A. Brink

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Antimicrobial stewardship across 47 South African hospitals: an implementation study.

D. Nathwani, C. Feldman, K. Bauer, 2016, The Lancet. Infectious diseases.

Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach

Matteo Bassetti, Emilio Bouza, Etienne Ruppe, 2017, Intensive Care Medicine.

Resistance to Colistin Associated with a Single Amino Acid Change in Protein PmrB among Klebsiella pneumoniae Isolates of Worldwide Origin

P. Nordmann, L. Poirel, A. Brink, 2014, Antimicrobial Agents and Chemotherapy.

Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System

P. Nordmann, L. Poirel, A. Brink, 2015, Antimicrobial Agents and Chemotherapy.

Epidemiology of Glycopeptide-Resistant Enterococci Colonizing High-Risk Patients in Hospitals in Johannesburg, Republic of South Africa

K. McCarthy, A. von Gottberg, H. Koornhof, 2000, Journal of Clinical Microbiology.

Antimicrobial susceptibility profile of selected bacteraemic pathogens from private institutions in South Africa.

J. Moolman, A. Brink, Mark Cruz da Silva, 2007, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa

L. McGee, K. Klugman, A. Wasas, 2001, Antimicrobial Agents and Chemotherapy.

A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail.

R. Kullar, D. Nathwani, M. Mendelson, 2017, The Lancet. Infectious diseases.

A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway.

M. Boermeester, K. Itani, Yonghong Xiao, 2017, Surgical infections.

Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients.

M. Mendelson, P. Nordmann, L. Poirel, 2016, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

The SASCM CRE-WG: consensus statement and working guidelines for the screening and laboratory detection of carbapenemase-producing Enterobacteriaceae

P. Moodley, Juno Thomas, O. Perovic, 2014 .

South African guideline for the management of community-acquired pneumonia in adults.

G. Maartens, T. Boyles, K. Dheda, 2017, Journal of thoracic disease.

Meningococcal Disease in South Africa, 1999-2002 Garry B. Coulson,* Anne von Gottberg,* Mignon du Plessis,* Anthony M. Smith,* Linda de Gouveia,* and Keith P. Klugman,*† for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)1

C. Feldman, A. Whitelaw, A. Brink, 2007 .

Multicenter, Prospective Validation of a Phenotypic Algorithm to Guide Carbapenemase Testing in Carbapenem-Resistant Pseudomonas aeruginosa Using the ERACE-PA Global Surveillance Program

Y. Carmeli, L. Bourassa, H. Seifert, 2021, Open forum infectious diseases.

Elevated MICs of Susceptible Antipseudomonal Cephalosporins in Non-Carbapenemase-Producing, Carbapenem-Resistant Pseudomonas aeruginosa: Implications for Dose Optimization

Y. Carmeli, C. Burnham, L. Westblade, 2021, Antimicrobial agents and chemotherapy.

Guideline for the prevention and management of nosocomial infections in South Africa

C. Feldman, A. Dusé, A. Brink, 2005 .

The role of appropriate diagnostic testing in acute respiratory tract infections: An antibiotic stewardship strategy to minimise diagnostic uncertainty in primary care.

M. Mendelson, T. Boyles, C. Feldman, 2016, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Essential and Forgotten antibiotics: an inventory in low- and middle-income countries.

D. Nathwani, H. Wertheim, B. Godman, 2019, International journal of antimicrobial agents.

Detection of sexually transmitted pathogens and co-infection with human papillomavirus in women residing in rural Eastern Cape, South Africa

A. Williamson, T. Meiring, A. Brink, 2021, PeerJ.

Multidrug-resistant (MDR) Gram-negative fermenters: “Our worst nightmare?”

A. Brink, 2007 .

Tackling antimicrobial resistance across sub-Saharan Africa: current challenges and implications for the future

Z. Saleem, J. Mwita, A. Guantai, 2022, Expert opinion on drug safety.

Challenges and research priorities to progress the impact of antimicrobial stewardship

M. Bassetti, A. Vena, D. Giacobbe, 2019, Drugs in context.

High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae

P. Nordmann, L. Poirel, V. Dubois, 2017, Antimicrobial Agents and Chemotherapy.

Multicomponent antibiotic substances produced by fermentation: implications for regulatory authorities, critically ill patients and generics.

P. Colombo, G. Colombo, A. Brink, 2014, International journal of antimicrobial agents.

Updated guideline for the management of upper respiratory tract infections in South Africa: 2008

A. Brink, 2009 .

The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship—results from an international cross-sectional survey

M. Catani, Yonghong Xiao, P. Barie, 2017, World Journal of Emergency Surgery.

Passing the baton to pharmacists and nurses: New models of antibiotic stewardship for South Africa?

