W. Tempel

发表

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Haruki Nakamura, Evan Bolton, Zukang Feng, 2016, Structure.

The First Agmatine/Cadaverine Aminopropyl Transferase: Biochemical and Structural Characterization of an Enzyme Involved in Polyamine Biosynthesis in the Hyperthermophilic Archaeon Pyrococcus furiosus

Francis E. Jenney, Michael W. W. Adams, Wolfram Tempel, 2007, Journal of bacteriology.

(NZ)CH...O Contacts assist crystallization of a ParB-like nuclease

J. Rose, Z. Rao, Bi-Cheng Wang, 2007, BMC Structural Biology.

Isolation, crystallization and preliminary X-ray analysis of a methanol-induced corrinoid protein from Moorella thermoacetica.

J. Rose, Lirong Chen, Bi-Cheng Wang, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Mechanism of Class 1 (Glycosylhydrolase Family 47) α-Mannosidases Involved in N-Glycan Processing and Endoplasmic Reticulum Quality Control*

Wolfram Tempel, Zhi-Jie Liu, Bi-Cheng Wang, 2005, Journal of Biological Chemistry.

Crystallization and preliminary X-ray analysis of GlcNAcα1,4Gal-releasing endo-β-galactosidase from Clostridium perfringens

J. Rose, Bi-Cheng Wang, P. Horanyi, 2004 .

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.

Ke Liu, Wolfram Tempel, Chao Xu, 2014, Nature chemical biology.

Structures of Human ALKBH5 Demethylase Reveal a Unique Binding Mode for Specific Single-stranded N6-Methyladenosine RNA Demethylation*

Wolfram Tempel, Chao Xu, Christopher J Schofield, 2014, The Journal of Biological Chemistry.

Comparative Structural Analysis of Human DEAD-Box RNA Helicases

Martin Hammarström, M. Högbom, S. van den Berg, 2010, PloS one.

Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin α1

Kaori H. Yamada, F. Mackenzie, A. Chishti, 2010, Proceedings of the National Academy of Sciences.

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

C. Arrowsmith, S. Houliston, M. Schapira, 2019, bioRxiv.

Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)*

M. Buck, Susmita Borthakur, Y. Tong, 2011, The Journal of Biological Chemistry.

A cellular chemical probe targeting the chromodomains of Polycomb Repressive Complex 1

Nancy Cheng, Su Qin, Bradley M Dickson, 2015, Nature chemical biology.

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

A. Emili, J. Greenblatt, Xi-Ping Huang, 2012, Nature chemical biology.

Structure of Mouse Golgi α-Mannosidase IA Reveals the Molecular Basis for Substrate Specificity among Class 1 (Family 47 Glycosylhydrolase) α1,2-Mannosidases*

J. Rose, Bi-Cheng Wang, Zhi-jie Liu, 2004, Journal of Biological Chemistry.

Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon

J. Richardson, D. Richardson, J. Rose, 2007, Journal of Structural and Functional Genomics.

Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions to Perform a Similar Function

Hee-won Park, W. Tempel, J. C. Cochran, 2019, bioRxiv.

Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9

Chao Xu, P. Pan, J. Min, 2011, PloS one.

Crystal structure of human eIF5A1: Insight into functional similarity of human eIF5A1 and eIF5A2

Y. Tong, L. Nedyalkova, Hee-won Park, 2009, Proteins.

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Peter A. DiMaggio, Tim J. Wigle, B. Garcia, 2011, Nature chemical biology.

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.

J. Min, J. Côté, P. Loppnau, 2020, Cell reports.

Structural basis for EPC1-mediated recruitment of MBTD1 into the NuA4/TIP60 acetyltransferase complex

J. Min, J. Côté, P. Loppnau, 2019, bioRxiv.

Allosteric Modu Specificity by A of Protein Cores

Philip M. Kim, Julia M. Shifman, J. Shifman, 2019 .

Allosteric Modulation of Binding Specificity by Alternative Packing of Protein Cores.

Philip M. Kim, Julia M. Shifman, J. Shifman, 2019, Journal of molecular biology.

ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model

William J. Israelsen, M. V. Heiden, C. Kung, 2013 .

Chromokinesins NOD and KID Use Distinct ATPase Mechanisms and Microtubule Interactions To Perform a Similar Function.

Hee-won Park, W. Tempel, J. C. Cochran, 2019, Biochemistry.

