O. Grygorenko

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The symbiotic relationship between drug discovery and organic chemistry.

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2020, Chemistry.

Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks.

N. A. Tolmacheva, C. Daniliuc, O. Grygorenko, 2019, The Journal of organic chemistry.

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

O. Grygorenko, 2020 .

Generating Multibillion Chemical Space of Readily Accessible Screening Compounds

Yurii S. Moroz, O. Grygorenko, D. Radchenko, 2020, iScience.

Following Ramachandran 2: exit vector plot (EVP) analysis of disubstituted saturated rings

I. Komarov, O. Grygorenko, D. Demenko, 2018 .

Following Ramachandran: exit vector plots (EVP) as a tool to navigate chemical space covered by 3D bifunctional scaffolds. The case of cycloalkanes

I. Komarov, O. Grygorenko, D. M. Volochnyuk, 2016 .

Conformationally restricted glutamic acid analogues: stereoisomers of 1-aminospiro[3.3]heptane-1,6-dicarboxylic acid

I. Komarov, O. Shishkin, S. Shishkina, 2014 .

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki-Miyaura Reactions of Bromooxazole Building Blocks

O. Grygorenko, D. Radchenko, Vitalii V. Solomin, 2019, European Journal of Organic Chemistry.

Conformational behaviour of peptides containing a 2-pyrrolidinemethanesulfonic acid (2PyMS) residue.

A. Tolmachev, O. Shishkin, O. Grygorenko, 2013, Organic & biomolecular chemistry.

4‐(Di‐/Trifluoromethyl)‐2‐heterabicyclo[2.1.1]hexanes: Advanced Fluorinated Phenyl Isosteres and Proline analogues

C. Daniliuc, Oleg M. Michurin, O. Grygorenko, 2021 .

Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space.

A. Tolmachev, Yu. G. Shermolovich, O. Grygorenko, 2019, Chemistry.

Last of the gem ‐Difluorocycloalkanes 2: Synthesis of Fluorinated Cycloheptane Building Blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2021 .

Multigram Synthesis of Advanced 6,6-Difluorospiro[3.3]heptane-derived Building Blocks.

O. Grygorenko, Anton V. Chernykh, D. Radchenko, 2020, European journal of organic chemistry.

Straightforward hit identification approach in fragment-based discovery of bromodomain-containing protein 4 (BRD4) inhibitors.

Yurii S. Moroz, V. Hurmach, S. Zozulya, 2018, Bioorganic & Medicinal Chemistry.

Recyclizations of 3-Formylchromones with Binucleophiles

O. Grygorenko, S. Ryabukhin, A. S. Plaskon, 2012 .

Twisting and turning the sulfonamide bond: synthetic, quantum chemical and crystallographic study.

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2020, The Journal of organic chemistry.

Scalable synthesis and properties of 7-methyl- 4-azaindole

O. Grygorenko, D. Volochnyuk, A. I. Subota, 2017 .

Synthesis of saturated and partially saturated heterocyclic boronic derivatives

O. Grygorenko, Viktoriya S. Moskvina, Ihor Kleban, 2021, Tetrahedron.

Fluorine‐Labelled Spiro[3.3]heptane‐Derived Building Blocks: Is Single Fluorine the Best?

O. Grygorenko, Anton V. Chernykh, Alexey V. Dobrydnev, 2021, European Journal of Organic Chemistry.

Synthesis and reactions of ω-CF3O-substituted aliphatic sulfonyl chlorides

O. Grygorenko, I. Kondratov, Alexey V. Dobrydnev, 2021, Journal of Fluorine Chemistry.

Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

Igor A. Levandovskiy, O. Grygorenko, Maksym Kurkunov, 2018, Synthesis.

Synthesis of gem ‐Difluorocyclopropanes

O. Grygorenko, D. Volochnyuk, 2020 .

A novel approach to 2,4-ethanoproline

C. Cativiela, I. Komarov, O. Grygorenko, 2009 .

Water Determination in Aromatic Sulfonyl Chlorides Using the Karl Fischer Titration Method: Scope and Limitations

O. Grygorenko, D. Radchenko, Olga B. Radchenko, 2022, ChemistrySelect.

GABA Analogues and Related Mono-/Bifunctional Building Blocks Derived from the Fluorocyclobutane Scaffold

G. Haufe, O. Grygorenko, I. Kondratov, 2020 .

Synthesis and structural analysis of angular monoprotected diamines based on spiro[3.3]heptane scaffold.

