Zhengqiang Wang

发表

3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations.

S. Sarafianos, F. Liu, E. Nagy, 2016, Journal of medicinal chemistry.

Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

T. Yan, Wei Li, Zhengqiang Wang, 2017, Oxidative medicine and cellular longevity.

Novel Hepatitis B Virus Capsid-Targeting Antiviral That Aggregates Core Particles and Inhibits Nuclear Entry of Viral Cores.

Andrew D. Huber, Emily M. Coonrod, S. Sarafianos, 2018, ACS infectious diseases.

Mutational and functional genetics mapping of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia

J. A. Patino-Galindo, M. Loh, A. Ferrando, 2020, Nature Cancer.

Core–shell metal–organic frameworks and hierarchical host–guest structures toward water-stable luminescence of lanthanide complexes in encoding beads

K. Cai, Jixi Zhang, Zhengqiang Wang, 2020 .

Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus.

M. Parniak, Nataliya S. Myshakina, Zhengqiang Wang, 2013, Journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2017, European journal of medicinal chemistry.

The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release

Rommie E. Amaro, K. Shi, P. Ieong, 2018, The Journal of Biological Chemistry.

New fluorescence‐based high‐throughput screening assay for small molecule inhibitors of tyrosyl‐DNA phosphodiesterase 2 (TDP2)

Y. Pommier, K. Shi, E. Kiselev, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

S. Sarafianos, E. Nagy, M. Parniak, 2014, Journal of medicinal chemistry.

Synthesis and antiviral evaluation of 4′-(1,2,3-triazol-1-yl)thymidines

Jeana Zacharias, R. Geraghty, Zhengqiang Wang, 2014 .

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.

Y. Pommier, Shar-yin N. Huang, H. Sasanuma, 2016, ACS chemical biology.

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, K. Kirby, 2017, European journal of medicinal chemistry.

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting HIV Reverse Transcriptase-Associated Ribonuclease H

S. Sarafianos, Zhengqiang Wang, Lei Wang, 2020 .

4-benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors

H. Aihara, Zhengqiang Wang, Tianyu He, 2020, Medicinal Chemistry Research.

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2017, Journal of medicinal chemistry.

Taurine ameliorated homocysteine-induced H9C2 cardiomyocyte apoptosis by modulating endoplasmic reticulum stress

Wei Li, Zhengqiang Wang, Zhimin Zhang, 2017, Apoptosis.

[4 + 1] cycloaddition of N-heterocyclic carbenes with vinyl isocyanates.

Zhengqiang Wang, J. H. Rigby, J. Rigby, 2002, Organic letters.

Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment

Jiashu Xie, Zhengqiang Wang, 2021, Acta Pharmaceutica Sinica B.

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.

Y. Sham, R. Geraghty, Jing Tang, 2012, Bioorganic & medicinal chemistry.

Synthesis of highly substituted cyclopentenones via the [4 + 1] cycloaddition of nucleophilic carbenes and vinyl ketenes.

Zhengqiang Wang, J. H. Rigby, 2003, Organic letters.

Rotten to the core: antivirals targeting the HIV-1 capsid core

William M. McFadden, S. Sarafianos, M. Raj, 2021, Retrovirology.

Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.

C. Salomon, Daniel J. Wilson, Zhengqiang Wang, 2007, Journal of medicinal chemistry.

Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.

Jiashu Xie, H. Aihara, Zhengqiang Wang, 2019, Bioorganic & medicinal chemistry letters.

Synthesis of pyrimidine and quinolone conjugates as a scaffold for dual inhibitors of HIV reverse transcriptase and integrase.

Zhengqiang Wang, R. Vince, 2008, Bioorganic & medicinal chemistry letters.

Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.

S. Sarafianos, Jiashu Xie, K. Kirby, 2021, RSC medicinal chemistry.

Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2019, European journal of medicinal chemistry.

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2018, European journal of medicinal chemistry.

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H.

Andrew D. Huber, S. Sarafianos, M. Parniak, 2018, European journal of medicinal chemistry.

A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

Andrew D. Huber, Skyler T. Kramer, S. Sarafianos, 2017, Antimicrobial Agents and Chemotherapy.

3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Andrew D. Huber, S. Sarafianos, H. Mitsuya, 2017, Antimicrobial Agents and Chemotherapy.

6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.

Andrew D. Huber, S. Sarafianos, Jing Tang, 2017, European journal of medicinal chemistry.

3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2016, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.

S. Sarafianos, F. Liu, E. Nagy, 2016, Journal of medicinal chemistry.

6-Benzoyl-3-hydroxypyrimidine-2,4-diones as dual inhibitors of HIV reverse transcriptase and integrase.

Y. Pommier, Y. Sham, Jing Tang, 2011, Bioorganic & medicinal chemistry letters.

3-Hydroxypyrimidine-2,4-diones as an inhibitor scaffold of HIV integrase.

Yves Pommier, Y. Pommier, Y. Sham, 2011, Journal of Medicinal Chemistry.

N-3 Hydroxylation of Pyrimidine-2,4-diones Yields Dual Inhibitors of HIV Reverse Transcriptase and Integrase.

Y. Pommier, Y. Sham, Jing Tang, 2011, ACS medicinal chemistry letters.

Pharmacophore and structure-activity relationships of integrase inhibition within a dual inhibitor scaffold of HIV reverse transcriptase and integrase.

C. Salomon, Jing Tang, Zhengqiang Wang, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: introducing a diketoacid functionality into delavirdine.

Zhengqiang Wang, R. Vince, 2008, Bioorganic & medicinal chemistry.

5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus.