Life in the fast lane for protein crystallization and X-ray crystallography.

Jeremy L. Praissman, Wolfram Tempel, Zhi-Jie Liu, 2005, Progress in biophysics and molecular biology.

Crystallization and preliminary X-ray diffraction analysis of lectin-1 from Pseudomonas aeruginosa.

Bi Cheng Wang, J. Rose, W. Tempel, 2003, Acta crystallographica. Section D, Biological crystallography.

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

L. Sibley, F. Mackenzie, M. Vedadi, 2010, Nature Structural &Molecular Biology.

Erratum: A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells (Nature Chemical Biology (2011) 7 (401-404))

Peter A. DiMaggio, Tim J. Wigle, B. Garcia, 2011 .

Structure of the conserved transcriptional repressor enhancer of rudimentary homolog.

R. Rose, Zhi-jie Liu, W. Tempel, 2005, Biochemistry.

Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 A resolution.

J. Richardson, D. Richardson, J. Rose, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Characterization of a corrinoid protein involved in the C1 metabolism of strict anaerobic bacterium Moorella thermoacetica

J. Rose, Lirong Chen, Jessie C. Chang, 2007, Proteins.

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain.

C. Arrowsmith, S. Houliston, M. Schapira, 2019, Journal of medicinal chemistry.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Matthieu Schapira, James E. Bradner, John R. Engen, 2012, Nature Communications.

Structural Genomics of Pyrococcus furiosus : X-Ray Crystallography Reveals 3 D Domain Swapping in Rubrerythrin

Ashit K Shah, W. B. Arendall, J. Richardson, 2004 .

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.

P. Fish, M. Schapira, M. Vedadi, 2016, Bioorganic & medicinal chemistry letters.

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

E. Eisenmesser, H. Ouyang, F. Mackenzie, 2010, PLoS biology.

First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor

Luke T. Dang, D. Baker, S. Orkin, 2017, Proceedings of the National Academy of Sciences.

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

Chao Xu, Wei Qiu, J. Min, 2011, PloS one.

Histone recognition by human malignant brain tumor domains.

C. Arrowsmith, Shili Duan, N. Zhong, 2012, Journal of molecular biology.

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

X. Shirley Liu, Gert Jan C. Veenstra, Wolfram Tempel, 2012, Cell.

Structure and Function of the Intracellular Region of the Plexin-B1 Transmembrane Receptor*

M. Buck, Y. Tong, P. Hota, 2009, Journal of Biological Chemistry.

Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain*

Matthias Buck, Wolfram Tempel, Hee-Won Park, 2007, Journal of Biological Chemistry.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Christian M. Metallo, William J. Israelsen, Abhishek K. Jha, 2012, Nature chemical biology.

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

Alexey Bochkarev, Wolfram Tempel, Anne Mulichak, 2007, Molecular and biochemical parasitology.

Structure and Function of a G-actin Sequestering Protein with a Vital Role in Malaria Oocyst Development inside the Mosquito Vector*

K. Matuschewski, H. Schüler, A. Dong, 2010, The Journal of Biological Chemistry.

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

Kyle V. Butler, C. Arrowsmith, M. Vedadi, 2016, Journal of medicinal chemistry.

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

H 3 K 14 ac is linked to methylation of H 3 K 9 by the triple Tudor domain of SETDB 1

R. Reinhardt, J. Min, Sara Weirich, 2017 .

Structural Basis of Substrate-binding Specificity of Human Arylamine N-Acetyltransferases*

Ludmila Dombrovsky, Wolfram Tempel, Peter Loppnau, 2007, Journal of Biological Chemistry.

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation–mediated 14-3-3 binding

M. Gottesman, M. Yohe, L. Jenkins, 2018, The Journal of Biological Chemistry.

Association of UHRF1 with H3K9 methylation directs the maintenance of DNA methylation

B. Strahl, C. Arrowsmith, K. Krajewski, 2012, Nature Structural &Molecular Biology.

Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities.

Gary D Bader, Philip M. Kim, J. Min, 2017, Structure.

Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.

K. Borden, A. Wernimont, N. Siddiqui, 2012, Journal of molecular biology.

Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

J. Min, R. Lam, W. Tempel, 2015, Acta crystallographica. Section F, Structural biology communications.

Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling

N. Katsanis, J. B. Rattner, Y. Tong, 2010, The Journal of Biological Chemistry.

RPRD 1 A and RPRD 1 B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser 5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014 .

Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53.

Yun-Xing Wang, C. Arrowsmith, N. Chirgadze, 2011, Structure.

Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation

P. Grant, J. Workman, Chao Xu, 2011, The EMBO journal.

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain

J. Min, M. Lei, Sizhuo Chen, 2019, bioRxiv.

Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain

J. Min, M. Lei, Ke Liu, 2019, bioRxiv.

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

T. Pawson, Chao Xu, J. Min, 2015, Structure.

Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus*

A. R. Merrill, Hee-won Park, W. Tempel, 2012, The Journal of Biological Chemistry.

Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Rafael Najmanovich, Alexey Bochkarev, Abdellah Allali-Hassani, 2007, PLoS biology.

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

J. Min, Sara Weirich, Alexander Bröhm, 2020, Communications Biology.

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

J. Min, Sara Weirich, A. Jeltsch, 2020, Communications Biology.

An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2

J. Min, W. Tempel, Li Li, 2018, Communications Biology.

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins*

J. Min, Xiao Liang, P. Loppnau, 2016, The Journal of Biological Chemistry.

Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway

J. Min, P. Loppnau, W. Tempel, 2018, Nature Chemical Biology.

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

A. Emili, Xinghua Guo, Joyce Li, 2014, Nature Structural &Molecular Biology.

Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1

J. Min, M. Lei, P. Loppnau, 2017, The Journal of Biological Chemistry.

Crystal structure solution of a ParB‐like nuclease at atomic resolution

J. Rose, Z. Rao, Jessie C. Chang, 2008, Proteins.

Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1

C. Bian, J. Min, M. Vedadi, 2014, Nature Communications.

Crystal Structure of the N-Acetylmannosamine Kinase Domain of GNE

F. Mackenzie, Y. Tong, L. Nedyalkova, 2009, PloS one.

Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

T. Pawson, Chao Xu, C. Bian, 2012, Science Signaling.

The xenograft antigen in complex with GS-1-B4 lectin: crystallization and preliminary X-ray analysis.

L. A. Lipscomb, J. Rose, R. Woods, 2001, Acta crystallographica. Section D, Biological crystallography.

An intact SAM‐dependent methyltransferase fold is encoded by the human endothelin‐converting enzyme‐2 gene

A. Bochkarev, A. Plotnikov, P. Loppnau, 2009, Proteins.

Crystal Structures of the Tetratricopeptide Repeat Domains of Kinesin Light Chains: Insight into Cargo Recognition Mechanisms

F. Mackenzie, Y. Tong, Hee-won Park, 2012, PloS one.

The dynamic conformational landscape of the protein methyltransferase SETD8

Cheng Luo, Jian Jin, Yujun George Zheng, 2019, eLife.

The Dynamic Conformational Landscapes of the Protein Methyltransferase SETD8

Cheng Luo, Jian Jin, Hualiang Jiang, 2018, bioRxiv.

Structural basis for a novel interaction between TXNIP and Vav2

P. Loppnau, W. Tempel, Yanli Liu, 2016, FEBS letters.

Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.

J. Min, A. Dong, W. Tempel, 2016, The Biochemical journal.

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold*

D. V. van Aalten, I. Batty, C. Downes, 2012, The Journal of Biological Chemistry.

Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+

Charles Brenner, Wolfram Tempel, Hee-Won Park, 2007, PLoS biology.

Human METTL3-METTL14 complex

Cheryl H. Arrowsmith, Wolfram Tempel, C. Bountra, 2016 .

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.

M. Vedadi, E. Strauss, A. Allali-Hassani, 2016, ACS Infectious Diseases.

Crystal Structures of Human Choline Kinase Isoforms in Complex with Hemicholinium-3

F. Mackenzie, M. Vedadi, A. Allali-Hassani, 2010, The Journal of Biological Chemistry.

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Abhishek K. Jha, G. Stephanopoulos, Noel Southall, 2012 .

Correction: Structural and Chemical Profiling of the Human Cytosolic Sulfotransferases

Janet M. Thornton, Abdellah Allali-Hassani, Alexander N. Plotnikov, 2007, PLoS Biology.

Salvaging Pyrococcus furiosus Protein Targets at SECSG

Ashit K Shah, J. Rose, D. Lin, 2005, Journal of Structural and Functional Genomics.

Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins

C. Bian, J. Min, R. Lam, 2012, FEBS letters.

Structural basis for substrate recognition by the human N-terminal methyltransferase 1

J. Min, P. Loppnau, W. Tempel, 2015, Genes & development.

Structural Basis for the Binding Selectivity of Human CDY Chromodomains.

J. Min, W. Tempel, Tian-Jie Lyu, 2020, Cell chemical biology.

Structural basis for the binding selectivity of human CDY chromodomains

J. Min, W. Tempel, Tian-Jie Lyu, 2019, bioRxiv.

ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2

L. Cantley, D. Auld, M. Boxer, 2013 .

Structural characterization of human cholesterol 7α-hydroxylase

F. Mackenzie, Hee-won Park, A. Gilep, 2014, Journal of Lipid Research.

High throughput crystallography at SGC Toronto: an overview.

Wolfram Tempel, Alexey Bochkarev, A. Bochkarev, 2008, Methods in molecular biology.

The high-throughput protein-to-structure pipeline at SECSG.

Hua Yang, Weihong Zhou, Doowon Lee, 2005, Acta crystallographica. Section D, Biological crystallography.

The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site.

Sarah M. Tschampel, Robert J Woods, Wolfram Tempel, 2002, The Journal of biological chemistry.

Crystal structure of the nucleotide-binding domain of Ras-related GTP-binding protein C

C. Bountra, C. Arrowsmith, J. Weigelt, 2010 .

Parameter-space screening: a powerful tool for high-throughput crystal structure determination.

Dawei Lin, Jeremy L. Praissman, Wolfram Tempel, 2005, Acta crystallographica. Section D, Biological crystallography.

A test of enhancing model accuracy in high-throughput crystallography

Shuren Wang, Weihong Zhou, David C. Richardson, 2005, Journal of Structural and Functional Genomics.

Crystal Structure of human NAD kinase

C. Bountra, C. Arrowsmith, J. Weigelt, 2010 .

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

R. Reinhardt, J. Min, Sara Weirich, 2017, Nature Communications.

Crystal structure of DPF3b in complex with an acetylated histone peptide.

P. Loppnau, W. Tempel, Yanli Liu, 2016, Journal of structural biology.

human SETD8 in complex with MS2177

Anqi Ma, Jian Jin, Nicolas Babault, 2016 .

Corrigendum: Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.

Zhike Lu, Chao Xu, J. Min, 2015, Nature chemical biology.

Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

J. Min, Y. Dou, P. Loppnau, 2018, Genes & development.

First crystallographic models of human TBC domains in the context of a family‐wide structural analysis

A. Bochkarev, Y. Tong, Hee-won Park, 2008, Proteins.

Away from the edge II: in-house Se-SAS phasing with chromium radiation.

Bi Cheng Wang, W. B. Arendall, J. Richardson, 2005, Acta crystallographica. Section D, Biological crystallography.

Crystal structure of human multiple copies in T‐cell lymphoma‐1 oncoprotein

Y. Tong, Hee-won Park, W. Tempel, 2013, Proteins.

Crystal structure of EHMT1

C. Bountra, C. Arrowsmith, Y. Tong, 2018 .

The Xenograft Antigen Bound to Griffonia simplicifolia Lectin 1-B4

Sarah M. Tschampel, R. Woods, W. Tempel, 2002, Journal of Biological Chemistry.

Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.

Chao Xu, C. Bian, F. Mackenzie, 2011, Biochemical and biophysical research communications.

Crystal structure of TBL1XR1 WD40 repeats

Chao Xu, J. Min, C. Bountra, 2014 .

A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

Xinghua Guo, J. Greenblatt, J. Min, 2019, bioRxiv.

Crystal Structure Analysis of Kelch protein from Plasmodium falciparum

C. Bountra, C. Arrowsmith, S. Gräslund, 2015 .

Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.

A. Dong, W. Tempel, Ashrut Narula, 2016, The Biochemical journal.

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.

Zhike Lu, Chao Xu, I. A. Roundtree, 2014, Nature chemical biology.

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.

Matthieu Schapira, Wenyu Yu, Wolfram Tempel, 2013, Bioorganic & medicinal chemistry.

Crystal structures of Klebsiella pneumoniae pantothenate kinase in complex with N‐substituted pantothenamides

M. Schapira, D. Smil, Hee-won Park, 2013, Proteins.

Human K-Ras in complex with a GTP analogue

Cheryl H. Arrowsmith, Hee-Won Park, J. Weigelt, 2007 .