I. Komarov, C. Daniliuc, O. Grygorenko, 2015, The Journal of organic chemistry.

Bicyclic β-Amino Acids

O. Grygorenko, 2015 .

Protecting Group Free Synthesis of Carboxyl‐substituted Dihydropyrimidines Through Biginelli Reaction

A. Tolmachev, O. Grygorenko, S. Ryabukhin, 2013 .

Acyl pyruvates as synthons in the Biginelli reaction

A. Tolmachev, O. Shishkin, O. Grygorenko, 2010 .

Fluoroalkyl‐Containing 1,2‐Disubstituted Cyclobutanes: Advanced Building Blocks for Medicinal Chemistry

O. Grygorenko, D. Volochnyuk, Kostiantyn P. Melnykov, 2020 .

Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery.

S. Zozulya, O. Grygorenko, Pavel K. Mykhailiuk, 2017, The Journal of organic chemistry.

Cyclopropyl boronic derivatives in parallel synthesis of sp3-enriched compound libraries

O. Grygorenko, D. Radchenko, Y. Rassukana, 2020, Monatshefte für Chemie - Chemical Monthly.

Regioselective synthesis of pyrazoles fused with heteroaliphatic amines at the [3,4-c] edges

O. Grygorenko, D. M. Volochnyuk, Dmitry M. Volochnyuk, 2015 .

Synthesis of Bi‐ and Polyfunctional Isoxazoles from Amino Acid Derived Halogenoximes and Active Methylene Nitriles

Daniil Bash, O. Grygorenko, K. Gavrilenko, 2018 .

Bicyclo[1.1.1]pentane‐Derived Building Blocks for Click Chemistry

I. Komarov, O. Grygorenko, A. V. Tymtsunik, 2017 .

Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties.

O. Grygorenko, D. Volochnyuk, Anton V. Chernykh, 2020, The Journal of organic chemistry.

Functionalization of 2-Trifluoromethyl-1H -pyrrole: A Convenient Entry into Advanced Fluorinated Building Blocks Including all Isomeric 2-(Trifluoromethyl)prolines

O. Karpenko, O. Grygorenko, V. Y. Hys, 2020 .

Multigram Synthesis and C−C/C−N Couplings of Functionalized 1,2‐Disubstituted Cyclopropyltrifluoroborates

I. Komarov, O. Grygorenko, V. O. Kovtunenko, 2019, Advanced Synthesis & Catalysis.

Reductive Recyclization of sp3-Enriched Functionalized Isoxazolines into α-Hydroxy Lactams.

A. O. Osipova, I. Komarov, O. Grygorenko, 2021, The Journal of organic chemistry.

Synthesis of Fused Pyridine Carboxylates by Reaction of β-Alkoxyvinyl Glyoxylates with Amino Heterocycles

A. Tolmachev, O. Grygorenko, I. Kondratov, 2020, Synthesis.

Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom

A. Tolmachev, O. Grygorenko, Yuliya O. Kuchkovska, 2020, European Journal of Organic Chemistry.

Focused enumeration and assessing the structural diversity of scaffold libraries: conformationally restricted bicyclic secondary diamines

I. Komarov, O. Grygorenko, D. Volochnyuk, 2012, Molecular Diversity.

A stereolibrary of conformationally restricted amino acids based on pyrrolidinyl/piperidinyloxazole motifs

O. Grygorenko, D. M. Volochnyuk, Evgeniy Y. Slobodyanyuk, 2015 .

Synthesis of racemic and enantiopure 3,4-methanonipecotic acid

I. Komarov, O. Grygorenko, A. V. Tymtsunik, 2015 .

Cycloadditions of Alkenylboronic Derivatives

O. Grygorenko, O. V. Hryshchuk, V. Moskvina, 2020, Synthesis.

Synthesis of a novel Boc-protected cyclopropane-modified proline analogue

I. Komarov, O. Grygorenko, A. V. Tymtsunik, 2012 .

Synthesis of spirocyclic β- and γ-sultams by one-pot reductive cyclization of cyanoalkylsulfonyl fluorides.

