C. Newton

发表

Analysis of any point mutation in DNA. The amplification refractory mutation system (ARMS).

C Summers, N. Kalsheker, A. Markham, 1989, Nucleic acids research.

Solid phase phosphotriester synthesis of large oligodeoxyribonucleotides on a polyamide support.

A. Markham, D. Scanlon, M. Edge, 1980, Nucleic acids research.

Ion-exchange high-performance liquid chromatography of oligodeoxyribonucleotides using formamide.

A. Markham, D. Holland, M. Edge, 1983, Analytical biochemistry.

Analysis of apolipoprotein E genotypes by the Amplification Refractory Mutation System.

C. Newton, P. Wenham, W. Price, 1991, Clinical chemistry.

Synthesis of some 5'-amino-2',5'-dideoxy-5-iodouridine derivatives and their antiviral properties against herpes simplex virus.

A. Markham, C. Newton, I. Sim, 1982, Antiviral research.

Molecular characterisation of three alpha-1-antitrypsin deficiency variants: proteinase inhibitor (Pi) nullcardiff (Asp256→Val); Pi Mmalton (Phe51→ deletion) and Pi I (Arg39→Cys)

F. Bamforth, N. Kalsheker, A. Markham, 1989, Human Genetics.

Molecular characterisation of two alpha-1-antitrypsin deficiency variants: proteinase inhibitor (Pi) NullNewport (Gly115→Ser) and (Pi) Z Wrexham (Ser−19→Leu)

F. Bamforth, N. Kalsheker, A. Markham, 1990, Human Genetics.

Functionally important conserved amino-acids in interferon-alpha 2 identified with analogues produced from synthetic genes.

F. Carr, R. Hockney, D. Holland, 1986, Biochemical and biophysical research communications.

Prenatal diagnosis of alpha-1-antitrypsin deficiency using polymerase chain reaction (PCR). Comparison of conventional RFLP methods with PCR used in combination with allele specific oligonucleotides or RFLP analysis.

K. B. Petersen, M. Schwartz, N. Gregersen, 1989, Clinical genetics.

Rapid diagnosis of familial defective apolipoprotein B-100 by Amplification Refractory Mutation System.

R. Houlston, C. Newton, P. Wenham, 1991, Clinical chemistry.

Genetic analysis in cystic fibrosis

A. Markham, D. Ogilvie, C. Newton, 2022 .

Molecular characterisation of two alpha-l-antitrypsin deficiency variants: proteinase inhibitor (Pi) NuliNew ort (GlyllS--- Ser)

F. Bamforth, N. Kalsheker, Cheshire Sk, 1990 .

Advances in approaches to DNA-based diagnostics.

D. Whitcombe, S. Little, C. Newton, 1998, Current opinion in biotechnology.

Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

A. Markham, R. Sheppard, M. Gait, 1980, Nucleic acids research.

The elimination of primer-dimer accumulation in PCR.

D. Whitcombe, J. Theaker, S. Little, 1997, Nucleic acids research.

Reagents for the preparation of two oligonucleotides per synthesis (TOPS).

A. Garman, M. J. Mclean, D. Holland, 1994, Nucleic acids research.

Total synthesis of a human leukocyte interferon gene

A. Markham, W. Schuch, D. Scanlon, 1981, Nature.

A homogeneous fluorescence assay for PCR amplicons: its application to real-time, single-tube genotyping.

D. Whitcombe, J. Theaker, S. Little, 1998, Clinical chemistry.

Highly polymorphic minisatellite DNA probes. Further evaluation for individual identification and paternity testing.

A. Markham, C. Newton, J. Smith, 1990, Journal - Forensic Science Society.

Amplification Refractory Mutation System Linear Extension: A Novel, Gel‐Free, Enzyme‐Linked Immunoassay Method for DNA Genotyping

S. Little, J. Fox, C. Newton, 1998, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

A homogeneous method for genotyping with fluorescence polarization.

N. J. Gibson, D. Whitcombe, S. Little, 1997, Clinical chemistry.

The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.

I. Talbot, S. Little, J. Fox, 1998, British Journal of Cancer.

Direct haplotype determination by double ARMS: specificity, sensitivity and genetic applications

Alexander F. Markham, P. Patel, Y. M. Lo, 1991, Nucleic Acids Res..

Diagnosis of alpha 1-antitrypsin deficiency by enzymatic amplification of human genomic DNA and direct sequencing of polymerase chain reaction products.

J. Riley, N. Kalsheker, A. Markham, 1988, Nucleic acids research.

A deletion mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) locus: Delta I507.

A. Markham, M. Schwarz, C. Newton, 1991, Advances in experimental medicine and biology.

AMPLIFICATION REFRACTORY MUTATION SYSTEM FOR PRENATAL DIAGNOSIS AND CARRIER ASSESSMENT IN CYSTIC FIBROSIS

A. Markham, M. Schwarz, C. Newton, 1989, The Lancet.

A colorimetric assay for phosphate to measure amplicon accumulation in polymerase chain reaction.

N. J. Gibson, S. Little, C. Newton, 1997, Analytical biochemistry.

The construction of a synthetic Escherichia coli trp promoter and its use in the expression of a synthetic interferon gene.

A. Markham, M. Edge, C. Newton, 1982, Nucleic acids research.

Development and validation of a screening test for 12 common mutations of the cystic fibrosis CFTR gene.

S. J. Kelly, S. Little, S. Pearce, 1998, The European respiratory journal.

Genetic analysis in cystic fibrosis using the amplification refractory mutation system (ARMS): the J3.11 MspI polymorphism.

A. Markham, D. Ogilvie, C. Newton, 1991, Journal of medical genetics.

Characterisation of the alpha-1-antitrypsin M3 gene, a normal variant

N. Kalsheker, A. Markham, C. Newton, 1990, Human Genetics.

Molecular characterization of a new alpha-1-antitrypsin M variant allele, Mwhitstable: implications for DNA-based diagnosis.

C. Newton, R. Ferrie, N. H. Robertson, 1999, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

ΔF508 testing of the DNA bank of the Royal Manchester Children's Hospital

A. Markham, M. Schwarz, C. Newton, 1990, Human Genetics.

Chemical synthesis of a human interferon-α2, gene and its expression in Escherichia coli

A. Markham, W. Schuch, M. Edge, 1983 .

Detection of ΔF508 deletion by amplification refractory mutation system

A. Markham, M. Schwarz, C. Newton, 1990, The Lancet.