Qihong Zhao

发表

Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases

Qihong Zhao, 2010, Journal of leukocyte biology.

Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phenyl)pyrrolidines as novel RORγt inverse agonists.

Michael A. Galella, D. Shen, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43

Y. Cong, Mingming Sun, Zhanju Liu, 2019, The Journal of Immunology.

The Vav Binding Site (Y315) in ZAP-70 Is Critical for Antigen Receptor–mediated Signal Transduction

Jun Wu, A. Weiss, T. Kurosaki, 1997, The Journal of experimental medicine.

Interdomain B in ZAP-70 Regulates but Is Not Required for ZAP-70 Signaling Function in Lymphocytes

A. Weiss, R. Abraham, Qihong Zhao, 1999, Molecular and Cellular Biology.

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

K. McIntyre, C. Chaudhry, L. Salter-Cid, 2019, Science Translational Medicine.

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

Y. Cong, L. Soong, Wei Wu, 2016, The Journal of Immunology.

Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis

F. Tacke, A. Geerts, B. Lapauw, 2022, International journal of molecular sciences.

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2014, Bioorganic & medicinal chemistry letters.

Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

J. Barrish, P. Scherle, M. Cvijic, 2012, Bioorganic & medicinal chemistry letters.

Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.

Michael G. Yang, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

Y. Cong, Y. Fofanov, Mingming Sun, 2017, Mucosal Immunology.

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors

Subhashish Banerjee, Qihong Zhao, M. Tagen, 2021, Dermatology and Therapy.

MCLR induces dysregulation of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in Sertoli cells.

Sujuan Zhao, Qihong Zhao, T. Shen, 2020, Chemosphere.

Tricyclic Sulfones as Potent, Selective and Efficacious RORγt Inverse Agonists - Exploring C6 and C8 SAR Using Late-Stage Functionalization.

Michael G. Yang, D. Shuster, C. Weigelt, 2020, Bioorganic & medicinal chemistry letters.

Receptor density dictates the behavior of a subset of steroid ligands in glucocorticoid receptor-mediated transrepression.

M. Favata, J. Trzăskos, Qihong Zhao, 2003, International immunopharmacology.

BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.

J. Barrish, S. Mandlekar, A. Mathur, 2021, ACS medicinal chemistry letters.

Chapter Twelve - Targeting the Nuclear Hormone Receptor RORγt for the Treatment of Autoimmune and Inflammatory Disorders

Qihong Zhao, T. G. Dhar, D. Markby, 2013 .

A CCR2/CCR5-dual antagonist, BMS-A, offers a potential novel oral therapy for the treatment of autoimmune disease (92.6)

K. McIntyre, J. Barrish, S. Mandlekar, 2009, Journal of Immunology.

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

Michael A. Galella, D. Shuster, D. Shen, 2019, ACS medicinal chemistry letters.

gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

Michael G. Yang, J. Barrish, A. Tebben, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5.

D. J. Nelson, J. Barrish, S. Mandlekar, 2015, ACS medicinal chemistry letters.

CCR2/CCR5 inhibitor permits the radiation-induced effector T cell infiltration in pancreatic adenocarcinoma

A. Narang, K. Fujiwara, Qihong Zhao, 2022, The Journal of experimental medicine.

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

Y. Cong, Mingming Sun, Zhanju Liu, 2018, Nature Communications.

Microbiota metabolite short chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

Han Liu, Y. Cong, Mingming Sun, 2016, Mucosal Immunology.

IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model

J. Starmer, M. Daniele, S. Magness, 2018, Cellular and molecular gastroenterology and hepatology.

RORγt Represses IL-10 Production in Th17 Cells To Maintain Their Pathogenicity in Inducing Intestinal Inflammation

Y. Cong, Mingming Sun, Zhanju Liu, 2018, The Journal of Immunology.

Genome-Wide Identification of Somatic Aberrations from Paired Normal-Tumor Samples

Ao Li, Huanqing Feng, Minghui Wang, 2014, PloS one.

GPR120 inhibits colitis through regulation of CD4+T cell IL-10 production.

S. Cohn, Xiuli Zuo, Y. Cong, 2021, Gastroenterology.

Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, ACS medicinal chemistry letters.

PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

John G Doench, W. Hahn, M. Wadsworth, 2022, Journal for ImmunoTherapy of Cancer.

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.

Michael A. Galella, J. Barrish, M. Cvijic, 2016, Bioorganic & medicinal chemistry letters.

Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function.

M. Levings, B. Bressler, D. Boardman, 2020, European Journal of Immunology.

Induction of a Th17 Phenotype in Human Skin—A Mimic of Dermal Inflammatory Diseases

C. Feghali-Bostwick, Qihong Zhao, S. Garrett, 2019, Methods and protocols.

Clinically validated approaches to the treatment of autoimmune diseases

P. Carter, Qihong Zhao, Qihong Zhao, 2010, Expert opinion on investigational drugs.

Liquid chromatography coupled with tandem mass spectrometry for the bioanalysis of proteins in drug development: practical considerations in assay development and validation.

Qin C Ji, Guowen Liu, Mark Arnold, 2013, Journal of chromatography. A.

Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.

Eugene Ciccimaro, T. Olah, P. Shipkova, 2017, Bioanalysis.

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt ‒ Identification of a Potent, Selective Series with Biologic-Like In Vivo Efficacy.

K. McIntyre, D. Shuster, J. Macor, 2019, Journal of medicinal chemistry.

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.

D. Shuster, J. Macor, C. Weigelt, 2020, ACS medicinal chemistry letters.

Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

M. Favata, J. Trzăskos, A. Tebben, 2007, Proceedings of the National Academy of Sciences.

Abstract CT124: A phase Ib/II study of BMS-813160, a CC chemokine receptor (CCR) 2/5 dual antagonist, in combination with chemotherapy or nivolumab in patients (pts) with advanced pancreatic or colorectal cancer

H. Lenz, M. Pishvaian, P. O'dwyer, 2018, Clinical Trials.

Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672.

Michael G. Yang, Michael A. Galella, J. Barrish, 2019, ACS medicinal chemistry letters.

Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity

Noah T. Ditto, M. Struthers, K. McIntyre, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.

Michael A. Galella, D. Shen, J. Barrish, 2018, Bioorganic & medicinal chemistry letters.

GPR120 promotes neutrophil control of intestinal bacterial infection

Y. Cong, Qihong Zhao, Xiaojing Zhao, 2023, Gut microbes.

A novel function of CXCL10 in mediating monocyte production of proinflammatory cytokines

M. Struthers, T. Olah, L. Salter-Cid, 2017, Journal of leukocyte biology.

Role of poly (ADP-ribose) polymerase-1 and NF-kappaB as potential risk factor in the development of non-small cell lung cancer in Chinese individuals

Renquan Zhang, Qihong Zhao, Jianjun Ge, 2018 .

Annulation Reaction Enables the identification of an Exocyclic Amide Tricyclic Chemotype as Retinoic Acid Receptor-Related Orphan Receptor Gamma (RORγ/RORc) Inverse Agonists.

Michael A. Galella, C. Weigelt, M. Cvijic, 2020, Bioorganic & medicinal chemistry letters.

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as ROR gamma t inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019 .

Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.

C. Weigelt, A. Mathur, Hai-yun Xiao, 2019, Bioorganic & medicinal chemistry letters.

Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.

Michael G. Yang, D. Shuster, C. Weigelt, 2021, Journal of medicinal chemistry.

Alternative Splicing ofPre-mRNAs Encoding theNonstructural Proteins ofMinute Virus ofMiceIsFacilitated by Sequences within theDownstream Intron

Qihong Zhao, J. Pintel, 1994 .

Inflammation, autoimmunity, and atherosclerosis.

Qihong Zhao, 2009, Discover medicine.

Clinically validated approaches to the treatment of autoimmune diseases

P. Carter, Qihong Zhao, 2010, Expert opinion on investigational drugs.

Endostar Synergizes with Radiotherapy to Inhibit Angiogenesis of Cervical Cancer in a Subcutaneous Xenograft Mouse Model.

Haochen Zhu, Qihong Zhao, Zhonghua Xu, 2022, Frontiers in bioscience.