Yurii S. Moroz, O. Grygorenko, Y. Volovenko, 2020, European journal of organic chemistry.

Strategy for the synthesis of 2,2-disubstituted 8-azachromanones via Horner–Wadsworth–Emmons olefination

O. Grygorenko, Alexey V. Dobrydnev, Eugeniy N. Ostapchuk, 2020, Chemistry of Heterocyclic Compounds.

N -Difluorocyclopropyl-Substituted Pyrazoles: Synthesis and Reactivity

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

Synthesis of 1-hetaryl-2,2-difluorocyclopropane-derived building blocks: The case of pyrazoles

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Journal of Fluorine Chemistry.

Formation of 10/12/14-Membered Rings is Favored over 5/6/7-Membered. An Unexpected Result from Oxazole Chemistry

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation

O. Grygorenko, Yuliya O. Kuchkovska, O. V. Hryshchuk, 2018, Tetrahedron Letters.

Hetaryl Bromides Bearing the SO2 F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions

A. Tolmachev, O. Grygorenko, B. Vashchenko, 2018, European Journal of Organic Chemistry.

Synthesis, physico-chemical properties and microsomal stability of compounds bearing aliphatic trifluoromethoxy group

G. Haufe, M. Kliachyna, O. Grygorenko, 2020, Journal of Fluorine Chemistry.

Focused enumeration and assessing the structural diversity of scaffold libraries: conformationally restricted bicyclic secondary diamines

I. Komarov, O. Grygorenko, D. Volochnyuk, 2012, Molecular Diversity.

Advancing molecular graphs with descriptors for the prediction of chemical reaction yields

Yurii S. Moroz, O. Grygorenko, D. Radchenko, 2022, J. Comput. Chem..

gem -Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF3 SiMe3 -NaI System

O. Grygorenko, Yuliya O. Kuchkovska, O. V. Hryshchuk, 2020 .

Synthesis of 2-azaspiro[3.3]heptane-derived amino acids: ornitine and GABA analogues

I. Komarov, O. Grygorenko, D. Radchenko, 2010, Amino Acids.

Metal-Free C-H Difluoromethylation of Imidazoles with the Ruppert-Prakash Reagent.

O. Grygorenko, D. Volochnyuk, A. Rozhenko, 2022, The Journal of organic chemistry.

Fluorine-Containing Diazines in Medicinal Chemistry and Agrochemistry

O. Grygorenko, D. Volochnyuk, Alina O. Gorlova, 2014, Fluorine in Heterocyclic Chemistry Volume 2.

Fluorine Containing Diazines. Synthesis and Properties

O. Grygorenko, D. Volochnyuk, Alina O. Gorlova, 2014 .

Azepines and Their Fused-Ring Derivatives

O. Grygorenko, Yuliya O. Kuchkovska, 2021, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering.

Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes.

Yurii S. Moroz, O. Grygorenko, K. Gavrilenko, 2019, The Journal of organic chemistry.

Reaction of β-alkoxyvinyl α-ketoesters with acyclic NCN binucleophiles – Scalable approach to novel functionalized pyrimidines

A. Tolmachev, O. Grygorenko, I. Kondratov, 2019, Tetrahedron.

[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ― an Approach to Pyrrolidine-3-sulfonyl Fluorides

A. Tolmachev, O. Grygorenko, R. Doroschuk, 2018, European Journal of Organic Chemistry.

3-haloquinolines by Friedländer reaction of α-haloketones.

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2011, The Journal of organic chemistry.

2,2-Difluorovinyl Pinacolborane - A New Versatile Reagent for the Suzuki-Miyaura Reaction

M. O. Redka, A. Kysil, O. Grygorenko, 2019, European Journal of Organic Chemistry.

Approach to the library of fused pyridine-4-carboxylic acids by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles.

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2010, Journal of combinatorial chemistry.

