K. Freeman

发表

An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.

R. Speth, Cody J Lensing, K. Freeman, 2016, Journal of medicinal chemistry.

Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2018, Journal of medicinal chemistry.

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.

I. Pogozheva, Mark D. Ericson, H. Mosberg, 2019, Journal of medicinal chemistry.

Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2017, Journal of medicinal chemistry.

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2017, Journal of medicinal chemistry.

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors.

R. Speth, Cody J Lensing, K. Freeman, 2019, Journal of medicinal chemistry.

Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2019, Journal of medicinal chemistry.

1,2,3-Triazole Rings as a Disulfide Bond Mimetic in Chimeric AGRP-Melanocortin Peptides: Design, Synthesis, and Functional Characterization.

J. Rocca, Cody J Lensing, K. Freeman, 2017, ACS chemical neuroscience.

Synthesis and Pharmacology of α/β(3)-Peptides Based on the Melanocortin Agonist Ac-His-dPhe-Arg-Trp-NH2 Sequence.

K. Freeman, C. Haskell-Luevano, S. R. Tala, 2015, ACS medicinal chemistry letters.

Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2022, ACS omega.

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2021, Journal of medicinal chemistry.

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020, ACS medicinal chemistry letters.

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2019, ACS medicinal chemistry letters.

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2019, Molecules.

Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2018, ACS chemical neuroscience.

Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.

Mark D. Ericson, M. M. Lunzer, K. Freeman, 2018, ACS chemical neuroscience.

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2015, Bioorganic & medicinal chemistry letters.

Peptoid NPhe4 in AGRP-Based c[Pro1-Arg2-Phe3-Phe4-Xxx5-Ala6-Phe7-DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020, ACS medicinal chemistry letters.

Peptoid NPhe in AGRP-Based c[Pro‐Arg‐Phe‐Phe‐Xxx‐Ala‐Phe‐DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020 .

Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.

Mark D. Ericson, R. Speth, B. Smeester, 2018, Journal of medicinal chemistry.

Neuroplasticity of Sensory and Sympathetic Nerve Fibers in the Painful Arthritic Joint

P. Mantyh, M. Kuskowski, K. Freeman, 2012 .

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.

Mark D. Ericson, R. Speth, K. Freeman, 2021, ACS chemical neuroscience.

Development of hMC1R Selective Small Agonists for Sunless Tanning and Prevention of Genotoxicity of UV in Melanocytes.

V. Swope, Renny J. Starner, Z. Abdel‐Malek, 2021, The Journal of investigative dermatology.

Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2009, Neuroscience.

Breast cancer-induced bone remodeling, skeletal pain, and sprouting of sensory nerve fibers.

P. Mantyh, M. Kuskowski, K. Freeman, 2011, The journal of pain : official journal of the American Pain Society.

Pathological Sprouting of Adult Nociceptors in Chronic Prostate Cancer-Induced Bone Pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, The Journal of Neuroscience.

Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint.

P. Mantyh, M. Kuskowski, K. Freeman, 2012, Arthritis and rheumatism.

Inhibition of Cancer Cell Proliferation and Metastasis by Insulin Receptor Downregulation

D. Yee, Hua Zhang, D. Sachdev, 2010, Oncogene.

Nerve growth factor sequestering therapy attenuates non-malignant skeletal pain following fracture

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2007, PAIN®.

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage.

R. Speth, Cody J Lensing, K. Freeman, 2017, ACS chemical neuroscience.

Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, Neuroscience.

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2021, Journal of medicinal chemistry.

Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2017, Journal of medicinal chemistry.

Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2010, Molecular pain.

LOCKADE OF NERVE SPROUTING AND NEUROMA FORMATION ARKEDLY ATTENUATES THE DEVELOPMENT OF LATE STAGE ANCER PAIN

K. Freeman, J. Ghilardi, M. Kaczmarska, 2022 .

Effects of a Monoclonal Antibody Raised Against Nerve Growth Factor on Skeletal Pain and Bone Healing After Fracture of the C57BL/6J Mouse Femur

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The effect of aging on the density of the sensory nerve fiber innervation of bone and acute skeletal pain

P. Mantyh, M. Kuskowski, W. Mantyh, 2012, Neurobiology of Aging.

The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2023, International journal of molecular sciences.

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and E ﬃ cacy

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020 .

Health behaviors and goal setting among Karen youth

K. Freeman, Christine C. Danner, D. Brandenburg, 2019 .

A Fracture Pain Model in the Rat: Adaptation of a Closed Femur Fracture Model to Study Skeletal Pain

Ryan J. Buus, P. Mantyh, M. Kuskowski, 2008, Anesthesiology.

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers.

P. Mantyh, M. Kuskowski, W. Mantyh, 2011, Bone.