C. Guillou

发表

The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.

Joel L Sussman, Israel Silman, Bernard Badet, 2004, Journal of the American Chemical Society.

Synthesis of γ-butenolides and α,β-unsaturated γ-butyrolactams by addition of vinylogous nucleophiles to Michael acceptors

C. Guillou, Xavier Jusseau, L. Chabaud, 2014 .

Trifluoroethanol Promoted Castagnoli–Cushman Cycloadditions of Imines with Homophthalic Anhydride

C. Guillou, Thibault Bayles, 2022, Molecules.

Discovery of two new inhibitors of Botrytis cinerea chitin synthase by a chemical library screening.

M. Soulie, M. Boccara, C. Guillou, 2013, Bioorganic & medicinal chemistry.

At a Supra-Physiological Concentration, Human Sexual Hormones Act as Quorum-Sensing Inhibitors

L. Soulère, D. Faure, Y. Dessaux, 2013, PloS one.

Identification of two compounds able to improve flax resistance towards Fusarium oxysporum infection.

Aline Planchon, Carole Plasson, J. Trouvé, 2020, Plant science : an international journal of experimental plant biology.

Catalytic enantioselective vinylogous Mukaiyama-Michael addition of 2-silyloxyfurans to cyclic unsaturated oxo esters.

P. Retailleau, C. Guillou, Xavier Jusseau, 2013, The Journal of organic chemistry.

Holaphyllamine, a steroid, is able to induce defense responses in Arabidopsis thaliana and increases resistance against bacterial infection

P. Lerouge, J. Leprince, A. Driouich, 2017, Planta.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

C. Hulme, A. Mangoni, M. Gütschow, 2017, Molecules.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

F. J. Luque, C. Hulme, A. Mangoni, 2018, Molecules.

New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations.

F. Kozielski, C. Guillou, S. Thoret, 2016, Bioorganic & medicinal chemistry.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

F. J. Luque, C. Hulme, A. Mangoni, 2017, Molecules.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes

F. J. Luque, C. Hulme, K. Chibale, 2017, Molecules.

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

B. Montanini, S. Ottonello, C. Guillou, 2022, Antibiotics.

Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement.

C. Vale, L. Botana, E. Alonso, 2013, Current Alzheimer research.

Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.

C. Guillou, C. Thal, Marie-Thérèse Martin, 2003, Bioorganic & medicinal chemistry letters.

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

B. Goud, A. Houdusse, O. Pylypenko, 2017, Nature Communications.

Hypervalent‐Iodine‐Mediated Synthesis of 1,2‐Dispirodienones: Experimental and Theoretical Investigations

P. Retailleau, V. Gandon, C. Guillou, 2015 .

Effects of sucrose and plant growth regulators on acetylcholinesterase inhibitory activity of alkaloids accumulated in shoot cultures of Amaryllidaceae

S. Bordage, M. Henry, Y. Chapleur, 2011, Plant Cell, Tissue and Organ Culture (PCTOC).

Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

O. Rath, Sergey O Tcherniuk, F. Kozielski, 2010, Angewandte Chemie.

Recent Advances in [Cp*MIII] (M = Co, Rh, Ir)‐Catalyzed Intramolecular Annulation Through C–H Activation

C. Guillou, L. Chabaud, Augustin Peneau, 2018 .

Iminosugars as a new class of cholinesterase inhibitors.

P. Compain, C. Guillou, O. Martin, 2015, Bioorganic & medicinal chemistry letters.

Rhodium(III)-Catalyzed Synthesis of Aryl Spirocycles by Aromatic CH Activation/Intramolecular Heck-Type Reaction

C. Guillou, L. Chabaud, Elvina Barré, 2015 .

Vinylogous Mukaiyama–Michael Reactions between 2‐Silyloxyfurans and Cyclic Enones or Unsaturated Oxo Esters

P. Retailleau, C. Guillou, L. Chabaud, 2010 .

Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization.

C. Guillou, Jennifer Pereira, M. Barlier, 2007, Organic letters.

Diastereoselective total synthesis of (+/-)-codeine.

B. Iorga, C. Guillou, Elvina Barré, 2008, Chemistry.

Mild rhodium(iii)-catalyzed intramolecular annulation of benzamides with allylic alcohols to access azepinone derivatives.

C. Guillou, L. Chabaud, Augustin Peneau, 2018, Chemical communications.

Enantioselective Synthesis of Spiroimines by Asymmetric Decarboxylative Alkylation/Isomerization/[3+2]‐Cycloaddition Reaction of Azidoalkenes

C. Guillou, L. Chabaud, Leslie Duroure, 2014 .

Total syntheses of crinine and related alkaloids

C. Guillou, Claire Bru, 2006 .

An Efficient Total Synthesis of (±)-Galanthamine

C. Guillou, C. Thal, E. Gras, 2001 .

Synthesis of 4-substituted-tricarbonyl(η4-cyclohexa-2,4-dien-1-one)iron complexes

C. Guillou, C. Thal, V. Reboul, 1999 .

A Phenotypic Assay to Identify Chikungunya Virus Inhibitors Targeting the Nonstructural Protein nsP2

P. Vidalain, H. Munier-Lehmann, P. Desprès, 2013, Journal of biomolecular screening.

Concise total synthesis of (+/-)-maritidine.