The PIFA-initiated oxidative cyclization of 2-(3-butenyl)quinazolin-4(3H)-ones – an efficient approach to 1-(hydroxymethyl)-2,3-dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones

O. Grygorenko, E. Rusanov, M. Vovk, 2021, Beilstein journal of organic chemistry.

Synthesis of azachromones and azachromanones

O. Grygorenko, V. Brovarets, V. Moskvina, 2019, Chemistry of Heterocyclic Compounds.

Synthesis of 4-Hetarylisoxazoles from Amino Acid-Derived Halogenoximes and Push-Pull Enamines

I. B. Kulik, O. Grygorenko, D. Volochnyuk, 2018, European Journal of Organic Chemistry.

Diastereoselective Synthesis of Cyclic sp3-Enriched cis-β-Alkoxysulfonyl Chlorides

A. Tolmachev, O. Grygorenko, Yuliya O. Kuchkovska, 2018, Synthesis.

Aliphatic α-Boryl-α-bromoketones: Synthesis and Reactivity

O. Grygorenko, Yuliya O. Kuchkovska, Yevhen M. Ivon, 2020 .

Robust and Scalable Approach to 1,3-Disubstituted Pyridylcyclobutanes

I. Komarov, O. Grygorenko, D. Radchenko, 2019, European Journal of Organic Chemistry.

Amino sulfonic acids, peptidosulfonamides and other related compounds

O. Grygorenko, Serhii Zhersh, A. Biitseva, 2018 .

Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, ACS omega.

Gram-Scale Synthesis of Amines Bearing a gem-Difluorocyclopropane Moiety

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2017 .

Tetrahydropyrido[d]pyridazinones—promising scaffolds for drug discovery

O. Grygorenko, D. Volochnyuk, V. V. Shelyakin, 2013 .

An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Journal of Fluorine Chemistry.

Chlorotrimethylsilane-Promoted Condensation of Ketones and Aminoazoles

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2012 .

Approach to the library of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a three-component condensation.

O. Grygorenko, S. Ryabukhin, A. S. Plaskon, 2012, ACS combinatorial science.

Reaction of Dialkylaminosulfur Trifluorides with β‐Keto Sulfonamides and β‐Keto Sulfones

M. V. Popova, S. Shishkina, O. Grygorenko, 2021 .

Synthesis of gem-difluorocyclopentane/hexane building blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2017 .

Bicyclic conformationally restricted diamines.

A. Tolmachev, I. Komarov, O. Grygorenko, 2011, Chemical reviews.

Monoprotected Diamines Derived from 1,5‐Disubstituted (Aza)spiro[2.3]hexane Scaffolds

I. Komarov, O. Grygorenko, Anton V. Chernykh, 2021 .

Synthesis of α-substituted 2-(1H-1,2,4-triazol-3-yl)acetates and 5-amino-2,4-dihydro-3H-pyrazol-3-ones via the Pinner strategy.

Yurii S. Moroz, O. Grygorenko, O. V. Vaschenko, 2021, Tetrahedron letters.

Bicyclic 6–6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms (2:1)

O. Grygorenko, Valeriia Hutskalova, V. Moskvina, 2020 .

Formyl MIDA Boronate: C 1 Building Block Enables Straightforward Access to α‐Functionalized Organoboron Derivatives

O. Grygorenko, Yuliya O. Kuchkovska, Yevhen M. Ivon, 2020, Angewandte Chemie.

Formyl MIDA Boronate: a C1 Building Block Enabling Straightforward Access to α-Functionalized Organoboron Derivatives.

O. Grygorenko, Yuliya O. Kuchkovska, Yevhen M. Ivon, 2020, Angewandte Chemie.

Regioselective Synthesis of Functionalized 3- or 5-Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles.

Yurii S. Moroz, O. Grygorenko, Yuliya O. Kuchkovska, 2019, The Journal of organic chemistry.

An approach to dihydroisoindolobenzodiazepinones—three-dimensional molecular frameworks

O. Grygorenko, D. Volochnyuk, E. Rusanov, 2013 .

One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles

Yurii S. Moroz, O. Grygorenko, D. Radchenko, 2021, Molecular Diversity.

One-pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles.

Yurii S. Moroz, O. Grygorenko, Yuliya O. Kuchkovska, 2019, ACS combinatorial science.

Synthesis of Functionalized 1,4-Dioxanes with an Additional (Hetero)Aliphatic Ring

A. Tolmachev, O. Grygorenko, B. Vashchenko, 2018, Synthesis.

Cyclobutane-derived diamines: synthesis and molecular structure.

I. Komarov, O. Shishkin, S. Shishkina, 2010, The Journal of organic chemistry.

Chlorotrimethylsilane‐Promoted Condensation of Ketones and Aminoazoles.

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2013 .

