C. Weinigel

发表

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy

S. Zahler, A. Vollmar, O. Werz, 2017, Scientific Reports.

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

G. Bifulco, O. Werz, R. Riccio, 2012, European journal of medicinal chemistry.

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

G. Schneider, O. Werz, J. Kunze, 2013, Journal of medicinal chemistry.

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

O. Werz, A. Minassi, A. Koeberle, 2014, Journal of medicinal chemistry.

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.

O. Werz, M. de Rosa, F. Bruno, 2015, European journal of medicinal chemistry.

Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.

O. Werz, A. Skaltsounis, N. Gaboriaud-Kolar, 2014, Journal of medicinal chemistry.

Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

O. Werz, A. Koeberle, G. Appendino, 2014 .

Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.

O. Werz, M. de Rosa, F. Bruno, 2014, European journal of medicinal chemistry.

Selective upregulation of TNF&agr; expression in classically‐activated human monocyte‐derived macrophages (M1) through pharmacological interference with V‐ATPase

O. Werz, R. Müller, A. Mosig, 2017, Biochemical pharmacology.

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.

O. Werz, S. Noha, D. Schuster, 2013, Biochemical pharmacology.

The novel benzimidazole derivative BRP‐7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5‐lipoxygenase‐activating protein (FLAP)

O. Werz, A. Rossi, L. Sautebin, 2014, British journal of pharmacology.

Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration

O. Werz, A. Atanasov, E. Heiss, 2013, Cardiovascular research.

Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase

Sandra K. Wittmann, G. Scriba, O. Werz, 2017, Scientific Reports.

Pathogen‐reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola‐specific neutralizing antibodies

M. Schmidt, E. Seifried, S. K. Fehling, 2016, Vox sanguinis.

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase

S. Lorkowski, O. Werz, D. Schuster, 2018, Nature Communications.

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

O. Werz, H. Stuppner, B. Waltenberger, 2021, Acta pharmaceutica Sinica. B.

Time‐resolved in situ assembly of the leukotriene‐synthetic 5‐lipoxygenase/5‐lipoxygenase‐activating protein complex in blood leukocytes

O. Werz, O. Rådmark, U. Garscha, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes

O. Werz, H. Northoff, O. Rådmark, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

O. Werz, H. Northoff, S. Laufer, 2017, The Journal of clinical investigation.

Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors.

G. Scriba, O. Werz, J. Haeggström, 2016, Biochimica et biophysica acta.

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly.

G. Scriba, O. Werz, U. Schubert, 2016, Biochemical pharmacology.

A procedure for efficient non-viral siRNA transfection of primary human monocytes using nucleofection.

S. Lorkowski, O. Werz, U. Garscha, 2015, Journal of immunological methods.

An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis.

O. Werz, U. Garscha, D. Barz, 2014, Biochimica et biophysica acta.

High capacity for leukotriene biosynthesis in peripheral blood during pregnancy.

O. Werz, H. Northoff, A. Koeberle, 2013, Prostaglandins, leukotrienes, and essential fatty acids.

Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase

O. Werz, D. Schuster, V. Temml, 2014, British journal of pharmacology.

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.

O. Werz, D. Schuster, H. Stuppner, 2016, Biochemical pharmacology.

Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "Cascade").

O. Werz, Markus Werner, M. Forino, 2016, Journal of natural products.

The effect of increased centrifugation temperature on the quality of red‐blood‐cell concentrates of automated whole blood processing

D. Barz, C. Weinigel, S. Rummler, 2013, Vox sanguinis.

Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

O. Werz, A. Rossi, L. Sautebin, 2017, Scientific Reports.

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

O. Werz, R. Müller, H. Steinmetz, 2014, Biochemical pharmacology.