M. Mendelson, A. Brink, G. Richards, 2016, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Appropriate use of the carbapenems.

A. Brink, G. Richards, M. Senekal, 2004, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Updated recommendations for the management of upper respiratory tract infections in South Africa.

S. Madhi, G. Maartens, C. Feldman, 2015, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Group A2 Analogs of Innovator Teicoplanin: Variability of their Ratio during Treatment Time Course in Human Blood; Consequences for the Generics

P. Colombo, A. Brink, F. Jehl, 2013 .

First confirmed case of infant botulism in Africa, caused by a dual-toxin-producing Clostridium botulinum strain.

Stanford Kwenda, Z. Khumalo, J. Frean, 2020, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

The ERACE-PA Global Surveillance Program: Ceftolozane/tazobactam and Ceftazidime/avibactam in vitro Activity against a Global Collection of Carbapenem-resistant Pseudomonas aeruginosa

Y. Carmeli, C. Burnham, L. Bourassa, 2021, European Journal of Clinical Microbiology & Infectious Diseases.

A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail.

R. Kullar, D. Nathwani, M. Mendelson, 2017, The Lancet. Infectious diseases.

Improved oral detection is a characteristic of Omicron infection and has implications for clinical sampling and tissue tropism.

C. Williamson, A. Iranzadeh, A. Brink, 2022, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Antimicrobial Stewardship: Leveraging the “Butterfly Effect” of Hand Hygiene

A. Brink, G. Richards, 2022, Antibiotics.

Emergence of extensive drug resistance (XDR) among Gram-negative bacilli in South Africa looms nearer.

C. Feldman, J. Moolman, A. Brink, 2008, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Survey of healthcare worker perceptions of changes in infection control and antimicrobial stewardship practices in India and South Africa during the COVID-19 pandemic

M. Mendelson, C. Tarrant, A. Holmes, 2022, IJID Regions.

Does resistance in severe infections caused by methicillin-resistant Staphylococcus aureus give you the ‘creeps’?

A. Brink, 2012, Current opinion in critical care.

Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice

N. Garrett, L. Bekker, K. Cohen, 2022, Southern African journal of HIV medicine.

A case for investment in clinical metagenomics in low-income and middle-income countries

A. Brink, G. Marais, D. Hardie, 2022, The Lancet Microbe.

Descriptive analysis of infections due to New Delhi metallo-β-lactamase-producing Enterobacterales in children at Red Cross War Memorial Children’s Hospital

A. Brink, James J C Nuttall, L. Greybe, 2022, Southern African journal of infectious diseases.

The spread of carbapenem-resistant Enterobacteriaceae in South Africa: risk factors for acquisition and prevention.

P. Nordmann, L. Poirel, C. Feldman, 2012, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Saliva swabs are the preferred sample for Omicron detection

C. Williamson, A. Iranzadeh, A. Brink, 2021, medRxiv.

Federation of Infectious Diseases Societies of Southern Africa guideline: Recommendations for the detection, management and prevention of healthcare-associated Candida auris colonisation and disease in South Africa

N. Govender, C. Maslo, A. Brink, 2019, Southern African journal of infectious diseases.

Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the Gastrointestinal Tract

P. Nordmann, L. Poirel, C. Feldman, 2012, Journal of Clinical Microbiology.

In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase.

N. Woodford, D. Livermore, J. Turton, 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Epidemiology of Gram-negative bacteria during coronavirus disease 2019. What is the real pandemic?

A. Brink, G. Richards, E. Prentice, 2022, Current opinion in infectious diseases.

Guideline for the management of nosocomial infections in South Africa.

C. Feldman, O. Perovic, S. Naicker, 2006, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Best practices: Appropriate use of the new β-lactam/β-lactamase inhibitor combinations, ceftazidime-avibactam and ceftolozane-tazobactam in South Africa

M. Mendelson, C. Feldman, O. Perovic, 2022, Southern African journal of infectious diseases.

Exogenous fungal endophthalmitis in a potato farm worker

A. Brink, P. Daries, C. Opperman, 2021, Southern African journal of infectious diseases.

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

M. Boermeester, Yonghong Xiao, Soumitra R. Eachempati, 2016, World Journal of Emergency Surgery.

The One Health stewardship of colistin as an antibiotic of last resort for human health in South Africa.