Organosilicon Compounds asWater Scavengers in Reactions of Carbonyl Compounds

Dmitriy M. Volochnyuk, O. Grygorenko, D. Volochnyuk, 2009 .

An approach to alicyclic ring-fused xanthines

A. Tolmachev, O. Grygorenko, Kostiantyn Liubchak, 2012 .

The catalytic asymmetric α-benzylation of aldehydes.

I. Komarov, Philip S. J. Kaib, O. Grygorenko, 2014, Angewandte Chemie.

1-Alkyl-5-((di)alkylamino) tetrazoles: building blocks for peptide surrogates.

I. Komarov, O. Grygorenko, D. Volochnyuk, 2012, The Journal of organic chemistry.

Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition.

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2018, Organic & biomolecular chemistry.

Trifluoromethyl-substituted cyclopropanes

I. Komarov, O. Grygorenko, Pavel K. Mykhailiuk, 2011 .

O -(α-Phenylethyl)hydroxylamine as a ‘chiral ammonia equivalent’: synthesis and resolution of 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids

O. Grygorenko, Y. Rassukana, Ihor Kleban, 2017 .

Approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines

O. Grygorenko, D. Volochnyuk, A. I. Subota, 2017 .

An approach to the synthesis of α,α,α - trisubstituted alkylhydrazine derivatives from carboxylic acids

O. Grygorenko, A. V. Tymtsunik, V. Moskvina, 2020 .

A bio-inspired approach to proline-derived 2,4-disubstituted oxazoles

I. B. Kulik, O. Grygorenko, D. Volochnyuk, 2018 .

Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4.

M. Platonov, C. Daniliuc, V. Hurmach, 2020, Journal of molecular structure.

An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates

O. Grygorenko, Eugeniy N. Ostapchuk, Artem Artemenko, 2017, Synthesis.

Synthesis of α-C-Stereochemically Pure Secondary Sulfonamides.

A. Tolmachev, O. Grygorenko, Serhii Zhersh, 2022, The Journal of organic chemistry.

Far away from flatland. Synthesis and molecular structure of di- and tri-hetera[3.3.n]propellanes - advanced analogues of morpholine/piperazine.

O. Grygorenko, Eugeniy N. Ostapchuk, B. Vashchenko, 2019, The Journal of organic chemistry.

Building the housane: diastereoselective synthesis and characterization of bicyclo[2.1.0]pentane carboxylic acids.

O. Grygorenko, B. Vashchenko, Rustam T. Iminov, 2019, The Journal of organic chemistry.

Multigram Synthesis of C4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Synthesis.

An approach to (4-fluoroalkyl-1-alkyl-1H-pyrazol-3-yl)methylamines

O. Grygorenko, D. M. Volochnyuk, Dmitry M. Volochnyuk, 2015 .

Reaction of hydrazones derived from electron-deficient ketones with Vilsmeier-Haack reagent

O. Grygorenko, D. M. Volochnyuk, S. Ivonin, 2014 .

Synthesis and chemical transformations of diazolyl α,α-difluoroacetates

A. Tolmachev, O. Grygorenko, Pavlo Khodakivskyi, 2020 .

Heterocyclizations of α-heteroatom-substituted organoboronates (microreview)

O. Grygorenko, Yevhen M. Ivon, 2020, Chemistry of Heterocyclic Compounds.

Saturated boronic acids, boronates, and trifluoroborates: an update on their synthetic and medicinal chemistry.

O. Grygorenko, D. Volochnyuk, Alina O. Gorlova, 2021, Chemistry.

Transition Metal‐free gem ‐difluorocyclopropanation of Alkenes with CF 3 SiMe 3 −NaI System: a Recipe for Electron‐deficient Substrates

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Advanced Synthesis & Catalysis.

Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico‐Chemical Properties

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2021 .

Conformational behavior of peptides containing residues of 3-azetidinesulfonic (3AzeS) and 4-piperidinemethanesulfonic (4PiMS) acids

A. Tolmachev, O. Shishkin, O. Grygorenko, 2014 .

The Boron-Wittig Olefination of Aldehydes and Ketones with Bis[(pinacolato)boryl]methane: an Extended Reaction Scope

A. Tolmachev, O. Grygorenko, Yuliya O. Kuchkovska, 2019, European Journal of Organic Chemistry.

Saturated Bicyclic Sultams

O. Grygorenko, B. Vashchenko, Serhii Zhersh, 2020 .

An approach to 2-cyanopyrrolidines bearing a chiral auxiliary

I. Komarov, O. Grygorenko, P. K. Mikhailiuk, 2007 .

Photochemical [2 + 2] cycloaddition of alkenyl boronic derivatives: an entry into 3-azabicyclo[3.2.0]heptane scaffold.

