G. Chaconas

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The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens

T. Bankhead, G. Chaconas, 2007, Molecular microbiology.

Association of Mu-containing plasm chromosome upon prophage inducti

R. Harshey, G. Chaconas, Ahmai, 2016 .

Structural aspects of a higher order nucleoprotein complex: induction of an altered DNA structure at the Mu‐host junction of the Mu type 1 transpososome.

G. Chaconas, B. Lavoie, B. Chan, 1991, The EMBO journal.

Studies on a "jumping gene machine": higher-order nucleoprotein complexes in Mu DNA transposition.

G. Chaconas, 1999, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Transposition of phage Mu DNA.

G. Chaconas, B. Lavoie, 1996, Current topics in microbiology and immunology.

DNA transposition: jumping gene machine, some assembly required.

G. Chaconas, M. A. Watson, B. Lavoie, 1996 .

Antibiotic induced electrophoretic mobility shifts of DNA restriction fragments.

R. Blakesley, R. Wells, J. Van De Sande, 1979, Nucleic acids research.

5'-32P labeling of RNA and DNA restriction fragments.

J. Van De Sande, G. Chaconas, G. Chaconas, 1980, Methods in enzymology.

Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C

J. Coburn, J. Leong, Yi-Pin Lin, 2020, PLoS pathogens.

Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi

G. Chaconas, M. Castellanos, T. Verhey, 2019, Molecular microbiology.

G. Chaconas, Rupali Walia, 2013, PloS one.

ResT, a telomere resolvase encoded by the Lyme disease spirochete.

G. Chaconas, K. Kobryn, 2002, Molecular cell.

Anatomy of a Flexer–DNA Complex inside a Higher-Order Transposition Intermediate

G. Shaw, G. Chaconas, B. Lavoie, 1996, Cell.

Differential Telomere Processing by Borrelia Telomere Resolvases In Vitro but Not In Vivo

P. Rosa, A. Barbour, T. Bankhead, 2006, Journal of bacteriology.

Predominant integration end products of infecting bacteriophage Mu DNA are simple insertions with no preference for integration of either Mu DNA strand.

G. Chaconas, D. Evans, D. Kennedy, 1983, Virology.

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force

B. Hahn, J. Coburn, J. Leong, 2022, PLoS pathogens.

Characterization and in Vitro Reaction Properties of 19 Unique Hairpin Telomeres from the Linear Plasmids of the Lyme Disease Spirochete*

G. Chaconas, Yvonne Tourand, T. Moriarty, 2009, Journal of Biological Chemistry.

Characterization and in Vitro Reaction Properties of 19 Unique Hairpin Telomeres from the Linear Plasmids of the

G. Chaconas, Yvonne Tourand, T. Moriarty, 2009 .

The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete

G. Chaconas, M. Castellanos, Madeleine Goldstein, 2022, Frontiers in Microbiology.

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

R. Strieter, P. Kubes, N. Rooijen, 2010, Nature Immunology.

End group labelling of RNA and double stranded DNA by phosphate exchange catalyzed by bacteriophage T4 induced polynucleotide kinase.

J. Van De Sande, G. Chaconas, R. Church, 1975, Biochemical and biophysical research communications.

Supercoiling-dependent site-specific binding of HU to naked Mu DNA.

G. Chaconas, B. Lavoie, K. Kobryn, 1999, Journal of molecular biology.

Site-specific HU binding in the Mu transpososome: conversion of a sequence-independent DNA-binding protein into a chemical nuclease.

M. R. Gerrero, G. Chaconas, B. Lavoie, 1993, Genes & development.

Amplification and purification of the bacteriophage Mu encoded B transposition protein.

G. Gloor, J. Miller, G. Chaconas, 1985, The Journal of biological chemistry.

Transpososomes: Stable protein-DNA complexes involved in the in vitro transposition of bacteriophage Mu DNA

M. Surette, S. Buch, G. Chaconas, 1987, Cell.

In vitro and in vivo manipulations of bacteriophage Mu DNA: cloning of Mu ends and construction of mini-Mu's carrying selectable markers.

J. Lupski, M. Dubow, F. D. de Bruijn, 1981, Gene.

Mutations in domain III alpha of the Mu transposase: evidence suggesting an active site component which interacts with the Mu-host junction.

Z. Wu, G. Chaconas, C. Coros, 1998, Journal of molecular biology.

The Mu transpositional enhancer can function in trans: Requirement of the enhancer for synapsis but not strand cleavage

M. Surette, G. Chaconas, 1992, Cell.

Action at a distance in Mu DNA transposition: an enhancer‐like element is the site of action of supercoiling relief activity by integration host factor (IHF).

