P. Reggio

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One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

M. Glass, J. Flanagan, Karan Govindpani, 2016, Trends in pharmacological sciences.

Computational methods in drug design: Modeling G protein-coupled receptor monomers, dimers, and oligomers

Patricia H. Reggio, P. Reggio, 2006, The AAPS Journal.

Models of Cannabinoid Inverse Agonism, Neutral Antagonism, and Agonism: Tools for Rational Drug Design

D. Hurst, P. Reggio, 2009 .

CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

D. Bolognini, S. McAllister, R. Pertwee, 2013, Molecular Pharmacology.

Cannabinoid receptors and their ligands: ligand-ligand and ligand-receptor modeling approaches.

P. Reggio, 2005, Handbook of experimental pharmacology.

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.

D. Lynch, D. Hurst, P. Reggio, 2002, Molecular pharmacology.

Opioid receptors: toward separation of analgesic from undesirable effects.

H. Loh, P. Law, P. Reggio, 2013, Trends in biochemical sciences.

Intensity fluctuation light scattering by bacteriophage particles

P. Reggio, J. A. Mayo, M. Gaertner, 1978 .

An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors

P. Morales, P. Reggio, 2017, Cannabis and cannabinoid research.

An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors

P. Morales, P. Reggio, 2017, Cannabis and cannabinoid research.

Methods for the Development of In Silico GPCR Models.

P. Morales, D. Hurst, P. Reggio, 2017, Methods in enzymology.

Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction.

M. Pitman, Derek M. Shore, D. Lynch, 2017, Methods in enzymology.

Inhibition of Milk Ingestion and Growth After Administration of a Neutral Cannabinoid CB1 Receptor Antagonist on the First Postnatal Day in the Mouse

P. Reggio, E. Fride, H. Seltzman, 2007, Pediatric Research.

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

G. Hynd, D. Selley, Ming-Jung Wu, 2005, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of GPR55 agonists.

M. Caron, D. Hurst, P. Reggio, 2017, Bioorganic & medicinal chemistry.

Synthesis, Pharmacological Evaluation, and Docking Studies of Novel Pyridazinone‐Based Cannabinoid Receptor Type 2 Ligands

S. Merighi, S. Gessi, P. Morales, 2018, ChemMedChem.

A Molecular Reactivity Template for Cannabinoid Activity

A. P. Mazurek, P. Reggio, 1987 .

Properties of atoms in molecules. IV. Atomic charges in some linear polyatomic molecules

P. Politzer, P. Reggio, 1972 .

Pregnenolone Can Protect the Brain from Cannabis Intoxication

P. Piazza, U. Spampinato, R. Maldonado, 2014, Science.

Characterization of a region of steric interference at the cannabinoid receptor using the active analog approach.

P. Reggio, A. Panu, S. Miles, 1993, Journal of medicinal chemistry.

Investigation of the role of the phenolic hydroxyl in cannabinoid activity.

D. R. Compton, B. Martin, P. Reggio, 1990, Molecular pharmacology.

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.

G. Thakur, Abhijit R. Kulkarni, R. Pertwee, 2016, ACS chemical neuroscience.

The therapeutic potential of orphan GPCRs, GPR35 and GPR55

Derek M. Shore, P. Reggio, Derek M Shore, 2015, Front. Pharmacol..

3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.

Ming-Jung Wu, B. Martin, J. Wiley, 2003, Bioorganic & medicinal chemistry.

Metabolic Profiling of CB1 Neutral Antagonists.

J. Tam, P. Reggio, R. Maitra, 2017, Methods in enzymology.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes.

K. Mackie, L. Marnett, A. Hohmann, 2018, Journal of medicinal chemistry.

Accelerating Membrane Simulations with Hydrogen Mass Repartitioning Hydrogen

J. Gumbart, Hyea Hwang, K. Lundquist, 2020 .

The NPXXY Motif Regulates β-Arrestin Recruitment by the CB1 Cannabinoid Receptor.

S. Schulz, D. Tilley, Luciana M. Leo, 2022, Cannabis and cannabinoid research.

Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies.

