Yuan Chen

发表

Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.

A. Chan, Dik‐Lung Ma, J. Tang, 2007, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer's disease.

Zhishu Huang, Tian-Miao Ou, Jia-Heng Tan, 2011, Bioorganic & medicinal chemistry.

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).

Adam R. Johnson, S. Bromidge, Lawren C. Wu, 2013, Bioorganic & medicinal chemistry letters.

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.

Adam R. Johnson, Lawren C. Wu, C. Eigenbrot, 2014, Bioorganic & medicinal chemistry letters.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, ACS medicinal chemistry letters.

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment.

Y. Hu, Jiong Lan, Haiying He, 2017, Bioorganic & medicinal chemistry letters.

Tetrahydroindazoles as Interleukin-2 Inducible T-Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo.

P. McEwan, J. DeVoss, A. Zarrin, 2015, Journal of medicinal chemistry.

4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, Bioorganic & medicinal chemistry letters.

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Adam R. Johnson, P. McEwan, A. Zarrin, 2014, Journal of medicinal chemistry.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

J. DeVoss, A. Zarrin, Lawren C. Wu, 2015, Science Signaling.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2016, Journal of medicinal chemistry.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Belen Dominguez-Fernandez, C. Eigenbrot, Ivana Yen, 2015, Journal of medicinal chemistry.

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2014, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).

Adam R. Johnson, P. McEwan, A. Zarrin, 2014, Bioorganic & medicinal chemistry letters.

Synthesis, discovery and preliminary SAR study of benzofuran derivatives as angiogenesis inhibitors.

Hao Cheng, Yuan Chen, Xin Lu, 2009, Bioorganic & medicinal chemistry letters.