I. Komarov, O. Grygorenko, B. Vashchenko, 2020, The Journal of organic chemistry.

[2+2]-Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes.

A. Tolmachev, O. Grygorenko, Pavel K. Mykhailiuk, 2018, The Journal of organic chemistry.

Synthesis of enantiopure (R,R)- and (S,S)-cis-2,3-propanoprolines

I. Komarov, O. Grygorenko, U. Groth, 2010 .

Stereoselective synthesis of 2,4-methanoproline homologues

R. Zubatyuk, I. Komarov, O. Shishkin, 2006 .

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Amino Acids.

Emerging building blocks for medicinal chemistry: recent synthetic advances

O. Grygorenko, D. Volochnyuk, B. Vashchenko, 2021, European Journal of Organic Chemistry.

Fluorinated Cycloalkyl Building Blocks for Drug Discovery

O. Grygorenko, Kostiantyn P. Melnykov, Oleksandr P. Demchuk, 2022, ChemMedChem.

Intramolecular functional group differentiation as a strategy for the synthesis of bridged bicyclic β-amino acids

I. Komarov, O. Grygorenko, A. V. Tymtsunik, 2016 .

Synthesis of Boc-protected 4,5-methano-β-proline

I. Komarov, O. Grygorenko, A. V. Tymtsunik, 2014 .

Confining the χ space of basic natural amino acids: cyclobutane-derived χ1,χ2-constrained analogues of arginine, lysine and ornithine

M. Dathe, I. Komarov, Oleg M. Michurin, 2013 .

1-(Trimethylsilyl)vinyl MIDA Boronate: A Trifunctional C2 Building Block

O. Grygorenko, Z. Voitenko, Yevhen M. Ivon, 2018 .

Synthesis of sp3-Enriched β-Fluoro Sulfonyl Chlorides

O. Grygorenko, Kostiantyn P. Melnykov, Alexey V. Dobrydnev, 2020, Synthesis.

Cyclopropylation of heterocyclic cores using cyclopropylboronic derivatives (microreview)

O. Grygorenko, O. V. Hryshchuk, O. Hryshchuk, 2020, Chemistry of Heterocyclic Compounds.

Improved Synthesis of Monoprotected 5- and 6-Amino-2-azanorbornanes

O. V. Manoylenko, A. Tolmachev, O. Shishkin, 2011 .

Expanding the chemical space of sp3-enriched 4,5-disubstituted oxazoles via synthesis of novel building blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Chemistry of Heterocyclic Compounds.

Synthesis of trans-disubstituted pyrazolylcyclopropane building blocks

O. Grygorenko, S. Ryabukhin, Oleksiy S. Artamonov, 2016, Monatshefte für Chemie - Chemical Monthly.

Synthesis of a 2,5-Diazabicyclo[2.2.1]heptane-Derived α,β-Diamino Acid

I. Komarov, O. Shishkin, O. Grygorenko, 2015, Synthesis.

Reaction of hydrazones derived from active methylene compounds with Vilsmeier–Haack reagent

O. Grygorenko, D. M. Volochnyuk, S. Ivonin, 2014, Monatshefte für Chemie - Chemical Monthly.

Synthesis of 3-Azabicyclo[3.2.0]heptane-Derived Building Blocks via [3+2] Cycloaddition

Oleg M. Michurin, O. Grygorenko, D. Radchenko, 2018, European Journal of Organic Chemistry.

An entry into hexahydro-2H-thieno[2,3-c]pyrrole 1,1-dioxide derivatives.

A. Tolmachev, I. Komarov, O. Shishkin, 2011, The Journal of organic chemistry.

Toward lead-oriented synthesis: one-pot version of Castagnoli condensation with nonactivated alicyclic anhydrides.