G. Chaconas, B. Lavoie, M.G. Surette, 1989, The EMBO journal.

Effect of Mutations in the C-terminal Domain of Mu B on DNA Binding and Interactions with Mu A Transposase*

T. Baker, G. Chaconas, C. Coros, 2003, Journal of Biological Chemistry.

The Mu three-site synapse: a strained assembly platform in which delivery of the L1 transposase binding site triggers catalytic commitment.

G. Chaconas, M. A. Watson, R. G. Allison, 2002, Molecular cell.

A protein factor which reduces the negative supercoiling requirement in the Mu DNA strand transfer reaction is Escherichia coli integration host factor.

M. Surette, G. Chaconas, 1989, The Journal of biological chemistry.

Effect of mutations in the Mu-host junction region on transpososome assembly.

G. Chaconas, C. Coros, 2001, Journal of molecular biology.

Disruption of target DNA binding in Mu DNA transposition by alteration of position 99 in the Mu B protein.

G. Chaconas, A. Millner, 1998, Journal of molecular biology.

A new set of Mu DNA transposition intermediates: alternate pathways of target capture preceding strand transfer

G. Chaconas, D. Z. Naigamwalla, Darius Z. Naigamwalla, 1997, The EMBO journal.

The Mu transposase tetramer is inactive in unassisted strand transfer: an auto-allosteric effect of Mu A promotes the reaction in the absence of Mu B.

Z. Wu, G. Chaconas, Z. Wu, 1997, Journal of molecular biology.

Characterization of a region in phage Mu transposase that is involved in interaction with the Mu B protein.

Z. Wu, G. Chaconas, 1994, The Journal of biological chemistry.

Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro mu DNA strand transfer reaction.

Z. Wu, G. Chaconas, Z. Wu, 1992, The Journal of biological chemistry.

Stimulation of the Mu DNA strand cleavage and intramolecular strand transfer reactions by the Mu B protein is independent of stable binding of the Mu B protein to DNA.

M. Surette, G. Chaconas, 1991, The Journal of biological chemistry.

Stimulation of the Mu A protein-mediated strand cleavage reaction by the Mu B protein, and the requirement of DNA nicking for stable type 1 transpososome formation. In vitro transposition characteristics of mini-Mu plasmids carrying terminal base pair mutations.

M. Surette, G. Chaconas, T. Harkness, 1991, The Journal of biological chemistry.

Primary structure of phage mu transposase: homology to mu repressor.

E. Getzoff, D. Baldwin, J. Miller, 1985, Proceedings of the National Academy of Sciences of the United States of America.

A truncated form of the bacteriophage Mu B protein promotes conservative integration, but not replicative Transposition, of Mu DNA

G. Gloor, G. Chaconas, E. Giddens, 1985, Cell.

Predominant end-products of prophage Mu DNA transposition during the lytic cycle are replicon fusions.

N. Sarvetnick, R. Harshey, G. Chaconas, 1981, Journal of molecular biology.

A second high affinity HU binding site in the phage Mu transpososome.

G. Chaconas, B. Lavoie, Brigitte D. Lavoie, 1994, The Journal of biological chemistry.

Role of the A protein-binding sites in the in vitro transposition of mu DNA. A complex circuit of interactions involving the mu ends and the transpositional enhancer.

G. Chaconas, R. G. Allison, 1992, The Journal of biological chemistry.

Mechanistic aspects of DNA transposition

G. Chaconas, D. Haniford, 1992, Current Biology.

Mechanistic aspects of DNA transposition.

G. Chaconas, D. Haniford, 1992 .

End labeling of enzymatically decapped mRNA.

F. Kafatos, A. Efstratiadis, H. Donis-Keller, 1977, Nucleic acids research.

Uncoupling the Chemical Steps of Telomere Resolution by ResT*

A. Burgin, G. Chaconas, K. Kobryn, 2005, Journal of Biological Chemistry.

Studies on the heterogeneity of the 5′ ends of the protamine mRNAs from rainbow trout testis

G. Chaconas, L. Gedamu, J. H. Sande, 1981, Bioscience reports.

Polyadenylic acid sequences in the RNA of Hyphomicrobium

G. Schultz, G. Chaconas, R. L. Moore, 1978, Journal of bacteriology.

Identification of the Determinant Conferring Permissive Substrate Usage in the Telomere Resolvase, ResT*♦

G. Chaconas, T. Moriarty, 2009, The Journal of Biological Chemistry.

Replication of Linear Bacterial Chromosomes: No Longer Going Around in Circles

G. Chaconas, Carton W. Chen, 2005 .

Convenient methods to determine the specific radioactivity of (gamma-32P)ATP of high specific activity.

J. Van De Sande, G. Chaconas, R. Church, 1975, Analytical biochemistry.

Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT implications for shaping a genome in flux.

G. Chaconas, K. Kobryn, 2005, Molecular cell.

Mixing active-site components: a recipe for the unique enzymatic activity of a telomere resolvase.