Hongmin Li, R. Geraghty, Zhengqiang Wang, 2015, Journal of medicinal chemistry.

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.

S. Sarafianos, Zhengqiang Wang, Zhengqiang Wang, 2019, Accounts of chemical research.

Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

Yan Wang, R. Geraghty, Zhengqiang Wang, 2018, ChemMedChem.

Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase

S. Sarafianos, M. Parniak, B. Marchand, 2012, Antimicrobial Agents and Chemotherapy.

Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited.

Y. Pommier, Y. Sham, Jing Tang, 2010, Bioorganic & medicinal chemistry letters.

4,5-Dihydroxypyrimidine Methyl Carboxylates, Carboxylic Acids, and Carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.

Jiashu Xie, R. Geraghty, H. Aihara, 2022, Journal of medicinal chemistry.

5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

Y. Pommier, F. Chen, Y. Sham, 2012, Journal of medicinal chemistry.

Discovery of New Small Molecule Hits as Hepatitis B Virus Capsid Assembly Modulators: Structure and Pharmacophore-Based Approaches

S. Sarafianos, Haijuan Du, Jiashu Xie, 2021, Viruses.

Effect of Mo Addition on the Precipitation Behavior of Carbide in Nb-Bearing HSLA Steel

Q. Yong, Zhengqiang Wang, Zhao-dong Li, 2016 .

The Heteroaryldihydropyrimidine Bay 38-7690 Induces Hepatitis B Virus Core Protein Aggregates Associated with Promyelocytic Leukemia Nuclear Bodies in Infected Cells

Andrew D. Huber, Emily M. Coonrod, S. Sarafianos, 2018, mSphere.

Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

Zhengke Li, J. Moorman, M. El Gazzar, 2020, Cell Death & Disease.

Repurposing N-hydroxy thienopyrimidine-2,4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: Synthesis and biological characterization.

Jiashu Xie, R. Geraghty, Zhengqiang Wang, 2022, Bioorganic chemistry.

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

S. Sarafianos, Haijuan Du, Jiashu Xie, 2020, Acta pharmaceutica Sinica. B.

Novel HIV-1 capsid-targeting small molecules of the PF74 binding site.

S. Sarafianos, Haijuan Du, Jiashu Xie, 2020, European journal of medicinal chemistry.

Chemical profiling of HIV-1 capsid-targeting antiviral PF74.

S. Sarafianos, Haijuan Du, Jiashu Xie, 2020, European journal of medicinal chemistry.

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

S. Sarafianos, Haijuan Du, Jiashu Xie, 2020, Viruses.

Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74

S. Sarafianos, Haijuan Du, Jiashu Xie, 2021, Viruses.

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage

Yan Wang, R. Geraghty, Zhengqiang Wang, 2016, Journal of Virology.

Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV)

Yan Wang, Jiashu Xie, R. Geraghty, 2021, Acta pharmaceutica Sinica. B.

Metal‐chelating 3‐hydroxypyrimidine‐2,4‐diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication

Yan Wang, R. Geraghty, Jing Tang, 2018, Antiviral research.

5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors.

Andrew D. Huber, S. Sarafianos, Jiashu Xie, 2019, European journal of medicinal chemistry.

Molecular Dynamics Free Energy Simulations Reveal the Mechanism for the Antiviral Resistance of the M66I HIV-1 Capsid Mutation

R. Levy, S. Sarafianos, N. Deng, 2021, Viruses.

Determinants of Active-Site Inhibitor Interaction with HIV-1 RNase H.

S. Sarafianos, R. Ishima, Nataliya S. Myshakina, 2019, ACS infectious diseases.

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.

Y. Pommier, Jiashu Xie, E. Kiselev, 2019, Journal of medicinal chemistry.

Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.

Y. Pommier, Jiashu Xie, E. Kiselev, 2019, DNA repair.

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

Y. Pommier, C. Marchand, H. Aihara, 2016, Journal of medicinal chemistry.

C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus.

Jeana Zacharias, R. Geraghty, Zhengqiang Wang, 2012, Bioorganic & medicinal chemistry.

Antiviral activities of two nucleos(t)ide analogs against vaccinia and mpox viruses in primary human fibroblasts

Zhilong Yang, Zhengqiang Wang, P. S. Satheshkumar, 2023, bioRxiv.

Antiviral activities of two nucleos(t)ide analogs against vaccinia, mpox, and cowpox viruses in primary human fibroblasts

Zhilong Yang, Zhengqiang Wang, P. S. Satheshkumar, 2023, Antiviral research.

Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

Zhengke Li, J. Moorman, M. El Gazzar, 2020, Cell Death & Disease.

8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease

R. Geraghty, Zhengqiang Wang, Ruben Soto-Acosta, 2022, ChemMedChem.

Metal binding 6-arylthio-3-hydroxypyrimidine-2,4-diones inhibited human cytomegalovirus by targeting the pUL89 endonuclease of the terminase complex.

Jiashu Xie, R. Geraghty, H. Aihara, 2021, European journal of medicinal chemistry.

Antiviral activities of two nucleos(t)ide analogs against vaccinia, mpox, and cowpox viruses in primary human fibroblasts

Zhilong Yang, Zhengqiang Wang, P. S. Satheshkumar, 2023, Antiviral research.

Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation

D. J. Clarke, M. Dasso, N. Saitoh, 2023, iScience.

C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus.

Jeana Zacharias, R. Geraghty, Zhengqiang Wang, 2012, Bioorganic & medicinal chemistry.

Inhibiting HCMV pUL89-C Endonuclease with Metal-Binding Compounds.

R. Geraghty, Zhengqiang Wang, A. Jagtap, 2023, Journal of medicinal chemistry.