S. Ryabukhin

发表

The symbiotic relationship between drug discovery and organic chemistry.

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2020, Chemistry.

Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks.

N. A. Tolmacheva, C. Daniliuc, O. Grygorenko, 2019, The Journal of organic chemistry.

Fluoral Hydrate: A Perspective Substrate for the Castagnoli–Cushman Reaction

D. Volochnyuk, S. Ryabukhin, Mykhailo I. Adamovskyi, 2020, ACS omega.

Last of the gem ‐Difluorocycloalkanes 2: Synthesis of Fluorinated Cycloheptane Building Blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2021 .

Recyclizations of 3-Formylchromones with Binucleophiles

O. Grygorenko, S. Ryabukhin, A. S. Plaskon, 2012 .

Protecting Group Free Synthesis of Carboxyl‐substituted Dihydropyrimidines Through Biginelli Reaction

A. Tolmachev, O. Grygorenko, S. Ryabukhin, 2013 .

Acyl pyruvates as synthons in the Biginelli reaction

A. Tolmachev, O. Shishkin, O. Grygorenko, 2010 .

Application of chlorotrimethylsilane in Pictet–Spengler reaction

A. Tolmachev, S. Ryabukhin, A. S. Plaskon, 2012, Monatshefte für Chemie - Chemical Monthly.

In Vitro Evaluation of In Silico Screening Approaches in Search for Selective ACE2 Binding Chemical Probes

D. Horvath, A. Varnek, O. Klimchuk, 2022, Molecules.

Scalable and Straightforward Synthesis of All Isomeric (Cyclo)alkylpiperidines

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

Neuromodulation by selective angiotensin-converting enzyme 2 inhibitors

D. Volochnyuk, S. Ryabukhin, Anton V. Chernykh, 2022, Neuroscience.

Neuromodulation by selective angiotensin-converting enzyme 2 inhibitors

D. Volochnyuk, S. Ryabukhin, Anton V. Chernykh, 2022, Neuroscience.

Combinatorial synthesis of chemical building blocks 1. Azomethines

A. Tolmachev, S. Ryabukhin, A. S. Plaskon, 2012, Molecular Diversity.

A synthesis of 5-hetaryl-3-(2-hydroxybenzoyl)pyrroles

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008 .

N -Difluorocyclopropyl-Substituted Pyrazoles: Synthesis and Reactivity

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

Synthesis of 1-hetaryl-2,2-difluorocyclopropane-derived building blocks: The case of pyrazoles

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Journal of Fluorine Chemistry.

Formation of 10/12/14-Membered Rings is Favored over 5/6/7-Membered. An Unexpected Result from Oxazole Chemistry

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, European Journal of Organic Chemistry.

In-situ formation of NixB/MIL-101(Cr) and Pd/MIL-101(Cr) composites for catalytic hydrogenation of quinoline

D. Volochnyuk, S. Ryabukhin, K. Gavrilenko, 2020 .

Modern Approaches to the Creation of Immobilized Metal-Complex Catalysts for Hydrogenation, Alkene Metathesis, and Cross-Coupling Processes: A Review

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2020, Theoretical and Experimental Chemistry.

Selective α-Methylation of Ketones.

D. Volochnyuk, S. Ryabukhin, Yaroslav O. Chuchvera, 2021, The Journal of organic chemistry.

Facile One-Pot Synthesis of 1,2,3,4-Tetrahydroquinoline-3-carboxylic Acids and Their Heterocyclic Analogs

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008 .

3-haloquinolines by Friedländer reaction of α-haloketones.

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2011, The Journal of organic chemistry.

Approach to the library of fused pyridine-4-carboxylic acids by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles.

A. Tolmachev, O. Grygorenko, D. Volochnyuk, 2010, Journal of combinatorial chemistry.

3‐Formylchromones in Guareschi Synthesis of 5‐(2‐Hydroxybenzoyl)‐2‐pyridones.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2004 .

Straightforward Synthesis of Functionalized 4,5,6,7‐Tetrahydro‐pyrazolo[1,5‐a]pyrazines – Important Building Blocks for Medicinal Chemistry

D. Volochnyuk, S. Ryabukhin, K. Gavrilenko, 2022, ChemistrySelect.

Electrochemical Scaled‐up Synthesis of Cyclic Enecarbamates as Starting Materials for Medicinal Chemistry Relevant Building Bocks

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2020 .