O. Grygorenko, S. Ryabukhin, Eugeniy N. Ostapchuk, 2014, ACS combinatorial science.

Synthesis of conformationally restricted glutamic acid analogs based on the spiro[3.3]heptane scaffold

I. Komarov, O. Grygorenko, D. Radchenko, 2008 .

3-Carboxy-/3-Aminobicyclo[1.1.1]pentane-Derived Sulfonamides and Sulfonyl Fluorides - Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery

I. Komarov, O. Grygorenko, S. O. Kokhan, 2020 .

Hetaryl-substituted bicyclo[1.1.1]pentanes (microreview)

O. Grygorenko, S. O. Kokhan, 2019, Chemistry of Heterocyclic Compounds.

(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library.

Yurii S. Moroz, M. Platonov, S. Zozulya, 2018, ACS combinatorial science.

SAR by Space: Enriching Hit Sets from the Chemical Space

Christian Lemmen, Franca-Maria Klingler, Marcus Gastreich, 2019, Molecules.

Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates

O. Grygorenko, Y. Rassukana, Ihor Kleban, 2020 .

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Amino Acids.

Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening

M. Platonov, S. Zozulya, O. Grygorenko, 2013, Acta Naturae.

Effect of gem-difluorination on the key physicochemical properties relevant to medicinal chemistry: the case of functionalized cycloalkanes.

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2022, Chemistry.

(Het)aryl Difluoromethyl-Substituted β-Alkoxyenones: Synthesis and Heterocyclizations

O. Grygorenko, I. Kondratov, B. Vashchenko, 2020 .

Screening of Palladium/Charcoal Catalysts for Hydrogenation of Diene Carboxylates with Isolated-Rings (Hetero)aliphatic Scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2023, Molecules.

Heterocyclizations of β-alkoxy, β-diaminoalkyl, and related β-functionalized enones (enals) with NCN-binucleophiles

O. Grygorenko, B. Vashchenko, Oleksandr Stepaniuk, 2022, Ukr. Bioorg. Acta 2022, Vol. 17, N1.

Synthesis of three-dimensional fused and spirocyclic oxygen-containing cyclobutanone derivatives

O. Grygorenko, S. Ryabukhin, Dmitriy A. Sibgatulin, 2014 .

Synthesis of 1,3-bifunctional cyclobutane derivatives with α-CHF2/CF3 group – advanced building blocks for medicinal chemistry

O. Grygorenko, I. Kondratov, Anton A. Homon, 2022, Journal of Fluorine Chemistry.

Expanding the Chemical Space of 1,2-Difunctionalized Cyclobutanes.

O. Grygorenko, D. Volochnyuk, Anton V. Chernykh, 2023, The Journal of organic chemistry.

Synthesis of bridged 1,4-diazepane derivatives via Schmidt reactions

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2010 .

N-Alkylhydrazones of aliphatic ketones in the synthesis of 1,3,4-trisubstituted non-symmetric pyrazoles

O. Grygorenko, Dmitry M. Volochnyuk, E. Rusanov, 2014 .

Organosilicon Compounds as Water Scavengers in Reactions of Carbonyl Compounds

O. Grygorenko, S. Ryabukhin, Sergey V. Ryabukhin, 2010 .

3-((Hetera)cyclobutyl)azetidines, "Stretched" Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery.

C. Daniliuc, O. Grygorenko, Anton V. Chernykh, 2019, The Journal of organic chemistry.

Enamine Ltd.: The Science and Business of Organic Chemistry and Beyond

O. Grygorenko, 2021, European Journal of Organic Chemistry.

Recent advances in (hetero)cyclizations of N-vinylazoles (microreview)

O. Grygorenko, Pavel S. Nosik, 2019, Chemistry of Heterocyclic Compounds.

Conformationally restricted nonchiral pipecolic acid analogues.

I. Komarov, O. Grygorenko, D. Radchenko, 2009, Journal of Organic Chemistry.

Multigram Synthesis of α‐ and γ‐((Hetera)cyclo)alkylpyridines through α‐Arylation of (Hetero)aliphatic Nitriles

O. Grygorenko, K. Nazarenko, Oleksandr S. Liashuk, 2023, European Journal of Organic Chemistry.

A chiral tricyclic proline analogue obtained from camphor

I. Komarov, O. Grygorenko, M. Gorichko, 2002 .

Beyond the Five and Six: Evaluation of Seven-Membered Cyclic Anhydrides in the Castagnoli-Cushman Reaction.