Sumanta Garai, G. Thakur, D. Hurst, 2019, ACS medicinal chemistry letters.

Identi ﬁ cation of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure − Activity Relationship Studies

Sumanta Garai, G. Thakur, D. Hurst, 2019 .

A dual substrate kinetic model for cytochrome P450BM3-F87G catalysis: simultaneous binding of long chain aldehydes and 4-fluorophenol

Ghalib Khan, G. Raner, D. Hurst, 2017, Biotechnology Letters.

The Nucleotide-Free State of the Cannabinoid CB2/Gi Complex

D. Lynch, D. Hurst, P. Reggio, 2020, Cell.

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

B. Martin, J. Wiley, D. Hurst, 2010, Bioorganic & medicinal chemistry.

Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593

Sumanta Garai, G. Thakur, R. Pertwee, 2022, Frontiers in Pharmacology.

The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor.

R. Pertwee, L. Stevenson, S. Fernando, 1995, Life sciences.

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.

M. García-Arencibia, J. Fernández-Ruiz, P. Morales, 2015, European journal of medicinal chemistry.

Ligand-ligand and ligand-receptor approaches to modeling the cannabinoid CB1 and CB2 receptors: achievements and challenges.

P. Reggio, 1999, Current medicinal chemistry.

Adamantyl cannabinoids: a novel class of cannabinergic ligands.

J. Deschamps, C. George, G. Thakur, 2005, Journal of medicinal chemistry.

The importance of the orientation of the C9 substituent to cannabinoid activity.

P. Reggio, K. Greer, S. M. Cox, 1989, Journal of medicinal chemistry.

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.

Alexandros Makriyannis, Patricia H Reggio, David R Janero, 2008, Chemistry & biology.

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.

R. Franco, Gemma Navarro, C. Guaza, 2016, Journal of medicinal chemistry.

Chromenopyrazoles: Non‐psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties

J. Cumella, J. Fernández-Ruiz, P. Morales, 2012, ChemMedChem.

Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation.

J. Ballesteros, P. Reggio, J A Ballesteros, 1995, Life sciences.

Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.

K. Mackie, A. Makriyannis, L. Bohn, 2015, ACS chemical neuroscience.

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

R. Hampson, D. Deutsch, S. Childers, 2011, British journal of pharmacology.

Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors

R. Osman, H. Weinstein, P. Reggio, 1981 .

Mild Generation of o-Quinone Methides. Synthesis of (-)-Hexahydrocannabinol and Dihydrocannabidiol

Tiansheng Wang, P. Reggio, H. Seltzman, 2000 .

Computational studies of the 3‐Dimensional structure of cyclopenta polycyclic aromatic hydrocarbons containing a gulf region

J. Rabinowitz, P. Reggio, R. Venegas, 1992 .

International Cannabis Research Society meeting summary, Keystone, CO (June 19-20, 1992).

S. Deadwyler, R. Mechoulam, B. Martin, 1993, Drug and alcohol dependence.

Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer

Diane L. Lynch, Patricia H. Reggio, D. Lynch, 2006, J. Comput. Aided Mol. Des..

Thienopyrimidine Derivatives as GPR55 Receptor Antagonists: Insight into Structure–Activity Relationship

J. Fernández-Ruiz, P. Morales, D. Hurst, 2022, ACS medicinal chemistry letters.

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

S. McAllister, Daniel Fleischer, D. Lynch, 2006, Journal of medicinal chemistry.

Design, synthesis, and evaluation of substituted alkylindoles that activate G protein-coupled receptors distinct from the cannabinoid CB1 and CB2 receptors.

A. Howlett, N. Stella, D. Hurst, 2023, European journal of medicinal chemistry.

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.

B. Thomas, R. Pertwee, B F Thomas, 1998, Journal of medicinal chemistry.

An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.

Mary E Abood, Sharon Anavi-Goffer, Dow P Hurst, 2003, Journal of medicinal chemistry.

Endocannabinoid structure-activity relationships for interaction at the cannabinoid receptors.

