 2008, Bioorganic & medicinal chemistry.

A continuous kinetic assay for adenylation enzyme activity and inhibition.

C. Aldrich, Daniel J. Wilson, 2010, Analytical biochemistry.

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

R. Petrelli, P. Kusumanchi, Daniel J. Wilson, 2011, Bioorganic & medicinal chemistry.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

The chemiluminescence based Ziplex® automated workstation focus array reproduces ovarian cancer Affymetrix GeneChip® expression profiles

Anne-Marie Mes-Masson, A. Mes-Masson, D. Provencher, 2009, Journal of Translational Medicine.

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.

C. Aldrich, C. Barry, H. Boshoff, 2007, Journal of medicinal chemistry.

5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors.

Swati S. More, Jiashu Xie, Daniel J. Wilson, 2016, Journal of medicinal chemistry.

Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay.

C. Aldrich, Daniel J. Wilson, B. Duckworth, 2016, Methods in molecular biology.

Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase.

R. Petrelli, M. Olesiak, Daniel J. Wilson, 2008, Bioorganic & medicinal chemistry.

Discovery of Irreversible p97 Inhibitors.

Y. Ye, Jiashu Xie, Yue Xu, 2019, Journal of medicinal chemistry.

The shikimic acid pathway and polyketide biosynthesis

K. Reynolds, D. Wilson, Daniel J. Wilson, 1998, Journal of Industrial Microbiology and Biotechnology.

Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High‐Throughput Screening

C. Aldrich, J. Neres, R. Remmel, 2010, ChemMedChem.

Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis

Linnan Zhu, D. Schnappinger, S. Ehrt, 2023, mBio.

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

B. Finzel, D. Schnappinger, S. W. Park, 2011, Journal of the American Chemical Society.

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Joshua A. Bittker, S. Schreiber, B. Finzel, 2015, Chemistry & biology.

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.

C. Aldrich, Daniel J. Wilson, C. Shi, 2013, Biochemistry.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Y. Sham, R. Petrelli, Daniel J. Wilson, 2010, Bioorganic & medicinal chemistry.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Daniel J. Wilson, Liqiang Chen, K. Pankiewicz, 2007, Journal of Medicinal Chemistry.

Inhibition of Mycobacterium tuberculosis Transaminase BioA by Aryl Hydrazines and Hydrazides

B. Finzel, C. Aldrich, Daniel J. Wilson, 2014, Chembiochem : a European journal of chemical biology.