T. Bankhead, G. Chaconas, 2004, Proceedings of the National Academy of Sciences of the United States of America.

CSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to mice.

G. Chaconas, 2012, Canadian journal of microbiology.

Investigation of the Genes Involved in Antigenic Switching at the vlsE Locus in Borrelia burgdorferi: An Essential Role for the RuvAB Branch Migrase

G. Chaconas, Ashley R. Dresser, Pierre-Olivier Hardy, 2009, PLoS pathogens.

Electron microscopic analysis of in vitro transposition intermediates of bacteriophage Mu DNA.

J. Miller, G. Chaconas, J. Miller, 1986, Gene.

Mechanism of bacteriophage Mu DNA transposition.

N. Sarvetnick, R. Harshey, G. Chaconas, 1981, Cold Spring Harbor symposia on quantitative biology.

Association of Mu-containing plasmids with the Escherichia coli chromosome upon prophage induction.

R. Harshey, G. Chaconas, A. I. Bukhari, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

P. Kubes, J. Coburn, G. Chaconas, 2015, PLoS pathogens.

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

P. Kubes, M. Norman, P. Colarusso, 2008, PLoS pathogens.

Immunoelectron microscopic analysis of the A, B, and HU protein content of bacteriophage Mu transpososomes.

G. Chaconas, B. Lavoie, 1990, The Journal of biological chemistry.

Topology‐dependent transcription in linear and circular plasmids of the segmented genome of Borrelia burgdorferi

G. Chaconas, C. Beaurepaire, 2007, Molecular microbiology.

A novel DNA binding and nuclease activity in domain III of Mu transposase: evidence for a catalytic region involved in donor cleavage.

Z. Wu, G. Chaconas, Z. Wu, 1995, The EMBO journal.

The circle is broken: telomere resolution in linear replicons.

G. Chaconas, K. Kobryn, 2001, Current opinion in microbiology.

Site‐specific DNA binding and bending by the Borrelia burgdorferi Hbb protein

G. Chaconas, K. Kobryn, D. Z. Naigamwalla, 2000, Molecular microbiology.

Three-Site Synapsis during Mu DNA Transposition: A Critical Intermediate Preceding Engagement of the Active Site

G. Chaconas, M. A. Watson, 1996, Cell.

Mechanism of Mu DNA transposition

M. Surette, G. Chaconas, 1988, BioEssays : news and reviews in molecular, cellular and developmental biology.

Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

S. Norris, Tao Lin, M. Philipp, 2012, PloS one.

DNA transposition: Assembly of a jumping gene machine

G. Chaconas, M. A. Watson, B. Lavoie, 1996, Current Biology.

Sequence of bacteriophage Mu N and P genes.

G. Gloor, G. Chaconas, 1988, Nucleic acids research.

Transposition of bacteriophage mu DNA: expression of the A and B proteins from lambda pL and analysis of infecting mu DNA.

G. Gloor, J. Miller, G. Chaconas, 1984, Cold Spring Harbor symposia on quantitative biology.

The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature

C. Jenne, R. Devinney, B. Petri, 2021, Molecular microbiology.

Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution

T. Bankhead, G. Chaconas, K. Kobryn, 2006, Molecular microbiology.

Changing of the guard: How the Lyme disease spirochete subverts the host immune response

G. Chaconas, M. Castellanos, T. Verhey, 2019, The Journal of Biological Chemistry.

Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline

G. Chaconas, M. Castellanos, T. Verhey, 2018, Molecular microbiology.

The nucleotide sequence of the B gene of bacteriophage Mu.

D. Baldwin, S. Anderson, D. Fujita, 1984, Nucleic acids research.

Hairpin Telomere Resolvases.

G. Chaconas, K. Kobryn, 2014, Microbiology spectrum.

Structure, function, and evolution of linear replicons in Borrelia.

G. Chaconas, K. Kobryn, 2010, Annual review of microbiology.

Catalytic Residues of the Telomere Resolvase ResT

A. Burgin, G. Chaconas, Sandra L. Wilson, 2004, Journal of Biological Chemistry.

Sequence‐specific recognition but position‐dependent cleavage of two distinct telomeres by the Borrelia burgdorferi telomere resolvase, ResT

G. Chaconas, Yvonne Tourand, K. Kobryn, 2003, Molecular microbiology.

Lightin Repair of DNA Damage by UV Borrelia burgdorferi Is the Sole Pathway The Nucleotide Excision Repair System of

G. Chaconas, Pierre-Olivier Hardy, 2014 .

The Nucleotide Excision Repair System of Borrelia burgdorferi Is the Sole Pathway Involved in Repair of DNA Damage by UV Light

G. Chaconas, Pierre-Olivier Hardy, 2013, Journal of bacteriology.

High-Throughput Screening Identifies Three Inhibitor Classes of the Telomere Resolvase from the Lyme Disease Spirochete

G. Chaconas, Georgia Lefas, 2009, Antimicrobial Agents and Chemotherapy.

Peaceful coexistence amongst Borrelia plasmids: getting by with a little help from their friends?