H. Rees, M. Mendelson, V. Naidoo, 2018, The Lancet. Infectious diseases.

Guideline: appropriate use of tigecycline.

C. Feldman, K. Boffard, A. Brink, 2010, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Antibiotic resistance and virulence

A. Brink, 2014 .

Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: phenotypic and genotypic analysis of isolates

Philip Smith, S. Madhi, C. Whitney, 2017, BMC Infectious Diseases.

Recommendations to achieve rapid therapeutic teicoplanin plasma concentrations in adult hospitalised patients treated for sepsis.

A. Brink, G. Richards, R. Cummins, 2008, International journal of antimicrobial agents.

Hypoalbuminaemia and Altered Protein Binding

A. Brink, 2018 .

Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis.

A. Brink, G. Richards, V. Schillack, 2009, International journal of antimicrobial agents.

Therapeutic drug monitoring: linezolid too?

A. Brink, G. Richards, 2014, Critical Care.

Treating bacterial infections with bacteriophages in the 21st century

A. Brink, J. Wojno, C. Opperman, 2022, Southern African journal of infectious diseases.

The Association between Tumour Markers and Meta-iodobenzylguanidine Scans in South African Children with High-risk Neuroblastoma.

M. Kruger, A. Brink, J. van Heerden, 2021, Clinical oncology (Royal College of Radiologists (Great Britain)).

Emergence of New Delhi Metallo-Beta-Lactamase (NDM-1) and Klebsiella pneumoniae Carbapenemase (KPC-2) in South Africa

P. Nordmann, L. Poirel, A. Brink, 2011, Journal of Clinical Microbiology.

Antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in South African hospitals (SMART Study 2004-2009): impact of the new carbapenem breakpoints.

C. Feldman, K. Boffard, M. Veller, 2012, Surgical infections.

Microbiology Assessments in Critically Ill Patients.

A. Brink, C. Centner, Stefan Opperman, 2022, Seminars in respiratory and critical care medicine.

Be AWaRe: new metrics for paediatric antibiotic stewardship.

M. Mendelson, A. Brink, 2019, Lancet. Infectious Diseases (Print).

Using mystery shoppers to determine practices pertaining to antibiotic dispensing without a prescription among community pharmacies in South Africa—a pilot survey

B. Godman, A. Brink, N. Schellack, 2022, JAC-antimicrobial resistance.

Epidemiology of carbapenem-resistant Gram-negative infections globally.

A. Brink, 2019, Current opinion in infectious diseases.

General aspect of antimicrobial stewardship

M. Bassetti, A. Vena, D. Giacobbe, 2019 .

A situational analysis of current antimicrobial governance, regulation, and utilization in South Africa.

M. Mendelson, S. Essack, O. Perovic, 2017, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Wake up South Africa! The antibiotic 'horse' has bolted.

M. Mendelson, M. Nicol, A. Whitelaw, 2012, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa.

M. Mendelson, C. Feldman, D. Goff, 2020, International journal of antimicrobial agents.

From guidelines to practice: a pharmacist-driven prospective audit and feedback improvement model for peri-operative antibiotic prophylaxis in 34 South African hospitals

C. Feldman, A. Brink, A. Messina, 2016, The Journal of antimicrobial chemotherapy.

Guideline for the management of upper respiratory tract infections.

S. Madhi, G. Swingler, G. Maartens, 2004, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

South African Society of Clinical Microbiology Clostridioides difficile infection diagnosis, management and infection prevention and control guideline

T. Boyles, J. Wadula, A. Brink, 2020, Southern African journal of infectious diseases.

Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa

P. Nordmann, L. Poirel, A. Brink, 2016, Antimicrobial Agents and Chemotherapy.

National surveillance of private sector respiratory tract pathogens in South Africa, 2010

A. Brink, I. Zietsman, 2011 .

Management of community-acquired pneumonia in adults

E. Bateman, G. Maartens, C. Feldman, 2007 .

The Federation of Infectious Diseases Societies of Southern Africa (FIDSSA) - four years since inception

C. Feldman, A. Brink, 2008 .

Fluconazole‐resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa

Philip Smith, Van Rensburg, Y. Coovadia, 2020, Mycoses.

Investigation of biofilm formation on a charged intravenous catheter relative to that on a similar but uncharged catheter

A. Brink, G. Richards, H. Steel, 2014, Medical devices.

Stepwise introduction of the 'Best Care Always' central-line-associated bloodstream infection prevention bundle in a network of South African hospitals.

