Ann Vos

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Preparing and Filtering Compound Databases for Virtual and Experimental Screening

J. Wegner, G. Tresadern, M. Cummings, 2011 .

Structure-based site of metabolism prediction for cytochrome P450 2D6.

Arnout Ceulemans, Maxwell D Cummings, Samuel L. C. Moors, 2011, Journal of medicinal chemistry.

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

M. Cummings, B. Devogelaere, F. Pauwels, 2010, Journal of Virology.

Resistance Mutations in Human Immunodeficiency Virus Type 1 Integrase Selected with Elvitegravir Confer Reduced Susceptibility to a Wide Range of Integrase Inhibitors

K. Hertogs, Peggy Geluykens, Inge Vereycken, 2008, Journal of Virology.

Discovery of 3 ({5 Chloro-1 [3 (methylsulfonyl)propyl]-1H indol-2 yl}methyl)-1 (2,2,2 trifluoroethyl)-1,3 dihydro-2H imidazo[4,5-c]pyridin-2 one (JNJ-53718678), a potent and orally bioavailable fusion inhibitor of respiratory syncytial virus.

L. Kwanten, J. McLellan, D. Roymans, 2020, Journal of medicinal chemistry.

JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.

D. Moechars, K. Kusakabe, L. Leclercq, 2021, Journal of medicinal chemistry.

3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and permeable BACE-1 inhibitors.

Frederik J. R. Rombouts, Daniel Oehlrich, Ann Vos, 2020, Bioorganic & medicinal chemistry letters.

Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.

Sergio A Alonso de Diego, Michiel Van Gool, G. Macdonald, 2019, ACS medicinal chemistry letters.

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).

Bing Huang, Ann Vos, Karen Vergauwen, 2018, Journal of medicinal chemistry.

Minisci-Photoredox-Mediated α-Heteroarylation of N-Protected Secondary Amines: Remarkable Selectivity of Azetidines.

J. Edwards, H. Beucher, L. Meerpoel, 2018, Organic letters.

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

Ó. Delgado, Michiel Van Gool, J. M. Alonso, 2015, Journal of medicinal chemistry.

Preparation of 4'-Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds.

V. Pande, Jonas Verhoeven, Weimei Sun, 2019, Chemistry.

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

Maxwell D. Cummings, M. Cummings, R. Clayton, 2010, Proceedings of the National Academy of Sciences.

Antiviral profiling of the capsid assembly modulator BAY41‐4109 on full‐length HBV genotype A‐H clinical isolates and core site‐directed mutants in vitro

F. Pauwels, Ann Vos, O. Lenz, 2017, Antiviral research.

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

D. Bertrand, G. Tresadern, C. Ulens, 2015, Proceedings of the National Academy of Sciences.

Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches

G. Tresadern, A. Pineda-Lucena, D. Moechars, 2017, ACS omega.

Divide and Conquer. Pocket-Opening Mixed-Solvent Simulations in the Perspective of Docking Virtual Screening Applications for Drug Discovery

E. Jacoby, G. Tresadern, J. Harvey, 2022, J. Chem. Inf. Model..

Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

Chien‐Chi Hsiao, Frederik J. R. Rombouts, Ann Vos, 2021, European journal of medicinal chemistry.

Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.

José Luís Dores-Sousa, U. Philippar, L. Urner, 2023, Journal of medicinal chemistry.

Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties.

R. DesJarlais, H. Ceulemans, V. Chupakhin, 2021, Future medicinal chemistry.

A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.

Michiel Van Gool, G. Macdonald, G. Tresadern, 2021, ACS medicinal chemistry letters.

Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor.

K. Hertogs, M. Cummings, R. Clayton, 2011, Antiviral research.

Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles.

Dominique Schols, Kurt Hertogs, K. Hertogs, 2010, Virology.

Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1.

U. Philippar, L. Szewczuk, Frederik J. R. Rombouts, 2023, ACS medicinal chemistry letters.

Structure-based site of metabolism prediction for cytochrome P450 2D6.

Samuel L. C. Moors, H. V. van Vlijmen, M. Cummings, 2011, Journal of medicinal chemistry.