P. Urban

发表

Access channels to the buried active site control substrate specificity in CYP1A P450 enzymes.

D. Pompon, P. Urban, G. Truan, 2015, Biochimica et biophysica acta.

Optimization of yeast-expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH-cytochrome P450 reductase and cytochrome b5.

D. Mansuy, J. Renaud, D. Pompon, 1992, European journal of biochemistry.

Ligand Access Channels in Cytochrome P450 Enzymes: A Review

D. Pompon, P. Urban, G. Truan, 2018, International journal of molecular sciences.

Enhanced in vivo monooxygenase activities of mammalian P450s in engineered yeast cells producing high levels of NADPH-P450 reductase and human cytochrome b5.

P. Reisdorf, D. Pompon, P. Urban, 1993, Gene.

Engineered yeast cells as model to study coupling between human xenobiotic metabolizing enzymes. Simulation of the two first steps of benzo[a]pyrene activation.

P. Beaune, D. Pompon, P. Urban, 1993, European journal of biochemistry.

Genetically engineered yeast cells and their applications.

D. Pompon, A. Bellamine, A. Perret, 1995, Toxicology letters.

Altered substrate specificity of the Pterygoplichthys sp. (Loricariidae) CYP1A enzyme.

D. Pompon, P. Urban, M. Rebelo, 2014, Aquatic toxicology.

Rat kidney L-2-hydroxyacid oxidase. Structural and mechanistic comparison with flavocytochrome b2 from baker's yeast.

F. Lederer, P. Urban, I. Chirat, 1988, Biochemistry.

Baker's yeast flavocytochrome b2. A mechanistic study of the dehydrohalogenation reaction.

F. Lederer, P. Urban, 1984, European journal of biochemistry.

On the transhydrogenase activity of baker's yeast flavocytochrome b2.

F. Lederer, P. Alliel, P. Urban, 1983, European journal of biochemistry.

Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1

D. Pompon, P. Urban, R. Morfin, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

Catalytic triad of microsomal epoxide hydrolase: replacement of Glu404 with Asp leads to a strongly increased turnover rate.

W. Hinz, F. Oesch, R. Kellner, 1999, The Biochemical journal.

Localization of I2-Imidazoline Binding Sites on Monoamine Oxidases (*)

F. Tesson, A. Parini, D. Pompon, 1995, The Journal of Biological Chemistry.

Pregnenolone-7 beta-hydroxylating activities of yeast-expressed mouse cytochrome P450-1A1 and mouse-tissue microsomes.

D. Pompon, P. Urban, R. Morfin, 1996, European journal of biochemistry.

Yeast expression of animal and plant P450s in optimized redox environments.

D. Pompon, P. Urban, D Pompon, 1996, Methods in enzymology.

Xenobiotic metabolism in humanized yeast: engineered yeast cells producing human NADPH-cytochrome P-450 reductase, cytochrome b5, epoxide hydrolase and P-450s.

D. Pompon, P. Urban, G. Truan, 1993, Biochemical Society transactions.

Comparative membrane locations and activities of human monoamine oxidases expressed in yeast

D. Pompon, P. Urban, H. Hsu, 1991, FEBS letters.

Inactivation of flavocytochrome b2 with fluoropyruvate. Reaction at the active-site histidine.

F. Lederer, P. Urban, 1988, European journal of biochemistry.

Characterization of recombinant plant cinnamate 4-hydroxylase produced in yeast. Kinetic and spectral properties of the major plant P450 of the phenylpropanoid pathway.

F. Durst, D. Pompon, S. Régnier, 1994, European journal of biochemistry.

Cloning, Yeast Expression, and Characterization of the Coupling of Two Distantly Related Arabidopsis thalianaNADPH-Cytochrome P450 Reductases with P450 CYP73A5*

D. Pompon, P. Urban, F. Delorme, 1997, The Journal of Biological Chemistry.

ENGINEERED YEASTS SIMULATING P450-DEPENDENT METABOLISMS: TRICKS, MYTHS AND REALITY

D. Pompon, A. Bellamine, P. Urban, 1994, Drug metabolism and drug interactions.

Exploration of Natural and Artificial Sequence Spaces: Towards a Functional Remodeling of Membrane-bound Cytochrome P450

D. Pompon, L. Aggerbeck, P. Urban, 2003 .

Recombinant yeast in drug metabolism.

P. Beaune, D. Mansuy, J. Renaud, 1993, Toxicology.

Confrontation of AlphaFold models with experimental structures enlightens conformational dynamics supporting CYP102A1 functions

D. Pompon, P. Urban, 2022, Scientific Reports.

Ordered chimerogenesis applied to CYP2B P450 enzymes.