P. Reggio, 2002, Prostaglandins, leukotrienes, and essential fatty acids.

Conformational requirements for endocannabinoid interaction with the cannabinoid receptors, the anandamide transporter and fatty acid amidohydrolase.

P. Reggio, H. Traore, Hassimi Traore, 2000, Chemistry and physics of lipids.

Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor

Derek M. Shore, P. Reggio, J. Marcu, 2013, The Journal of Biological Chemistry.

Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor.

D. Hurst, P. Reggio, M. Abood, 2017, Biochemistry.

Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.

M. Caron, T. Chung, Yushi Bai, 2011, Biochemistry.

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues.

Nicholas H Oberlies, Dow P Hurst, Patricia H Reggio, 2015, Bioorganic & medicinal chemistry.

The Relationship between Endocannabinoid Conformation and Endocannabinoid Interaction at the Cannabinoid Receptors

P. Reggio, 2005 .

Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories.

F Guarnieri, F. Guarnieri, D. Hurst, 1998, Journal of medicinal chemistry.

Cannabinoid Ligands Targeting TRP Channels

P. Morales, P. Reggio, Chanté Muller, 2019, Front. Mol. Neurosci..

An Analysis of the Putative CBD Binding Site in the Ionotropic Cannabinoid Receptors

P. Reggio, Chanté Muller, 2020, Frontiers in Cellular Neuroscience.

Emerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models.

P. Morales, P. Reggio, 2020, Advances in experimental medicine and biology.

Structural Insights into CB1 Receptor Biased Signaling

P. Morales, P. Reggio, Rufaida M. Al-Zoubi, 2019, International journal of molecular sciences.

Stereoselective synthesis of the epimeric Δ7-tetrahydrocannabinols

D. R. Compton, B. Martin, P. Reggio, 1995 .

GPR6 Structural Insights: Homology Model Construction and Docking Studies

Israa H Isawi, Paula Morales, Noori Sotudeh, 2020, Molecules.

Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity

P. Morales, D. Lynch, D. Hurst, 2019, International journal of molecular sciences.

A Lipid Pathway for Ligand Binding Is Necessary for a Cannabinoid G Protein-coupled Receptor*

Tod D Romo, Alan Grossfield, Dow P Hurst, 2010, The Journal of Biological Chemistry.

Conformational memories with variable bond angles

Robert M. Whitnell, Patricia H. Reggio, Dow P. Hurst, 2008, J. Comput. Chem..

Cysteine 2.59(89) in the Second Transmembrane Domain of Human CB2 Receptor Is Accessible within the Ligand Binding Crevice: Evidence for Possible CB2 Deviation from a Rhodopsin Template

D. Hurst, P. Reggio, J. Barnett-Norris, 2005, Molecular Pharmacology.

Structural Mimicry in Class A G Protein-coupled Receptor Rotamer Toggle Switches

S. McAllister, D. Lynch, D. Hurst, 2004, Journal of Biological Chemistry.

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.

F Guarnieri, F. Guarnieri, D. Lynch, 2002, The journal of peptide research : official journal of the American Peptide Society.

Agonist alkyl tail interaction with cannabinoid CB1 receptor V6.43/I6.46 groove induces a helix 6 active conformation

J. Ballesteros, F. Guarnieri, D. Hurst, 2002 .

Molecular Targets of the Phytocannabinoids: A Complex Picture.

P. Morales, D. Hurst, P. Reggio, 2017, Progress in the chemistry of organic natural products.

Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.

Patricia H Reggio, D. Lynch, P. Reggio, 2005, Life sciences.

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

H. Loh, P. Law, Yali Zhou, 2012, BMC Cell Biology.

A review of recent advances in cannabinoid research and the 1994 International Symposium on Cannabis and the Cannabinoids.

R. Musty, P. Reggio, P. Consroe, 1995, Life sciences.

The Difference between the CB1 and CB2Cannabinoid Receptors at Position 5.46 Is Crucial for the Selectivity of WIN55212-2 for CB2

Patricia H. Reggio, Dow P. Hurst, D. Hurst, 1999 .