Semi-Industrial Fluorination of β-Keto Esters with SF4: Safety vs Efficacy

D. Volochnyuk, S. Ryabukhin, S. Semenov, 2020, Synlett.

Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, ACS omega.

Gram-Scale Synthesis of Amines Bearing a gem-Difluorocyclopropane Moiety

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2017 .

An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Journal of Fluorine Chemistry.

Chlorotrimethylsilane-Promoted Condensation of Ketones and Aminoazoles

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2012 .

CF3-substituted 1,3-dicarbonyl compounds in the Biginelli reaction promoted by chlorotrimethylsilane

A. Tolmachev, O. Shishkin, D. Volochnyuk, 2008 .

Approach to the library of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a three-component condensation.

O. Grygorenko, S. Ryabukhin, A. S. Plaskon, 2012, ACS combinatorial science.

Aminoheterocycles as synthons for combinatorial Biginelli reactions

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2011, Molecular Diversity.

Cu-Catalyzed Pyridine Synthesis via Oxidative Annulation of Cyclic Ketones with Propargylamine.

D. Volochnyuk, S. Ryabukhin, A. Lytvynenko, 2021, Journal of Organic Chemistry.

Evolution of commercially available compounds for HTS.

Alexandre Varnek, Dragos Horvath, Olena Savych, 2019, Drug discovery today.

Practical Synthetic Method for Functionalized 1-Methyl-3/5-(trifluoromethyl)-1H-pyrazoles

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2020 .

Synthesis of gem-difluorocyclopentane/hexane building blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2017 .

Catalytic Oxidation of Benzoins by Hydrogen Peroxide on Nanosized HKUST-1: Influence of Substituents on the Reaction Rates and DFT Modeling of the Reaction Path

D. Volochnyuk, S. Ryabukhin, K. Gavrilenko, 2023, Molecules.

N‐Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1‐Alkyl‐, N1‐Aryl‐, and N1,N3‐Dialkyl‐3,4‐dihydropyrimidin‐2(1H)‐(thi)ones.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

N-Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1-Alkyl-, N1-Aryl-, and N1,N3-Dialkyl-3,4-Dihydropyrimidin-2(1H)-(thi)ones

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

Chlorotrimethylsilane‐Promoted Condensation of Ketones and Aminoazoles.

V. S. Naumchik, A. Tolmachev, O. Grygorenko, 2013 .

Organosilicon Compounds asWater Scavengers in Reactions of Carbonyl Compounds

Dmitriy M. Volochnyuk, O. Grygorenko, D. Volochnyuk, 2009 .

A one-step fusion of 1,3-thiazine and pyrimidine cycles.

A. Tolmachev, O. Shishkin, D. Volochnyuk, 2007, Organic letters.

CF3‐Substituted 1,3‐Dicarbonyl Compounds in the Biginelli Reaction Promoted by Chlorotrimethylsilane.

A. Tolmachev, O. Shishkin, D. Volochnyuk, 2008 .

Chlorotrimethylsilane-Mediated Synthesis of 2-Aryl-1-chloro-1-heteroarylalkenes

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

Chlorotrimethylsilane-Mediated Synthesis of Functionalized 2-(2-Hydroxybenzoyl)pyrido[1,2-a]benzimidazoles

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

Chlorotrimethylsilane-Mediated Synthesis of Functionalized Fused Pyridines: Reaction of 3-Formylchromones with Electron-Rich Aminoheterocycles

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

High throughput synthesis of extended pyrazolo[3,4-d]dihydropyrimidines.

A. Tolmachev, S. Ryabukhin, Y. Volovenko, 2012, ACS combinatorial science.

Heterocyclic Ortho-Aminocarbonyl Compounds in the Friedländer Reaction Promoted by Chlorotrimethylsilane

V. S. Naumchik, A. Tolmachev, D. Volochnyuk, 2007 .

Synthesis of pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones

S. Ryabukhin, O. Lukin, Dmitry S. Granat, 2014 .

Combinatorial Knoevenagel reactions.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007, Journal of combinatorial chemistry.

Synthesis of Fused Imidazoles and Benzothiazoles from (Hetero)aromatic ortho‐Diamines of ortho‐Aminothiophenol and Aldehydes Promoted by Chlorotrimethylsilane.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007 .