D. Pompon, P. Urban, G. Truan, 2016, Biochimica et biophysica acta.

Yeast Expression , and Characterization of the Coupling of Two Distantly Related Arabidopsis thaliana NADPH-Cytochrome P 450 Reductases with P 450 CYP 73 A 5 *

D. Pompon, P. Urban, F. Delorme, 1997 .

Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants.

P. Urban, J. Rueff, D. Moutinho, 2016, Mutation research. Genetic toxicology and environmental mutagenesis.

High-Throughput Functional Screening of Steroid Substrates with Wild-Type and Chimeric P450 Enzymes

D. Pompon, P. Urban, G. Truan, 2014, BioMed research international.

Differences in Functional Clustering of Endogenous and Exogenous Substrates Between Members of the CYP1A Subfamily

D. Pompon, P. Urban, G. Truan, 2009 .

High-throughput enzymology and combinatorial mutagenesis for mining cytochrome P450 functions

D. Pompon, P. Urban, G. Truan, 2008 .

Simulation of human benzo[a]pyrene metabolism deduced from the analysis of individual kinetic steps in recombinant yeast.

P. Beaune, D. Pompon, P. Urban, 1996, Chemical research in toxicology.

Development of a Biosensor for Detection of Benzoic Acid Derivatives in Saccharomyces cerevisiae

J. Faulon, Sara Castaño-Cerezo, P. Urban, 2020, Frontiers in Bioengineering and Biotechnology.

The use of Yarrowia lipolytica for the expression of human cytochrome P450 CYP1A1

J. Nicaud, M. Smit, D. Pompon, 2004, Yeast.

Contribution of human cytochrome P450 to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol metabolism, as predicted from heterologous expression in yeast.

P. Beaune, D. Pompon, A. Perret, 1996, Pharmacogenetics.

Simulation of human xenobiotic metabolism in microorganisms. Yeast a good compromise between E. coli and human cells.

D. Pompon, A. Perret, P. Urban, 1997, Journal of hepatology.

The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners

S. Bozonnet, P. Urban, G. Truan, 2020, Frontiers in Pharmacology.

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450

P. Urban, G. Truan, Thomas Lautier, 2018, International journal of molecular sciences.

The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

S. Bozonnet, P. Urban, G. Truan, 2017, Front. Pharmacol..

Intermolecular hydrogen transfer catalyzed by a flavodehydrogenase, bakers' yeast flavocytochrome b2.

F. Lederer, P. Urban, 1985, The Journal of biological chemistry.

Confrontation of AlphaFold2 models with cryo-EM and crystal structures enlightens alternate geometries of the CYP102A1 multidomain protein

D. Pompon, P. Urban, 2022, bioRxiv.

Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1.

D. Pompon, P. Urban, R. Morfin, 2006, The Journal of steroid biochemistry and molecular biology.

Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast.

J. Goldstone, J. Stegeman, L. Behrendt, 2015, Biochimica et biophysica acta.

Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism

D. Pompon, P. Urban, G. Truan, 2023, Biomolecules.

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding

P. Urban, G. Truan, J. Rueff, 2020, International journal of molecular sciences.

Human cytochrome P450 expression in bacteria: Whole‐cell high‐throughput activity assay for CYP1A2, 2A6 and 3A4

S. Bozonnet, P. Urban, G. Truan, 2018, Biochemical pharmacology.

Maximizing the expression of mammalian cytochrome P-450 monooxygenase activities in yeast cells.

D. Pompon, P. Urban, C. Cullin, 1990, Biochimie.

Expression in yeast of three allelic cDNAs coding for human liver P-450 3A4. Different stabilities, binding properties and catalytic activities of the yeast-produced enzymes.

D. Mansuy, J. Renaud, D. Pompon, 1993, European journal of biochemistry.

Chimeras of the human cytochrome P450 1A family produced in yeast. Accumulation in microsomal membranes, enzyme kinetics and stability.

D. Pompon, A. Bellamine, P. Urban, 1994, European journal of biochemistry.

A combinatorial approach to substrate discrimination in the P450 CYP1A subfamily.

Valérie Taly, Denis Pompon, Gilles Truan, 2007, Biochimica et biophysica acta.

Corrigendum: The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners

S. Bozonnet, P. Urban, G. Truan, 2020, Frontiers in Pharmacology.

Cytochrome P450 (CYP) mutants and substrate-specificity alterations: segment-directed mutagenesis applied to human CYP1A1.

A. Jobert, D. Pompon, P. Urban, 2001, Biochemical Society Transactions.

Ordered chimerogenesis applied to CYP2B P450 enzymes.

D. Pompon, P. Urban, G. Truan, 2016, Biochimica et biophysica acta.

Expression of Cytochromes P450 in Yeast: Practical Aspects

D. Pompon, A. Bellamine, P. Urban, 1994 .