O. Grygorenko, S. Ryabukhin, Mykhailo I. Adamovskyi, 2017, Organic letters.

Multigram Synthesis of Functionalized Spirocyclic Diazirines

O. Grygorenko, Oleksandr V. Martyloga, Yuliya O. Kuchkovska, 2019, European Journal of Organic Chemistry.

Synthesis of Spirocyclic and Fused Isoxazoline Building Blocks

O. Grygorenko, D. Volochnyuk, B. Vashchenko, 2023, Annalen der Pharmacie.

The Synthesis and Acid-base Properties of α-(Fluoromethyl)- and α-(Difluoromethyl)-substituted Cyclobutane Building Blocks

O. Grygorenko, Oleksandr Demchuk, 2023, Journal of Organic and Pharmaceutical Chemistry.

Two‐Step Synthesis of Trisubstituted Trifluoromethyl Cyclopropanes Using in situ Generated CF3CHN2

O. Grygorenko, Oleksandr S. Liashuk, Pavel S. Nosik, 2023, ChemistrySelect.

Saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties (microreview)

O. Grygorenko, Kostiantyn P. Melnykov, 2019, Chemistry of Heterocyclic Compounds.

4-Fluoro-2,4-methanoproline.

A. N. Tkachenko, I. Komarov, O. Grygorenko, 2009, Organic letters.

Novel approach to saturated amino acid derivatives with isolated (hetero)cyclic rings via the hydrogenation of dienes

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2023, Chemistry of Heterocyclic Compounds.

Chemistry in Ukraine

M. Kovalenko, O. Grygorenko, R. Lampeka, 2024, Chemical record.

Chemoselective Reactions of Functionalized Sulfonyl Halides.

O. Grygorenko, Oleksandr S. Liashuk, Vladyslav A Andriashvili, 2023, Chemical record.

An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries.

Yurii S. Moroz, M. Platonov, V. Hurmach, 2018, ACS combinatorial science.

Regioselective synthesis of isoxazole and 1,2,4-oxadiazole-derived phosphonates via [3 + 2] cycloaddition.

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2018, Organic & biomolecular chemistry.

Synthesis and Physicochemical Evaluation of Tetrafluorinated GABA Analogue

O. Grygorenko, Oleksandr S. Liashuk, Vitaliy A. Bilenko, 2024, Journal of Fluorine Chemistry.

Generating Multibillion Chemical Space of Readily Accessible Screening Compounds

Yurii S. Moroz, O. Grygorenko, D. Radchenko, 2020, iScience.

Bicyclic conformationally restricted diamines.

A. Tolmachev, I. Komarov, O. Grygorenko, 2011, Chemical reviews.

Synthesis and enzymatic resolution of novel analogs of alicyclic and heterocyclic mandelic acid derivatives

O. Grygorenko, O. B. Smolii, B. Vashchenko, 2024, Tetrahedron.

Parallel Minisci Reaction of gem-Difluorocycloalkyl Building Blocks

O. Grygorenko, Kostiantyn P. Melnykov, S. Kolotilov, 2024, ACS organic & inorganic Au.

Reactions of cyclic β-alkoxyvinyl α-keto esters with heteroaromatic NCC-binucleophiles

A. Tolmachev, O. Grygorenko, I. Kondratov, 2020, Chemistry of Heterocyclic Compounds.

Insights into Modeling Approaches in Chemistry: Assessing Ligand‐Protein Binding Thermodynamics Based on Rigid‐Flexible Model Molecules

I. Komarov, O. Grygorenko, V. Bugrov, 2023, Chemical record.

Mono- and Difluorinated Saturated Heterocyclic Amines for Drug Discovery: Systematic Study of Their Physicochemical Properties.

S. Shishkina, O. Grygorenko, D. Volochnyuk, 2023, Chemistry.

Fluorinated building blocks in drug design: new pathways and targets.

O. Grygorenko, Kostiantyn P. Melnykov, 2024, Future medicinal chemistry.

Impact of Fluoroalkyl Substituents on Physicochemical Properties of Saturated Heterocyclic Amines.

O. Grygorenko, Kostiantyn P. Melnykov, Yuliya O. Kuchkovska, 2022, Chemistry.