S. Norris, G. Chaconas, 2013, Plasmid.

Molecular Mechanisms Involved in Vascular Interactions of the Lyme Disease Pathogen in a Living Host

P. Kubes, M. Norman, G. Chaconas, 2008, PLoS pathogens.

Live Imaging.

G. Chaconas, J. Skare, J. Hyde, 2020, Current issues in molecular biology.

Telomere resolution in the Lyme disease spirochete

P. Stewart, P. Rosa, K. Tilly, 2001, The EMBO journal.

Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end

G. Chaconas, George Chaconas, 2005, Molecular microbiology.

The solution structure of the C‐terminal domain of the Mu B transposition protein

Ling-Hong Hung, G. Shaw, G. Chaconas, 2000, The EMBO journal.

Telomere resolution by Borrelia burgdorferi ResT through the collaborative efforts of tethered DNA binding domains

G. Chaconas, Yvonne Tourand, Linda Lee, 2007, Molecular microbiology.

A Borrelia burgdorferi mini‐vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat

G. Chaconas, M. Castellanos, T. Verhey, 2018, Molecular microbiology.

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

Woo-Yong Lee, Christopher H Mody, Paul Kubes, 2014, Proceedings of the National Academy of Sciences.

HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete

J. Radolf, M. Caimano, G. Chaconas, 2013, PLoS pathogens.

THE EFFECT OF AGEING ON RNA/DNA RATIOS IN BRAIN REGIONS OF THE C57BL/6J MALE MOUSE

C. Finch, G. Chaconas, C E Finch, 1973, Journal of neurochemistry.

3D reconstruction of the Mu transposase and the Type 1 transpososome: a structural framework for Mu DNA transposition.

F. Ottensmeyer, D. Beniac, G. Chaconas, 2005, Genes & development.

The bacteriophage Mu N gene encodes the 64-kDa virion protein which is injected with, and circularizes, infecting Mu DNA.

G. Gloor, G. Chaconas, 1986, The Journal of biological chemistry.

Illuminating the roles of the Borrelia burgdorferi adhesins.

J. Coburn, J. Leong, G. Chaconas, 2013, Trends in microbiology.

Conservation of Plasmid Maintenance Functions between Linear and Circular Plasmids in Borrelia burgdorferi

P. Stewart, P. Rosa, G. Chaconas, 2003, Journal of bacteriology.

Purification and Properties of the Plasmid Maintenance Proteins from the Borrelia burgdorferi Linear Plasmid lp17

G. Chaconas, J. Deneke, 2008, Journal of bacteriology.

Purification and Properties of the Plasmid Maintenance Proteins from the Borrelia burgdorferi Linear Plasmid lp 17

G. Chaconas, J. Deneke, 2008 .

HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete

G. Chaconas, Ashley R. Dresser, Pierre-Olivier Hardy, 2011, PloS one.

Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors.

J. Manfredi, D. Maier, M. Rosenfeld, 1993, Genes & development.

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair.

G. Chaconas, M. Castellanos, T. Verhey, 2018, Cell reports.

DNA lipid nanoparticle vaccine targeting outer surface protein C affords protection against homologous Borrelia burgdorferi needle challenge in mice

M. Johnston, Jianguo Wu, Xuguang Li, 2023, Frontiers in Immunology.

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

P. Kubes, T. Odisho, J. Leong, 2012, Molecular Microbiology.

Characterization and in Vitro Reaction Properties of 19 Unique Hairpin Telomeres from the Linear Plasmids of the Lyme Disease Spirochete*

G. Chaconas, Yvonne Tourand, T. Moriarty, 2009, Journal of Biological Chemistry.

Choreography of Lyme Disease Spirochete Adhesins To Promote Vascular Escape

G. Chaconas, Xi Tan, M. Castellanos, 2023, Microbiology spectrum.

Construction and Characterization of a Borrelia burgdorferi Strain with Conditional Expression of the Essential Telomere Resolvase, ResT

G. Chaconas, Aydan Salman-Dilgimen, Nicholas J Bandy, 2014, Journal of bacteriology.

Live Imaging.

G. Chaconas, J. Skare, J. Hyde, 2020, Current issues in molecular biology.

Metabolic Interactive Nodular Network for Omics (MINNO): Refining and investigating metabolic networks based on empirical metabolomics data

G. Chaconas, J. Davidsen, M. Castellanos, 2023, bioRxiv.

Hairpin Telomere Resolvases

G. Chaconas, K. Kobryn, 2014, Microbiology spectrum.