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

M. Caron, T. Chung, Yushi Bai, 2011, Biochemistry.

Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations.

D. Hurst, P. Reggio, Marianne G. Schmeisser, 2013, Chemistry and physics of lipids.

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12

P. Morales, P. Reggio, Israa H. Isawi, 2018, Drug metabolism reviews.

Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown.

P. Reggio, 2010, Current medicinal chemistry.

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

E. Brǎiloiu, P. Morales, D. Hurst, 2020, Journal of medicinal chemistry.

Overview of Non-CB1/CB2 Cannabinoid Receptors: Chemistry and Modeling

P. Reggio, Evangelia Kotsikorou, 2013 .

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

Benjamin J. Whalley, M. Pistis, M. Melis, 2018 .

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

D. Lynch, P. Reggio, M. Abood, 2011, Chemistry and physics of lipids.

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

P. Morales, P. Reggio, N. Jagerovic, 2017, Front. Pharmacol..

Toward the design of cannabinoid CB1 receptor inverse agonists and neutral antagonists

P. Reggio, 2009 .

Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor.

Dow P Hurst, Patricia H Reggio, N. M. Nebane, 2008, Biochemistry.

Pharmacophores for ligand recognition and activation/inactivation of the cannabinoid receptors.

Patricia H Reggio, P. Reggio, 2003, Current pharmaceutical design.

CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

Brandie M. Ehrmann, V. Di Marzo, A. Ligresti, 2014, Journal of medicinal chemistry.

Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7

Daniel Fleischer, Mary E Abood, Alexandros Makriyannis, 2007, Molecular Pharmacology.

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators

P. Morales, P. Reggio, N. Jagerovic, 2022, Frontiers in Molecular Biosciences.

Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity.

D. Holt, A. Hoffman, C. Lupica, 2009, European journal of medicinal chemistry.

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.

J. Andreassi, S. McAllister, G. Cabral, 1999, Molecular pharmacology.

The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2).

D. Hurst, P. Reggio, D P Hurst, 1999, Molecular pharmacology.

A search for properties which produce discrimination between cannabinoid psychoactivity and analgesic activity

P. Reggio, 1992 .

CBD: A New Hope?

P. Morales, P. Reggio, 2019, ACS medicinal chemistry letters.

A Closer Look at Anandamide Interaction With TRPV1

D. Lynch, D. Hurst, P. Reggio, 2020, Frontiers in Molecular Biosciences.

Global Fold of Human Cannabinoid Type 2 Receptor Probed by Solid-State NMR and Molecular Dynamics Simulations

M. Pitman, K. Gawrisch, A. Grossfield, 2015 .

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.

F. Guarnieri, A. Makriyannis, D. Lynch, 2002, Journal of medicinal chemistry.

Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior

R. Spanagel, O. Manzoni, B. Lutz, 2015, The Journal of Neuroscience.

The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).

Evangelia Kotsikorou, Herbert H Seltzman, Dow P Hurst, 2013, Journal of medicinal chemistry.

The Cannabinoid Receptors

P. Reggio, 2009 .

Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.

M. Caron, M. E. Meza-Aviña, T. Gamage, 2016, Bioorganic & medicinal chemistry letters.

Targeting of the Orphan Receptor GPR35 by Pamoic Acid: A Potent Activator of Extracellular Signal-Regulated Kinase and β-Arrestin2 with Antinociceptive Activity

M. Caron, T. Chung, M. Adler, 2010, Molecular Pharmacology.

Helix 8 Leu in the CB1 Cannabinoid Receptor Contributes to Selective Signal Transduction Mechanisms*

A. Howlett, Daniel Fleischer, D. Lynch, 2007, Journal of Biological Chemistry.

Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.

J. Deschamps, S. Schulz, Sumanta Garai, 2021, Journal of Medicinal Chemistry.

Structural Basis of G Protein-coupled Receptor-Gi Protein Interaction

Alan Grossfield, Nicholas Leioatts, Dow P Hurst, 2014, The Journal of Biological Chemistry.

