Mark Smith

发表

Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Max A. Horlbeck, Luke A. Gilbert, Martin Kampmann, 2016, Nature chemical biology.

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

Taraneh Mirzadegan, Klaus Klumpp, S. Tsing, 2008, Journal of medicinal chemistry.

Peptidomimetics Therapeutics for Retinal Disease

G. Velez, A. Bassuk, V. Mahajan, 2021, Biomolecules.

Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways

K. Davis, K. Sakamoto, H. Chae, 2017, Oncotarget.

Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.

Stephanie C. Kabeche, Michael J. Pulkoski-Gross, Mark Smith, 2021, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

Wen Jiang, R. Devos, J. Symons, 2007, Bioorganic & medicinal chemistry letters.

2′-Deoxy-4′-azido Nucleoside Analogs Are Highly Potent Inhibitors of Hepatitis C Virus Replication Despite the Lack of 2′-α-Hydroxyl Groups*

M. Irwin, S. Eriksson, N. Cammack, 2007, Journal of Biological Chemistry.

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

C. Khosla, J. Carette, M. Bassik, 2020, bioRxiv.

Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism

C. Khosla, J. Carette, M. Bassik, 2020, Cell Chemical Biology.

Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection

G. Ruthel, M. Kinch, M. Aman, 2010, Antimicrobial Agents and Chemotherapy.

Structure-aided development of small molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP

Lingyin Li, Jacqueline A. Carozza, Mark Smith, 2020, bioRxiv.

Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.

T. Montine, R. Nichols, Mark Smith, 2022, ACS medicinal chemistry letters.

The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.

K. Benkestock, N. Cammack, S. Le Pogam, 2009, Journal of medicinal chemistry.

Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.

T. Montine, R. Nichols, Mark Smith, 2022, European journal of medicinal chemistry.

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues

G. Miller, Mark Smith, Mieke Guinan, 2020, Molecules.

CpG oligodeoxyribonucleotides protect mice from Burkholderia pseudomallei but not Francisella tularensis Schu S4 aerosols

D. Waag, H. C. Gelhaus, Mark Smith, 2010, Journal of immune based therapies and vaccines.

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

J. Symons, N. Cammack, S. Ali, 2008, Antimicrobial Agents and Chemotherapy.

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

N. Arora, S. Harris, Mark Smith, 2010 .

Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Y. Li, D. Stefanidis, N. Arora, 2009, ChemMedChem.

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase.

Yu Li, Andrew Briggs, Klaus Klumpp, 2008, Bioorganic & medicinal chemistry letters.

The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.

K. Benkestock, N. Cammack, S. Le Pogam, 2009, Journal of medicinal chemistry.

Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells.

Sooyeon Lee, Mark Smith, T. Horton, 2019, Cell chemical biology.

A Gut Commensal-Produced Metabolite Mediates Colonization Resistance to Salmonella Infection.

William W. Van Treuren, K. C. Huang, J. Sonnenburg, 2018, Cell host & microbe.

Design and Characterization of R1626, A Prodrug of the HCV Replication Inhibitor R1479 (4′-Azidocytidine) With Enhanced Oral Bioavailability

G. Dore, Xiaoyang Wu, D. Shaw, 2007 .

PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma

P. Brown, K. Shokat, I. Wistuba, 2020, Science Translational Medicine.

Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters

K. McLure, K. Sakamoto, E. Eklund, 2016, Oncotarget.

CC-401 Promotes &bgr;-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition

Benjamin T Yeh, R. Nichols, Sooyeon Lee, 2018, Endocrinology.

Extracellular cGAMP is a cancer-cell-produced immunotransmitter involved in radiation-induced anticancer immunity

E. Graves, J. Glenn, Lingyin Li, 2020, Nature Cancer.

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

E. Graves, J. Glenn, Lingyin Li, 2019 .

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization.

Benjamin T Yeh, Mark Smith, J. Annes, 2019, Bioorganic & medicinal chemistry.

Targeting LRRK2 mutations in Parkinson's disease.

T. Montine, R. Nichols, Mark Smith, 2022, Future medicinal chemistry.

Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.

T. Montine, W. Fitch, Mark Smith, 2021, European journal of medicinal chemistry.

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

S. Tsing, T. Mirzadegan, S. Harris, 2008, Journal of medicinal chemistry.