C. Feldman, A. Brink, A. Messina, 2017, The Journal of hospital infection.

Development and impact of a massive open online course (MOOC) for antimicrobial stewardship

G. Barlow, D. Nathwani, S. Chandy, 2018, The Journal of antimicrobial chemotherapy.

South African guideline for the management of community-acquired pneumonia in adults

G. Maartens, T. Boyles, K. Dheda, 2018 .

The emergence of carbapenem resistance in Enterobacteriaceae in South Africa

A. Brink, J. Coetzee, 2011 .

Erratum: Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). [World J Emerg Surg. 11, (2016) (33)] DOI: 10.1186/s13017-016-0089-y

M. Boermeester, Yonghong Xiao, J. Vincent, 2017 .

Erratum to South African guideline for the management of community-acquired pneumonia in adults.

G. Maartens, T. Boyles, K. Dheda, 2018, Journal of thoracic disease.

Performance of saliva and mid-turbinate swabs for detection of the beta variant in South Africa

C. Williamson, A. Iranzadeh, H. Cox, 2021, The Lancet Infectious Diseases.

Guideline for the management of nosocomial infections in South Africa

C. Feldman, O. Perovic, S. Naicker, 2006 .

Antimicrobial Stewardship (AMS) in the Community

A. Brink, 2016 .

A commitment and call to strengthen and expand qualitative research efforts to improve the impact of antimicrobial stewardship

A. Brink, D. van den Bergh, 2021, JAC-antimicrobial resistance.

Best practice: antibiotic decision-making in ICUs

A. Brink, G. Richards, 2020, Current opinion in critical care.

The role of multidrug and extensive-drug resistant Gam-negative bacteria in skin and soft tissue infections.

A. Brink, G. Richards, 2020, Current opinion in infectious diseases.

Optimising the administration of antibiotics in critically ill patients

A. Brink, G. Richards, I. Joubert, 2015 .

Implementing a multifaceted framework for proprietorship of hand hygiene compliance in a network of South African hospitals - Leveraging the Ubuntu philosophy.

C. Maslo, A. Brink, A. Messina, 2019, The Journal of hospital infection.

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.

M. Ouellette, O. Dyar, L. Moja, 2017, The Lancet. Infectious diseases.

Procalcitonin and C-reactive protein levels in HIV-positive subjects with tuberculosis and pneumonia

J. Galpin, A. Brink, A. Brink, 2005, European Respiratory Journal.

Undergraduate antibiotic stewardship training: Are we leaving our future prescribers 'flapping in the wind'?

G. Muntingh, A. Brink, J. Schoeman, 2017, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Erratum to: Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

M. Boermeester, Yonghong Xiao, Soumitra R. Eachempati, 2017, World Journal of Emergency Surgery.

Opportunities to optimise colistin stewardship in hospitalised patients in South Africa: Results of a multisite utilisation audit.

A. Brink, A. Messina, G. Richards, 2017, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

Guideline summary: appropriate use of tigecycline.

C. Feldman, K. Boffard, A. Brink, 2012, South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie.

A survey of patient and public perceptions and awareness of SARS-CoV-2-related risks among participants in India and South Africa

M. Mendelson, C. Tarrant, A. Holmes, 2022, medRxiv.

Clarithromycin alone and in combination with ceftriaxone inhibits the production of pneumolysin by both macrolide-susceptible and macrolide-resistant strains of Streptococcus pneumoniae.

T. Mitchell, R. Anderson, A. von Gottberg, 2006, The Journal of antimicrobial chemotherapy.

Erratum: Southern African HIV Clinicians Society 2022 guideline for the management of sexually transmitted infections: Moving towards best practice

N. Garrett, L. Bekker, K. Cohen, 2022, Southern African Journal of HIV Medicine.

The genomic characterization of carbapenem-resistant Serratia marcescens at a tertiary hospital in South Africa

K. Lennard, A. Brink, E. Prentice, 2023, JAC-antimicrobial resistance.

Resistance to Colistin Associated with a Single Amino Acid Change in Protein PmrB among Klebsiella pneumoniae Isolates of Worldwide Origin

P. Nordmann, L. Poirel, A. Brink, 2014, Antimicrobial Agents and Chemotherapy.

Operational assessment of isoniazid prophylaxis in a community AIDS service organisation in Uganda.

M. Nanyunja, N. French, C. Gilks, 2002, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis.

Jerome J. Schentag, A. Brink, G. Richards, 2009, International journal of antimicrobial agents.

Statement on analysis and interpretation of clinical human gastrointestinal microbiome testing using next-generation sequencing in South Africa.

A. Brink, A. Brink, A. Deffur, 2021, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.