Synthesis of Fused Imidazoles and Benzothiazoles from (Hetero)Aromatic ortho-Diamines or ortho-Aminothiophenol and Aldehydes Promoted by Chlorotrimethylsilane

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2006 .

Dry HCl in parallel synthesis of fused pyrimidin-4-ones.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008, Journal of combinatorial chemistry.

Multigram Synthesis of C4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Synthesis.

Transition Metal‐free gem ‐difluorocyclopropanation of Alkenes with CF 3 SiMe 3 −NaI System: a Recipe for Electron‐deficient Substrates

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Advanced Synthesis & Catalysis.

Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines

Andrii Hrebonkin, D. Volochnyuk, S. Ryabukhin, 2021 .

One-pot synthesis of β-imidazolylpropionamides

A. Tolmachev, S. Ryabukhin, Dmitry S. Granat, 2008 .

Synthesis of quinolines from 3-formylchromone.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008, The Journal of organic chemistry.

One-pot synthesis of 2,3-dihydro-1H-benzimidazoles.

A. Tolmachev, S. Ryabukhin, D. M. Volochnyuk, 2007, The Journal of organic chemistry.

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Amino Acids.

Multi-faceted Commercially Sourced Pd-Supported Reduction: A View from Practical Experience

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2022, Journal of Organic and Pharmaceutical Chemistry.

A facile synthesis of unsymmetrical ureas

A. Tolmachev, S. Ryabukhin, O. Lukin, 2011 .

Expanding the chemical space of sp3-enriched 4,5-disubstituted oxazoles via synthesis of novel building blocks

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2019, Chemistry of Heterocyclic Compounds.

Synthesis of trans-disubstituted pyrazolylcyclopropane building blocks

O. Grygorenko, S. Ryabukhin, Oleksiy S. Artamonov, 2016, Monatshefte für Chemie - Chemical Monthly.

Trifluoromethyl Vinamidinium Salt as a Promising Precursor for Fused β-Trifluoromethyl Pyridines.

D. Volochnyuk, S. Ryabukhin, E. Rusanov, 2023, The Journal of organic chemistry.

Catalytic Reductive Amination of Aromatic Aldehydes on Co-Containing Composites

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2023, Chemistry.

Toward lead-oriented synthesis: one-pot version of Castagnoli condensation with nonactivated alicyclic anhydrides.

O. Grygorenko, S. Ryabukhin, Eugeniy N. Ostapchuk, 2014, ACS combinatorial science.

Efficient Route for the Synthesis of Diverse Heteroannelated 5-Cyanopyridines

Andrii Hrebonkin, D. Volochnyuk, S. Ryabukhin, 2020, Synthesis.

Modelling of an autonomous Nav1.5 channel system as a part of in silico pharmacology study

M. Platonov, V. Hurmach, D. Volochnyuk, 2021, Journal of Molecular Modeling.

Catalysis and Multi-Component Reactions

O. V. Koryakova, M. Khorasani, D. Dorsch, 2011 .

A Close-up Look at the Chemical Space of Commercially Available Building Blocks for Medicinal Chemistry

Dragos Horvath, Gilles Marcou, Alexandre Varnek, 2021, J. Chem. Inf. Model..

Chlorotrimethylsilane-Mediated Friedländer Synthesis of Polysubstituted Quinolines

V. S. Naumchik, D. Volochnyuk, S. Ryabukhin, 2007 .

A conformationally restricted GABA analogue based on octahydro-1H-cyclopenta[b]pyridine scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2018, Amino Acids.

Effect of gem-difluorination on the key physicochemical properties relevant to medicinal chemistry: the case of functionalized cycloalkanes.

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2022, Chemistry.

Screening of Palladium/Charcoal Catalysts for Hydrogenation of Diene Carboxylates with Isolated-Rings (Hetero)aliphatic Scaffold

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2023, Molecules.

Air-Stable Efficient Nickel Catalyst for Hydrogenation of Organic Compounds

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2023, Catalysts.