Accelerating Membrane Simulations with Hydrogen Mass Repartitioning.

J. Gumbart, A. Pavlova, Hyea Hwang, 2019, Journal of chemical theory and computation.

TRPV1 Activation by Anandamide via a Unique Lipid Pathway

Diane L. Lynch, Patricia H. Reggio, Dow P. Hurst, 2021, J. Chem. Inf. Model..

A Molecular Reactivity Template for Cannabinoid Analgesic Activity

A. P. Mazurek, P. Reggio, V. Frecer, 1990 .

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols

Rishi Sharma, S. Nikas, A. Makriyannis, 2014, Journal of medicinal chemistry.

Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of CB1 Receptor Positive Allosteric Modulators.

K. Mackie, A. Hohmann, Sumanta Garai, 2019, Journal of medicinal chemistry.

Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.

D. R. Compton, B. Martin, J. Wiley, 1996, Journal of medicinal chemistry.

Molecular determinants for the agonist activity of 2-methylhistamine and 4-methylhistamine at H2-receptors.

H. Weinstein, P. Reggio, S. Topiol, 1986, Journal of medicinal chemistry.

A rational search for the separation of psychoactivity and analgesia in cannabinoids

G. McGaughey, D. R. Compton, B. Martin, 1991, Pharmacology Biochemistry and Behavior.

Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels

M. Rice, P. Reggio, Zsuzsanna Sidló, 2008, Neurochemistry International.

GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect.

Chongguang Chen, L. Liu-Chen, D. Lynch, 2009, The Journal of biological chemistry.

(4-(Bis(4-Fluorophenyl)Methyl)Piperazin-1-yl)(Cyclohexyl)Methanone Hydrochloride (LDK1229): A New Cannabinoid CB1 Receptor Inverse Agonist from the Class of Benzhydryl Piperazine Analogs

Derek M. Shore, D. Hurst, P. Reggio, 2015, Molecular Pharmacology.

Crucial Positively Charged Residues for Ligand Activation of the GPR35 Receptor*

E. Brǎiloiu, Helen G. L. Gao, D. Hurst, 2013, The Journal of Biological Chemistry.

Ligand Activation of the GPR 35 Receptor Crucial Positively Charged Residues for Signal Transduction :

E. Brǎiloiu, Helen G. L. Gao, D. Hurst, 2014 .

GPCRs Moonlighting as Scramblases: Mechanism Revealed.

P. Reggio, 2018, Structure.

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

H. Loh, P. Law, Yali Zhou, 2012, BMC Cell Biology.

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition.

F. Guarnieri, S. McAllister, G. Cabral, 2002, Biochemical pharmacology.

One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?

M. Glass, J. Flanagan, Karan Govindpani, 2016, Trends in pharmacological sciences.

D. Lynch, D. Hurst, P. Reggio, 2002, Molecular pharmacology.

Structural Insights from Recent CB1 X-Ray Crystal Structures

D. Hurst, P. Reggio, Rufaida M. Al-Zoubi, 2018, Recent Advances in Cannabinoid Research.

Construction of a steric map of the binding pocket for cannabinoids at the cannabinoid receptor.

P. Reggio, J. Chambers, S. Lagu, 1995, Drug design and discovery.

Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols

Rishi Sharma, S. Nikas, A. Makriyannis, 2014, Journal of medicinal chemistry.

Endocannabinoid tone versus constitutive activity of cannabinoid receptors

R. Hampson, D. Deutsch, S. Childers, 2011, British journal of pharmacology.

Global fold of human cannabinoid type 2 receptor probed by solid‐state 13C‐, 15N‐MAS NMR and molecular dynamics simulations

M. Pitman, K. Gawrisch, A. Grossfield, 2014, Proteins.

Evidence against cannabinoid receptor involvement in intraocular pressure effects of cannabinoids in rabbits.

K. Green, P. Reggio, L. Hodges, 1997, Ophthalmic research.

Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.

M. Caron, T. Chung, Yushi Bai, 2011, Biochemistry.