C. Guillou, C. Thal, Claire Bru, 2003, Organic letters.

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

F. J. Luque, Ornella Di Pietro, R. Lamuela-Raventós, 2014, Bioorganic & medicinal chemistry.

6,6-Spiroimine analogs of (-)-gymnodimine A: synthesis and biological evaluation on nicotinic acetylcholine receptors.

P. Retailleau, J. Molgó, C. Guillou, 2011, Organic & biomolecular chemistry.

Reactivity of cationic 1-substituted dicarbonyl (η5-4-methoxycyclohexadienyl)(triphenylphosphine)iron complexes☆

Nicolas Millot, C. Guillou, C. Thal, 1998 .

A formal synthesis of (±) lycoramine via an intramolecular Heck reaction

C. Guillou, C. Thal, E. Gras, 1999 .

A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases

S. Sagan, G. Bolbach, C. Guillou, 2017, Analytical and Bioanalytical Chemistry.

A rapid in vivo colorimetric library screen for inhibitors of microbial respiration.

B. Meunier, C. Guillou, C. Vallieres, 2012, ACS chemical biology.

Kinetic study of the rearrangement of deuterium-labeled 4'-O-methylnorbelladine in Leucojum aestivum shoot cultures by mass spectrometry. Influence of precursor feeding on amaryllidaceae alkaloid accumulation.

M. Henry, F. Chrétien, Y. Chapleur, 2011, Journal of natural products.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Rhodium(III)-Catalyzed Synthesis of Spiropiperidine Derivatives via C-H Activation.

P. Retailleau, C. Guillou, L. Chabaud, 2018, Journal of Organic Chemistry.

Hypervalent iodine-mediated oxidative cyclisation of p-hydroxy acetanilides to 1,2-dispirodienones.

P. Retailleau, C. Guillou, L. Chabaud, 2013, Chemical communications.

Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.

C. Guillou, C. Thal, E. Gras, 2000, Bioorganic & medicinal chemistry letters.

Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.

C. Guillou, C. Thal, D. Renko, 1998, Bioorganic & medicinal chemistry.

Selective N-demethylation of galanthamine to norgalanthamine via a non classical Polonovski reaction

C. Guillou, C. Thal, D. Renko, 1997 .

Acetylcholine nicotinic receptors: finding the putative binding site of allosteric modulators using the “blind docking” approach

B. Iorga, C. Guillou, D. Herlem, 2006, Journal of molecular modeling.

The progressive elimination task in dogs (Canis familiaris): The case of divergence

C. Dumas, C. Guillou, Jacinthe Leblanc, 2018 .

Structural features of neutral and protonated galanthamine: A crystallographic database and computational investigation

C. Guillou, C. Laurence, J. Graton, 2006 .

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.

L. Meijer, O. Lozach, C. Guillou, 2016, European journal of medicinal chemistry.

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

B. Goud, A. Houdusse, O. Pylypenko, 2017, Nature Communications.

New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.

B. Iorga, C. Guillou, J. Rouleau, 2011, European journal of medicinal chemistry.

Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats

H. Simon, C. Guillou, C. Thal, 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Studies on the asymmetric Birch reductive alkylation to access spiroimines

P. Retailleau, C. Guillou, L. Chabaud, 2012 .

(−)-9-Dehydrogalanthaminium bromide, a new cholinesterase inhibitor, enhances place and object recognition memory in young and old rats

H. Simon, C. Guillou, C. Thal, 2003, Neurobiology of Learning and Memory.

Diastereoselective total synthesis of (+/-)-codeine.

B. Iorga, C. Guillou, Elvina Barré, 2008, Chemistry.

Synthesis of γ‐Butenolides and α,β‐Unsaturated γ‐Butyrolactams by Addition of Vinylogous Nucleophiles to Michael Acceptors

C. Guillou, Xavier Jusseau, L. Chabaud, 2014 .

Hypervalent‐Iodine‐Mediated Synthesis of 1,2‐Dispirodienones: Experimental and Theoretical Investigations

P. Retailleau, V. Gandon, C. Guillou, 2015 .

An Unexpected Double-Bond Isomerization Catalyzed by Crabtree’s Iridium(I) Catalyst

J. Lallemand, C. Guillou, Michael Krel, 2005 .

New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.

N. Gresh, C. Guillou, D. Guénard, 2007, Journal of medicinal chemistry.