Composites Based on Nanodispersed Nickel, Graphene-Like Carbon, and Aerosil for Catalytic Hydrogenation of Furfural and Quinoline

D. Volochnyuk, S. Ryabukhin, S. Kolotilov, 2020, Theoretical and Experimental Chemistry.

Synthesis of three-dimensional fused and spirocyclic oxygen-containing cyclobutanone derivatives

O. Grygorenko, S. Ryabukhin, Dmitriy A. Sibgatulin, 2014 .

Third Generation Buchwald Precatalysts with XPhos and RuPhos: Multigram Scale Synthesis, Solvent-Dependent Isomerization of XPhos Pd G3 and Quality Control by 1H- and 31P-NMR Spectroscopy

D. Volochnyuk, S. Ryabukhin, K. Gavrilenko, 2021, Molecules.

Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes

J. Hartwig, D. Volochnyuk, S. Ryabukhin, 2023, Nature Chemistry.

SynthI: A New Open-Source Tool for Synthon-Based Library Design

D. Horvath, A. Varnek, O. Klimchuk, 2021, J. Chem. Inf. Model..

Combinatorial synthesis of chemical building blocks 1. Azomethines

A. Tolmachev, S. Ryabukhin, A. S. Plaskon, 2012, Molecular Diversity.

Organosilicon Compounds as Water Scavengers in Reactions of Carbonyl Compounds

O. Grygorenko, S. Ryabukhin, Sergey V. Ryabukhin, 2010 .

SynthI: a new open-source tool for synthon-based library design

Dragos Horvath, Gilles Marcou, Alexandre Varnek, 2021 .

Synthesis of thieno[2,3-d]pyrimidin-2-ylmethanamine combinatorial library with four diversity points.

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2007, Journal of combinatorial chemistry.

Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents

D. Volochnyuk, S. Ryabukhin, A. Pashenko, 2023, Organic Process Research & Development.

Beyond the Five and Six: Evaluation of Seven-Membered Cyclic Anhydrides in the Castagnoli-Cushman Reaction.

O. Grygorenko, S. Ryabukhin, Mykhailo I. Adamovskyi, 2017, Organic letters.

A facile synthesis of imidazo[1,5-b]pyridazines from 3-formylchromones

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008 .

[3-(Dimethylamino)-2-(trifluoromethyl)prop-2-en-1-ylidene]dimethylazanium hexafluorophosphate – efficient reagent for the formation of trifluoromethyl-substituted azaheterocycles (microreview)

S. Ryabukhin, Andrey P. Mityuk, 2020, Chemistry of Heterocyclic Compounds.

Sulfo-Biginelli reaction: an insight into interaction between sulfamides and enolizable ketones

S. Shishkina, D. Volochnyuk, S. Ryabukhin, 2023, Chemistry of Heterocyclic Compounds.

Chlorotrimethylsilane mediated synthesis of 5-(2-hydroxybenzoyl)pyrimidines from 3-formylchromones

A. Tolmachev, D. Volochnyuk, S. Ryabukhin, 2008 .

Virtual Screening in Search for a Chemical Probe for Angiotensin-Converting Enzyme 2 (ACE2)

Dmytro V. Dudenko, D. Volochnyuk, S. Ryabukhin, 2021, Molecules.

Focused small molecule library of 5,6,7,8-tetrahydro[1,2,4]triazolo-[4,3-a]pyrazines: a brick for the house of medicinal chemistry

D. Volochnyuk, S. Ryabukhin, D. Lega, 2023, Chemistry of Heterocyclic Compounds.

Monosubstituted 3,3‐Difluorocyclopropenes as Bench‐Stable Reagents: Scope and Limitations

D. Volochnyuk, S. Ryabukhin, A. Rozhenko, 2021, European Journal of Organic Chemistry.

Catalytic reactions of epoxides and aziridines with carbon dioxide in the presence of salen-type complexes of 3d metals

D. Volochnyuk, S. Ryabukhin, K. Gavrilenko, 2023, Chemistry of Heterocyclic Compounds.

Novel approach to saturated amino acid derivatives with isolated (hetero)cyclic rings via the hydrogenation of dienes

O. Grygorenko, D. Volochnyuk, S. Ryabukhin, 2023, Chemistry of Heterocyclic Compounds.

Influence of bicyclic anhydride structure on the outcome of the Castagnoli–Cushman reaction

D. Volochnyuk, S. Ryabukhin, Kostiantyn P. Melnykov, 2023, Chemistry of Heterocyclic Compounds.